公开(公告)号：US07217457B2

公开(公告)日：2007-05-15

申请号：US10475709

申请日：2002-05-06

申请人： Abdelhamid Elaissari ,  Franck Montagne ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jérôme Bibette ,  Olivier Mondain-Monval

发明人： Abdelhamid Elaissari ,  Franck Montagne ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jérôme Bibette ,  Olivier Mondain-Monval

IPC分类号： B32B5/16 ,  C08K3/00

CPC分类号： C08K9/08 ,  A61K41/0052 ,  A61K49/1854 ,  A61K49/1857 ,  A61K49/1887 ,  C08F291/00 ,  C08F292/00 ,  Y10T428/2991 ,  Y10T428/2998

摘要： The invention relates to composite particles comprising a hydrophobic polymer core and inorganic nanoparticles. Said hydrophobic polymer forms a polymer matrix inside which the inorganic nanoparticles are stabilized and distributed in a relatively homogenous manner. Said particles are at least partially surrounded by an amphophilic copolymer comprising a hydrophobic part and a hydrophilic part, said hydrophobic part being at least partially immobilized in the polymer matrix. The inventor also relates to the preparation method thereof, the conjugates comprising such particles and a ligand and the use of same in reactants and therapeutic compositions.

摘要翻译： 本发明涉及包含疏水聚合物芯和无机纳米颗粒的复合颗粒。 所述疏水性聚合物形成聚合物基质，无机纳米颗粒在该聚合物基质内稳定并以相对均匀的方式分布。 所述颗粒至少部分被包含疏水部分和亲水部分的两亲共聚物包围，所述疏水部分至少部分地固定在聚合物基质中。 发明人还涉及其制备方法，包含这种颗粒的配偶体和配体以及其在反应物和治疗组合物中的用途。

公开(公告)号：US07001589B2

公开(公告)日：2006-02-21

申请号：US11022885

申请日：2004-12-28

申请人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jérôme Bibette

发明人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jérôme Bibette

IPC分类号： A61B8/00 ,  A61K9/14 ,  B01J13/02

CPC分类号： G01N33/5434 ,  G01N2446/20 ,  G01N2446/64 ,  G01N2446/66 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987

摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

摘要翻译： 本发明涉及直径范围在约50和1000nm之间的复合纳米球，加上或减少5％，优选在大约100和500nm之间加或减5％，有利地在100和200nm之间加或减5％，并且包括基本上 分布在有机相内部的有机相和无机纳米颗粒组成的液体芯，以及至少由至少一种水溶性单体，特别是N-烷基丙烯酰胺或NN-二烷基丙烯酰胺的聚合衍生的亲水性聚合物组成的皮肤; 衍生自所述纳米球的共轭物; 其制备方法及其用途。

公开(公告)号：US20050137334A1

公开(公告)日：2005-06-23

申请号：US11022885

申请日：2004-12-28

申请人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jerome Bibette

发明人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jerome Bibette

IPC分类号： G01N33/545 ,  A61K9/51 ,  A61K31/7088 ,  A61K45/00 ,  A61K47/02 ,  A61K47/04 ,  A61K47/32 ,  A61K47/48 ,  A61K48/00 ,  A61P43/00 ,  C09D11/00 ,  G01N33/543 ,  C08L51/04

CPC分类号： G01N33/5434 ,  G01N2446/20 ,  G01N2446/64 ,  G01N2446/66 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987

摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

公开(公告)号：US06866838B1

公开(公告)日：2005-03-15

申请号：US10129141

申请日：2000-11-06

申请人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jérôme Bibette

发明人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jérôme Bibette

IPC分类号： G01N33/545 ,  A61K9/51 ,  A61K31/7088 ,  A61K45/00 ,  A61K47/02 ,  A61K47/04 ,  A61K47/32 ,  A61K47/48 ,  A61K48/00 ,  A61P43/00 ,  C09D11/00 ,  G01N33/543 ,  A61B8/00 ,  A61K9/14 ,  B01J13/02

CPC分类号： G01N33/5434 ,  G01N2446/20 ,  G01N2446/64 ,  G01N2446/66 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987

摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N—N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

摘要翻译： 本发明涉及直径范围在约50和1000nm之间的复合纳米球，加上或减少5％，优选在约100和500nm之间加上或减少5％，并且有利地在100和200nm之间加上或减少5％，并且包括基本上 分布在有机相内部的有机相和无机纳米颗粒组成的液体芯，以及至少由至少一种水溶性单体，特别是N-烷基丙烯酰胺或NN-二烷基丙烯酰胺的聚合衍生的亲水性聚合物组成的皮肤; 源自所述纳米球的共轭物; 其制备方法及其用途。