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公开(公告)号：US20170049561A1
公开(公告)日：2017-02-23
申请号：US15345020
申请日：2016-11-07
IPC分类号： A61F2/16
CPC分类号： A61F2/1601 , A61F2/1624 , A61F2/1648 , A61F2002/1682 , A61F2002/169 , A61F2230/0006 , A61F2230/0008
摘要： Accommodating intraocular lenses including an optic having an anterior element and a posterior element defining an optic fluid chamber, wherein the optic is aspheric across all powers throughout accommodation or disaccommodation. Intraocular lenses, optionally accommodating, where an optic portion is centered with a midline of a height of the peripheral portion, the height measured in the anterior to posterior direction.
摘要翻译： 容纳眼内透镜，包括具有限定光学流体室的前部元件和后部元件的光学元件，其中所述光学器件在整个调节或不适应位置中跨越所有能量而非球面。 可选地容纳的眼内透镜，其中光学部分与周边部分的高度的中线对中，在前后方向上测量的高度。
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2.发明申请CARDIAC MYOCYTE MORPHOGENIC COMPOSITIONS AND METHODS OF USE THEREFOR 审中-公开CARDIAC MYOCYTE MORPHOGENIC COMPOSITIONS AND METHODS OF THEREFOR公开(公告)号：US20110052551A1
公开(公告)日：2011-03-03
申请号：US12919648
申请日：2009-02-26
CPC分类号： A61K35/28 , A61K35/12 , C12N5/0657 , C12N2501/415 , C12N2502/99
摘要： Disclosed are methods for inducing cardiomyogenic differentiation in cells that are competent for differentiation along the cardiomyogenic lineage such as certain unfractionated bone marrow mononuclear cells (BMMNCs). In some embodiments, the methods include contacting a plurality of unfractionated, density gradient-separated BMMNCs with a cardiomyocyte differentiation-inducing amount of a Wnt11 gene product for a time and under conditions sufficient to induce cardiomyocyte differentiation in at least a subset of the BMMNCs. Also provided are methods for treating an injury to cardiac tissue in a subject using cells that have been induced to differentiate along the cardiomyogenic lineage, recombinant host cells comprising an expression vector that encodes a Wnt11 polypeptide or a functional fragment thereof, and systems for inducing cardiomyogenic differentiation in a cultured cell.
摘要翻译： 公开了用于诱导沿着心肌发生谱系分化的细胞中的心肌分化的方法，例如某些未分级的骨髓单核细胞（BMMNC）。 在一些实施方案中，所述方法包括使多个未分级，密度梯度分离的BMMNC与心肌细胞分化诱导量的Wnt11基因产物在足以在至少一个BMMNC的子集中诱导心肌细胞分化的时间和条件下接触。 还提供了用于使用沿着心肌发生谱系诱导分化的细胞来治疗受试者心脏组织损伤的方法，包含编码Wnt11多肽或其功能片段的表达载体的重组宿主细胞，以及用于诱导心肌发生的系统 培养细胞中的分化。
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公开(公告)号：US06632181B2
公开(公告)日：2003-10-14
申请号：US09412295
申请日：1999-10-05
IPC分类号： A61B502
CPC分类号： A61B5/022 , A61B5/02133
摘要： A blood pressure can be obtained by supplying an external pressure to a portion of an artery. The external pressure is preferably between the systolic and diastolic pressure. An event which occurs at least once a cycle can then be identified. This event can be, for example, a peak in the arterial compliance that occurs at a transmural pressure approximately equal to zero. A pair of signals, one that is an arterial volume-indicating signal, and one that is an arterial pressure-indicating signal can be used to identify this event. Alternately, a small signal high-frequency exciter component can be placed upon the pressure or volume of the artery and detected to determine the time that the transmural pressure is equal to zero.
摘要翻译： 通过向动脉的一部分供给外部压力可以获得血压。 外部压力优选在收缩压和舒张压之间。 然后可以识别发生至少一次循环的事件。 该事件可以是例如在大约等于零的透壁压力下发生的动脉顺应性的峰值。 可以使用一对信号，一个是动脉体积指示信号，另一个是动脉压指示信号，用于识别该事件。 或者，可以将小信号高频激励器部件放置在动脉的压力或体积上并检测以确定透壁压力等于零的时间。
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公开(公告)号：US20180132586A1
公开(公告)日：2018-05-17
申请号：US15812240
申请日：2017-11-14
CPC分类号： A45C13/02 , A45C11/20 , A45C13/005 , A45C13/008 , A45C13/103 , A45C13/1069 , A45C2013/026 , A45C2200/20 , A45F3/02 , A45F2003/001 , A45F2200/0583 , B65D81/3813
摘要： A cooler and methods of storing the cooler in a bag such as a purse are described herein. The cooler can have a strap allowing it to be used as a stand-alone device. The cooler can have securing devices such as magnets embedded within two pockets on a side wall of the cooler. The pockets can be located on the top half of the cooler to prevent tipping and are movable within the pockets so that the magnets can be positioned to avoid obstructions on the bag. The cooler magnets can be magnetically mated with magnets used with protective covers on the outside of the purse (zero purse modifications) or with magnets embedded within the purse wall.
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5.发明授权Sterilization system with ultraviolet emitter for eradicating biological contaminants 有权具有紫外线发射器的消毒系统用于消除生物污染物公开(公告)号：US08779391B2
公开(公告)日：2014-07-15
申请号：US13404781
申请日：2012-02-24
CPC分类号： A61L2/24 , A47L2201/04 , A47L2201/06 , A61L2/10 , A61L2202/14 , A61L2202/16 , A61L2202/25 , G05D1/0242 , G05D2201/0203
摘要： An exemplary sterilization system includes a self-propelled robotic mobile platform for locating and eradicating infectious bacterial and virus strains on floors (and objects thereon), walls, cabinets, angled structures, etc., using one or more ultraviolet light sources. A controller allows the system to adjust the quantity of ultraviolet light received by a surface by, for example, changing the intensity of energy input to a ultraviolet light source, changing a distance between a ultraviolet light source and a surface being irradiated, changing the speed/movement of the mobile platform to affect time of exposure, and/or by returning to contaminated areas for additional passes. The mobile platform may include a sensor capable of detecting fluorescence of biological contaminants irradiated with ultraviolet light to locate contaminated areas. The system is thus capable of “seek and destroy” functionality by navigating towards contaminated areas and irradiating those areas with ultraviolet light accordingly.
摘要翻译： 示例性灭菌系统包括使用一个或多个紫外光源来定位和消除地板（及其上的物体），墙壁，橱柜，倾斜结构等上的感染性细菌和病毒株的自推进机器人移动平台。 控制器允许系统通过例如改变输入到紫外光源的能量的强度来改变紫外线光源和被照射的表面之间的距离来改变速度来调节由表面接收的紫外线的量 /移动平台的移动以影响接触时间，和/或返回到受污染的地区进行额外的通行证。 移动平台可以包括能够检测用紫外线照射的生物污染物的荧光的传感器，以定位受污染的区域。 因此，该系统能够通过导航到受污染的区域并且相应地用紫外线照射这些区域来“寻求和破坏”功能。
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公开(公告)号：US07951086B2
公开(公告)日：2011-05-31
申请号：US12617648
申请日：2009-11-12
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02133
摘要： A measurement device for generating an arterial volume-indicative signal includes an exciter and a detector. The exciter is adapted to receive an oscillating signal and generate a pressure wave based at least in part on the oscillating signal on the artery at a measurement site on a patient. The pressure wave includes a frequency. The detector is placed sufficiently near the measurement site to detect a volumetric signal indicative of arterial volume of the patient.
摘要翻译： 用于产生动脉体积指示信号的测量装置包括激励器和检测器。 激励器适于接收振荡信号并且至少部分地基于患者的测量部位上的动脉上的振荡信号产生压力波。 压力波包括一个频率。 将检测器放置在测量位置附近，以检测指示患者的动脉体积的体积信号。
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公开(公告)号：US20070118261A1
公开(公告)日：2007-05-24
申请号：US11654078
申请日：2007-01-17
IPC分类号： B60G17/018
CPC分类号： G09B9/042
摘要： The present invention provides a motorized vehicle of the type having a chassis supported by a set of wheels, at least one of which being driven by a motor. The vehicle is operable to simulate impaired driving. In particular, a vehicle control system is provided that controls at least one aspect of vehicle operation in response to an operator input intended to produce an expected vehicular response. An impairment simulator is provided that is operable in a first mode whereby the vehicle control system produces the expected vehicular response, and a second mode whereby the vehicle control system produces a response inconsistent with the expected vehicular response.
摘要翻译： 本发明提供一种具有由一组车轮支撑的底盘的机动车辆，其中至少一个由电动机驱动。 车辆可操作以模拟驾驶受损。 特别地，提供了一种车辆控制系统，其响应于旨在产生预期车辆响应的操作员输入来控制车辆操作的至少一个方面。 提供了能够以第一模式操作的障碍模拟器，由此车辆控制系统产生预期的车辆响应，以及第二模式，由此车辆控制系统产生与期望的车辆响应不一致的响应。
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公开(公告)号：US06939305B2
公开(公告)日：2005-09-06
申请号：US10685068
申请日：2003-10-14
CPC分类号： A61B5/022 , A61B5/02133
摘要： A measurement device for generating an arterial volume-indicative signal includes an exciter and a detector. The exciter is adapted to receive an oscillating signal and generate a pressure wave based at least in part on the oscillating signal on the artery at a measurement site on a patient. The pressure wave includes a frequency. The detector is placed sufficiently near the measurement site to detect a volumetric signal indicative of arterial volume of the patient.
摘要翻译： 用于产生动脉体积指示信号的测量装置包括激励器和检测器。 激励器适于接收振荡信号并且至少部分地基于患者的测量部位上的动脉上的振荡信号产生压力波。 压力波包括一个频率。 将检测器放置在测量位置附近，以检测指示患者的动脉体积的体积信号。
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公开(公告)号：US6027452A
公开(公告)日：2000-02-22
申请号：US672218
申请日：1996-06-26
CPC分类号： A61B5/022 , A61B5/02133
摘要： A blood pressure can be obtained by supplying an external pressure to a portion of an artery. The external pressure is preferably between the systolic and diastolic pressure. An event which occurs at least once a cycle can then be identified. This event can be, for example, a peak in the arterial compliance that occurs at a transmural pressure approximately equal to zero. A pair of signals, one that is an arterial volume-indicating signal, and one that is an arterial pressure-indicating signal can be used to identify this event. Alternately, a small signal high-frequency exciter component can be placed upon the pressure or volume of the artery and detected to determine the time that the transmural pressure is equal to zero.
摘要翻译： 通过向动脉的一部分供给外部压力可以获得血压。 外部压力优选在收缩压和舒张压之间。 然后可以识别发生至少一次循环的事件。 该事件可以是例如在大约等于零的透壁压力下发生的动脉顺应性的峰值。 可以使用一对信号，一个是动脉体积指示信号，另一个是动脉压指示信号，用于识别该事件。 或者，可以将小信号高频激励器部件置于动脉的压力或体积上，并检测以确定透壁压力等于零的时间。
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公开(公告)号：US20230365508A1
公开(公告)日：2023-11-16
申请号：US18026236
申请日：2021-09-14
申请人： Chen LIU , Kathryn Neely , Patrick Flaherty , Kevin Janak , Rochelle Bradford , ARXADA AG
发明人： Chun Liu , Kathryn Neely , Patrick Flaherty , Kevin Janak , Rochelle Bradford
IPC分类号： C07D233/74 , C09D11/023 , C09D11/033 , C09D5/02
CPC分类号： C07D233/74 , C09D11/023 , C09D11/033 , C09D5/024
摘要： The present disclosure is generally directed to an open time additive composition that includes at least two, different open time additives having the structure of Compound I, a salt thereof, or both. Compound I having the following formula:
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