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    Miniaturized immunosensor assembled from colloidal particles between micropatterned electrodes
    1.
    发明授权
    Miniaturized immunosensor assembled from colloidal particles between micropatterned electrodes 失效
    由微图案电极之间的胶体颗粒组装的小型化免疫传感器

    公开(公告)号：US06333200B1

    公开(公告)日：2001-12-25

    申请号：US09358494

    申请日：1999-07-21

    Applicant: Eric W. Kaler ,  Orlin D. Velev

    Inventor： Eric W. Kaler ,  Orlin D. Velev

    IPC: G01N33543

    CPC classification number: G01N33/5438

    Abstract: The invention is a sensor for the presence of bio-specific (e.g., immunological) molecules. It is aimed to giving an alternative, highly advanced method for performing different tests for the presence of immuno-specific molecules in liquid environments such as body liquids, biological cultures, environmental samples, etc. Gold patterns are photolithoghraphyically fabricated onto glass substrates to form addressable electrodes of micron size. The sensor is assembled when colloidal particles from suspension are deposited dielectrophoretically in the microscopic gaps between the electrodes. The surfaces of these particles carry immuno-active binding sites that collect the target molecules. The sensor readout is accomplished by secondary tagging of the target molecules with colloidal gold and its enhancement by silver nucleation, which leads to short-circuiting of the electrodes. The device allows extreme miniaturization and direct electric readout. We anticipate detection levels as low as 10−21M, which is a 200 times gain in sensitivity over the conventional techniques.

    Abstract translation: 本发明是用于存在生物特异性（例如免疫学）分子的传感器。 目的是为了在液体环境如体液，生物培养物，环境样品等中对免疫特异性分子的存在进行不同的测试，目的是提供一种替代的，高度先进的方法。将金图案光刻地制造到玻璃基底上以形成可寻址的 微米电极。 当来自悬浮液的胶体颗粒在电极之间的微观间隙中介电泳地沉积时，传感器被组装。 这些颗粒的表面带有收集目标分子的免疫活性结合位点。 传感器读出是通过用胶体金二次标记目标分子并通过银成核而增强的，这导致电极的短路。 该器件允许极小型化和直接电子读出。 我们预计检测水平低至10-21M，这比常规技术灵敏度提高了200倍。

    Method for fabricating nanofibers
    2.
    发明授权
    Method for fabricating nanofibers 有权
    制造纳米纤维的方法

    公开(公告)号：US09217211B2

    公开(公告)日：2015-12-22

    申请号：US13473327

    申请日：2012-05-16

    Applicant: Orlin D. Velev ,  Stoyan Smoukov ,  Peter Geisen ,  Miles C. Wright ,  Sumit Gangwal

    Inventor： Orlin D. Velev ,  Stoyan Smoukov ,  Peter Geisen ,  Miles C. Wright ,  Sumit Gangwal

    IPC: B29B9/10 ,  C08F6/00 ,  C08J3/11 ,  D01D5/18 ,  D01F1/10 ,  D01D5/40

    CPC classification number: D01F1/10 ,  D01D5/40

    Abstract: Nanofibers are fabricated in a continuous process by introducing a polymer solution into a dispersion medium, which flows through a conduit and shears the dispersion medium. Liquid strands, streaks or droplets of the polymer solution are continuously shear-spun into elongated fibers. An inorganic precursor may be introduced with the polymer solution, resulting in fibers that include inorganic fibrils. The resulting composite inorganic/polymer fibers may be provided as an end product. Alternatively, the polymer may be removed to liberate the inorganic fibrils, which may be of the same or smaller cross-section as the polymer fibers and may be provided as an end product.

    Abstract translation: 通过将聚合物溶液引入分散介质中，在连续方法中制造纳米纤维，分散介质流过管道并剪切分散介质。 将聚合物溶液的液体线，条纹或液滴连续地剪切成细长纤维。 可以将聚合物溶液引入无机前体，产生包含无机原纤维的纤维。 所得到的复合无机/聚合物纤维可以作为最终产品提供。 或者，可以除去聚合物以释放无机纤维，其可以与聚合物纤维具有相同或更小的横截面，并且可以作为最终产品提供。

    APPARATUS AND METHODS FOR FABRICATING NANOFIBERS FROM SHEARED SOLUTIONS UNDER CONTINUOUS FLOW
    6.
    发明申请
    APPARATUS AND METHODS FOR FABRICATING NANOFIBERS FROM SHEARED SOLUTIONS UNDER CONTINUOUS FLOW 有权
    在连续流动下从剪切解决方案制备纳米纤维的装置和方法

    公开(公告)号：US20130012598A1

    公开(公告)日：2013-01-10

    申请号：US13473327

    申请日：2012-05-16

    Applicant: ORLIN D. VELEV ,  STOYAN SMOUKOV ,  PETER GEISEN ,  MILES C. WRIGHT ,  SUMIT GANGWAL

    Inventor： ORLIN D. VELEV ,  STOYAN SMOUKOV ,  PETER GEISEN ,  MILES C. WRIGHT ,  SUMIT GANGWAL

    IPC: B29B9/10 ,  A61K47/32 ,  C08L25/06 ,  C01G23/047 ,  B01J31/06

    CPC classification number: D01F1/10 ,  D01D5/40

    Abstract: Nanofibers are fabricated in a continuous process by introducing a polymer solution into a dispersion medium, which flows through a conduit and shears the dispersion medium. Liquid strands, streaks or droplets of the polymer solution are continuously shear-spun into elongated fibers. An inorganic precursor may be introduced with the polymer solution, resulting in fibers that include inorganic fibrils. The resulting composite inorganic/polymer fibers may be provided as an end product. Alternatively, the polymer may be removed to liberate the inorganic fibrils, which may be of the same or smaller cross-section as the polymer fibers and may be provided as an end product.

    Abstract translation: 通过将聚合物溶液引入分散介质中，在连续方法中制造纳米纤维，分散介质流过管道并剪切分散介质。 将聚合物溶液的液体线，条纹或液滴连续地剪切成细长纤维。 可以将聚合物溶液引入无机前体，产生包含无机原纤维的纤维。 所得到的复合无机/聚合物纤维可以作为最终产品提供。 或者，可以除去聚合物以释放无机纤维，其可以与聚合物纤维具有相同或更小的横截面，并且可以作为最终产品提供。

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