公开(公告)号：US20190091322A1

公开(公告)日：2019-03-28

申请号：US16087146

申请日：2017-03-21

申请人： David B. Weiner ,  Karuppiah Muthumani ,  Seleeke Flingai ,  Niranjan Sardesai ,  Sarah Elliott ,  Jian Yan ,  Ami Patel

发明人： David B. Weiner ,  Karuppiah Muthumani ,  Seleeke Flingai ,  Niranjan Sardesai ,  Sarah Elliott ,  Jian Yan ,  Ami Patel

IPC分类号： A61K39/12 ,  A61K39/42 ,  C07K16/10

摘要： Disclosed herein is a composition comprising the combination of a nucleic acid sequence encoding a desired polypeptide that elicits an immune response in a mammal and a nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof.

公开(公告)号：US10087240B2

公开(公告)日：2018-10-02

申请号：US15103970

申请日：2014-12-13

申请人： David Weiner ,  Karuppiah Muthumani ,  Seleeke Flingai ,  Niranjan Sardesai

发明人： David Weiner ,  Karuppiah Muthumani ,  Seleeke Flingai ,  Niranjan Sardesai

IPC分类号： C07K16/10 ,  A61K48/00 ,  C07K16/32 ,  A61K39/00 ,  C12N7/00 ,  C07K14/005 ,  A61K39/12 ,  A61K39/42 ,  A61M37/00

摘要： The present invention relates to a composition including a recombinant nucleic acid sequence that encodes an antibody and a method of generating a synthetic antibody in a subject by administering the composition to the subject. The invention also provides a method of preventing and/or treating disease in a subject using the composition and method of generation.

公开(公告)号：US09987347B2

公开(公告)日：2018-06-05

申请号：US14775069

申请日：2014-03-14

申请人： INOVIO PHARMACEUTICALS, INC. ,  David B. Weiner ,  Jian Yan ,  Niranjan Sardesai

发明人： David B. Weiner ,  Jian Yan ,  Niranjan Sardesai

IPC分类号： C07H21/04 ,  A61K31/70 ,  A61K39/12 ,  A61K31/7088 ,  A61N1/04 ,  A61N1/32 ,  C07K14/005 ,  C12N7/00 ,  A01K67/00 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K31/7088 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55527 ,  A61K2039/55538 ,  A61K2039/575 ,  A61N1/0412 ,  A61N1/0476 ,  A61N1/327 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24141 ,  Y02A50/386 ,  Y02A50/394

摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.

公开(公告)号：US20160311891A1

公开(公告)日：2016-10-27

申请号：US15103970

申请日：2014-12-13

申请人： David Weiner ,  Karuppiah Mathumani ,  Seleeke Flingai ,  Niranjan Sardesai

发明人： David Weiner ,  Karuppiah Mathumani ,  Seleeke Flingai ,  Niranjan Sardesai

IPC分类号： C07K16/10 ,  A61N1/32 ,  A61M37/00 ,  C07K16/32 ,  C12N7/00

CPC分类号： C07K16/1081 ,  A61K48/005 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61M2037/0007 ,  C07K16/10 ,  C07K16/1063 ,  C07K16/32 ,  C07K2317/10 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/60 ,  C07K2317/76 ,  C07K2319/00 ,  C12N7/00 ,  C12N2740/16032 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2770/24111 ,  C12N2770/24122 ,  C12N2770/24133 ,  C12N2770/24171 ,  C12N2770/36111 ,  C12N2770/36122 ,  C12N2770/36133 ,  C12N2770/36171 ,  Y02A50/383 ,  Y02A50/386

摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.

摘要翻译： 本文公开了包含编码抗体的重组核酸序列的组合物。 本文还公开了通过将所述组合物施用于受试者来在受试者中产生合成抗体的方法。 本公开还提供了使用所述组合物和产生方法预防和/或治疗受试者的疾病的方法。

公开(公告)号：US11116838B2

公开(公告)日：2021-09-14

申请号：US15546740

申请日：2016-01-28

申请人： The Trustees of the University of Pennsylvania ,  INOVIO PHARMACEUTICALS, INC. ,  David Weiner ,  Karuppiah Muthumani ,  Niranjan Sardesai

发明人： David Weiner ,  Karuppiah Muthumani ,  Niranjan Sardesai

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/28 ,  A61K39/12

摘要： Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.

公开(公告)号：US20180015161A1

公开(公告)日：2018-01-18

申请号：US15546740

申请日：2016-01-28

申请人： David WEINER ,  Karuppiah MUTHUMANI ,  Niranjan SARDESAI ,  The Trustees of the University of Pennsylvania ,  INOVIO PHARMACEUTICALS, INC.

发明人： David Weiner ,  Karuppiah Muthumani ,  Niranjan Sardesai

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC分类号： A61K39/395 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/585 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/76 ,  C12N2710/20034 ,  Y02A50/412 ,  A61K2300/00

摘要： Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.

公开(公告)号：US20160022802A1

公开(公告)日：2016-01-28

申请号：US14775069

申请日：2014-03-14

申请人： David WEINER ,  Jian YAN ,  Niranjan SARDESAI ,  INOVIO PHARMACEUTICALS, INC.

发明人： David B. Weiner ,  Jian Yan ,  Niranjan Sardesai

IPC分类号： A61K39/12 ,  A61N1/32 ,  A61N1/04 ,  C07K14/005 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K31/7088 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55527 ,  A61K2039/55538 ,  A61K2039/575 ,  A61N1/0412 ,  A61N1/0476 ,  A61N1/327 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24141 ,  Y02A50/386 ,  Y02A50/394

摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.

摘要翻译： 本发明的一个方面涉及能够表达多肽的核酸构建体，例如在哺乳动物中针对多于一种登革热病毒亚型引起免疫应答的共有登革热prME及其使用方法。 此外，存在能够在哺乳动物中产生针对多种登革热病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂及其使用方法。 DNA质粒能够在哺乳动物细胞中以有效引发对所有4种登革热亚型交叉反应的哺乳动物的免疫应答的量表达共有登革热抗原。

公开(公告)号：US20060014221A1

公开(公告)日：2006-01-19

申请号：US11040215

申请日：2005-01-21

申请人： Daniel O'Shannessy ,  Niranjan Sardesai ,  Jennifer Bones

发明人： Daniel O'Shannessy ,  Niranjan Sardesai ,  Jennifer Bones

IPC分类号： G01N33/53

CPC分类号： G01N33/57407 ,  G01N33/57488 ,  G01N2333/52

摘要： The invention relates to methods and kits for assessing occurrence in patient urine of peptides having amino acid sequences related to those of mesothelin, megakaryocyte potentiating factor, and other peptides that have been associated with occurrence in the serum of mesothelioma patients. The methods and kits can be used to diagnose mesothelioma in a patient, to predict development of mesothelioma in an otherwise asymptomatic patient, or to assess the efficacy of a mesothelioma therapeutic method.

摘要翻译： 本发明涉及用于评估患者尿中具有与间皮素，巨核细胞增强因子以及与间皮瘤患者的血清中发生相关的其它肽相关的氨基酸序列的肽的发生的方法和试剂盒。 方法和试剂盒可用于诊断患者的间皮瘤，以预测其他无症状患者的间皮瘤的发展，或评估间皮瘤治疗方法的功效。

公开(公告)号：US09446114B2

公开(公告)日：2016-09-20

申请号：US14232110

申请日：2012-07-11

申请人： Kate Broderick ,  Niranjan Sardesai ,  Kathleen Cashman ,  Connie Schmaljohn

发明人： Kate Broderick ,  Niranjan Sardesai ,  Kathleen Cashman ,  Connie Schmaljohn

IPC分类号： A61K39/12 ,  A61N1/32 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61N1/327 ,  A61P31/14 ,  C12N2760/10022 ,  C12N2760/10034

摘要： The invention relates to DNA vaccines that target multiple arenavirus agents singly or simultaneously.

摘要翻译： 本发明涉及单独或同时靶向多种病毒药物的DNA疫苗。

公开(公告)号：US08835620B2

公开(公告)日：2014-09-16

申请号：US12812268

申请日：2009-01-12

申请人： Mathura P. Ramanathan ,  Niranjan Sardesai

发明人： Mathura P. Ramanathan ,  Niranjan Sardesai

IPC分类号： C07H21/02 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  C07K14/005 ,  C12N2770/24122 ,  C12N2770/24134 ,  Y02A50/386 ,  Y02A50/394

摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal.

摘要翻译： 本发明的一个方面涉及能够表达在哺乳动物中针对多于一种登革热病毒亚型引起免疫应答的多肽的核酸构建体及其使用方法。 此外，存在能够在哺乳动物中产生针对多种登革病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂及其使用方法。 DNA质粒能够以有效引发哺乳动物免疫应答的量在哺乳动物细胞中表达一致性登革热抗原。