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公开(公告)号：US12129301B2
公开(公告)日：2024-10-29
申请号：US17932450
申请日：2022-09-15
发明人： Mitsuro Kanda
IPC分类号： C07K16/28 , A61K39/00 , A61P35/04 , C12N15/113 , G01N33/574
CPC分类号： C07K16/286 , A61P35/04 , C12N15/1138 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57438 , G01N33/57446 , G01N33/57492 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2310/141
摘要： From gene expression analysis with a long-term recurrence-free group and a recurrence metastasis group of stomach cancer, CHRNB2 and NPTXR were identified as drug discovery targets. Tumor growth was successfully inhibited by an antibody medicine or a nucleic acid medicine targeting CHRNB2 or NPTXR. Furthermore, a polyclonal antibody and a monoclonal antibody linking to CHRNB2 or NPTXR are provided. Since these receptor molecules are novel molecular targets, treatment of cases which the existing therapeutic drugs have no effect on is made possible.
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公开(公告)号：US12126141B2
公开(公告)日：2024-10-22
申请号：US17229875
申请日：2021-04-14
申请人： ASAHI KASEI KABUSHIKI KAISHA , National University Corporation Tokai National Higher Education and Research System
发明人： Ziyi Zhang , Maki Kushimoto , Chiaki Sasaoka , Hiroshi Amano
CPC分类号： H01S5/32308 , H01S5/0206 , H01S5/04256 , H01S5/2275 , H01S5/3215
摘要： A method of producing an ultraviolet laser diode with a low oscillation threshold current density includes stacking a first cladding layer, a light-emitting layer, and a second cladding layer on a substrate in this order to form a nitride semiconductor laminate (step S101), etching at least a portion of the nitride semiconductor laminate to form a mesa structure and setting the ratio between the length of the resonator end faces and the length of the side surfaces of the mesa structure in plan view between 1:5 and 1:500 (step S102), disposing first conductive material on a portion of a first area and applying heat treatment of 400° C. or higher to form a first electrode (step S103), and disposing a second conductive material in an area on the second cladding layer, at a distance of 5 μm or more from the side surfaces, to form a second electrode (step S104).
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公开(公告)号：US20240338867A1
公开(公告)日：2024-10-10
申请号：US18625365
申请日：2024-04-03
申请人： National University Corporation Tokai National Higher Education and Research System , CANON MEDICAL SYSTEMS CORPORATION
CPC分类号： G06T11/206 , G06T7/0012 , G06T7/11 , G06T2207/10088 , G06T2207/20021 , G06T2207/20092 , G06T2207/30016
摘要： An image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain pixel values of at least three Magnetic Resonance (MR) images of mutually-different types. The processing circuitry is configured to generate a scatter diagram in which values based on the pixel values are arranged in a region having at least three-dimensional axes and which displays a value group related to a target tissue in such a manner that a value group related to a specific target serving as a reference is always displayed in the same position, and then cause a display to display the scatter diagram.
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公开(公告)号：US20240325426A1
公开(公告)日：2024-10-03
申请号：US18575623
申请日：2022-06-30
申请人： KYOWA KIRIN CO., LTD. , National University Corporation Tokai National Higher Education and Research System
发明人： Hiroto Iwai , Masakazu HOMMA , Takayuki ATAGO , Junichiro YAMAMOTO , Hiroshi ABE , Yasuaki KIMURA
IPC分类号： A61K31/7125 , C07H21/02 , C07H21/04
CPC分类号： A61K31/7125 , C07H21/02 , C07H21/04
摘要： The present invention relates to a polynucleotide, containing a translated region from a start codon to a stop codon, a 5′ untranslated region, and a poly A chain, in which 65% or more of nucleotides contained in the poly A chain are sugar-modified nucleotides.
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5.发明公开公开(公告)号：US20240288453A1
公开(公告)日：2024-08-29
申请号：US18030534
申请日：2021-10-08
申请人： National University Corporation Tokai National Higher Education and Research System , PERSEUS PROTEOMICS INC.
发明人： Hitoshi KIYOI , Yuichi ISHIKAWA , Marie NAKASHIMA , Yuta OHIRA , Junpei OYA , Fumiko NOMURA , Keiko KATSUMI , Aya SAKAMOTO , Yoshinori UKAI , Tadashi MATSUURA
IPC分类号： G01N33/84 , C07K16/28 , G01N33/574
CPC分类号： G01N33/84 , C07K16/2881 , G01N33/57426 , C07K2317/34 , C07K2317/565 , C07K2317/76 , G01N2333/70582 , G01N2333/79 , G01N2800/52
摘要： It is an object of the present invention to provide a method for determining the medicinal effect or sensitivity of an anti-transferrin receptor antibody. According to the present invention, provided is a method for determining the medicinal effect or sensitivity of an anti-human transferrin receptor antibody having an action to inhibit the binding between human transferrin and a human transferrin receptor, wherein the method uses an intracellular iron content as an indicator.
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公开(公告)号：US20240288225A1
公开(公告)日：2024-08-29
申请号：US18572593
申请日：2022-06-24
申请人： CHUBU ELECTRIC POWER MIRAIZ CO., INC. , CHUBU ELECTRIC POWER CO., INC. , NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
发明人： Akihiro TAKEUCHI , Hideki KITA , Seiji YAMASHITA
IPC分类号： F28D21/00 , C04B35/117
CPC分类号： F28D21/0001 , C04B35/117 , C04B2235/6022 , C04B2235/9607
摘要： A ceramic heat storage body includes a shell that contains alumina as a main component and has an average absorbance larger than 0.3 at 1.7 μm to 2.7 μm, which is a center wavelength of radiant heat at 800° C. to 1400° C. In addition to alumina, the shell contains oxides containing Cr, Fe, Mn, and Co in an amount of 1 weight % or more in compound equivalent. Furthermore, the shell is a shell that has an outer surface in a shape of a spheroid including a sphere and internally has a hollow portion. Moreover, in the shell, during heat storage, a center temperature of a hollow portion is higher than an inner surface temperature of the shell.
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公开(公告)号：US12074253B2
公开(公告)日：2024-08-27
申请号：US18053057
申请日：2022-11-07
申请人： OSAKA UNIVERSITY , National University Corporation Tokai National Higher Education and Research System , NICHIA CORPORATION
发明人： Susumu Kuwabata , Taro Uematsu , Kazutaka Wajima , Tsukasa Torimoto , Tatsuya Kameyama , Daisuke Oyamatsu
CPC分类号： H01L33/26 , B82Y20/00 , B82Y40/00 , H01L33/005 , H01L33/50
摘要： Provided is a method of producing semiconductor nanoparticles that exhibit a band-edge emission, and are superior in quantum yield. The method includes raising the temperature of a first mixture containing a silver (Ag) salt, a salt containing at least one of indium (In) and gallium (Ga), a solid compound that serves as a supply source of sulfur (S), and an organic solvent to a temperature in a range of from 125 □C to 175 □C, and heat-treating, subsequent to the raising of the temperature, the first mixture at a temperature in a range of from 125 □C to 175 □C for three seconds or more to obtain a solution containing semiconductor nanoparticles, and decreasing the temperature of the solution containing semiconductor nanoparticles. The solid compound that serves as a supply source of S contains thiourea.
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8.发明公开公开(公告)号：US20240263174A1
公开(公告)日：2024-08-08
申请号：US17284597
申请日：2019-10-11
发明人： Yukihiro Akao , Hironobu Murase
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/141
摘要： To provide a strong candidate for prevention or treatment of a disease or disorder related to glucose metabolism, by discovering a substance capable of inducing the expression of the GLUT family. The followings are provided by some aspects of the present invention: an expression inducer of class I glucose transporter (GLUT) comprising, as an active ingredient, at least one oligonucleotide selected from the group consisting of hvu-miR168-3p and ata-miR168-5p, their precursors and their derivatives; a pharmaceutical composition and a food or beverage composition containing the expression inducer (for example, a composition for prevention or treatment (improvement) of a disease or disorder related to glucose metabolism).
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公开(公告)号：US20240209177A1
公开(公告)日：2024-06-27
申请号：US18510774
申请日：2023-11-16
申请人： TOYODA GOSEI CO., LTD. , NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
发明人： Yuki OKABE , Akishige SEO , Aya IKEDA , Toshiaki MURAI
IPC分类号： C08J11/28
CPC分类号： C08J11/28 , C08J2323/32
摘要： A method of desulfurizing sulfur-crosslinked rubber includes adding a radical precursor that generates a radical active species that acts on a sulfur bond in the sulfur-crosslinked rubber and cleaves the sulfur bond and a radical initiator for generating a radical for converting the radical precursor into the radical active species to the sulfur-crosslinked rubber and performing heating.
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公开(公告)号：US20240161940A1
公开(公告)日：2024-05-16
申请号：US18421726
申请日：2024-01-24
申请人： DENSO CORPORATION , National University Corporation Tokai National Higher Education and Research System
发明人： TAKAHISA YAMAMOTO , TOMOHARU TOKUNAGA , RYOTA KONO , KOUHEI HIEDA , YASUYUKI HIKITA , KAZUHIKO KANO
CPC分类号： H01B1/08 , H01B13/003
摘要： A conductive film includes a metal oxide as a main component. The metal oxide contains the same components as components of a compound represented by a formula (I):
(AO)2B6O11 (I)
where A in the formula (I) is a metal element capable of having a valence of +1 or +2, B in the formula (I) is a transition metal element capable of having a valence of +4 or +5, O in the formula (I) is an oxygen element, and an average valence of B in the formula (I) is less than the maximum oxidation number of B. The metal oxide has a crystal structure in which diffraction peaks in an X-ray diffraction pattern of the metal oxide appear at same diffraction angles as diffraction angles at which diffraction peaks in an X-ray diffraction pattern of the compound represented by the formula (I) appear.
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