公开(公告)号：US07001589B2

公开(公告)日：2006-02-21

申请号：US11022885

申请日：2004-12-28

申请人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jérôme Bibette

发明人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jérôme Bibette

IPC分类号： A61B8/00 ,  A61K9/14 ,  B01J13/02

CPC分类号： G01N33/5434 ,  G01N2446/20 ,  G01N2446/64 ,  G01N2446/66 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987

摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

摘要翻译： 本发明涉及直径范围在约50和1000nm之间的复合纳米球，加上或减少5％，优选在大约100和500nm之间加或减5％，有利地在100和200nm之间加或减5％，并且包括基本上 分布在有机相内部的有机相和无机纳米颗粒组成的液体芯，以及至少由至少一种水溶性单体，特别是N-烷基丙烯酰胺或NN-二烷基丙烯酰胺的聚合衍生的亲水性聚合物组成的皮肤; 衍生自所述纳米球的共轭物; 其制备方法及其用途。

公开(公告)号：US5128204A

公开(公告)日：1992-07-07

申请号：US634908

申请日：1990-12-27

申请人： Dominique Charmot

发明人： Dominique Charmot

IPC分类号： C08K3/22 ,  A61K9/50 ,  B01J13/02 ,  B01J13/14 ,  C08J3/12 ,  C08J3/20 ,  C08L83/04

CPC分类号： C08J3/20 ,  A61K9/5094 ,  B01J13/14 ,  C08J2383/04 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/64 ,  G01N2446/66 ,  Y10T428/257 ,  Y10T428/2982

摘要： Magnetizable microspheres comprising a polysilsesquioxane network and, distributed within the network, a magnetizable filler chemically bonded to polysilsesquioxane units. The magnetizable microspheres are prepared by dispersing an aqueous suspension of a magnetizable filler, not coated with a dispersing agent, in a solvent, dissolving an alkoxysilane or an alkoxysiloxane in the organic phase, polycondensating to a polysilsesquioxane, removing water, separating, and optionally redispersing the microspheres in water.

摘要翻译： 包含聚倍半硅氧烷网络的可磁化微球体，并且在网络内分布有化学键合到倍半硅氧烷单元的可磁化填料。 可磁化微球通过将未分散剂的可磁化填料的水悬浮液分散在溶剂中，将烷氧基硅烷或烷氧基硅氧烷溶解在有机相中，缩聚成聚倍半硅氧烷，除去水，分离和任选地再分散 水中的微球。

公开(公告)号：US20100068823A1

公开(公告)日：2010-03-18

申请号：US11922755

申请日：2006-06-21

申请人： Thomas Ehben

发明人： Thomas Ehben

IPC分类号： G01N33/545 ,  C08F116/06

CPC分类号： G01N33/54333 ,  G01N2446/20 ,  G01N2446/66

摘要： An embodiment of the present invention relates to a carrier material which is used in a method of diagnosis and which comprises a base material which is provided with a surface which is equipped with at least two different affinity ligands.

摘要翻译： 本发明的一个实施方案涉及用于诊断方法的载体材料，其包含基材，该基材具有配备有至少两种不同亲和配体的表面。

公开(公告)号：US20050137334A1

公开(公告)日：2005-06-23

申请号：US11022885

申请日：2004-12-28

申请人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jerome Bibette

发明人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jerome Bibette

IPC分类号： G01N33/545 ,  A61K9/51 ,  A61K31/7088 ,  A61K45/00 ,  A61K47/02 ,  A61K47/04 ,  A61K47/32 ,  A61K47/48 ,  A61K48/00 ,  A61P43/00 ,  C09D11/00 ,  G01N33/543 ,  C08L51/04

CPC分类号： G01N33/5434 ,  G01N2446/20 ,  G01N2446/64 ,  G01N2446/66 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987

摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

公开(公告)号：US5232782A

公开(公告)日：1993-08-03

申请号：US634910

申请日：1990-12-27

申请人： Dominique Charmot

发明人： Dominique Charmot

IPC分类号： C08G77/04 ,  A61K9/50 ,  B01J13/02 ,  B01J13/18 ,  C08J3/12 ,  C08K9/06 ,  C08L83/02 ,  C08L83/04 ,  C12N11/08 ,  G01N33/553 ,  H01F1/34

CPC分类号： B01J13/18 ,  A61K9/5031 ,  A61K9/5094 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/64 ,  G01N2446/66 ,  Y10T428/2995 ,  Y10T428/2998

摘要： Magnetizable "core-shell" microspheres comprising a core of a magnetizable filler and a shell of crosslinked organopolysiloxane obtained by dispersing an aqueous suspension of a magnetizable filler, not coated with a dispersing agent, in an organic solvent, dissolving an organopolysiloxane and an organohydrogenpolysiloxane in the organic phase, crosslinking, removing water, separating and, if appropriate, redispersing the magnetizable microspheres in water.

摘要翻译： 可磁化的“核 - 壳”微球，其包含可磁化填料的芯和通过将未涂覆有分散剂的可磁化填料的水悬浮液分散在有机溶剂中而获得的交联的有机聚硅氧烷的壳，将有机聚硅氧烷和有机氢聚硅氧烷溶解在 有机相，交联，除去水分离，如果合适的话，将可磁化的微球再分散在水中。

公开(公告)号：US06866838B1

公开(公告)日：2005-03-15

申请号：US10129141

申请日：2000-11-06

申请人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jérôme Bibette

发明人： Olivier Mondain-Monval ,  Abdelhamid Elaissari ,  Eric Bosc ,  Christian Pichot ,  Bernard Mandrand ,  Jérôme Bibette

IPC分类号： G01N33/545 ,  A61K9/51 ,  A61K31/7088 ,  A61K45/00 ,  A61K47/02 ,  A61K47/04 ,  A61K47/32 ,  A61K47/48 ,  A61K48/00 ,  A61P43/00 ,  C09D11/00 ,  G01N33/543 ,  A61B8/00 ,  A61K9/14 ,  B01J13/02

CPC分类号： G01N33/5434 ,  G01N2446/20 ,  G01N2446/64 ,  G01N2446/66 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987

摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N—N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

摘要翻译： 本发明涉及直径范围在约50和1000nm之间的复合纳米球，加上或减少5％，优选在约100和500nm之间加上或减少5％，并且有利地在100和200nm之间加上或减少5％，并且包括基本上 分布在有机相内部的有机相和无机纳米颗粒组成的液体芯，以及至少由至少一种水溶性单体，特别是N-烷基丙烯酰胺或NN-二烷基丙烯酰胺的聚合衍生的亲水性聚合物组成的皮肤; 源自所述纳米球的共轭物; 其制备方法及其用途。

公开(公告)号：US5356713A

公开(公告)日：1994-10-18

申请号：US70053

申请日：1993-06-01

申请人： Dominique Charmot ,  Christine Vidil

发明人： Dominique Charmot ,  Christine Vidil

IPC分类号： G01N33/545 ,  A61K39/00 ,  A61L31/00 ,  B22F1/02 ,  C01G49/00 ,  C08F2/44 ,  C08F12/00 ,  C08F292/00 ,  C08K9/04 ,  C08K9/10 ,  C08L25/00 ,  C08L25/04 ,  G01N33/543 ,  G01N33/553 ,  H01F1/44 ,  B32B5/16

CPC分类号： G01N33/5434 ,  C08F292/00 ,  C08K9/10 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/64 ,  G01N2446/66 ,  G01N2446/84 ,  Y10T428/2991 ,  Y10T428/2998

摘要： Magnetizable composite microspheres approximately from 0.05 to 10 .mu.m in diameter, comprising a core of magnetizable particles and a shell of a hydrophobic crosslinked copolymer formed from a vinylaromatic monomer and a crosslinking emulsifying polymer. The microspheres are obtained by the pre-emulsification in water of a magnetic fluid composed of magnetizable particles dispersed in a vinylaromatic monomer and in a crosslinking emulsifying polymer, polymerization, separation of the magnetizable microspheres and optional redispersion in water. The microspheres are useful in biological applications.

摘要翻译： 直径约为0.05-10μm的可磁化复合微球，包含可磁化颗粒的芯和由乙烯基芳族单体和交联乳化聚合物形成的疏水性交联共聚物的壳。 微球是通过在水中预先乳化在由可分散在乙烯基芳族单体中的可磁化颗粒和交联乳化聚合物，聚合，可磁化微球分离和任选的再分散在水中的磁性流体获得的。 微球可用于生物应用。

公开(公告)号：US5178947A

公开(公告)日：1993-01-12

申请号：US634909

申请日：1990-12-27

申请人： Dominique Charmot ,  Andre Thibon

发明人： Dominique Charmot ,  Andre Thibon

IPC分类号： C08G77/12 ,  A61K9/50 ,  C08G77/20 ,  C08G77/22 ,  C08J3/12 ,  C08K9/06 ,  C08L83/05 ,  C08L83/07 ,  C12N11/08 ,  C12N11/14 ,  G01N33/553 ,  H01F1/34 ,  H01F1/44

CPC分类号： C08J3/12 ,  A61K9/5094 ,  C08J3/126 ,  C12N11/14 ,  H01F1/44 ,  C08J2383/04 ,  C08J2483/02 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/64 ,  G01N2446/66 ,  Y10T428/2995

摘要： Magnetizable composite microspheres comprising a core of a magnetizable filler distributed uniformly in a network of a polysilsesquioxane SiVi containing double bonds and a shell of a crosslinked organosilicon polymer derived from the hydrosilylation of an organohydrogenopolysiloxane SiH with the ethylenically unsaturated groups of the polysilsesquioxane. The magnetizable composite microspheres are obtained by dispersing an aqueous suspension of a magnetizable filler, not coated with a dispersing agent, in a solvent, dissolving an alkoxysilane or an alkoxysiloxane containing double bonds, polycondensing to a SiVi group-containing polysilsesquioxane SiVi, removing water, dissolving the organohydrogenopolysiloxane SiH polymer in the organic phase, crosslinking the mixture of polymers, removing water, separating the microspheres and, if appropriate, redispersing the microspheres in water. The magnetizable composite microspheres are preferably used as an active supports in biology.

摘要翻译： 可磁化的复合微球，其包含均匀分布在含有双键的聚倍半硅氧烷SiVi的网络中的可磁化填料的芯和衍生自有机氢聚硅氧烷SiH与聚倍半硅氧烷的烯键式不饱和基团的氢化硅烷化的交联的有机硅聚合物的壳。 可磁化复合微球是通过将未涂覆分散剂的可磁化填料的水性悬浮液分散在溶剂中，将含有双键的烷氧基硅烷或烷氧基硅氧烷，缩聚反应分散在含SiVi的聚倍半硅氧烷SiVi中，除去水， 将有机氢聚硅氧烷SiH聚合物溶解在有机相中，交联聚合物的混合物，除去水，分离微球体，如果合适的话，将微球体再分散在水中。 可磁化复合微球优选用作生物学中的活性载体。

公开(公告)号：US4965007A

公开(公告)日：1990-10-23

申请号：US192753

申请日：1988-05-10

申请人： Joseph S. Yudelson

发明人： Joseph S. Yudelson

IPC分类号： B01J13/10 ,  B03C1/01 ,  G01N33/543 ,  H01F1/00 ,  H01F1/44

CPC分类号： G01N33/5434 ,  B03C1/01 ,  H01F1/445 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/66 ,  G01N2446/84 ,  Y10T428/2991 ,  Y10T428/2998

摘要： Stable, encapsulated superparamagnetic magnetite particles having a narrow particle size distribution with average particle diameters in the range of from about 50 .ANG. to about 350 .ANG. are prepared by forming an aqueous dispersion of magnetite particles having the above particle size characteristics in the presence of a surfactant, coacervating a mixture of gelatin and a carboxyl containing hydrophilic polymer such as gum arabic to form a thin coating of coacervate on the magnetite particles and crosslinking the coacervate coating with a gelatin hardener such as glutaraldehyde.

摘要翻译： 通过在表面活性剂的存在下形成具有上述粒径特性的磁铁矿颗粒的水性分散体，制备具有窄平均粒径在约50至约350范围内的窄粒度分布的稳定的，包封的超顺磁性磁铁矿颗粒 凝胶化明胶和含羧基的亲水性聚合物如阿拉伯树胶的混合物，以在磁铁矿颗粒上形成薄层的凝聚层，并用明胶固化剂如戊二醛交联凝聚层。