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    In situ crystal growth and crystallization
    1.
    发明授权
    In situ crystal growth and crystallization 失效
    原位晶体生长和结晶

    公开(公告)号：US06719840B2

    公开(公告)日：2004-04-13

    申请号：US09877405

    申请日：2001-06-08

    申请人： Peter R. David ,  Nathaniel E. David

    发明人： Peter R. David ,  Nathaniel E. David

    IPC分类号： C30B702

    CPC分类号： G01N25/147 ,  B01J2219/00274 ,  B33Y80/00 ,  C30B7/00 ,  C30B29/58 ,  Y10S117/90 ,  Y10T117/10 ,  Y10T117/1008 ,  Y10T117/1024

    摘要： A method is provided for determining crystallization conditions for a material, the method comprising: taking a plurality of different crystallization samples in an enclosed microvolume, the plurality of crystallization samples comprising a material to be crystallized and crystallization conditions which vary among the plurality of crystallization samples; allowing crystals of the material to form in plurality of crystallization samples; and identifying which of the plurality of crystallization samples form crystals.

    摘要翻译： 提供了一种用于确定材料的结晶条件的方法，所述方法包括：在封闭的微体积中取多个不同的结晶样品，所述多个结晶样品包含待结晶的材料和在多个结晶样品中变化的结晶条件 ; 允许在多个结晶样品中形成材料的晶体; 并确定多个结晶样品中的哪一个形成晶体。

    Microvolume crystallization method employing multiple lumens
    2.
    发明授权
    Microvolume crystallization method employing multiple lumens 失效
    采用多流明的微量体积结晶法

    公开(公告)号：US06872250B2

    公开(公告)日：2005-03-29

    申请号：US10060853

    申请日：2002-01-29

    申请人： Peter R. David ,  Nathaniel E. David

    发明人： Peter R. David ,  Nathaniel E. David

    IPC分类号： C30B7/00 ,  G01N25/14 ,  C30B7/08

    CPC分类号： G01N25/147 ,  B01J2219/00274 ,  B33Y80/00 ,  C30B7/00 ,  C30B29/58 ,  Y10S117/90 ,  Y10T117/10 ,  Y10T117/1008 ,  Y10T117/1024

    摘要： A method for determining crystallization conditions for a material, the method comprising: taking a microfluidic device comprising one or more lumens having microvolume dimensions and a plurality of different crystallization samples within the one or more lumens, the plurality of crystallization samples comprising a material to be crystallized and crystallization conditions that vary among the plurality of crystallization samples; transporting the plurality of different crystallization samples within the lumens; and identifying a precipitate or crystal formed in the one or more lumens.

    摘要翻译： 一种用于确定材料的结晶条件的方法，所述方法包括：获取包含一个或多个具有微体积尺寸的内腔和在所述一个或多个腔内的多个不同结晶样品的微流体装置，所述多个结晶样品包括待 在多个结晶样品中变化的结晶和结晶条件; 在腔内输送多个不同的结晶样品; 以及鉴定在所述一个或多个内腔中形成的沉淀物或晶体。

    Compositions and methods for producing fermentation products and residuals
    4.
    发明授权
    Compositions and methods for producing fermentation products and residuals 有权
    用于生产发酵产物和残留物的组合物和方法

    公开(公告)号：US07309602B2

    公开(公告)日：2007-12-18

    申请号：US11383748

    申请日：2006-05-16

    申请人： Peter R. David

    发明人： Peter R. David

    IPC分类号： C12N1/19 ,  A23B7/10 ,  A23B7/154 ,  C12P7/06

    CPC分类号： C12P7/06 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17

    摘要： The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microoganism.

    摘要翻译： 本发明提供了旨在增加发酵反应价值的组合物和方法。 特别地，本发明提供了增加发酵设备的价值产出的商业方法。 本发明还提供了具有较高商业价值的改良发酵残渣。 本发明还提供了完整的动物饲料，包含受试者发酵残留物的营养补充剂。 本发明进一步提供了一种进行发酵的方法，改良的发酵微生物和用于修饰这种微生物的遗传载体。

    Determining structures by performing comparisons between molecular replacement results for multiple different biomolecules
    5.
    发明授权
    Determining structures by performing comparisons between molecular replacement results for multiple different biomolecules 失效
    通过对多种不同生物分子的分子置换结果进行比较来确定结构

    公开(公告)号：US07158888B2

    公开(公告)日：2007-01-02

    申请号：US09848866

    申请日：2001-05-04

    申请人： Duncan McRee ,  Peter R. David ,  Frank von Delft ,  John Rammelkamp ,  Enrique Abola

    发明人： Duncan McRee ,  Peter R. David ,  Frank von Delft ,  John Rammelkamp ,  Enrique Abola

    IPC分类号： G06F17/11 ,  G06F17/50 ,  G06F19/00

    CPC分类号： G06F19/16

    摘要： A method is provided for identifying a search model to use in molecular replacement for determining a structure of a target biomolecule, such as a protein, from X-ray diffraction data, the method comprising: employing computer executable logic to perform multiple molecular replacement searches on X-ray diffraction data of the target biomolecule where a group of different biomolecule structures are used as search models for the multiple molecular replacement searches; and employing computer executable logic to compare solutions from the multiple molecular replacement searches, the comparison producing data from which biomolecule structures can be identified as having superior structural identity with the target biomolecule as compared to the other biomolecule structures in the group.

    摘要翻译： 提供了一种用于鉴定用于分子替代以从X射线衍射数据确定靶生物分子例如蛋白质的结构的搜索模型的方法，所述方法包括：使用计算机可执行逻辑来对 其中一组不同的生物分子结构用作多分子替代搜索的搜索模型的目标生物分子的X射线衍射数据; 并且使用计算机可执行逻辑来比较来自多个分子替代搜索的解决方案，比较产生生物分子结构与生物分子组织中其他生物分子结构相比具有优异的结构同一性的数据。

    Compositions and Methods for Producing Fermentation Products and Residuals
    6.
    发明申请
    Compositions and Methods for Producing Fermentation Products and Residuals 审中-公开
    用于生产发酵产品和残留物的组合物和方法

    公开(公告)号：US20090291469A1

    公开(公告)日：2009-11-26

    申请号：US11795659

    申请日：2007-04-05

    申请人： Peter R. David

    发明人： Peter R. David

    IPC分类号： C12P21/00 ,  C12P13/04 ,  C12P19/00 ,  C12P7/06 ,  C12N1/19 ,  C12N1/21 ,  C12N15/63 ,  G06Q90/00

    CPC分类号： C12P13/04 ,  C12N1/18 ,  C12N1/20 ,  C12P21/06 ,  G06Q99/00 ,  Y02E50/17

    摘要： The present invention provides compositions and methods designed to increase value output of a fermentation reaction that yields a first product, intended for commercialization, such as ethanol, and a fermentation residual used, for example, as animal feed. The methods involve using microorganisms in the fermentation process that have been modified so as to yield a residual having greater value that a residual produced in the process by a microorganism not so modified. In particular, the present invention contemplates using microorganisms in a fermentation process that have been modified to increase production of a nutrient, such as an essential amino acid, thereby reducing the need to supplement the nutrient in the animal's diet. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.

    摘要翻译： 本发明提供组合物和方法，其设计用于增加产生用于商业化的第一产物（例如乙醇）的发酵反应的价值产物，以及例如用作动物饲料的发酵残余物。 所述方法涉及在发酵过程中使用微生物进行修饰，从而得到具有较大值的残留物，即微生物在该过程中产生的残留物未被修饰。 特别地，本发明考虑在发酵过程中使用微生物，该发酵过程已被修饰以增加诸如必需氨基酸的营养物质的产生，从而减少补充动物饮食中营养物质的需要。 本发明还提供了具有较高商业价值的改良发酵残渣。 本发明还提供了完整的动物饲料，包含受试者发酵残留物的营养补充剂。 本发明还提供一种进行发酵的方法，改良的发酵微生物和用于修饰这种微生物的遗传载体。

    COMPOSITIONS AND METHODS FOR PRODUCING FERMENTATION PRODUCTS AND RESIDUALS
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR PRODUCING FERMENTATION PRODUCTS AND RESIDUALS 审中-公开
    用于生产发酵产品和残留物的组合物和方法

    公开(公告)号：US20090006280A1

    公开(公告)日：2009-01-01

    申请号：US12209127

    申请日：2008-09-11

    申请人： Peter R. David

    发明人： Peter R. David

    IPC分类号： G06Q90/00 ,  C12P7/06 ,  G06Q50/00

    CPC分类号： C12P7/16 ,  C12P7/04 ,  C12P7/06 ,  G06Q50/22 ,  G06Q99/00 ,  Y02A90/22 ,  Y02E50/10 ,  Y02E50/17

    摘要： The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.

    摘要翻译： 本发明提供了旨在增加发酵反应价值的组合物和方法。 特别地，本发明提供了增加发酵设备的价值产出的商业方法。 本发明还提供了具有较高商业价值的改良发酵残渣。 本发明还提供了完整的动物饲料，包含受试者发酵残留物的营养补充剂。 本发明还提供一种进行发酵的方法，改良的发酵微生物和用于修饰这种微生物的遗传载体。

    MICROFLUIDIC DEVICE WITH DIFFUSION BETWEEN ADJACENT LUMENS
    8.
    发明申请
    MICROFLUIDIC DEVICE WITH DIFFUSION BETWEEN ADJACENT LUMENS 审中-公开
    具有相似性之间扩散的微流体装置

    公开(公告)号：US20080216736A1

    公开(公告)日：2008-09-11

    申请号：US12126824

    申请日：2008-05-23

    申请人： Peter R. David

    发明人： Peter R. David

    IPC分类号： H01L21/322

    CPC分类号： C30B7/00 ,  C30B29/58

    摘要： A microfluidic method is provided that comprises: delivering a first fluid to a first lumen of a microfluidic device and a second, different fluid to a second lumen of the microfluidic device, the first and second lumens sharing a common wall which allows for diffusion between the lumens over at least a portion of the length of the lumens; and having the first and second fluids diffuse between the first and second lumens.

    摘要翻译： 提供了一种微流体方法，其包括：将第一流体输送到微流体装置的第一腔，将第二流体递送至微流体装置的第二腔，所述第一和第二流体共享公共壁，其允许在所述微流体装置之间扩散 在流明的长度的至少一部分上的流明; 并且使第一和第二流体在第一和第二腔之间扩散。

    Compositions and Methods for Producing Fermentation Products and Residuals
    9.
    发明申请
    Compositions and Methods for Producing Fermentation Products and Residuals 审中-公开
    用于生产发酵产品和残留物的组合物和方法

    公开(公告)号：US20110223284A1

    公开(公告)日：2011-09-15

    申请号：US12904947

    申请日：2010-10-14

    申请人： Peter R. David

    发明人： Peter R. David

    IPC分类号： A23K1/16 ,  C12P21/00 ,  C12P13/08 ,  C12P13/12 ,  C12P13/22 ,  C12P13/06 ,  C12P13/10 ,  C12P13/24 ,  C12P13/00 ,  C12P1/00 ,  C12P1/04 ,  C12P1/02 ,  C12N1/00

    CPC分类号： C12P7/06 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17

    摘要： The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.

    摘要翻译： 本发明提供了旨在增加发酵反应价值的组合物和方法。 特别地，本发明提供了增加发酵设备的价值产出的商业方法。 本发明还提供了具有较高商业价值的改良发酵残渣。 本发明还提供了完整的动物饲料，包含受试者发酵残留物的营养补充剂。 本发明还提供一种进行发酵的方法，改良的发酵微生物和用于修饰这种微生物的遗传载体。

    Compositions And Methods For Producing Fermentation Products And Residuals
    10.
    发明申请
    Compositions And Methods For Producing Fermentation Products And Residuals 审中-公开
    用于生产发酵产品和残留物的组合物和方法

    公开(公告)号：US20090239270A1

    公开(公告)日：2009-09-24

    申请号：US12240864

    申请日：2008-09-29

    申请人： Peter R. David

    发明人： Peter R. David

    IPC分类号： C12P13/04 ,  C12P13/08 ,  C12P17/12 ,  C12N1/21

    CPC分类号： C12P7/06 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17

    摘要： The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.

    摘要翻译： 本发明提供了旨在增加发酵反应价值的组合物和方法。 特别地，本发明提供了增加发酵设备的价值产出的商业方法。 本发明还提供了具有较高商业价值的改良发酵残渣。 本发明还提供了完整的动物饲料，包含受试者发酵残留物的营养补充剂。 本发明还提供一种进行发酵的方法，改良的发酵微生物和用于修饰这种微生物的遗传载体。