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1.发明申请公开(公告)号：US20190153147A1
公开(公告)日：2019-05-23
申请号：US16195724
申请日：2018-11-19
IPC分类号： C08G18/40 , C08G18/44 , C08G18/61 , C08G18/32 , C08G18/66 , C08G18/65 , C08G18/76 , A61M25/01 , A61M25/00 , A61L29/06
摘要： An alcohol-resistant siliconized polycarbonate polyurethane can include a soft segment and a hard segment. The soft segment can include a polycarbonate polyol and a polysiloxane, which can be present in an amount less than the polycarbonate polyol. The hard segment can include an isocyanate and a chain extender. Peripherally inserted central catheter (PICC) devices can include one or more components that are at least partially formed from one or more formulations of the siliconized polycarbonate polyurethane catheter. The PICC devices can withstand alcohol locking, and can be power injectable both before and after alcohol locking events.
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2.发明授权公开(公告)号：US11746181B2
公开(公告)日：2023-09-05
申请号：US16195724
申请日：2018-11-19
IPC分类号： A61L29/06 , A61L29/16 , A61L29/18 , A61M25/00 , A61M25/01 , C08G18/32 , C08G18/40 , C08G18/44 , C08G18/61 , C08G18/65 , C08G18/66 , C08G18/76 , C08K3/30
CPC分类号： C08G18/4009 , A61L29/06 , A61L29/16 , A61L29/18 , A61M25/0054 , A61M25/0105 , C08G18/3206 , C08G18/44 , C08G18/61 , C08G18/6511 , C08G18/664 , C08G18/7664 , C08G18/7671 , C08K3/30 , A61L2300/404 , C08K3/30 , C08L75/04 , A61L29/06 , C08L75/04
摘要： An alcohol-resistant siliconized polycarbonate polyurethane can include a soft segment and a hard segment. The soft segment can include a polycarbonate polyol and a polysiloxane, which can be present in an amount less than the polycarbonate polyol. The hard segment can include an isocyanate and a chain extender. Peripherally inserted central catheter (PICC) devices can include one or more components that are at least partially formed from one or more formulations of the siliconized polycarbonate polyurethane catheter. The PICC devices can withstand alcohol locking, and can be power injectable both before and after alcohol locking events.
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公开(公告)号：US08734851B2
公开(公告)日：2014-05-27
申请号：US11414818
申请日：2006-05-01
CPC分类号： A61L31/16 , A61K48/0008 , A61K48/0041 , A61L31/10 , A61L2300/258 , A61L2300/61
摘要： The present invention provides implantable medical devices coated with polyelectrolyte assemblies that are fabricated by layer-by-layer deposition of nucleic acid and polycation. Such devices facilitate the local delivery of a nucleic acid contained in the polyelectrolyte assembly into a cell or tissue at an implantation site. Also provided are methods of fabricating and using implantable medical devices according to the invention.
摘要翻译： 本发明提供涂覆有聚电解质组件的可植入医疗装置，其通过核酸和聚阳离子的逐层沉积制造。 这样的装置有助于将聚电解质组合物中包含的核酸局部递送到植入部位的细胞或组织。 还提供了制造和使用根据本发明的可植入医疗装置的方法。
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