-
公开(公告)号：US20110104777A1
公开(公告)日：2011-05-05
申请号：US12880113
申请日：2010-09-12
CPC分类号： A61F2/022
摘要： A method is disclosed for making an artificial micro-gland having a continuous anisotropic membrane of two or more types of living cells. A first step includes forming a carrier fluid in a microchannel in a laminar flow of two distinct fluid flows. Another step includes introducing a template, which may itself be anisotropic, into the microchannel in a manner such that the template straddles the interface between the first fluid-flow and the second fluid-flow. In some embodiments two types of living cells within the template are separately attracted one of the fluid flows by the presence of an agent of taxis. In other embodiments, cells within one or the other of the fluid flows are attracted to agents within the template. Membranes form on the template and join together to form a complete cellular membrane around a reservoir.
摘要翻译： 公开了一种用于制造具有两种或更多种类型活细胞的连续各向异性膜的人造微腺的方法。 第一步骤包括在两个不同流体流的层流中在微通道中形成载流体。 另一步骤包括将模板本身可以是各向异性的，以使模板跨越第一流体流与第二流体流之间的界面的方式引入微通道。 在一些实施方案中，模板内的两种类型的活细胞通过出租车的出现分开地吸引流体流中的一种。 在其它实施例中，一个或另一个流体流中的细胞被吸引到模板内的试剂上。 在模板上形成膜并连接在一起以在储存器周围形成完整的细胞膜。
-
2.发明申请MONODISPERSE THERMO-RESPONSIVE MICROGELS OF POLY(ETHYLENE GLYCOL) ANALOGUE-BASED BIOPOLYMERS, THEIR MANUFACTURE, AND THEIR APPLICATIONS 审中-公开聚乙二醇（乙烯甘油）基于模拟物的生物聚合物的单体热响应微胶囊，其制备及其应用公开(公告)号：US20100076105A1
公开(公告)日：2010-03-25
申请号：US12502842
申请日：2009-07-14
申请人： Zhibing Hu , Tong Cai , Chenglin Chi , Manuel Marquez
发明人： Zhibing Hu , Tong Cai , Chenglin Chi , Manuel Marquez
CPC分类号： C08F2/48 , C08L33/02 , C08L33/26 , C08L2666/04
摘要： Composition, processes, techniques, and apparatus for synthesizing monodisperse microgels based on poly(ethylene glycol) (PEG) derivative polymers by using precipitation polymerization. These microgels are hydrophilic and have the adjustable volume phase transition temperature in aqueous environment. Microgels can be added with various functional groups. These microgels in water can self-assemble into various phases, including a crystalline phase. Hydrogel films with iridescent colors were formed using these microgels as crosslinkers to connect poly(ethylene glycol) chains. The colors of these hydrogel films change with changes of environment such temperature, pH, salt concentration, etc.
摘要翻译： 通过使用沉淀聚合法合成基于聚（乙二醇）（PEG）衍生物聚合物的单分散微凝胶的组合物，方法，技术和装置。 这些微凝胶是亲水性的，并且在水性环境中具有可调节的体积相转变温度。 微凝胶可以加入各种官能团。 水中的这些微凝胶可以自组装成各种相，包括结晶相。 使用这些微凝胶作为交联剂形成具有彩虹色的水凝胶膜以连接聚（乙二醇）链。 这些水凝胶膜的颜色随温度，pH，盐浓度等环境变化而变化。
-
公开(公告)号：US20170275584A1
公开(公告)日：2017-09-28
申请号：US15606042
申请日：2017-05-26
IPC分类号： C12N5/00 , C12N1/26 , A61K35/74 , A61K35/742
CPC分类号： C12N5/0062 , A61K35/74 , A61K35/742 , C12N1/26 , A61K2300/00
摘要： A method is used for making an artificial micro-gland by taxis. A monodisperse multiple emulsion is produced with a first fluid; a second fluid confined within the first fluid; a third fluid within the second fluid. Interfaces between the fluids permit living cells dispersed in the one of the fluids to migrate towards an adjacent fluid having a different concentration of an agent affecting the metabolic activity of the living cells. Waiting, usually about 30 minutes, allows the living cells to migrate to the interface, forming the continuous membrane. Once formed, the artificial micro-gland is removed from the remains of the emulsion. The artificial micro-gland may also be given a second layer of different cells when the emission of the cells of the artificial micro-gland is used as the agent to attract the different cells. The method may also be used to produce an artificial micro-gland within an artificial micro-gland.
-
公开(公告)号：USRE44508E1
公开(公告)日：2013-09-24
申请号：US13406180
申请日：2012-02-27
申请人： Antonio Barrero Ripoll , Alfonso M Ganan-Calvo , Ignacio Gonzalez Loscertales , Raul Cortijo Bon , Manuel Marquez
发明人： Antonio Barrero Ripoll , Alfonso M Ganan-Calvo , Ignacio Gonzalez Loscertales , Raul Cortijo Bon , Manuel Marquez
IPC分类号： A23P1/04
摘要： The present invention is related to the production of capsules or particles of micro and nanometric size, for introduction into food, using stable electrified coaxial jets of two immiscible liquids with diameters in the micro and nanometric range. An aerosol of charged structured droplets forms when the jets dissociate by capillary instabilities. The structured droplets, which are mano-dispersed in size, contain a first liquid (generally the material desired to be added) that is surrounded by a second liquid. Generally the second liquid provides a barrier or protective coating which allows the addition of the first liquid to a food product without adversely affecting the organoleptic or other properties of the food product.
摘要翻译： 本发明涉及使用具有微米和纳米范围直径的两种不混溶液体的稳定带电的同轴射流来生产用于引入食品的微米和纳米尺寸的胶囊或颗粒。 当喷流通过毛细管不稳定性分解时，形成带电结构的液滴的气溶胶。 手工分散尺寸的结构化液滴含有由第二液体包围的第一液体（通常是期望添加的材料）。 通常，第二液体提供阻挡或保护涂层，其允许将第一液体添加到食品中，而不会不利地影响食品的感官或其他性质。
-
公开(公告)号：US20120298121A1
公开(公告)日：2012-11-29
申请号：US13570012
申请日：2012-08-08
申请人： Ashok KUMAR , Carolina MARUN , Gregory J. GRISCIK , David R. GOLOB , Jon REGRUT , Suresh SHENOY , William R. SWEENEY , Manuel Marquez-Sanchez
发明人： Ashok KUMAR , Carolina MARUN , Gregory J. GRISCIK , David R. GOLOB , Jon REGRUT , Suresh SHENOY , William R. SWEENEY , Manuel Marquez-Sanchez
摘要： A consumable compressed tobacco product adapted to dissolve in an oral cavity. The compressed tobacco product is formed from a composition that includes at least one tobacco component, at least one flavorant, at least one filler-binder, at least one lubricant, at least one desiccant and at least one glidant. The compressed tobacco products are adapted to dissolve and provide tobacco satisfaction. A method of making a dissolvable compressed tobacco product is also provided.
摘要翻译： 适于溶解在口腔中的消耗性压缩烟草制品。 压缩烟草制品由包含至少一种烟草成分，至少一种调味剂，至少一种填料 - 粘合剂，至少一种润滑剂，至少一种干燥剂和至少一种助流剂的组合物形成。 压缩的烟草制品适应于溶解和提供烟草满意度。 还提供了制造可溶解压缩烟草制品的方法。
-
6.发明授权Synthesis of columnar hydrogel colloidal crystals in water-organic solvent mixture 失效在水 - 有机溶剂混合物中合成柱状水凝胶胶体晶体公开(公告)号：US07989505B2
公开(公告)日：2011-08-02
申请号：US11524703
申请日：2006-09-21
申请人： Zhibing Hu , Jun Zhou , Tong Cai , Shijun Tang , Manuel Marquez
发明人： Zhibing Hu , Jun Zhou , Tong Cai , Shijun Tang , Manuel Marquez
摘要： The compositions of hydrogel colloidal crystals are made from mixing an aqueous suspension of poly-N-isopropylacrylamide (“PNIPAM”)-co-allylamine microgels with dichloromethane, forming a PNIPAM-co-allylamine/dichloromethane mixture. The PNIPAM-co-allylamine/dichloromethane mixture is incubated for a period of time at a given temperature, forming the colloidal crystal material. The colloidal crystals can be stabilized by diffusing a glutaric dialdehyde solution into the colloidal crystal material. The concentration of polymer matrix microgels can determine the orientation of random or columnar crystals.
摘要翻译： 水凝胶胶体晶体的组成通过将聚-N-异丙基丙烯酰胺（“PNIPAM”） - 共 - 烯丙基胺微凝胶的水悬浮液与二氯甲烷混合，形成PNIPAM-共 - 烯丙基胺/二氯甲烷混合物来制备。 将PNIPAM-共 - 烯丙基胺/二氯甲烷混合物在给定温度下温育一段时间，形成胶体晶体材料。 可以通过将戊二醛溶液扩散到胶体晶体材料中来稳定胶体晶体。 聚合物基质微凝胶的浓度可以确定随机或柱状晶体的取向。
-
公开(公告)号：US20100255059A1
公开(公告)日：2010-10-07
申请号：US12726158
申请日：2010-03-17
IPC分类号： A61K35/14 , A61K9/00 , A61K35/16 , A61K35/18 , A61K35/12 , A61P5/00 , C12N5/07 , C12N5/0789 , C12N5/073 , C12N5/09 , C12N5/078
CPC分类号： C12N5/0062 , A61F2/022 , A61K35/28 , A61K35/36 , A61K35/39 , A61K35/54 , A61L27/3804 , A61L27/60 , A61L2400/12
摘要： A micro-scale artificial gland is disclosed in the form of an independent unit for promoting biological activity. The artificial gland includes cells formed in a membrane enclosing a reservoir. The reservoir is a bio-reactor capable of containing a product of activity of the cells. The reservoir comprises a gas, a liquid, and a gel and preferably also contains nanoparticles, a buffer, a surfactant, and, a gel precursor. The reservoir may also contain cells. Nanoparticles may also surround the artificial gland to form a protective coating. A variety of methods are disclosed for making the artificial gland by directed assembly of cells into the artificial micro-gland by gel, liquid or bubble templating. All involve coating the surface of gel, droplet or bubble with the living cells and the stabilizing the cells on the surface of gels, droplets or bubbles.
摘要翻译： 微生物人工腺体以用于促进生物活性的独立单元的形式被公开。 人造腺包括在包围储存器的膜中形成的细胞。 储层是能够容纳细胞活性产物的生物反应器。 储存器包括气体，液体和凝胶，并且优选地还含有纳米颗粒，缓冲液，表面活性剂和凝胶前体。 贮存器还可以含有细胞。 纳米颗粒也可以围绕人造腺体形成保护性涂层。 公开了通过凝胶，液体或气泡模板将细胞定向组装到人造微腺体中来制备人造腺体的各种方法。 所有这些都涉及用活细胞涂覆凝胶表面，液滴或气泡，并将细胞稳定在凝胶，液滴或气泡表面。
-
公开(公告)号：USD545000S1
公开(公告)日：2007-06-19
申请号：US29246922
申请日：2006-05-22
-
9.发明授权Metastable mineral-amino acid preparations for food and beverage fortification 失效用于食品和饮料强化的亚稳态矿物氨基酸制剂公开(公告)号：US07175867B2
公开(公告)日：2007-02-13
申请号：US10665829
申请日：2003-09-18
IPC分类号： A23L1/304
摘要： The present invention is directed to metastable mineral-amino acid complexes that are formed by combining a mineral oxide, hydroxide, or carbonate an amino acid and an organic acid. The complexes may be used to fortify a variety of food and beverage products.
摘要翻译： 本发明涉及通过将矿物氧化物，氢氧化物或碳酸盐与氨基酸和有机酸结合而形成的亚稳态矿物 - 氨基酸复合物。 复合物可用于强化各种食品和饮料产品。
-
公开(公告)号：US20060163385A1
公开(公告)日：2006-07-27
申请号：US11246911
申请日：2005-10-07
IPC分类号： B05B7/06
CPC分类号： B01L3/502784 , B01F5/0682 , B01F13/0062 , B01F13/0071 , B01F13/0076 , B01F2215/0431 , B01J2/04 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2300/0867 , B01L2400/02 , B01L2400/0415 , B01L2400/0424 , B05B5/03 , B05B7/061
摘要： This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.
-
-
-
-
-
-
-
-
-
搜索结果
41 条记录 (耗时 0.025 秒)