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1.发明授权公开(公告)号：US11746181B2
公开(公告)日：2023-09-05
申请号：US16195724
申请日：2018-11-19
IPC分类号： A61L29/06 , A61L29/16 , A61L29/18 , A61M25/00 , A61M25/01 , C08G18/32 , C08G18/40 , C08G18/44 , C08G18/61 , C08G18/65 , C08G18/66 , C08G18/76 , C08K3/30
CPC分类号： C08G18/4009 , A61L29/06 , A61L29/16 , A61L29/18 , A61M25/0054 , A61M25/0105 , C08G18/3206 , C08G18/44 , C08G18/61 , C08G18/6511 , C08G18/664 , C08G18/7664 , C08G18/7671 , C08K3/30 , A61L2300/404 , C08K3/30 , C08L75/04 , A61L29/06 , C08L75/04
摘要： An alcohol-resistant siliconized polycarbonate polyurethane can include a soft segment and a hard segment. The soft segment can include a polycarbonate polyol and a polysiloxane, which can be present in an amount less than the polycarbonate polyol. The hard segment can include an isocyanate and a chain extender. Peripherally inserted central catheter (PICC) devices can include one or more components that are at least partially formed from one or more formulations of the siliconized polycarbonate polyurethane catheter. The PICC devices can withstand alcohol locking, and can be power injectable both before and after alcohol locking events.
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公开(公告)号：US20100029802A1
公开(公告)日：2010-02-04
申请号：US12226508
申请日：2007-04-19
CPC分类号： C08G77/38 , A61K31/695 , A61L27/18 , A61L27/52 , A61L2400/06 , C08G18/10 , C08G18/61 , C08G18/8108 , C08G77/14 , C08G77/16 , C08G77/18 , C08G77/20 , C08G77/26 , C08G77/388 , C08G77/46 , C08G2220/00 , C08L83/04
摘要： The present invention relates to biostable gel comprising: (a) at least one silicon-containing polyol, polyamine, polyepoxy or polyisocyanate having 1 or more functional groups and a molecular weight of at least 20,000 which is cured in the presence of: (b) at least one diol, diamine or diisocyanate having a molecular weight of less than 10,000; and/or (c) an initiator, processes for their preparation and their use in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of asoft tissue implant such as breast implants and the repair of orthopaedic joints such as spinal discs.
摘要翻译： 本发明涉及生物稳定凝胶，其包含：（a）至少一种含硅多元醇，多胺，聚环氧或多异氰酸酯，其具有一个或多个官能团，分子量至少为20,000，其在以下存在下固化：（b） 至少一种分子量小于10,000的二醇，二胺或二异氰酸酯; 和/或（c）引发剂，其制备方法及其在制造和修复生物材料和医疗装置，制品或植入物中的用途，特别是软骨组织植入物如乳房植入物的制造和矫形关节的修复 作为脊椎盘。
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公开(公告)号：US20140323676A1
公开(公告)日：2014-10-30
申请号：US14148044
申请日：2014-01-06
IPC分类号： C08G77/38 , C08G77/388
CPC分类号： C08G77/38 , A61K31/695 , A61L27/18 , A61L27/52 , A61L2400/06 , C08G18/10 , C08G18/61 , C08G18/8108 , C08G77/14 , C08G77/16 , C08G77/18 , C08G77/20 , C08G77/26 , C08G77/388 , C08G77/46 , C08G2220/00 , C08L83/04
摘要： The present invention relates to biostable gel comprising: (a) at least one silicon-containing polyol, polyamine, polyepoxy or polyisocyanate having 1 or more functional groups and a molecular weight of at least 20,000 which is cured in the presence of: (b) at least one diol, diamine or diisocyanate having a molecular weight of less than 10,000; and/or (c) an initiator, processes for their preparation and their use in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of a soft tissue implant such as breast implants and the repair of orthopaedic joints such as spinal discs.
摘要翻译： 本发明涉及生物稳定凝胶，其包含：（a）至少一种含硅多元醇，多胺，聚环氧或多异氰酸酯，其具有一个或多个官能团，分子量至少为20,000，其在以下存在下固化：（b） 至少一种分子量小于10,000的二醇，二胺或二异氰酸酯; 和/或（c）引发剂，其制备方法及其在制造和修复生物材料和医疗装置，制品或植入物中的用途，特别是软组织植入物的制造，例如乳房植入物和修复矫形关节 如脊椎盘。
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公开(公告)号：US10730994B2
公开(公告)日：2020-08-04
申请号：US15735054
申请日：2016-06-08
IPC分类号： C08G18/61 , A61L31/06 , A61L15/26 , C08G64/02 , C08G64/30 , A61L27/18 , A61L29/06 , C08G64/18 , C08G77/448
摘要： The present invention provides silicon-based polycarbonates, processes for their preparation and their use in the synthesis of copolymers, in particular segmented copolymers such as polyurethanes for biomedical applications.
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公开(公告)号：US08623986B2
公开(公告)日：2014-01-07
申请号：US12226508
申请日：2007-04-19
CPC分类号： C08G77/38 , A61K31/695 , A61L27/18 , A61L27/52 , A61L2400/06 , C08G18/10 , C08G18/61 , C08G18/8108 , C08G77/14 , C08G77/16 , C08G77/18 , C08G77/20 , C08G77/26 , C08G77/388 , C08G77/46 , C08G2220/00 , C08L83/04
摘要： The present invention relates to biostable gel comprising: (a) at least one silicon-containing polyol, polyamine, polyepoxy or polyisocyanate having 1 or more functional groups and a molecular weight of at least 20,000 which is cured in the presence of: (b) at least one diol, diamine or diisocyanate having a molecular weight of less than 10,000; and/or (c) an initiator, processes for their preparation and their use in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of a soft tissue implant such as breast implants and the repair of orthopaedic joints such as spinal discs.
摘要翻译： 本发明涉及生物稳定凝胶，其包含：（a）至少一种含硅多元醇，多胺，聚环氧或多异氰酸酯，其具有一个或多个官能团，分子量至少为20,000，其在以下存在下固化：（b） 至少一种分子量小于10,000的二醇，二胺或二异氰酸酯; 和/或（c）引发剂，其制备方法及其在制造和修复生物材料和医疗装置，制品或植入物中的用途，特别是软组织植入物的制造，例如乳房植入物和修复矫形关节 如脊椎盘。
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公开(公告)号：US08207245B2
公开(公告)日：2012-06-26
申请号：US11663870
申请日：2005-09-28
IPC分类号： A61F2/00 , C08F283/12 , C08G18/61 , C08G77/452 , C08G77/14 , C08G77/458
CPC分类号： C08G77/46 , A61L27/18 , A61L27/52 , C07F7/0838 , C08G18/283 , C08G18/3284 , C08G18/61 , C08G77/442 , C08G77/445 , C08G77/458 , C08L83/04
摘要： The present invention relates to silicon-containing biostable gels and processes for their preparation. The gels possess properties which make them useful in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of soft tissue implants such as breast implants and the repair of orthopaedic joints such as spinal discs.
摘要翻译： 本发明涉及含硅生物稳定凝胶及其制备方法。 凝胶具有使其在生物材料和医疗装置，制品或植入物的制造和修复中有用的特性，特别是制造软组织植入物例如乳房植入物以及修复诸如脊椎盘的矫形关节。
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公开(公告)号：US20080293844A1
公开(公告)日：2008-11-27
申请号：US11663870
申请日：2005-09-28
CPC分类号： C08G77/46 , A61L27/18 , A61L27/52 , C07F7/0838 , C08G18/283 , C08G18/3284 , C08G18/61 , C08G77/442 , C08G77/445 , C08G77/458 , C08L83/04
摘要： The present invention relates to silicon-containing biostable gels and processes for their preparation. The gels possess properties which make them useful in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of soft tissue implants such as breast implants and the repair of orthopaedic joints such as spinal discs.
摘要翻译： 本发明涉及含硅生物稳定凝胶及其制备方法。 凝胶具有使其在生物材料和医疗装置，制品或植入物的制造和修复中有用的特性，特别是制造软组织植入物例如乳房植入物以及修复诸如脊椎盘的矫形关节。
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公开(公告)号：US08882832B2
公开(公告)日：2014-11-11
申请号：US13557580
申请日：2012-07-25
IPC分类号： A61F2/12
CPC分类号： A61F2/12 , A61F2/0059 , A61F2250/0003 , A61F2250/0015 , A61L27/18 , A61L27/56 , A61L2430/04 , C08L83/04
摘要： The invention relates to an implantable prosthesis and a shell for an implantable prosthesis and methods for making them, in particular a light weight implantable prosthesis containing a biocompatible filler which is suitable for use as a breast implant.
摘要翻译： 本发明涉及可植入假体和用于可植入假体的外壳，以及用于制造它们的方法，特别是包含适合用作乳房植入物的生物相容性填充物的轻质可植入假体。
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9.发明申请公开(公告)号：US20190153147A1
公开(公告)日：2019-05-23
申请号：US16195724
申请日：2018-11-19
IPC分类号： C08G18/40 , C08G18/44 , C08G18/61 , C08G18/32 , C08G18/66 , C08G18/65 , C08G18/76 , A61M25/01 , A61M25/00 , A61L29/06
摘要： An alcohol-resistant siliconized polycarbonate polyurethane can include a soft segment and a hard segment. The soft segment can include a polycarbonate polyol and a polysiloxane, which can be present in an amount less than the polycarbonate polyol. The hard segment can include an isocyanate and a chain extender. Peripherally inserted central catheter (PICC) devices can include one or more components that are at least partially formed from one or more formulations of the siliconized polycarbonate polyurethane catheter. The PICC devices can withstand alcohol locking, and can be power injectable both before and after alcohol locking events.
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公开(公告)号：US20180179324A1
公开(公告)日：2018-06-28
申请号：US15735054
申请日：2016-06-08
摘要： The present invention provides silicon-based polycarbonates, processes for their preparation and their use in the synthesis of copolymers, in particular segmented copolymers such as polyurethanes for biomedical applications.
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