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公开(公告)号：US06303143B1
公开(公告)日：2001-10-16
申请号：US09095616
申请日：1998-06-10
申请人： Suggy S. Chrai , Ramaswamy Murari , Eugene Samuel Poliniak , Hoi Cheong (Steve) Sun , Nitin Vithalbhai Desai , Dominic Stephen Rosati , Nalin Kumar , William Ronald Roach , Lawrence Harrison Hammer , Peter David Southgate , Bawa Singh , Howard Christopher Rivenburg , David Keller , Peter John Zanzucchi , Aaron William Levine , Prince Lal
发明人： Suggy S. Chrai , Ramaswamy Murari , Eugene Samuel Poliniak , Hoi Cheong (Steve) Sun , Nitin Vithalbhai Desai , Dominic Stephen Rosati , Nalin Kumar , William Ronald Roach , Lawrence Harrison Hammer , Peter David Southgate , Bawa Singh , Howard Christopher Rivenburg , David Keller , Peter John Zanzucchi , Aaron William Levine , Prince Lal
IPC分类号： A61K948
摘要： A substrate is roboticaly picked up at a station and transported to a measuring station to measure the distance to a reference. The substrate is aligned to a robot before measurement. The measured substrate is then transported to a pharmaceutical or diagnostic powder/grain deposition station where the powder/grains are controllably deposited on the substrate to predetermined thicknesses over a plurality of powder/grain collection zones. The deposited powder/grains are then measured to determine the thickness and area covered by the deposited powder/grains at each collection zone. The substrate is then transported to a lamination station and each collection zone of powder/grains is welded to a cover substrate. The system remembers which collection zones are out of specification so that they can be later selectively discarded.
摘要翻译： 机器人被机器人拾取并运送到测量站以测量到参考的距离。 在测量之前，将基板与机器人对准。 然后将测量的基底输送到药物或诊断粉末/颗粒沉积站，其中粉末/颗粒可控地沉积在基底上至多个粉末/颗粒收集区域上的预定厚度。 然后测量沉积的粉末/颗粒以确定在每个收集区域沉积的粉末/颗粒覆盖的厚度和面积。 然后将基板输送到层压站，并将粉末/颗粒的每个收集区域焊接到覆盖基板。 系统会记住哪些收集区域超出规范，以便随后可以选择性地丢弃它们。
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公开(公告)号：US20050013924A1
公开(公告)日：2005-01-20
申请号：US10332255
申请日：2001-07-06
申请人： Ramaswamy Murari , Ashok Katdare , Suggy Chrai , Troy Harmon
发明人： Ramaswamy Murari , Ashok Katdare , Suggy Chrai , Troy Harmon
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K9/28 , A61K9/48 , A61K31/198 , A61K31/4178 , A61K47/30 , A61K47/32 , A61K47/38 , A61K47/42 , A61L2/00
CPC分类号： A61K9/2095 , A61K9/146 , A61K9/1676 , A61K9/2086
摘要： A method is disclosed for formulating healthcare products, including solid pharmaceutical compositions, while avoiding instability caused ba interaction of the active ingredient with excipients. The method comprises the steps of: (a) selecting an active ingredient that loses stability or potency upon interaction with pharmaceutical excipients; and (b) depositing the active ingredient, preferably electrostatically, as a dry powder substantially free of excipients, onto a pharmaceutically acceptable polymer substrate.
摘要翻译： 公开了一种用于配制保健产品（包括固体药物组合物）的方法，同时避免不稳定性引起活性成分与赋形剂的相互作用。 该方法包括以下步骤：（a）选择与药物赋形剂相互作用时失去稳定性或效力的活性成分; 和（b）将优选静电的活性成分作为基本不含赋形剂的干燥粉末沉积到药学上可接受的聚合物基质上。
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公开(公告)号：US06616932B2
公开(公告)日：2003-09-09
申请号：US09404412
申请日：1999-09-23
申请人： Suggy S. Chrai , Ramaswamy Murari
发明人： Suggy S. Chrai , Ramaswamy Murari
IPC分类号： A61K900
CPC分类号： A61K9/2086 , A61K9/0056
摘要： A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.
摘要翻译： 一种用于口服递送的液体药物，其中在使用时将固体单位剂型加入到液体中，其中单位剂型由可溶于液体的底物和药学有效量的药物活性物质组成。 在使用时，将单位剂型添加到液体中，而不需要测量液体，并且消耗整个液体以提供药学上有效量的材料的口服递送。
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公开(公告)号：US06702803B2
公开(公告)日：2004-03-09
申请号：US09766695
申请日：2001-01-22
IPC分类号： A61K924
CPC分类号： A61K9/4808 , A61K9/209
摘要： Controlled release, multi-step drug dosage forms comprising a plurality of dose units and a plurality of separators that control release of drug from the dose units. In one embodiment, a dose unit is a single dosage amount of a drug that is electrostatically deposited onto a substrate. The dosage forms are designed to deliver a drug to exhibit a desired pharmacokinetic profile.
摘要翻译： 控制释放的多步药物剂型包括多个剂量单位和多个分离器，其控制药物从剂量单位的释放。 在一个实施方案中，剂量单位是静电沉积在基底上的药物的单次剂量。 剂型被设计成递送药物以显示所需的药代动力学特征。
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公开(公告)号：US06394306B1
公开(公告)日：2002-05-28
申请号：US09602314
申请日：2000-06-23
IPC分类号： G07F1100
CPC分类号： A61J7/0409 , A61J1/035 , B65D83/0409 , B65D83/0463 , B65D83/0472
摘要： A dispenser for storing/dispensing pharmaceutical dosages that are provided in a stamp-like (flat) dosage form. In some embodiments, the present dispenser includes a housing for retaining a plurality of stacked, individual “stamp-like” pharmaceutical dosages. Disposed within the housing beneath the dosages is a bias element, such as a helical spring, that urges the dosages towards a dosage delivery port of the housing. From the dosage delivery port, dosages are dispensed through an aperture. In other embodiments, the instant dispenser includes a cylindrical main body for retaining pharmaceutical dosages having a stamp-like dosage form that are collectively organized in a roll. A dosage delivery port depending from the cylindrical main body receives dosages one at a time therefrom. The present dispenser is configured, in various embodiments, for manual, mechanically assisted, or automated dispensing. Moreover, the present dispenser includes, when appropriately automated, control electronics that (1) alert a user of a scheduled dosage, and/or (2) dispense a dosage at a prescribed time or at a prescribed time interval, and/or (3) maintain a dosage record.
摘要翻译： 用于存储/分配以邮票状（平坦）剂型提供的药物剂量的分配器。 在一些实施例中，本发明的分配器包括用于保持多个堆叠的，单独的“邮票状”药物剂量的壳体。 在剂量下的壳体内设置有偏压元件，例如螺旋弹簧，其将剂量推向壳体的剂量输送端口。 从剂量递送口中，通过孔分配剂量。 在其它实施方案中，瞬时分配器包括圆柱形主体，用于保持药物剂量，其具有共同组织成卷的戳状剂型。 从圆柱形主体悬挂的剂量输送口从其一次接收剂量。 在各种实施例中，本发明的分配器被配置用于手动，机械辅助或自动分配。 此外，当适当地自动化时，本发明的分配器包括控制电子设备，（1）向用户警告计划的剂量，和/或（2）在规定的时间或以规定的时间间隔分配剂量，和/或（3 ）维持剂量记录。
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公开(公告)号：US06844048B2
公开(公告)日：2005-01-18
申请号：US09903394
申请日：2001-07-11
申请人： Ramaswamy Murari , Jen-Chi Chen , Suggy S. Chrai
发明人： Ramaswamy Murari , Jen-Chi Chen , Suggy S. Chrai
CPC分类号： A61K9/7007 , A61J3/00 , Y10T428/24331 , Y10T428/24372
摘要： Provided is, among other things, a conductive inlay film comprising: a layer of dielectric film having a pattern of holes suitable to define selected regions to which particles will be deposited by electrostatic deposition; and a conductive element comprising polymer, which element comprises (a) a conductive film laminated against the dielectric film or (b) a conductive film embedded within the holes, the portion of the conductive element appearing within the holes comprising conductive inlays, wherein the conductive element is adapted to contact one or more electrode pads and provide electrical potentials at the selected regions, and wherein the dielectric film electrically isolates the selected regions.
摘要翻译： 提供了一种导电嵌体膜，其包括：具有适合于限定通过静电沉积将沉积颗粒的选定区域的孔图案的电介质膜层; 以及包含聚合物的导电元件，所述元件包括（a）层压在电介质膜上的导电膜或（b）嵌入孔内的导电膜，导电元件中出现在导电嵌件内的导电元件的部分，其中导电 元件适于接触一个或多个电极焊盘并在所选择的区域提供电势，并且其中所述电介质膜电隔离所选择的区域。
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公开(公告)号：US06527138B2
公开(公告)日：2003-03-04
申请号：US10122808
申请日：2002-04-15
IPC分类号： B65H358
CPC分类号： A61J7/0409 , A61J1/035 , B65D83/0409 , B65D83/0463 , B65D83/0472
摘要： A dispenser for storing/dispensing pharmaceutical dosages that are provided in a stamplike (flat) dosage form. In some embodiments, the present dispenser includes a housing for retaining a plurality of stacked, individual “stamp-like” pharmaceutical dosages. Disposed within the housing beneath the dosages is a bias element, such as a helical spring, that urges the dosages towards a dosage delivery port of the housing. From the dosage delivery port, dosages are dispensed through an aperture. In other embodiments, the instant dispenser includes a cylindrical main body for retaining pharmaceutical dosages having a stamp-like dosage form that are collectively organized in a roll. A dosage delivery port depending from the cylindrical main body receives dosages one at a time therefrom. The present dispenser is configured, in various embodiments, for manual, mechanically assisted, or automated dispensing. Moreover, the present dispenser includes, when appropriately automated, control electronics that (1) alert a user of a scheduled dosage, and/or (2) dispense a dosage at a prescribed time or at a prescribed time interval, and/or (3) maintain a dosage record.
摘要翻译： 用于存储/分配以stamplike（扁平）剂型提供的药物剂量的分配器。 在一些实施例中，本发明的分配器包括用于保持多个堆叠的，单独的“邮票状”药物剂量的壳体。 在剂量下的壳体内设置有偏压元件，例如螺旋弹簧，其将剂量推向壳体的剂量输送端口。 从剂量递送口中，通过孔分配剂量。 在其它实施方案中，瞬时分配器包括圆柱形主体，用于保持药物剂量，其具有共同组织成卷的戳状剂型。 从圆柱形主体悬挂的剂量输送口从其一次接收剂量。 在各种实施例中，本发明的分配器被配置用于手动，机械辅助或自动分配。 此外，当适当地自动化时，本发明的分配器包括控制电子设备，（1）向用户警告计划的剂量，和/或（2）在规定的时间或以规定的时间间隔分配剂量，和/或（3 ）维持剂量记录。
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