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公开(公告)号：US5877296A
公开(公告)日：1999-03-02
申请号：US452164
申请日：1995-05-26
申请人： Philip Ross Hamann , Lois Hinman , Irwin Hollander , Ryan Holcomb , William Hallett , Hwei-Ru Tsou , Martin J. Weiss
发明人： Philip Ross Hamann , Lois Hinman , Irwin Hollander , Ryan Holcomb , William Hallett , Hwei-Ru Tsou , Martin J. Weiss
IPC分类号： C07H15/20 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K38/00 , A61K38/22 , A61K39/395 , A61K39/44 , A61K47/48 , A61P35/00 , C07H15/203 , C07K1/113 , C07K16/00 , A01N43/04 , C12P19/44
CPC分类号： A61K47/48238 , A61K47/48407
摘要： This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
摘要翻译： 本发明描述由强效抗肿瘤抗生素及其衍生物的加利车霉素家族的二硫化物类似物制备的载体 - 药物偶联物，以及来自相关抗肿瘤抗生素如精蛋白的类似类似物。 载体可以是靶向不想要的细胞群的抗体，生长因子或类固醇，例如肿瘤的细胞。 全蛋白质载体以及它们的抗原识别片段及其化学或遗传操作的对应物可用于缀合物的靶向部分。 本发明包括合成这些缀合物所需的化合物，载体 - 药物共轭物的合适药物组合物及其使用方法。
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公开(公告)号：US08044178B2
公开(公告)日：2011-10-25
申请号：US11684329
申请日：2007-03-09
申请人： Erwin R. Boghaert , Nitin K. Damle , Philip Ross Hamann , Kiran Khandke , Arthur Kunz , Kimberly A. Marquette , Lioudmila Tchistiakova , Davinder Gill , Kodangattil Sreekumar
发明人： Erwin R. Boghaert , Nitin K. Damle , Philip Ross Hamann , Kiran Khandke , Arthur Kunz , Kimberly A. Marquette , Lioudmila Tchistiakova , Davinder Gill , Kodangattil Sreekumar
CPC分类号： C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K14/82 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/92
摘要： Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
摘要翻译： 抗5T4抗体，抗5T4抗体/药物偶联物，以及制备和使用该抗体的方法。
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3.发明申请公开(公告)号：US20100173382A1
公开(公告)日：2010-07-08
申请号：US12580702
申请日：2009-10-16
申请人： Erwin R. Boghaert , Nitin K. Damle , Davinder S. Gill , Kimberly A. Marquette , Lioudmila Tchistiakova , Philip Ross Hamann , Arthur Kunz
发明人： Erwin R. Boghaert , Nitin K. Damle , Davinder S. Gill , Kimberly A. Marquette , Lioudmila Tchistiakova , Philip Ross Hamann , Arthur Kunz
CPC分类号： C07K16/3046 , A61K47/60 , A61K47/6809 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K2317/24 , C07K2317/56 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same.
摘要翻译： 嵌合和人源化抗5T4抗体和抗体/药物共轭物及其制备和使用方法。
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公开(公告)号：US07626023B2
公开(公告)日：2009-12-01
申请号：US12104921
申请日：2008-04-17
申请人： Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
发明人： Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
IPC分类号： C07D241/02 , A61K31/495
CPC分类号： C07K5/0205 , C07K5/06078
摘要： The invention provides compounds of formula (I): wherein E, A, B′, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
摘要翻译： 本发明提供式（I）化合物：其中E，A，B'，R 6，R 7，R 8和R 9在本说明书中定义，其中化合物表现出抗癌活性，可用于治疗癌症。
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公开(公告)号：US20080221181A1
公开(公告)日：2008-09-11
申请号：US12104921
申请日：2008-04-17
申请人： Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
发明人： Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
IPC分类号： A61K31/164 , C07C237/00 , C07D233/80 , A61K31/4164 , A61K31/40 , C07D207/04 , A61K31/421 , A61P35/00
CPC分类号： C07K5/0205 , C07K5/06078
摘要： The invention provides compounds of formula (I): wherein E, A, B′, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
摘要翻译： 本发明提供式（I）化合物：其中E，A，B'，R 6，R 7，R 8和R 在说明书中定义了这些化合物表现出抗癌活性并且可用于治疗癌症。
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公开(公告)号：US08759495B2
公开(公告)日：2014-06-24
申请号：US13208162
申请日：2011-08-11
申请人： Erwin R. Boghaert , Nitin K. Damle , Philip Ross Hamann , Kiran Khandke , Arthur Kunz , Kimberly A. Marquette , Lioudmila Tchistiakova , Davinder Gill , Kodangattil R. Sreekumar
发明人： Erwin R. Boghaert , Nitin K. Damle , Philip Ross Hamann , Kiran Khandke , Arthur Kunz , Kimberly A. Marquette , Lioudmila Tchistiakova , Davinder Gill , Kodangattil R. Sreekumar
CPC分类号： C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K14/82 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/92
摘要： Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
摘要翻译： 抗5T4抗体，抗5T4抗体/药物偶联物，以及制备和使用该抗体的方法。
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公开(公告)号：US20100021483A1
公开(公告)日：2010-01-28
申请号：US12496609
申请日：2009-07-01
申请人： ERWIN R. BOGHAERT , Nitin K. Damle , Davinder S. Gill , Kimberly A. Marquette , Lioudmila Tchistiakova , Philip Ross Hamann , Arthur Kunz
发明人： ERWIN R. BOGHAERT , Nitin K. Damle , Davinder S. Gill , Kimberly A. Marquette , Lioudmila Tchistiakova , Philip Ross Hamann , Arthur Kunz
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/3046 , A61K47/60 , A61K47/6809 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K2317/24 , C07K2317/56 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same.
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公开(公告)号：US20090105461A1
公开(公告)日：2009-04-23
申请号：US12221551
申请日：2008-08-04
申请人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Erwin Raymond Arsene Boghaert , Philip Ross Hamann , Mark Edward Ruppen , Nitin Krishnaji Damle , Eugene Vidunas , Lyka Kalyandrug
发明人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Erwin Raymond Arsene Boghaert , Philip Ross Hamann , Mark Edward Ruppen , Nitin Krishnaji Damle , Eugene Vidunas , Lyka Kalyandrug
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K39/395 , A61K47/6829 , A61K47/6849 , A61K47/6851 , C07K2317/24 , C07K2317/52 , C07K2317/73
摘要： Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译： 描述了抗Lewis Y抗体。 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。 具体地，还描述了单体加利车霉素衍生物/抗 - 路易斯Y抗体缀合物，包含缀合物的组合物和缀合物的用途。
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公开(公告)号：US07390910B2
公开(公告)日：2008-06-24
申请号：US10911300
申请日：2004-08-04
申请人： Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
发明人： Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
IPC分类号： C07D207/04 , A61K31/40
CPC分类号： C07K5/0205 , C07K5/06078
摘要： The invention provides compounds of formula (I): wherein E, A, B′, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
摘要翻译： 本发明提供式（I）化合物：其中E，A，B'，R 6，R 7，R 8和R 在说明书中定义了这些化合物表现出抗癌活性并且可用于治疗癌症。
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10.发明授权Conjugates of methyltrithio antitumor agents and intermediates for their synthesis 失效甲基三硫代抗肿瘤剂及其合成中间体的缀合物
公开(公告)号：US5773001A
公开(公告)日：1998-06-30
申请号：US253877
申请日：1994-06-03
申请人： Philip Ross Hamann , Lois Hinman , Irwin Hollander , Ryan Holcomb , William Hallett , Hwei-Ru Tsou , Martin J. Weiss
发明人： Philip Ross Hamann , Lois Hinman , Irwin Hollander , Ryan Holcomb , William Hallett , Hwei-Ru Tsou , Martin J. Weiss
IPC分类号： C07H15/20 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K38/00 , A61K38/22 , A61K39/395 , A61K39/44 , A61K47/48 , A61P35/00 , C07H15/203 , C07K1/113 , C07K16/00 , C07G11/00
CPC分类号： A61K47/48238 , A61K47/48407
摘要： This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
摘要翻译： 本发明描述由强效抗肿瘤抗生素及其衍生物的加利车霉素家族的二硫化物类似物制备的载体 - 药物偶联物，以及来自相关抗肿瘤抗生素如精蛋白的类似类似物。 载体可以是靶向不想要的细胞群的抗体，生长因子或类固醇，例如肿瘤的细胞。 全蛋白质载体以及它们的抗原识别片段及其化学或遗传操作的对应物可用于缀合物的靶向部分。 本发明包括合成这些缀合物所需的化合物，载体 - 药物共轭物的合适药物组合物及其使用方法。
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