公开(公告)号：US08551378B2

公开(公告)日：2013-10-08

申请号：US12730644

申请日：2010-03-24

Applicant: Orlin D. Velev ,  Stoyan Smoukov ,  Manuel Marquez

Inventor： Orlin D. Velev ,  Stoyan Smoukov ,  Manuel Marquez

IPC: C08F6/00 ,  C08J3/11 ,  D01D5/18 ,  D01D5/40

CPC classification number: D01F1/10 ,  D01D5/40

Abstract: Nanofibers are fabricated by introducing a polymer solution into a dispersion medium and shearing the dispersion medium. Droplets of the polymer solution are spun into elongated fibers that are insoluble in the dispersion medium.

Abstract translation: 通过将聚合物溶液引入分散介质并剪切分散介质来制造纳米纤维。 将聚合物溶液的液滴纺丝成不溶于分散介质的细长纤维。

公开(公告)号：US20100247908A1

公开(公告)日：2010-09-30

申请号：US12730644

申请日：2010-03-24

Applicant: Orlin D. Velev ,  Stoyan Smoukov ,  Manuel Marquez

Inventor： Orlin D. Velev ,  Stoyan Smoukov ,  Manuel Marquez

IPC: D02G3/02 ,  B29C41/24

CPC classification number: D01F1/10 ,  D01D5/40

Abstract: Nanofibers are fabricated by introducing a polymer solution into a dispersion medium and shearing the dispersion medium. Droplets of the polymer solution are spun into elongated fibers that are insoluble in the dispersion medium.

Abstract translation: 通过将聚合物溶液引入分散介质并剪切分散介质来制造纳米纤维。 将聚合物溶液的液滴纺丝成不溶于分散介质的细长纤维。

公开(公告)号：US20080149119A1

公开(公告)日：2008-06-26

申请号：US11878741

申请日：2007-07-26

Applicant: Manuel Marquez ,  Samuel Isaac Ogle ,  Zhihao Shen

Inventor： Manuel Marquez ,  Samuel Isaac Ogle ,  Zhihao Shen

IPC: A24D1/04 ,  A24D3/06 ,  D02G3/00 ,  D02G1/00 ,  A24D3/02

CPC classification number: A24B15/28 ,  A24B15/283 ,  A24D3/0287 ,  A24D3/048 ,  A24D3/065 ,  A24D3/08 ,  D01D5/0069 ,  D01D5/24 ,  D01D5/34 ,  D01F1/10 ,  Y10T428/2927

Abstract: A large variety of electrospun fibers can be produced to encapsulate a large variety of additives within the subcompartments or substructures of the manufactured electrospun fiber. Furthermore, the manufactured electrospun fibers can be electrostatically arranged within a filter component of a smoking article during the manufacturing process. By modifying the various parameters that control the electrospinning process, a diverse set of electrospun fibers can be manufactured that vary in composition, in substructural organization, and in dimension. The electrospun fiber produced by electrospinning comprises at least one type of polymeric material that encapsulates or supports the retention of at least one type of a flavorant or a non-flavorant within the electrospun fiber. A polymeric material provides a supporting structure for encapsulating at least one type of a flavorant or a non-flavorant. The electrospun fibers that can be produced by various electrospinning processes described below include microfibers in a micro-scaled range, nanofibers in a nano-scaled range, and various mixtures of microfibers and nanofibers.

Abstract translation: 可以生产各种各样的电纺纤维，以将大量各种添加剂包封在制造的电纺纤维的子隔室或子结构内。 此外，制造的电纺纤维可以在制造过程中静电地布置在吸烟制品的过滤器部件内。 通过修改控制静电纺丝过程的各种参数，可以制造不同组合的电纺纤维，其组成，子结构和尺寸都不同。 通过静电纺丝产生的电纺纤维包括至少一种类型的聚合物材料，其包封或支持在电纺纤维内至少一种类型的调味剂或非调味剂的保留。 聚合物材料提供用于包封至少一种类型的调味剂或非风味剂的支撑结构。 可以通过下面描述的各种静电纺丝方法生产的电纺纤维包括微尺度范围的微纤维，纳米级范围的纳米纤维，以及微纤维和纳米纤维的各种混合物。

公开(公告)号：US06503476B1

公开(公告)日：2003-01-07

申请号：US09624423

申请日：2000-07-24

Applicant: Steven L. Suib ,  Oscar Giraldo ,  Manuel Marquez ,  Stephanie Brock

Inventor： Steven L. Suib ,  Oscar Giraldo ,  Manuel Marquez ,  Stephanie Brock

IPC: C01G4500

CPC classification number: B82Y30/00 ,  C01G45/1221 ,  C01P2002/72 ,  C01P2002/76 ,  C01P2002/77 ,  C01P2004/64 ,  C01P2006/40

Abstract: Methods for the preparation of mixed-valence manganese oxide compositions with quaternary ammonium ions are described. The compositions self-assemble into helices, rings, and strands without any imposed concentration gradient. These helices, rings, and strands, as well as films having the same composition, undergo rapid ion exchange to replace the quaternary ammonium ions with various metal ions. And the metal-ion-containing manganese oxide compositions so formed can be heat treated to form semi-conducting materials with high surface areas.

Abstract translation: 描述了制备具有季铵离子的混合价锰氧化物组合物的方法。 组合物自组装成螺旋，环和股，没有任何强加的浓度梯度。 这些螺旋，环和线以及具有相同组成的膜经历快速离子交换以用各种金属离子代替季铵离子。 这样形成的含金属离子的氧化锰组合物可以进行热处理以形成具有高表面积的半导体材料。

公开(公告)号：US06479684B1

公开(公告)日：2002-11-12

申请号：US09799996

申请日：2001-03-06

Applicant: Ahmad Akashe ,  Manuel Marquez

Inventor： Ahmad Akashe ,  Manuel Marquez

IPC: C07C5100

CPC classification number: A61K8/41 ,  A23D7/0056 ,  A23D9/007 ,  A61K8/922 ,  A61Q19/00 ,  C11B15/00

Abstract: The present invention generally relates to a process for hardening lipids, especially unsaturated lipids such as unsaturated fatty oils, by mixing and interacting lipids with polyamines such that the peak melting point of the resulting combination is higher than that of the lipid alone. In this way, the polyamine-treated unsaturated lipid can be converted into a solid or semi-solid state at a relatively lower temperature than the unsaturated lipid alone. The lipid and polyamine combination displays physical attributes that mimic the crystalline structures of saturated lipids and fats without the incurring the associated negative health implications of such saturated lipids and fats.

Abstract translation: 本发明一般涉及通过将脂质与多胺混合和相互作用使脂质，特别是不饱和脂肪如不饱和脂肪油硬化的方法，使得所得组合的峰值熔点高于单独脂质的峰值熔点。 以这种方式，多胺处理的不饱和脂质可以在比单独的不饱和脂肪相对较低的温度下转化为固体或半固体状态。 脂质和多胺组合显示模拟饱和脂质和脂肪的晶体结构的物理属性，而不会引起这种饱和脂质和脂肪的相关负面健康影响。

公开(公告)号：US20110104777A1

公开(公告)日：2011-05-05

申请号：US12880113

申请日：2010-09-12

Applicant: Manuel Marquez ,  Samantha M. Marquez

Inventor： Manuel Marquez ,  Samantha M. Marquez

IPC: C12N5/02 ,  C12N1/00

CPC classification number: A61F2/022

Abstract: A method is disclosed for making an artificial micro-gland having a continuous anisotropic membrane of two or more types of living cells. A first step includes forming a carrier fluid in a microchannel in a laminar flow of two distinct fluid flows. Another step includes introducing a template, which may itself be anisotropic, into the microchannel in a manner such that the template straddles the interface between the first fluid-flow and the second fluid-flow. In some embodiments two types of living cells within the template are separately attracted one of the fluid flows by the presence of an agent of taxis. In other embodiments, cells within one or the other of the fluid flows are attracted to agents within the template. Membranes form on the template and join together to form a complete cellular membrane around a reservoir.

Abstract translation: 公开了一种用于制造具有两种或更多种类型活细胞的连续各向异性膜的人造微腺的方法。 第一步骤包括在两个不同流体流的层流中在微通道中形成载流体。 另一步骤包括将模板本身可以是各向异性的，以使模板跨越第一流体流与第二流体流之间的界面的方式引入微通道。 在一些实施方案中，模板内的两种类型的活细胞通过出租车的出现分开地吸引流体流中的一种。 在其它实施例中，一个或另一个流体流中的细胞被吸引到模板内的试剂上。 在模板上形成膜并连接在一起以在储存器周围形成完整的细胞膜。

公开(公告)号：US20100076105A1

公开(公告)日：2010-03-25

申请号：US12502842

申请日：2009-07-14

Applicant: Zhibing Hu ,  Tong Cai ,  Chenglin Chi ,  Manuel Marquez

Inventor： Zhibing Hu ,  Tong Cai ,  Chenglin Chi ,  Manuel Marquez

IPC: C08L33/10 ,  C08F2/48

CPC classification number: C08F2/48 ,  C08L33/02 ,  C08L33/26 ,  C08L2666/04

Abstract: Composition, processes, techniques, and apparatus for synthesizing monodisperse microgels based on poly(ethylene glycol) (PEG) derivative polymers by using precipitation polymerization. These microgels are hydrophilic and have the adjustable volume phase transition temperature in aqueous environment. Microgels can be added with various functional groups. These microgels in water can self-assemble into various phases, including a crystalline phase. Hydrogel films with iridescent colors were formed using these microgels as crosslinkers to connect poly(ethylene glycol) chains. The colors of these hydrogel films change with changes of environment such temperature, pH, salt concentration, etc.

Abstract translation: 通过使用沉淀聚合法合成基于聚（乙二醇）（PEG）衍生物聚合物的单分散微凝胶的组合物，方法，技术和装置。 这些微凝胶是亲水性的，并且在水性环境中具有可调节的体积相转变温度。 微凝胶可以加入各种官能团。 水中的这些微凝胶可以自组装成各种相，包括结晶相。 使用这些微凝胶作为交联剂形成具有彩虹色的水凝胶膜以连接聚（乙二醇）链。 这些水凝胶膜的颜色随温度，pH，盐浓度等环境变化而变化。

公开(公告)号：US20170275584A1

公开(公告)日：2017-09-28

申请号：US15606042

申请日：2017-05-26

Applicant: Manuel Marquez ,  Samantha M. Marquez

Inventor： Manuel Marquez ,  Samantha M. Marquez

IPC: C12N5/00 ,  C12N1/26 ,  A61K35/74 ,  A61K35/742

CPC classification number: C12N5/0062 ,  A61K35/74 ,  A61K35/742 ,  C12N1/26 ,  A61K2300/00

Abstract: A method is used for making an artificial micro-gland by taxis. A monodisperse multiple emulsion is produced with a first fluid; a second fluid confined within the first fluid; a third fluid within the second fluid. Interfaces between the fluids permit living cells dispersed in the one of the fluids to migrate towards an adjacent fluid having a different concentration of an agent affecting the metabolic activity of the living cells. Waiting, usually about 30 minutes, allows the living cells to migrate to the interface, forming the continuous membrane. Once formed, the artificial micro-gland is removed from the remains of the emulsion. The artificial micro-gland may also be given a second layer of different cells when the emission of the cells of the artificial micro-gland is used as the agent to attract the different cells. The method may also be used to produce an artificial micro-gland within an artificial micro-gland.

公开(公告)号：USRE44508E1

公开(公告)日：2013-09-24

申请号：US13406180

申请日：2012-02-27

Applicant: Antonio Barrero Ripoll ,  Alfonso M Ganan-Calvo ,  Ignacio Gonzalez Loscertales ,  Raul Cortijo Bon ,  Manuel Marquez

Inventor： Antonio Barrero Ripoll ,  Alfonso M Ganan-Calvo ,  Ignacio Gonzalez Loscertales ,  Raul Cortijo Bon ,  Manuel Marquez

IPC: A23P1/04

Abstract: The present invention is related to the production of capsules or particles of micro and nanometric size, for introduction into food, using stable electrified coaxial jets of two immiscible liquids with diameters in the micro and nanometric range. An aerosol of charged structured droplets forms when the jets dissociate by capillary instabilities. The structured droplets, which are mano-dispersed in size, contain a first liquid (generally the material desired to be added) that is surrounded by a second liquid. Generally the second liquid provides a barrier or protective coating which allows the addition of the first liquid to a food product without adversely affecting the organoleptic or other properties of the food product.

Abstract translation: 本发明涉及使用具有微米和纳米范围直径的两种不混溶液体的稳定带电的同轴射流来生产用于引入食品的微米和纳米尺寸的胶囊或颗粒。 当喷流通过毛细管不稳定性分解时，形成带电结构的液滴的气溶胶。 手工分散尺寸的结构化液滴含有由第二液体包围的第一液体（通常是期望添加的材料）。 通常，第二液体提供阻挡或保护涂层，其允许将第一液体添加到食品中，而不会不利地影响食品的感官或其他性质。

公开(公告)号：US07989505B2

公开(公告)日：2011-08-02

申请号：US11524703

申请日：2006-09-21

Applicant: Zhibing Hu ,  Jun Zhou ,  Tong Cai ,  Shijun Tang ,  Manuel Marquez

Inventor： Zhibing Hu ,  Jun Zhou ,  Tong Cai ,  Shijun Tang ,  Manuel Marquez

IPC: C08J3/05 ,  C08J3/075 ,  B01F3/12

CPC classification number: C30B5/00 ,  C30B29/58

Abstract: The compositions of hydrogel colloidal crystals are made from mixing an aqueous suspension of poly-N-isopropylacrylamide (“PNIPAM”)-co-allylamine microgels with dichloromethane, forming a PNIPAM-co-allylamine/dichloromethane mixture. The PNIPAM-co-allylamine/dichloromethane mixture is incubated for a period of time at a given temperature, forming the colloidal crystal material. The colloidal crystals can be stabilized by diffusing a glutaric dialdehyde solution into the colloidal crystal material. The concentration of polymer matrix microgels can determine the orientation of random or columnar crystals.

Abstract translation: 水凝胶胶体晶体的组成通过将聚-N-异丙基丙烯酰胺（“PNIPAM”） - 共 - 烯丙基胺微凝胶的水悬浮液与二氯甲烷混合，形成PNIPAM-共 - 烯丙基胺/二氯甲烷混合物来制备。 将PNIPAM-共 - 烯丙基胺/二氯甲烷混合物在给定温度下温育一段时间，形成胶体晶体材料。 可以通过将戊二醛溶液扩散到胶体晶体材料中来稳定胶体晶体。 聚合物基质微凝胶的浓度可以确定随机或柱状晶体的取向。