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    Bak binding protein, DNA encoding the protein, and methods of use thereof
    1.
    发明授权
    Bak binding protein, DNA encoding the protein, and methods of use thereof 有权
    Bak结合蛋白，编码蛋白的DNA及其使用方法

    公开(公告)号：US07316915B2

    公开(公告)日：2008-01-08

    申请号：US10189294

    申请日：2002-07-01

    申请人： Michael C. Kiefer ,  Paul A. Fitzpatrick ,  Helen L. Gibson ,  Philip J. Barr

    发明人： Michael C. Kiefer ,  Paul A. Fitzpatrick ,  Helen L. Gibson ,  Philip J. Barr

    IPC分类号： C12P21/06

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  G01N2333/47 ,  G01N2500/02 ,  G01N2510/00

    摘要： The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which are involved in the interaction between Bak and BBP.

    摘要翻译： 本发明提供编码Bak结合蛋白（BBP）的多核苷酸序列（bbp）及其与Bak结合的片段。 本发明还提供了结合Bak的BBP。 本发明还提供含有编码BBP的多核苷酸的重组宿主细胞。 本发明还提供了特异性结合BBP的抗体。 本发明还提供了用于检测诸如改变BBP与Bak蛋白的结合的药物的药物的方法。 本发明还提供了用于检测生物样品中bbp或BBP的存在的方法，并且还提供了调节细胞中BBP水平的方法。 本发明另外包括称为“BBP结合域”的新肽，以及涉及Bak和BBP之间的相互作用的“bbpbd-1”和“bbpbd-2”的相应核苷酸。

    Bak binding protein, DNA encoding the protein, and methods of use thereof
    2.
    发明授权
    Bak binding protein, DNA encoding the protein, and methods of use thereof 有权
    Bak结合蛋白，编码蛋白的DNA及其使用方法

    公开(公告)号：US06441135B1

    公开(公告)日：2002-08-27

    申请号：US09381488

    申请日：2000-02-11

    申请人： Michael C. Kiefer ,  Paul A. Fitzpatrick ,  Helen L. Gibson ,  Philip J. Barr

    发明人： Michael C. Kiefer ,  Paul A. Fitzpatrick ,  Helen L. Gibson ,  Philip J. Barr

    IPC分类号： C07K100

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  G01N2333/47 ,  G01N2500/02 ,  G01N2510/00

    摘要： The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention neither provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which arc involved in the interaction between Bak and BBP.

    摘要翻译： 本发明提供编码Bak结合蛋白（BBP）的多核苷酸序列（bbp）及其与Bak结合的片段。 本发明还提供了结合Bak的BBP。 本发明还提供含有编码BBP的多核苷酸的重组宿主细胞。 本发明还提供了特异性结合BBP的抗体。 本发明还提供了用于检测诸如改变BBP与Bak蛋白的结合的药物的药物的方法。 本发明既没有提供用于检测生物样品中bbp或BBP的存在的方法，并且还提供了调节细胞中BBP水平的方法。 本发明还包括命名为“BBP结合域”的新肽，以及涉及Bak和BBP之间相互作用的“bbpbd-1”和“bbpbd-2”的相应核苷酸。

    Shotgun disabling device
    3.
    发明授权
    Shotgun disabling device 失效
    霰弹枪禁用装置

    公开(公告)号：US4969284A

    公开(公告)日：1990-11-13

    申请号：US413107

    申请日：1989-09-27

    申请人： Christopher T. Healey ,  Paul A. Fitzpatrick

    发明人： Christopher T. Healey ,  Paul A. Fitzpatrick

    IPC分类号： F41A17/44

    CPC分类号： F41A17/44

    摘要： A disabling device for a shotgun comprises a generally elongate and rigid rod which has an opening therethrough towards a first end of the rod, and there being a cap secured to the second end of the rod, the cap having an outwardly extending flange, the rod being adapted to be received in a barrel of the shotgun by inserting the first end of the rod into a chamber end of the barrel and relatively moving longitudinally the barrel and the rod until the flange of the cap engages the chamber end of the barrel, with at least part of the opening at the first end of the rod extending from the muzzle end of the barrel, the cap comprising a sprung element which projects from an end of the cap to a position where the element would be struck by a hammer of the shotgun firing mechanism in the event that the firing mechanism is actuated with the disabling device received in the barrel.

    摘要翻译： 用于霰弹枪的禁用装置包括大致细长且刚性的杆，其具有穿过其朝向杆的第一端的开口，并且存在固定到杆的第二端的帽，帽具有向外延伸的凸缘，杆 通过将杆的第一端插入枪管的腔室端部并相对于枪管和杆的纵向方向相对移动，直到帽的凸缘与枪管的腔室端部接合，从而适应于容纳在枪管的枪管中， 杆的第一端处的开口的至少一部分从枪管的枪口端延伸，帽包括从帽的端部突出到弹簧元件，该弹簧元件从元件将被锤 霰弹枪击发机构在发射机构被接收在枪管中的禁用装置致动的情况下。

    NOVEL BAK BINDING PROTEIN, DNA ENCODING THE PROTEIN, AND METHODS OF USE THEREOF
    9.
    发明申请
    NOVEL BAK BINDING PROTEIN, DNA ENCODING THE PROTEIN, AND METHODS OF USE THEREOF 审中-公开
    新蛋白结合蛋白，编码蛋白的DNA及其使用方法

    公开(公告)号：US20120142099A1

    公开(公告)日：2012-06-07

    申请号：US13009228

    申请日：2011-01-19

    申请人： Michael C. Kiefer ,  Paul A. Fitzpatrick ,  Helen L. Gibson ,  Philip J. Barr

    发明人： Michael C. Kiefer ,  Paul A. Fitzpatrick ,  Helen L. Gibson ,  Philip J. Barr

    IPC分类号： C12N5/02

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  G01N2333/47 ,  G01N2500/02 ,  G01N2510/00

    摘要： The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which are involved in the interaction between Bak and BBP.

    摘要翻译： 本发明提供编码Bak结合蛋白（BBP）的多核苷酸序列（bbp）及其与Bak结合的片段。 本发明还提供了结合Bak的BBP。 本发明还提供含有编码BBP的多核苷酸的重组宿主细胞。 本发明还提供了特异性结合BBP的抗体。 本发明还提供了用于检测诸如改变BBP与Bak蛋白的结合的药物的药物的方法。 本发明还提供了用于检测生物样品中bbp或BBP的存在的方法，并且还提供了调节细胞中BBP水平的方法。 本发明另外包括称为“BBP结合域”的新肽，以及涉及Bak和BBP之间的相互作用的“bbpbd-1”和“bbpbd-2”的相应核苷酸。