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公开(公告)号：US08835620B2
公开(公告)日：2014-09-16
申请号：US12812268
申请日：2009-01-12
IPC分类号： C07H21/02 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/394
摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal.
摘要翻译： 本发明的一个方面涉及能够表达在哺乳动物中针对多于一种登革热病毒亚型引起免疫应答的多肽的核酸构建体及其使用方法。 此外，存在能够在哺乳动物中产生针对多种登革病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂及其使用方法。 DNA质粒能够以有效引发哺乳动物免疫应答的量在哺乳动物细胞中表达一致性登革热抗原。
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2.发明授权DNA constructs eliciting immune response against flavivirus and effective adjuvants 有权引发针对黄病毒和有效佐剂的免疫应答的DNA构建体公开(公告)号：US08961994B2
公开(公告)日：2015-02-24
申请号：US13129599
申请日：2009-11-17
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/55527 , C12N2770/24134 , Y02A50/39 , Y02A50/394
摘要： Aspects of the present invention relate to isolated nucleic acids that encode a consensus DIII domain of protein E and vaccines made using same, and also methods for using the aforementioned to generate in a host an immune response against multiple serotypes of flavivirus, particularly West Nile virus and Japanese encephalitis virus.
摘要翻译： 本发明的方面涉及编码蛋白质E的共有DIII结构域的分离的核酸和使用其的疫苗的制备方法，以及使用上述在宿主中产生针对多种血清型黄病毒，特别是西尼罗河病毒的免疫应答的方法 和日本脑炎病毒。
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3.发明申请FOOT AND MOUTH DISEASE VIRUS (FMDV) CONSENSUS PROTEINS, CODING SEQUENCES THEREFOR AND VACCINES MADE THEREFROM 有权FOOD和MOUD疾病病毒（FMDV）共识蛋白，其编码序列及其制备的疫苗公开(公告)号：US20120282217A1
公开(公告)日：2012-11-08
申请号：US13503828
申请日：2010-11-02
申请人： David B. Weiner , Bernadette Ferraro , Jian Yan , Patricia A. Brown , Rodney A. Bowling , Douglas R. Kern , Mathura P. Ramanathan , Niranjan Y. Sardesai , Karuppiah Muthumani
发明人： David B. Weiner , Bernadette Ferraro , Jian Yan , Patricia A. Brown , Rodney A. Bowling , Douglas R. Kern , Mathura P. Ramanathan , Niranjan Y. Sardesai , Karuppiah Muthumani
IPC分类号： A61K39/135 , C12N15/62 , C12N15/57 , C12N15/63 , A61M37/00 , C07K14/09 , C07K19/00 , C12N9/50 , C12Q1/70 , G01N33/569 , C12N15/42 , A61K38/20
CPC分类号： C07K14/005 , A61K39/12 , A61K39/135 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/552 , A61M37/00 , A61N1/327 , C12N7/00 , C12N2770/32122 , C12N2770/32134 , G01N33/56983 , G01N2333/09 , G01N2469/20
摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
摘要翻译： 本文提供的是包含FMDV亚型A，亚洲1，C，O，SAT1，SAT2和SAT3的口蹄疫FMDV VP1-4外壳蛋白的共有氨基酸序列的核酸，以及表达 序列。 本文还提供了使用上述疫苗产生针对一种或多种FMDV亚型的免疫应答的方法以及用疫苗接种的哺乳动物和用FMDV感染的哺乳动物之间进行解密的方法。
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4.发明申请DNA CONSTRUCTS ELICITING IMMUNE RESPONSE AGAINST FLAVIVIRUS AND EFFECTIVE ADJUVANTS 有权DNA构建对抗病毒和有效的免疫反应的免疫反应公开(公告)号：US20110262394A1
公开(公告)日：2011-10-27
申请号：US13129599
申请日：2009-11-17
IPC分类号： A61K39/12 , C07H21/04 , C07K14/18 , A61N1/30 , A61K39/39 , A61P37/04 , A61P31/14 , C12N15/85 , C07K19/00
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/55527 , C12N2770/24134 , Y02A50/39 , Y02A50/394
摘要： Aspects of the present invention relate to isolated nucleic acids that encode a consensus DIII domain of protein E and vaccines made using same, and also methods for using the aforementioned to generate in a host an immune response against multiple serotypes of flavivirus, particularly West Nile virus and Japanese encephalitis virus.
摘要翻译： 本发明的方面涉及编码蛋白质E的共有DIII结构域的分离的核酸和使用其的疫苗的制备方法，以及使用上述在宿主中产生针对多种血清型黄病毒，特别是西尼罗河病毒的免疫应答的方法 和日本脑炎病毒。
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公开(公告)号：US08216585B2
公开(公告)日：2012-07-10
申请号：US10478896
申请日：2002-05-28
CPC分类号： C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要： Drug delivery compositions and methods of delivering compounds into a cell or into an individual are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译： 公开了将化合物递送到细胞或个体中的药物递送组合物和方法。 公开了免疫个体的疫苗和方法。 公开了用于药物递送的组合物，包括基因治疗和使用这些组合物治疗个体的方法。
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公开(公告)号：US20120230945A1
公开(公告)日：2012-09-13
申请号：US13422864
申请日：2012-03-16
IPC分类号： A61K39/395 , A61P37/02 , C07K16/18 , C12N5/02 , A61K38/20
CPC分类号： C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要： Drug delivery compositions and methods of delivering compounds are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译： 公开了递送组合物和递送化合物的方法。 公开了免疫个体的疫苗和方法。 公开了用于药物递送的组合物，包括基因治疗和使用这些组合物治疗个体的方法。
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公开(公告)号：US07625751B2
公开(公告)日：2009-12-01
申请号：US10478743
申请日：2002-05-28
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/393
摘要： Substantially pure WIP-1 and its use in assays to identify PAP-1/WIP-1 interaction inhibitors or WIP-I/WNV Cp interaction inhibitors are disclosed. Compositions comprising antisense sequences to prevent expression of WIP-1 and methods of treating cancer using the same are disclosed.
摘要翻译： 公开了基本上纯的WIP-1及其在鉴定PAP-1 / WIP-1相互作用抑制剂或WIP-I / WNV Cp相互作用抑制剂的测定中的用途。 公开了包含用于预防WIP-1表达的反义序列的组合物和使用其的治疗癌症的方法。
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