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12 条记录 (耗时 0.017 秒)

    Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of mesothelioma
    2.
    发明申请
    Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of mesothelioma 审中-公开
    检测尿间皮素/巨核细胞增强因子相关肽用于评估间皮瘤

    公开(公告)号：US20060014221A1

    公开(公告)日：2006-01-19

    申请号：US11040215

    申请日：2005-01-21

    申请人： Daniel O'Shannessy ,  Niranjan Sardesai ,  Jennifer Bones

    发明人： Daniel O'Shannessy ,  Niranjan Sardesai ,  Jennifer Bones

    IPC分类号： G01N33/53

    CPC分类号： G01N33/57407 ,  G01N33/57488 ,  G01N2333/52

    摘要： The invention relates to methods and kits for assessing occurrence in patient urine of peptides having amino acid sequences related to those of mesothelin, megakaryocyte potentiating factor, and other peptides that have been associated with occurrence in the serum of mesothelioma patients. The methods and kits can be used to diagnose mesothelioma in a patient, to predict development of mesothelioma in an otherwise asymptomatic patient, or to assess the efficacy of a mesothelioma therapeutic method.

    摘要翻译： 本发明涉及用于评估患者尿中具有与间皮素，巨核细胞增强因子以及与间皮瘤患者的血清中发生相关的其它肽相关的氨基酸序列的肽的发生的方法和试剂盒。 方法和试剂盒可用于诊断患者的间皮瘤，以预测其他无症状患者的间皮瘤的发展，或评估间皮瘤治疗方法的功效。

    Detection of mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of the peritoneum and the peritoneal cavity
    4.
    发明申请
    Detection of mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of the peritoneum and the peritoneal cavity 审中-公开
    用于评估腹膜和腹腔的间皮素/巨核细胞增强因子相关肽的检测

    公开(公告)号：US20060014211A1

    公开(公告)日：2006-01-19

    申请号：US11040240

    申请日：2005-01-21

    申请人： Daniel O'Shannessy ,  Niranjan Sardesai ,  Elizabeth Somers

    发明人： Daniel O'Shannessy ,  Niranjan Sardesai ,  Elizabeth Somers

    IPC分类号： G01N33/53 ,  G01N33/537 ,  G01N33/543

    CPC分类号： G01N33/57407 ,  G01N33/57488 ,  G01N2800/50

    摘要： The invention relates to methods and kits for assessing occurrence in patient mesothelial fluid of peptides having amino acid sequences related to those of mesothelin, megakaryocyte potentiating factor, and other peptides that have been associated with occurrence in the serum of mesothelioma patients. The methods and kits can be used to monitor the biochemical or pathological status of a component of the corresponding mesothelial cavity in a patient, to predict development of such a pathological status in an otherwise asymptomatic patient, or to assess the efficacy of a therapeutic method.

    摘要翻译： 本发明涉及用于评估患者间皮细胞中具有与间皮素，巨核细胞增强因子以及与间皮瘤患者的血清中发生相关的氨基酸序列相关的氨基酸序列的发生的方法和试剂盒。 方法和试剂盒可用于监测患者中相应间皮腔的组分的生物化学或病理状态，以预测其他无症状患者中这种病理状态的发展，或评估治疗方法的功效。

    Vaccines against multiple subtypes of dengue virus
    8.
    发明授权
    Vaccines against multiple subtypes of dengue virus 有权
    疫苗针对登革热病毒的多种亚型

    公开(公告)号：US08835620B2

    公开(公告)日：2014-09-16

    申请号：US12812268

    申请日：2009-01-12

    申请人： Mathura P. Ramanathan ,  Niranjan Sardesai

    发明人： Mathura P. Ramanathan ,  Niranjan Sardesai

    IPC分类号： C07H21/02 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

    CPC分类号： A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  C07K14/005 ,  C12N2770/24122 ,  C12N2770/24134 ,  Y02A50/386 ,  Y02A50/394

    摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal.

    摘要翻译： 本发明的一个方面涉及能够表达在哺乳动物中针对多于一种登革热病毒亚型引起免疫应答的多肽的核酸构建体及其使用方法。 此外，存在能够在哺乳动物中产生针对多种登革病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂及其使用方法。 DNA质粒能够以有效引发哺乳动物免疫应答的量在哺乳动物细胞中表达一致性登革热抗原。