-
公开(公告)号：US20080279769A1
公开(公告)日：2008-11-13
申请号：US11575977
申请日：2005-09-23
申请人： Magne Solbakken , Alan Cuthbertson , Anthony Eamon Storey , Alexander Jackson , Sally-Ann Ricketts , Peter Brian Iveson
发明人： Magne Solbakken , Alan Cuthbertson , Anthony Eamon Storey , Alexander Jackson , Sally-Ann Ricketts , Peter Brian Iveson
IPC分类号： A61K51/04 , C07C233/47 , C07D209/20 , A61K31/404 , A61K31/16
CPC分类号： A61K49/10 , A61K49/085 , A61K51/0497
摘要： The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imaging and diagnosis of the mammalian body.
摘要翻译： 本发明公开了包含用成像部分标记的异羟肟酸酯类型的特定类型的基质金属蛋白酶抑制剂（MMPi）的成像剂是用于哺乳动物身体的体内成像和诊断的有用的诊断显像剂。
-
公开(公告)号：US07431914B2
公开(公告)日：2008-10-07
申请号：US10559880
申请日：2004-11-23
申请人： Alan Cuthbertson , Magne Solbakken , Dagfinn Lovhaug , Philip Duncanson , Harry John Wadsworth , Anthony Eamon Storey , Nigel Anthony Powell
发明人： Alan Cuthbertson , Magne Solbakken , Dagfinn Lovhaug , Philip Duncanson , Harry John Wadsworth , Anthony Eamon Storey , Nigel Anthony Powell
IPC分类号： A61K51/00
CPC分类号： A61K51/0497
摘要： A contrast agent of formula I: V-L-R (I) where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linear or branched amino acid-comprising biomodifier or linker moiety, and R is a reporter moiety detectable in in vivo imaging of a human or animal body.
摘要翻译： 式I的造影剂：VLR（I）其中V是对血管紧张素II受体位点具有结合亲和力的有机基团，L是包含直链或支链氨基酸的生物改性剂或连接体部分，R是可检测的报道部分 人体或动物身体的体内成像。
-
公开(公告)号：US20070071670A1
公开(公告)日：2007-03-29
申请号：US10544945
申请日：2004-02-10
申请人： Anthony Storey , Julie Davis , Sally-Ann Ricketts , Marivi Medizabal , Alan Cuthbertson , Joseph Arukwe , Kirsty Heywood , Ian Wilson , Duncan Wynn , Michael Schafers , Bodu Levkau , Stefan Wagner , Hans-Jorg Breyholz , Klaus Kopka
发明人： Anthony Storey , Julie Davis , Sally-Ann Ricketts , Marivi Medizabal , Alan Cuthbertson , Joseph Arukwe , Kirsty Heywood , Ian Wilson , Duncan Wynn , Michael Schafers , Bodu Levkau , Stefan Wagner , Hans-Jorg Breyholz , Klaus Kopka
IPC分类号： A61K51/00 , C07D401/02
CPC分类号： A61K51/0497
摘要： The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
摘要翻译： 本发明涉及诊断成像领域。 具体地，本发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。 本发明的一个实施方案是具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。 本发明还公开了一种药物组合物，其包含适合哺乳动物给药形式的本发明的诊断显像剂。 本发明还公开了合成本发明的诊断显像剂的中间体和用于制备本发明的药物组合物的试剂盒。 本发明的药物组合物可用于诊断已知涉及特定基质金属蛋白酶的疾病。
-
公开(公告)号：US08231858B2
公开(公告)日：2012-07-31
申请号：US10544945
申请日：2004-02-10
申请人： Anthony Storey , Julie Davis , Sally-Ann Ricketts , Marivi Mendizabal , Alan Cuthbertson , Joseph Arukwe , Kirsty Heywood , Ian Wilson , Duncan Wynn , Michael Schafers , Bodo Levkau , Stefan Wagner , Hans-Jörg Breyholz , Klaus Kopka
发明人： Anthony Storey , Julie Davis , Sally-Ann Ricketts , Marivi Mendizabal , Alan Cuthbertson , Joseph Arukwe , Kirsty Heywood , Ian Wilson , Duncan Wynn , Michael Schafers , Bodo Levkau , Stefan Wagner , Hans-Jörg Breyholz , Klaus Kopka
CPC分类号： A61K51/0497
摘要： The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
摘要翻译： 本发明涉及诊断成像领域。 具体地，本发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。 本发明的一个实施方案是具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。 本发明还公开了一种药物组合物，其包含适合哺乳动物给药形式的本发明的诊断显像剂。 本发明还公开了合成本发明的诊断显像剂的中间体和用于制备本发明的药物组合物的试剂盒。 本发明的药物组合物可用于诊断已知涉及特定基质金属蛋白酶的疾病。
-
公开(公告)号：US08216548B2
公开(公告)日：2012-07-10
申请号：US12518728
申请日：2007-12-27
申请人： Alan Cuthbertson , Magne Solbakken , Hege Karlsen
发明人： Alan Cuthbertson , Magne Solbakken , Hege Karlsen
IPC分类号： A61K51/00
CPC分类号： A61K51/08 , A61K51/088 , C07B59/001
摘要： The invention relates to conjugates of formula (V) or (VI), their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
摘要翻译： 本发明涉及式（Ⅴ）或（Ⅵ）的结合物，它们作为放射性药物的用途，其制备方法以及在这些方法中使用的合成中间体。
-
公开(公告)号：US07875701B2
公开(公告)日：2011-01-25
申请号：US11575163
申请日：2005-09-14
IPC分类号： A61K38/04
CPC分类号： A61K51/088
摘要： The invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
摘要翻译： 本发明涉及式（III）或（IIIa）的缀合物或其盐，它们作为放射性药物的用途，其制备方法以及在这些方法中使用的合成中间体。
-
公开(公告)号：US20090203584A1
公开(公告)日：2009-08-13
申请号：US12423953
申请日：2009-04-15
申请人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin MIll Archer , Harry John Wadsworth
发明人： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin MIll Archer , Harry John Wadsworth
CPC分类号： C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
摘要： The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
摘要翻译： 本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。
-
公开(公告)号：US20080095701A1
公开(公告)日：2008-04-24
申请号：US11575163
申请日：2005-09-14
CPC分类号： A61K51/088
摘要： The invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
摘要翻译： 本发明涉及式（III）或（IIIa）的缀合物或其盐，它们作为放射性药物的用途，其制备方法以及在这些方法中使用的合成中间体。
-
公开(公告)号：US20070148647A1
公开(公告)日：2007-06-28
申请号：US10560508
申请日：2005-05-11
申请人： Sajinder Luthra , Frank Brady , Nicholas Jeffery , Erik Arstad , Alexander Gibson , Duncan Wynn , Alan Cuthbertson , Magne Solbakken
发明人： Sajinder Luthra , Frank Brady , Nicholas Jeffery , Erik Arstad , Alexander Gibson , Duncan Wynn , Alan Cuthbertson , Magne Solbakken
IPC分类号： C12Q1/68
CPC分类号： C07B59/00 , C07B63/00 , C07B2200/11
摘要： The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme:
摘要翻译： 本发明涉及使用固体支持结合清除剂组来纯化放射性标记的示踪剂的新方法。 计划说明的一般概念：
-
公开(公告)号：US08221720B2
公开(公告)日：2012-07-17
申请号：US10560508
申请日：2005-05-11
申请人： Sajinder Kaur Luthra , Frank Brady , Nicholas Toby Jeffery , Erik Arstad , Alexander Mark Gibson , Duncan Wynn , Alan Cuthbertson , Magne Solbakken
发明人： Sajinder Kaur Luthra , Frank Brady , Nicholas Toby Jeffery , Erik Arstad , Alexander Mark Gibson , Duncan Wynn , Alan Cuthbertson , Magne Solbakken
CPC分类号： C07B59/00 , C07B63/00 , C07B2200/11
摘要： The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme:
摘要翻译： 本发明涉及使用固体支持结合清除剂组来纯化放射性标记的示踪剂的新方法。 计划说明的一般概念：
-
-
-
-
-
-
-
-
-
搜索结果
95 条记录 (耗时 0.036 秒)
