摘要:
A method of connecting three-dimensional structured meshes to form a conformal mesh, for solutions of flow problems, including: forming an interface by overlaying surfaces of two structured meshes; defining an interface set of mesh points in the interface; merging mesh points in the interface set that are within a predetermined distance of each other and projecting mesh points of one mesh in the interface that are within a predetermined distance of a line of the other mesh; generating an interface layer in the form of an unstructured mesh; and inserting a node at the center of each hexahedra, and producing an unstructured layer of cells between the two structured meshes by joining the nodes to the mesh points of the interface layer.
摘要:
A method of connecting three-dimensional structured meshes to form a conformal mesh, for solutions of flow problems, including: forming an interface by overlaying surfaces of two structured meshes; defining an interface set of mesh points in the interface; merging mesh points in the interface set that are within a predetermined distance of each other and projecting mesh points of one mesh in the interface that are within a predetermined distance of a line of the other mesh; generating an interface layer in the form of an unstructured mesh; and inserting a node at the centre of each hexahedra, and producing an unstructured layer of cells between the two structured meshes by joining the nodes to the mesh points of the interface layer.
摘要:
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要:
It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.
摘要:
A microfluidic viscometer measures the viscosity of a microliter-volume fluid sample using a microfluidic chip having a microchannel with a high aspect ratio (˜10), allowing the microflow therein to be approximated as a rectangular slit flow. The microfluidic chip is fabricated by stacking rigid sheet materials that can be laser cut to specified shapes and sizes. The microchannel, rendered smooth and hydrophobic by a repellant coating, provides a straight flow path for the sample to approach flow equilibrium as it moves through. By applying corrections related to the visual bias from the camera and the capillary pressure difference at the air-liquid interface, the viscosity of the fluid sample can be calculated based on differential pressure data, sample length, velocity, volumetric flow rate, and contact angle from captured video, and the channel dimension, given that the sample has reached a flow equilibrium condition.
摘要:
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要:
The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要:
The present invention provides nucleic acid and polypeptide sequences describing an isoform of the α2δ-4 subunit of a voltage gated calcium channel. The nucleic acids described herein can be used to produce functional α2δ-4 protein. The calcium channel α2δ-4 protein may be isolated for the purposes of binding experiments or may be used in cells to form a functional calcium channel complex.
摘要:
It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.
摘要:
A recombinant canine TRPV2 channel which has been prepared by cDNA cloning and polymerase chain reaction techniques is disclosed. Expression systems for these channels and an assay using the expression systems are also disclosed. The recombinant TRPV2 channel can be used in assays to evaluate compounds which directly or indirectly interact with or bind to TRPV2 channel.