摘要:
The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
摘要:
Compounds and methods are provided for treating patients suffering from health condition associated with an expression state of a gene such as fertility disorders, cancer, proliferative diseases, vascular diseases, wounds requiring therapeutic intervention, inflammation, and pulmonary disorders by administering to said patient a compound capable of modulating egr-1 and/or an egr-1 response element consensus sequence thereby altering the expression state of said gene. Also described are new methods for screening compounds to identify effectors of egr-1 and/or egr-1 consensus sequence elements and methods for treating patients by administering such effectors to modulate egr-1 and/or egr-1 consensus sequences to thereby modify expression of genes associated therewith to in turn treat diseases or other physiological conditions associated with such gene expression.
摘要:
Compounds and methods are provided for treating patients suffering from any of hypercholesterolemia, vascular oxidative stress and endothelial dysfunction.
摘要:
Methods for treating disease and health conditions associated with the presence of TGF-β including cancers, are provided comprising administering a therapeutically effective agent which acts as a TGF-β antagonist and cathepsin B inhibitor or lymphocytes transformed with a gene for expressing such an agent for overcoming the lymphocyte evading effect of TGF-β.
摘要:
Various improvements for video production switchers are disclosed. In a user input module, a Link button is operable to link key functions with a user controllable input device. A multicolor lighting arrangement may be provided, and possibly calibrated, for illuminating each button of a switcher with a controllable color and/or intensity. In an improved Pulse-Width Modulation (PWM) scheme, a PWM output is dependent on a pseudo-random number and a threshold. A display on a keyer module may be used to provide indications of a key source and type currently associated with the keyer module. A switcher menu system may be enhanced by providing a first display for accessing a full menu system, and a second display for accessing at least a portion of the full menu system. In a modular switcher panel, a panel structure carries button modules, at least one of which is interchangeable without displacing other button modules.
摘要:
Various improvements for video production switchers are disclosed. In a user input module, a Link button is operable to link key functions with a user controllable input device. A multicolor lighting arrangement may be provided, and possibly calibrated, for illuminating each button of a switcher with a controllable color and/or intensity. In an improved Pulse-Width Modulation (PWM) scheme, a PWM output is dependent on a pseudo-random number and a threshold. A display on a keyer module may be used to provide indications of a key source and type currently associated with the keyer module. A switcher menu system may be enhanced by providing a first display for accessing a full menu system, and a second display for accessing at least a portion of the full menu system. In a modular switcher panel, a panel structure carries button modules, at least one of which is interchangeable without displacing other button modules.
摘要:
The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
摘要:
Described are new methods for promoting the expression of apolipoprotein A1 (APO A1) for increasing levels of HDL, and assays for screening and identifying compounds for regulating expression of the APO A1 protein.
摘要:
Compounds comprising nitric oxide derivatives of stilbenes, polyphenols and flavonoids and methods of their use are provided for treating patients suffering from any of hypercholesterolemia, vascular oxidative stress and endothelial dysfunction.