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公开(公告)号:US07390910B2
公开(公告)日:2008-06-24
申请号:US10911300
申请日:2004-08-04
申请人: Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
发明人: Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
IPC分类号: C07D207/04 , A61K31/40
CPC分类号: C07K5/0205 , C07K5/06078
摘要: The invention provides compounds of formula (I): wherein E, A, B′, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
摘要翻译: 本发明提供式(I)化合物:其中E,A,B',R 6,R 7,R 8和R 在说明书中定义了这些化合物表现出抗癌活性并且可用于治疗癌症。
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公开(公告)号:US07626023B2
公开(公告)日:2009-12-01
申请号:US12104921
申请日:2008-04-17
申请人: Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
发明人: Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
IPC分类号: C07D241/02 , A61K31/495
CPC分类号: C07K5/0205 , C07K5/06078
摘要: The invention provides compounds of formula (I): wherein E, A, B′, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
摘要翻译: 本发明提供式(I)化合物:其中E,A,B',R 6,R 7,R 8和R 9在本说明书中定义,其中化合物表现出抗癌活性,可用于治疗癌症。
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公开(公告)号:US20080221181A1
公开(公告)日:2008-09-11
申请号:US12104921
申请日:2008-04-17
申请人: Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
发明人: Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan S. Niu , Gary Harold Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Ross Hamann , Semiramis Ayral-Kaloustian
IPC分类号: A61K31/164 , C07C237/00 , C07D233/80 , A61K31/4164 , A61K31/40 , C07D207/04 , A61K31/421 , A61P35/00
CPC分类号: C07K5/0205 , C07K5/06078
摘要: The invention provides compounds of formula (I): wherein E, A, B′, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
摘要翻译: 本发明提供式(I)化合物:其中E,A,B',R 6,R 7,R 8和R 在说明书中定义了这些化合物表现出抗癌活性并且可用于治疗癌症。
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公开(公告)号:US20050037977A1
公开(公告)日:2005-02-17
申请号:US10911300
申请日:2004-08-04
申请人: Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan Niu , Gary Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Hamann , Semiramis Ayral-Kaloustian
发明人: Arie Zask , Joshua Kaplan , Ayako Yamashita , Chuan Niu , Gary Birnberg , Emily Norton , Kinwang Cheung , Ronald Suayan , Vincent Sandanayaka , Philip Hamann , Semiramis Ayral-Kaloustian
IPC分类号: A61K31/277 , A61K38/00 , A61K38/04 , A61K38/05 , A61K38/06 , A61K38/07 , C07K5/00 , C07K5/02 , C07K5/04 , C07K5/06 , C07K5/065 , C07K5/08 , C07K5/10
CPC分类号: C07K5/0205 , C07K5/06078
摘要: The invention provides compounds of formula (I): wherein E, A, B′, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
摘要翻译: 本发明提供式(I)化合物:其中E,A,B',R 6,R 7,R 8和R 9在本说明书中定义,其中化合物表现出抗癌活性,可用于治疗癌症。
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5.Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof 失效
标题翻译: 取代的异喹啉-1,3(2H,4H) - 二酮,1-硫代,1,4-二氢-2H-异喹啉-3-酮和1,4-二羟基-3(2H) - 异喹诺酮及其使用方法公开(公告)号:US07713994B2
公开(公告)日:2010-05-11
申请号:US11728897
申请日:2007-03-26
申请人: Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Harold Birnberg , Middleton Brawner Floyd , Joshua Kaplan , Kristina M. Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Adufa Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Christian Mayer , Annette L. Banker , Marvin Reich
发明人: Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Harold Birnberg , Middleton Brawner Floyd , Joshua Kaplan , Kristina M. Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Adufa Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Christian Mayer , Annette L. Banker , Marvin Reich
IPC分类号: A61K31/47 , C07D217/08
CPC分类号: C07D217/24 , C07D237/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
摘要: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
摘要翻译: 本发明提供具有本文定义的G1,G2,G3,G4,A1,A2,Y1,Y2,L1,Z,e和f的结构的式(I)化合物或其药学上可接受的盐, 可用于治疗或预防癌症。
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6.4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS 审中-公开
标题翻译: 4-ARYLOXYQUINOLIN-2(1H) - 作为MTOR激酶和PI3激酶抑制剂,用作抗癌剂公开(公告)号:US20100068204A1
公开(公告)日:2010-03-18
申请号:US12558661
申请日:2009-09-14
申请人: Hwei-Ru Tsou , Gary Harold Birnberg , Gloria Jean MacEwan , Mercy Adufa Otteng , Pawel Wojciech Nowak , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Arie Zask , Ker Yu
发明人: Hwei-Ru Tsou , Gary Harold Birnberg , Gloria Jean MacEwan , Mercy Adufa Otteng , Pawel Wojciech Nowak , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Arie Zask , Ker Yu
IPC分类号: A61K39/395 , C07D215/00 , A61K31/47
CPC分类号: C07D215/22 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12
摘要: Compounds of the formula I and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, R3, R4, R5, R6, and R7 are defined as set forth herein are disclosed. Also disclosed are pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier, methods of making the compounds of the invention and methods of using the compounds for inhibiting mTOR and PI3 kinases and for treating cancers.
摘要翻译: 公开了式I化合物及其药学上可接受的盐,其中A,B,R 1,R 2,R 3,R 4,R 5,R 6和R 7如本文所述。 还公开了包含本发明化合物和药学上可接受的载体的药物组合物,制备本发明化合物的方法和使用该化合物抑制mTOR和PI3激酶和治疗癌症的方法。
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7.IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS 审中-公开
标题翻译: 咪唑吡嗪类似物及其作为PI3激酶和MT抑制剂的用途公开(公告)号:US20080233127A1
公开(公告)日:2008-09-25
申请号:US12044500
申请日:2008-03-07
申请人: Matthew Gregory Bursavich , Aranapakam Mudumbai Venkatesan , Pawel Wojciech Nowak , Sabrina Lombardi , Adam Matthew Gilbert , Christoph Martin Denhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Natasja Brooijmans , Semiramis Ayral-Kaloustian , Zecheng Chen , Jeroen Cunera Verheijen , Joshua Kaplan , Arie Zask
发明人: Matthew Gregory Bursavich , Aranapakam Mudumbai Venkatesan , Pawel Wojciech Nowak , Sabrina Lombardi , Adam Matthew Gilbert , Christoph Martin Denhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Natasja Brooijmans , Semiramis Ayral-Kaloustian , Zecheng Chen , Jeroen Cunera Verheijen , Joshua Kaplan , Arie Zask
IPC分类号: A61K39/395 , C07D473/00 , A61K31/5377 , A61P35/04 , A61P3/00 , A61P1/00 , A61P29/00 , A61P19/00 , A61K31/52
CPC分类号: C07D473/34
摘要: The present invention relates to Imidazolopyrimidine Analogs, methods of making Imidazolopyrimidine Analogs, compositions comprising an Imidazolopyrimidine Analog, and methods for treating or preventing a PI3K-related disorder comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog. The invention also relates to methods for treating or preventing mTOR-related disorders comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog.
摘要翻译: 本发明涉及咪唑并嘧啶类似物,制备咪唑并嘧啶类似物的方法,包含咪唑并嘧啶类似物的组合物,以及用于治疗或预防PI3K相关病症的方法,其包括向有需要的受试者施用有效量的咪唑并嘧啶类似物。 本发明还涉及治疗或预防mTOR相关病症的方法,包括向有需要的受试者施用有效量的咪唑并嘧啶类似物。
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8.PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS 审中-公开
标题翻译: 吡唑并嘧啶类似物及其作为MTOR激酶和PI3激酶抑制剂的用途公开(公告)号:US20080234262A1
公开(公告)日:2008-09-25
申请号:US12050445
申请日:2008-03-18
申请人: Arie Zask , Pawel Wojciech Nowak , Jeroen Cunera Verheijen , Kevin J. Curran , Joshua Kaplan , David Malwitz , Matthew Gregory Bursavich , Derek Cecil Cole , Semiramis Ayral-Kaloustian , Ker Yu , David James Richard , Mark Lefever
发明人: Arie Zask , Pawel Wojciech Nowak , Jeroen Cunera Verheijen , Kevin J. Curran , Joshua Kaplan , David Malwitz , Matthew Gregory Bursavich , Derek Cecil Cole , Semiramis Ayral-Kaloustian , Ker Yu , David James Richard , Mark Lefever
IPC分类号: A61K31/5377 , A61K31/519 , A61P35/00 , C07D413/14 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.
摘要翻译: 本发明涉及吡唑并嘧啶类似物,制备吡唑并嘧啶类似物的方法,包含吡唑并嘧啶类似物的组合物和用于治疗mTOR相关病症的方法,其包括向有需要的受试者施用有效量的吡唑并嘧啶类似物。 本发明还涉及治疗PI3K相关疾病,包括向有需要的受试者施用有效量的吡唑并嘧啶类似物。
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9.Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof 失效
标题翻译: 取代的异喹啉-1,3(2H,4H) - 二酮,1-硫代-1,4-二氢-2H-异喹啉-3-酮和1,4-二氢-3(2H) - 异喹诺酮及其使用方法公开(公告)号:US20080085890A1
公开(公告)日:2008-04-10
申请号:US11728897
申请日:2007-03-26
申请人: Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Birnberg , Middleton Floyd , Joshua Kaplan , Kristina Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Mayer , Annette Banker , Marvin Reich
发明人: Hwei-Ru Tsou , Semiramis Ayral-Kaloustian , Gary Birnberg , Middleton Floyd , Joshua Kaplan , Kristina Kutterer , Xiaoxiang Liu , Ramaswamy Nilakantan , Mercy Otteng , Zhilian Tang , Arie Zask , Tritin Tran , Scott Mayer , Annette Banker , Marvin Reich
IPC分类号: A61K31/55 , A61K31/47 , A61K31/496 , A61K31/497 , A61K31/501 , A61P1/00 , A61P17/06 , A61P3/10 , A61P31/12 , C07D295/00 , C07D241/02 , C07D239/02 , C07D237/26 , C07D237/02 , C07D223/02 , C07D217/00 , A61P9/00 , A61P35/00 , A61P31/10 , A61P19/02 , A61P11/00 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/541
CPC分类号: C07D217/24 , C07D237/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
摘要: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
摘要翻译: 本发明提供式(I)化合物,其具有如下结构:其中G 1,G 2,G 3,G 4, / SUP>,A 1,A 2,Y 1,Y 2,L 1, / SUP>,Z,e和f如本文所定义,或其药学上可接受的盐,其可用于治疗或预防癌症。
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10.3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开
标题翻译: 3-取代的1H-吲哚化合物,它们作为MTOR激酶和PI3激酶抑制剂使用,以及它们的合成公开(公告)号:US20090311217A1
公开(公告)日:2009-12-17
申请号:US12473605
申请日:2009-05-28
申请人: Matthew Gregory Bursavich , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Thai Hiep Nguyen , Sabrina Lombardi , David Malwitz , Natasja Brooijmans , Derek Cecil Cole , Adam Matthew Gilbert , Pawel Wojciech Nowak , Kaapjoo Park , Sasmita Das , Hwei-Ru Tsou , Aranapakam Mudumbai Venkatesan , Mercy Adufa Otteng , Gary Harold Birnberg , Gloria Jean MacEwan
发明人: Matthew Gregory Bursavich , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Thai Hiep Nguyen , Sabrina Lombardi , David Malwitz , Natasja Brooijmans , Derek Cecil Cole , Adam Matthew Gilbert , Pawel Wojciech Nowak , Kaapjoo Park , Sasmita Das , Hwei-Ru Tsou , Aranapakam Mudumbai Venkatesan , Mercy Adufa Otteng , Gary Harold Birnberg , Gloria Jean MacEwan
IPC分类号: A61K31/404 , C07D405/02 , C07D403/14 , C07D413/02 , A61K31/496 , A61K31/5377 , A61K38/21 , A61K39/395 , A61P35/00
CPC分类号: C07D405/14 , C07D405/06
摘要: The invention relates to 3-substituted-1H-indole compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译: 本发明涉及式I的3-取代-1H-吲哚化合物或其药学上可接受的盐,其中组分变量如本文所定义,包含该化合物的组合物,以及制备和使用该化合物的方法。
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