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    Anti-(influenza a virus subtype H5 hemagglutinin) monoclonal antibody
    1.
    发明授权
    Anti-(influenza a virus subtype H5 hemagglutinin) monoclonal antibody 失效
    抗 - （流感病毒亚型H5血凝素）单克隆抗体

    公开(公告)号：US08658354B2

    公开(公告)日：2014-02-25

    申请号：US12934908

    申请日：2009-03-26

    申请人： Hiroshi Kida ,  Yoshihiro Sakoda ,  Eiji Miyagawa ,  Nobuyuki Fujii ,  Yoshiaki Uchida ,  Takashi Shirakawa ,  Hiroyuki Kogaki

    发明人： Hiroshi Kida ,  Yoshihiro Sakoda ,  Eiji Miyagawa ,  Nobuyuki Fujii ,  Yoshiaki Uchida ,  Takashi Shirakawa ,  Hiroyuki Kogaki

    IPC分类号： C12Q1/70

    CPC分类号： G01N33/56983 ,  C07K16/1018 ,  C07K2317/34 ,  G01N2333/11

    摘要： A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus.

    摘要翻译： 一种H5亚型甲型流感病毒的免疫测定方法，即使在H5亚型甲型流感病毒中发生一定程度的突变的情况下，也能够准确测定病毒，以及其用途，以及新的抗H5亚型流感 公开了可用于免疫测定的病毒单克隆抗体。 本发明的抗体或其抗原结合片段与H5亚型甲型流感病毒的血凝素进行抗原抗体反应，抗体或其抗原结合片段的相应表位位于受体以外的区域 子结构域（不包括由11个氨基酸组成的C末端区域），该抗体或其抗原结合片段不具有针对甲型流感病毒的中和活性。

    METHOD FOR DETECTION OF INFECTION WITH HUMAN CYTOMEGALOVIRUS
    2.
    发明申请
    METHOD FOR DETECTION OF INFECTION WITH HUMAN CYTOMEGALOVIRUS 审中-公开
    用人类细胞病毒检测感染的方法

    公开(公告)号：US20130109010A1

    公开(公告)日：2013-05-02

    申请号：US13808465

    申请日：2011-07-05

    申请人： Nobuyuki Fujii ,  Hideo Honda ,  Yoshiaki Uchida ,  Kazuya Omi

    发明人： Nobuyuki Fujii ,  Hideo Honda ,  Yoshiaki Uchida ,  Kazuya Omi

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6854 ,  C07K14/005 ,  C12N2710/16122 ,  G01N33/56994 ,  G01N2333/045 ,  G01N2469/20

    摘要： A novel means by which HCMV infection can be detected with a high sensitivity and whose practicality is high is disclosed. The present inventors synthesized as many as 15 kinds of HCMV proteins in their full length forms, and intensively studied their reactivities with sera from HCMV-infected patients to find that all the infected patients can be detected without fail when using the pp28 full length protein as an antigen. The pp28 full length protein can be synthesized and purified as a recombinant protein in a large scale by using Escherichia coli, and can be commercially used as an antigen for HCMV tests.

    摘要翻译： 公开了一种以高灵敏度检测HCMV感染并且其实用性高的新颖手段。 本发明人以其全长形式合成了多达15种HCMV蛋白，并且深入研究了与HCMV感染患者的血清的反应性，发现使用pp28全长蛋白时所有感染的患者都可以被检测到， 抗原。 通过使用大肠杆菌可以大量合成和纯化pp28全长蛋白质作为重组蛋白质，并且可以商业上用作HCMV测试的抗原。

    PORTABLE ELECTRONIC EQUIPMENT AND METHOD OF CONTROLLING THE SAME
    3.
    发明申请
    PORTABLE ELECTRONIC EQUIPMENT AND METHOD OF CONTROLLING THE SAME 有权
    便携式电子设备及其控制方法

    公开(公告)号：US20120133218A1

    公开(公告)日：2012-05-31

    申请号：US13112445

    申请日：2011-05-20

    申请人： Nobuyuki FUJII

    发明人： Nobuyuki FUJII

    IPC分类号： H01H35/00

    CPC分类号： H04M1/72569 ,  H04M2250/12 ,  Y10T307/766 ,  Y10T307/799

    摘要： When portable electronic equipment drops, CPU stops power supply to a prescribed unit. A prescribed unit is a unit that is not necessary for the continuous operation of the portable electronic equipment. When the portable electronic equipment collides with the floor or the ground, the battery terminal may be momentarily detached from the connector. In this case, instantaneous voltage drop or momentary power failure may occur. Power supply to a prescribed unit is stopped while power supply to CPU and RAM is continued. Therefore, power supply to CPU and RAM can be continued with electric charge stored in a capacitor inside the portable electronic equipment.

    摘要翻译： 当便携式电子设备掉电时，CPU停止向规定单元供电。 规定的单位是便携式电子设备的连续操作不需要的单元。 当便携式电子设备与地板或地面碰撞时，电池端子可能会从连接器瞬间脱离。 在这种情况下，可能会发生瞬时电压降或瞬间停电。 在继续向CPU和RAM供电时，停止对规定单元的供电。 因此，可以通过存储在便携式电子设备内的电容器中的电荷来继续向CPU和RAM供电。

    Clock generating circuit
    4.
    发明授权
    Clock generating circuit 失效
    时钟发生电路

    公开(公告)号：US06781431B2

    公开(公告)日：2004-08-24

    申请号：US10349033

    申请日：2003-01-23

    申请人： Yasuhiko Taito ,  Akira Yamazaki ,  Fukashi Morishita ,  Nobuyuki Fujii ,  Mihoko Akiyama ,  Mako Okamoto

    发明人： Yasuhiko Taito ,  Akira Yamazaki ,  Fukashi Morishita ,  Nobuyuki Fujii ,  Mihoko Akiyama ,  Mako Okamoto

    IPC分类号： G06F104

    CPC分类号： H03K3/0315 ,  H02M3/07 ,  H03K3/013 ,  H03K3/70

    摘要： The clock-generating circuit for generating a clock signal, includes a ring oscillator having an odd number of inverters connected in a ring configuration. The ring oscillator is activated to generate a clock signal when an activating signal is at a first level and is de-activated to cease generation of the clock signal when the activating signal is at a second level. A latch circuit is connected to an output node of the ring oscillator, and holds a level of the output node of the ring oscillator in response to transition of the activating signal from the first level to the second level. When the activating signal is lowered from the H level to the L level, the level of the clock signal is latched such that generation of a glitch in the clock signal will be prevented from occurring.

    摘要翻译： 用于产生时钟信号的时钟发生电路包括具有以环形配置连接的奇数个反相器的环形振荡器。 当激活信号处于第一电平时，环形振荡器被激活以产生时钟信号，并且当激活信号处于第二电平时被停止产生时钟信号。 锁存电路连接到环形振荡器的输出节点，并且响应于激活信号从第一电平到第二电平的转变而保持环形振荡器的输出节点的电平。 当激活信号从H电平降低到L电平时，锁存时钟信号的电平，从而防止产生时钟信号中的毛刺。

    Portable electronic equipment and method of controlling the same
    7.
    发明授权
    Portable electronic equipment and method of controlling the same 有权
    便携式电子设备及其控制方法

    公开(公告)号：US08975786B2

    公开(公告)日：2015-03-10

    申请号：US13112445

    申请日：2011-05-20

    申请人： Nobuyuki Fujii

    发明人： Nobuyuki Fujii

    IPC分类号： H01H35/00 ,  H04M1/725

    CPC分类号： H04M1/72569 ,  H04M2250/12 ,  Y10T307/766 ,  Y10T307/799

    摘要： When portable electronic equipment drops, CPU stops power supply to a prescribed unit. A prescribed unit is a unit that is not necessary for the continuous operation of the portable electronic equipment. When the portable electronic equipment collides with the floor or the ground, the battery terminal may be momentarily detached from the connector. In this case, instantaneous voltage drop or momentary power failure may occur. Power supply to a prescribed unit is stopped while power supply to CPU and RAM is continued. Therefore, power supply to CPU and RAM can be continued with electric charge stored in a capacitor inside the portable electronic equipment.

    摘要翻译： 当便携式电子设备掉电时，CPU停止向规定单元供电。 规定的单位是便携式电子设备的连续操作不需要的单元。 当便携式电子设备与地板或地面碰撞时，电池端子可能会从连接器瞬间脱离。 在这种情况下，可能会发生瞬时电压降或瞬间停电。 在继续向CPU和RAM供电时，停止对规定单元的供电。 因此，可以通过存储在便携式电子设备内的电容器中的电荷来继续向CPU和RAM供电。

    ANTI-(INFLUENZA A VIRUS SUBTYPE H5 HEMAGGLUTININ) MONOCLONAL ANTIBODY
    8.
    发明申请
    ANTI-(INFLUENZA A VIRUS SUBTYPE H5 HEMAGGLUTININ) MONOCLONAL ANTIBODY 失效
    ANTI-（流感病毒亚型H5 HEMAGGLUTININ）单克隆抗体

    公开(公告)号：US20110065095A1

    公开(公告)日：2011-03-17

    申请号：US12934908

    申请日：2009-03-26

    申请人： Hiroshi Kida ,  Yoshihiro Sakoda ,  Eiji Miyagawa ,  Nobuyuki Fujii ,  Yoshiaki Uchida ,  Takashi Shirakawa ,  Hiroyuki Kogaki

    发明人： Hiroshi Kida ,  Yoshihiro Sakoda ,  Eiji Miyagawa ,  Nobuyuki Fujii ,  Yoshiaki Uchida ,  Takashi Shirakawa ,  Hiroyuki Kogaki

    IPC分类号： C12Q1/70 ,  C07K16/10

    CPC分类号： G01N33/56983 ,  C07K16/1018 ,  C07K2317/34 ,  G01N2333/11

    摘要： A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus.

    摘要翻译： 一种H5亚型甲型流感病毒的免疫测定方法，即使在H5亚型甲型流感病毒中发生一定程度的突变的情况下也能够准确测定病毒，以及其用于该药物的试剂盒，以及新的抗H5亚型流感 公开了可用于免疫测定的病毒单克隆抗体。 本发明的抗体或其抗原结合片段与H5亚型甲型流感病毒的血凝素进行抗原抗体反应，抗体或其抗原结合片段的相应表位位于受体以外的区域 子结构域（不包括由11个氨基酸组成的C末端区域），该抗体或其抗原结合片段不具有针对甲型流感病毒的中和活性。