公开(公告)号：US20090131410A1

公开(公告)日：2009-05-21

申请号：US12089150

申请日：2006-10-05

Applicant: Naresh Kumar ,  Kirandeep Kaur ,  Suman Gupta ,  Anita Chugh ,  Mohammad Salman ,  Raj Kumar Shirumalla ,  Shivani Malhotra

Inventor： Naresh Kumar ,  Kirandeep Kaur ,  Suman Gupta ,  Anita Chugh ,  Mohammad Salman ,  Raj Kumar Shirumalla ,  Shivani Malhotra

IPC: A61K31/55 ,  C07D223/14 ,  A61P3/10

CPC classification number: C07D221/24 ,  C07D405/12 ,  C07D409/12

Abstract: Provided are muscarinic receptor antagonists, which can be useful in treating various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Also provided are processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 提供毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 还提供了用于制备本文所述的化合物的方法，其药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20090137623A1

公开(公告)日：2009-05-28

申请号：US12158435

申请日：2007-01-02

Applicant: Naresh Kumar ,  Ian Anthony Cliffe ,  Mohammad Salman ,  Venkata P. Palle ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

Inventor： Naresh Kumar ,  Ian Anthony Cliffe ,  Mohammad Salman ,  Venkata P. Palle ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

IPC: A61K31/439 ,  C07D487/08 ,  A61P1/00 ,  A61P3/10 ,  A61P3/04 ,  A61P11/06

CPC classification number: C07D209/52

Abstract: The present invention relates to muscarinic receptor modulators, specifically, 7-oxo-2-azabicyclo[2.2.1]heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, particularly schizophrenia or schizophreniform conditions, mania, pain, bipolar disorder, depression, sleeping disorders, epilepsy, gastrointestinal motility disorders, urinary incontinence, and cognition enhancement.

Abstract translation: 本发明涉及可用于治疗各种疾病和病症（例如阿尔茨海默病，青光眼，精神病）的式（I）的毒蕈碱受体调节剂，具体地，7-氧代-2-氮杂双环[2.2.1]庚烷 特别是精神分裂症或精神分裂症状，躁狂症，疼痛，双相情感障碍，抑郁症，睡眠障碍，癫痫，胃肠动力障碍，尿失禁和认知增强。

公开(公告)号：US20090048186A1

公开(公告)日：2009-02-19

申请号：US11912064

申请日：2005-04-19

Applicant: Vishwajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Mohammad Salman ,  Venkata P. Palle ,  Ashis Mukherjee ,  Abhijit Ray ,  Raj Kumar Shirumalla

Inventor： Vishwajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Mohammad Salman ,  Venkata P. Palle ,  Ashis Mukherjee ,  Abhijit Ray ,  Raj Kumar Shirumalla

IPC: A61K31/7052 ,  C07H15/18 ,  A61K31/7034 ,  C07D493/04 ,  C07H17/02

CPC classification number: C07H9/04 ,  C07H3/02 ,  C07H15/00

Abstract: The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

Abstract translation: 本发明涉及作为抗炎剂的单糖衍生物。 本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

公开(公告)号：US20100168197A1

公开(公告)日：2010-07-01

申请号：US12528987

申请日：2008-02-27

Applicant: Naresh Kumar ,  Jaskiran Kaur ,  Shelly Aeron ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Raj Kumar Shirumalla

Inventor： Naresh Kumar ,  Jaskiran Kaur ,  Shelly Aeron ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Raj Kumar Shirumalla

IPC: A61K31/4164 ,  C07D233/54

CPC classification number: C07D235/08 ,  C07D233/54 ,  C07D409/06

Abstract: This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20090326004A1

公开(公告)日：2009-12-31

申请号：US12473481

申请日：2009-05-28

Applicant: Naresh KUMAR ,  Jitendra A. SATTIGERI ,  Shelly AERON ,  Malvika GARG ,  Abhijit RAY ,  Suman GUPTA ,  Shivani MALHOTRA ,  Raj Kumar SHIRUMALLA

Inventor： Naresh KUMAR ,  Jitendra A. SATTIGERI ,  Shelly AERON ,  Malvika GARG ,  Abhijit RAY ,  Suman GUPTA ,  Shivani MALHOTRA ,  Raj Kumar SHIRUMALLA

IPC: A61K31/439 ,  C07D453/02 ,  A61P1/06

CPC classification number: C07D453/02

Abstract: The present invention relates generally to muscarinic receptor antagonist, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and the method for treating diseases mediated through muscarinic receptors. Also provided herein are pharmaceutical composition comprising one or more muscarinic receptor antagonists and at least one other active ingredients include, but are not limited to, corticosteroids, beta agonists, leukotriene antagonists, 5-lipoxygenase inhibitors, anti-histamines, antitussives, dopamine receptor antagonists, chemokine inhibitors, p38 MAP Kinase inhibitors, and PDE-IV inhibitors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物和用于治疗通过毒蕈碱受体介导的疾病的方法。 本文还提供包含一种或多种毒蕈碱受体拮抗剂的药物组合物，并且至少一种其它活性成分包括但不限于皮质类固醇，β激动剂，白细胞三烯拮抗剂，5-脂氧合酶抑制剂，抗组胺药，止咳药，多巴胺受体拮抗剂 ，趋化因子抑制剂，p38 MAP激酶抑制剂和PDE-IV抑制剂。

公开(公告)号：US20090054519A1

公开(公告)日：2009-02-26

申请号：US11996407

申请日：2006-07-20

Applicant: Abhijit Ray ,  Raj Kumar Shirumalla ,  Kasim Mookhtiar ,  Viswajanani J. Sattigeri ,  Venkata Palle ,  Mohammad Salman

Inventor： Abhijit Ray ,  Raj Kumar Shirumalla ,  Kasim Mookhtiar ,  Viswajanani J. Sattigeri ,  Venkata Palle ,  Mohammad Salman

IPC: A61K31/36 ,  A61P43/00

CPC classification number: A61K31/70

Abstract: The present invention relates to the use of derivatives of monosaccharides as 5-lipoxygenase inhibitor.

Abstract translation: 本发明涉及单糖衍生物作为5-脂氧合酶抑制剂的用途。

公开(公告)号：US20100222393A1

公开(公告)日：2010-09-02

申请号：US12159505

申请日：2006-12-21

Applicant: Naresh Kumar ,  Jaskiran Kaur ,  Venkata P. Palle ,  Beenu Bhatt ,  Shelly Jindal ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

Inventor： Naresh Kumar ,  Jaskiran Kaur ,  Venkata P. Palle ,  Beenu Bhatt ,  Shelly Jindal ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

IPC: A61K31/4439 ,  C07D233/54 ,  A61K31/4164 ,  C07D401/02 ,  A61P11/00 ,  A61P13/00 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10

CPC classification number: C07D233/54 ,  C07D233/14 ,  C07D233/56 ,  C07D233/64 ,  C07D401/12

Abstract: Compounds of Formula (I), wherein represents a single bond when G is —OH and double bond when G is —O; R1 and R2 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclylalkyl or heteroarylalkyl; R3 is selected from the group selected from hydrogen, hydroxy, alkoxy, alkenyloxy or alkynyloxy; X is selected from oxygen, —NH, —NR (wherein R is alkyl, alkenyl, alkenyl, alkynyl or aryl), sulphur or no atom; Het is heterocyclyl or heteroaryl; n is an integer from 1 to 6; are muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and 4 i gastrointestinal systems mediated through muscarinic receptors.

Abstract translation: 式（I）的化合物，当G为-OH时，当G为-O时，表示单键; R 1和R 2独立地选自氢，烷基，烯基，炔基，芳烷基，环烷基，芳基，杂芳基，杂环基，杂环基烷基或杂芳基烷基; R3选自氢，羟基，烷氧基，烯氧基或炔氧基; X选自氧，-NH，-NR（其中R是烷基，烯基，烯基，炔基或芳基），硫或无原子; Het是杂环基或杂芳基; n是1至6的整数; 是毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和4I胃肠系统的各种疾病，以及其它用途。

公开(公告)号：US20090221515A1

公开(公告)日：2009-09-03

申请号：US11574465

申请日：2005-08-31

Applicant: Viswajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Venkata P. Palle ,  Mohammad Salman ,  Abhijit Ray ,  Raj Kumar Shirumalla ,  Abdul Rehaman Abdul Rauf

Inventor： Viswajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Venkata P. Palle ,  Mohammad Salman ,  Abhijit Ray ,  Raj Kumar Shirumalla ,  Abdul Rehaman Abdul Rauf

IPC: A61K31/7008 ,  C07H5/04

CPC classification number: C07H15/18

Abstract: The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis. Pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

Abstract translation: 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮 ，动脉粥样硬化，癌症，瘙痒症或过敏性鼻炎。 包含本发明化合物的药物组合物，治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症， 还提供了使用该化合物的瘙痒症，过敏性鼻炎和其它炎性和/或自身免疫性疾病。