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1.发明授权Inducing cellular immune responses to hepatitis B virus using peptide compositions 有权使用肽组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US07611713B2
公开(公告)日：2009-11-03
申请号：US10654601
申请日：2003-09-04
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
CPC分类号： C07K14/005 , A61K38/00 , C07K14/70539 , C12N2730/10122
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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2.发明申请Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 有权使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US20050063983A1
公开(公告)日：2005-03-24
申请号：US10654601
申请日：2003-09-04
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
CPC分类号： C07K14/005 , A61K38/00 , C07K14/70539 , C12N2730/10122
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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3.发明授权Methods for ex vivo therapy using peptide-loaded antigen presenting cells for the activation of CTL 失效使用加载肽的抗原呈递细胞进行CTL激活的体外治疗方法
公开(公告)号：US5846827A
公开(公告)日：1998-12-08
申请号：US468454
申请日：1995-06-06
申请人： Esteban Celis , Ralph Kubo , Horacio Serra , Van Tsai , Peggy Wentworth
发明人： Esteban Celis , Ralph Kubo , Horacio Serra , Van Tsai , Peggy Wentworth
IPC分类号： A61K35/14 , A61K38/00 , A61K39/00 , A61P31/00 , A61P35/00 , C12N5/0783 , C12N5/06 , A61K45/00
CPC分类号： C12N5/0636 , A61K2039/5158 , C12N2502/11
摘要： Methods for activating cytotoxic T lymphocytes (CTL) in vitro are presented in conjunction with methods for using the activated CTL for therapy in vivo. Additionally, a method for killing specific CTL in vivo is presented using antigen presenting cells which were modified in vitro.
摘要翻译： 结合使用活化的CTL进行体内治疗的方法，结合体外激活细胞毒性T淋巴细胞（CTL）的方法。 另外，使用在体外修饰的抗原呈递细胞来呈现体内杀死特异性CTL的方法。
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公开(公告)号：US20070055049A1
公开(公告)日：2007-03-08
申请号：US10817970
申请日：2004-04-06
申请人： Howard Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph Kubo , Esteban Celis , Robert Chesnut , W. Kast
发明人： Howard Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph Kubo , Esteban Celis , Robert Chesnut , W. Kast
IPC分类号： C07K14/74
CPC分类号： A61K38/00 , A61K38/10 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K39/145 , A61K2039/5158 , A61K2039/55516 , A61K2039/55566 , A61K2039/572 , C07K7/06 , C07K14/70539 , C07K2319/01 , C07K2319/33 , C07K2319/40 , C12N2710/00088 , C12N2710/20034 , C12N2730/10134 , C12N2740/16034 , C12N2770/24234
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen.
摘要翻译： 本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。 所述肽可用于引发针对所需抗原的免疫应答。
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5.发明申请Inducing Cellular Immune Responses to Hepatitis B Virus Using Peptide and Nucleic Acid Compositions 审中-公开使用肽和核酸组合诱导乙型肝炎病毒的细胞免疫应答公开(公告)号：US20100068228A1
公开(公告)日：2010-03-18
申请号：US12535966
申请日：2009-08-05
申请人： Alessandro SETTE , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
发明人： Alessandro SETTE , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
IPC分类号： A61K39/29 , C07K7/06 , C07K7/08 , C07K2/00 , C07K14/00 , C07H21/00 , A61K38/02 , G01N33/567 , A61P31/12
CPC分类号： C07K14/005 , A61K38/00 , C07K14/70539 , C12N2730/10122
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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6.发明申请Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US20070059799A1
公开(公告)日：2007-03-15
申请号：US11522314
申请日：2006-09-18
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria Vitiello , Brian Livingston , Esteban Celis , Ralph Kubo , Howard Grey , Robert Chesnut
CPC分类号： C07K14/005 , A61K38/00 , A61K2039/5154 , C12N2730/10122
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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7.发明申请Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导人免疫缺陷病毒-1的细胞免疫应答公开(公告)号：US20050271676A1
公开(公告)日：2005-12-08
申请号：US11045024
申请日：2005-01-28
申请人： Alessandro Sette , John Sidney , Scott Southwood , Brian Livingston , Robert Chesnut , Denise Baker , Esteban Celis , Ralph Kubo , Howard Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Brian Livingston , Robert Chesnut , Denise Baker , Esteban Celis , Ralph Kubo , Howard Grey
CPC分类号： C07K14/005 , A61K2039/5154 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/6018 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human immunodeficiency virus (HIV) epitopes, and to develop epitope-based vaccines directed towards HIV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HIV infection.
摘要翻译： 本发明使用我们对抗原被T细胞识别并制备人免疫缺陷病毒（HIV）表位的机制的知识，并开发针对HIV的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗HIV感染。
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