公开(公告)号：US11858878B2

公开(公告)日：2024-01-02

申请号：US18052231

申请日：2022-11-03

Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

Inventor： Syed M. Shakil Hussain ,  Muhammad Shahzad Kamal ,  Abdullah S. Sultan

IPC: C07C237/16 ,  C09K8/584 ,  C07C381/06 ,  C11D1/00 ,  C07C233/36 ,  C07C233/38 ,  C07C231/02 ,  E21B43/16

CPC classification number: C07C237/16 ,  C07C233/36 ,  C07C233/38 ,  C07C381/06 ,  C09K8/584 ,  C11D1/00 ,  C07C231/02 ,  C09K2208/30 ,  E21B43/16

Abstract: The invention concerns synthesized amido-amine-based cationic gemini surfactants with flexible and rigid spacers and different hydrophobic. These gemini surfactants were prepared by modified procedure through amidation of long chain carboxylic acids using 3-(dimethylamino)-1-propylamine followed by treatment with halohydrocarbons and showed excellent thermal stability and surface properties useful for various oilfield applications such as enhanced oil recovery.

公开(公告)号：US4908144A

公开(公告)日：1990-03-13

申请号：US292065

申请日：1988-12-30

Applicant: Robert H. Davis ,  Liehpao O. Farng ,  Andrew G. Horodysky

Inventor： Robert H. Davis ,  Liehpao O. Farng ,  Andrew G. Horodysky

IPC: C07C55/10 ,  C07C381/06 ,  C07D285/12 ,  C07D285/125 ,  C10L1/24 ,  C10M135/36

CPC classification number: C07D285/125 ,  C07C381/06 ,  C07C55/10 ,  C10L1/2456 ,  C10L10/04 ,  C10L10/08 ,  C10M135/36 ,  C10M2219/10 ,  C10M2219/102 ,  C10M2219/104 ,  C10M2219/106 ,  C10N2240/10 ,  C10N2240/101 ,  C10N2240/104 ,  C10N2240/106

Abstract: Reaction products of Dimercaptothiadiazole-derived alcohols and alkenyl succinic anhydrides and their subsequent amine reaction products have been found to be effective antiwear/antioxidant multifunctional additives for lubricants.

Abstract translation: 已经发现二巯基噻二唑衍生的醇和烯基琥珀酸酐的反应产物及其随后的胺反应产物是用于润滑剂的有效的抗磨/抗氧化剂多功能添加剂。

公开(公告)号：US06258976B1

公开(公告)日：2001-07-10

申请号：US09272102

申请日：1999-03-19

Applicant: Francis Johnson ,  Ramesh C. Gupta

Inventor： Francis Johnson ,  Ramesh C. Gupta

IPC: C07C26100

CPC classification number: C07C279/24 ,  C07C209/48 ,  C07C209/62 ,  C07C269/06 ,  C07C335/08 ,  C07C335/26 ,  C07C381/06 ,  Y02P20/55 ,  C07C211/14 ,  C07C271/20

Abstract: Disclosed are processes for the preparation of compounds of the formula (I): H2N—(CH2)n—A—(CH2)m—NH2, or (II): H2N—(CH2)n—NH—C(═NR1)—NH—(CH2)m—NH2, wherein n and m are each independently an integer from 2 to 8; A is selected from the group consisting of —NR1—, —NR1—(CH2)r—NR1— and —NR1—(CH2)r—NR1—(CH2)z—NR1—, wherein r and z are an integer ranging from 2 to 8; and R1 is hydrogen or a protecting group having a carbonyl group.

Abstract translation: 公开了制备式（I）化合物的方法：H 2 N-（CH 2）nA-（CH 2）m -NH 2或（II）：H 2 N-（CH 2）n -NH-C（= NR 1）-NH - （CH 2）m -NH 2，其中n和m各自独立地为2至8的整数; A选自-NR1-，-NR1-（CH2）r-NR1-和-NR1-（CH2）r-NR1-（CH2）z-NR1-，其中r和z是从 2至8; 并且R 1是氢或具有羰基的保护基。

公开(公告)号：US06380392B1

公开(公告)日：2002-04-30

申请号：US09607005

申请日：2000-06-29

Applicant: Xumu Zhang

Inventor： Xumu Zhang

IPC: C07D21353

CPC classification number: C07D213/53 ,  C07C45/505 ,  C07C45/69 ,  C07C45/72 ,  C07C215/86 ,  C07C251/24 ,  C07C275/32 ,  C07C311/09 ,  C07C311/21 ,  C07C381/06 ,  C07D213/38 ,  C07D213/81 ,  C07D231/12 ,  C07D233/56 ,  C07D235/06 ,  C07D237/08 ,  C07D237/24 ,  C07D249/08 ,  C07D307/52 ,  C07D333/22 ,  C07F9/5022 ,  C07F9/58 ,  C07F9/657154 ,  C07F9/65842

Abstract: The present invention includes array of new chiral ligands that are optically active or racemic. These ligands are bidentate, tridentate, tetradentate or pentadentate ligands which include P-P, P-N, N-N, mixed P-N, Schiff base or carbene sites. The present invention further includes a catalyst prepared by a process, which includes contacting a transition metal salt, or a complex thereof, and a ligand according to the present invention. The present invention still further includes a process for preparation of an asymmetric compound. In this process, a substrate capable of forming an asymmetric product by an asymmetric reaction and a catalyst according to the present invention are contacted to produce an asymmetric product. Transition metal complexes with these ligands are effective catalysts for asymmetric reactions. Applicant has discovered that asymmetric products can be prepared using the chiral catalysts according to the present invention in enantioselective reactions, such as hydrogenation, hydroformylation, Michael addition, Heck reaction, Aldol reaction, allylic alkylation, cyclopropanation, epoxidation, and olefin metathesis.

Abstract translation: 本发明包括旋光或外消旋的新手性配体阵列。 这些配体是二齿，三齿，四齿或五齿配体，其包括P-P，P-N，N-N，混合的P-N，席夫碱或卡宾位点。 本发明还包括通过包括使过渡金属盐或其配合物与本发明的配体接触的方法制备的催化剂。 本发明还包括制备不对称化合物的方法。 在该方法中，使能够通过不对称反应形成不对称产物的基板和根据本发明的催化剂接触以产生不对称产物。 与这些配体的过渡金属络合物是不对称反应的有效催化剂。 申请人已经发现，使用根据本发明的手性催化剂可以在对映选择性反应如氢化，加氢甲酰化，迈克尔加成，Heck反应，醛醇反应，烯丙基烷基化，环丙烷化，环氧化和烯烃复分解中制备不对称产物。

公开(公告)号：US20080242656A1

公开(公告)日：2008-10-02

申请号：US11765136

申请日：2007-06-19

Applicant: Andrew M. Fryer ,  Makoto Shiozaki ,  Nicole M. Littmann ,  Takashi Inaba ,  Steven W. Andrews ,  Katsutaka Yasue ,  Ellen R. Laird ,  Masahiro Yokota ,  Julia Haas ,  Hiroto Imai ,  Katsuya Maeda ,  Yuichi Shinozaki ,  Yoshikazu Hori

Inventor： Andrew M. Fryer ,  Makoto Shiozaki ,  Nicole M. Littmann ,  Takashi Inaba ,  Steven W. Andrews ,  Katsutaka Yasue ,  Ellen R. Laird ,  Masahiro Yokota ,  Julia Haas ,  Hiroto Imai ,  Katsuya Maeda ,  Yuichi Shinozaki ,  Yoshikazu Hori

IPC: A01N43/00

CPC classification number: C07C311/20 ,  C07C311/51 ,  C07C381/06 ,  C07C381/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/34 ,  C07D209/52 ,  C07D211/46 ,  C07D211/60 ,  C07D213/42 ,  C07D213/65 ,  C07D213/74 ,  C07D213/79 ,  C07D213/80 ,  C07D231/14 ,  C07D231/20 ,  C07D233/90 ,  C07D235/14 ,  C07D249/10 ,  C07D257/04 ,  C07D257/06 ,  C07D261/18 ,  C07D271/07 ,  C07D277/56 ,  C07D285/06 ,  C07D285/08 ,  C07D295/088 ,  C07D295/13 ,  C07D295/15 ,  C07D295/185 ,  C07D307/68 ,  C07D333/18 ,  C07D333/34 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12

Abstract: The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1) wherein R1 is —W-A1-W1-A2, W is —(CH2)m—X—(CH2)n—, wherein W1 is —(CH2)m1—X1—(CH2)n1—, m, m1, n and n1 are the same or different and each is 0 to 6, X and X1 are the same or different and each is a single bond, etc., A1 is an optionally substituted C3-14 hydrocarbon ring group, etc. and A2 is a substituted C3-14 hydrocarbon ring group etc.; R2 is —(CH2)r—CO—R8, etc., wherein r is 0 to 6 and R8 is a C1-6 alkoxy group, etc.; R3 and R4 are the same or different and each is a hydrogen atom, a C1-6 alkyl group, etc.; and R5 is —CO2R21, etc.; R30 and R31 are the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体地，可以使用式（1）的N-取代-N-磺酰氨基环丙烷化合物，其中 R 1是-WA 1 -W 1 -A 2，W是 - （CH 2）2 其中W 1 - （CH 2）n - （CH 2）n - 其中W 1是 - （ CH 2 - （CH 2）n1 - - - - - （CH 2）n1 - m，m1，n和n1相同或不同，各自为0〜6，X和X 1相同或不同，分别为单键等。 任选取代的C 3-14-14烃环基等，并且A 2是取代的C 3-14烃基 戒指组等 R 2是 - （CH 2 CH 2）n -CO-R 8等，其中r是0 至6和R 8是C 1-6烷氧基等; R 3和R 4相同或不同，各自为氢原子，C 1-6烷基等; 和R 5是-CO 2 R 21等; R 30和R 31相同或不同，各自为氢原子等; 或其前药或其药学上可接受的盐。

公开(公告)号：US20050222146A1

公开(公告)日：2005-10-06

申请号：US11011781

申请日：2004-12-15

Applicant: Andrew Fryer ,  Makoto Shiozaki ,  Nicole Littmann ,  Takashi Inaba ,  Steven Andrews ,  Katsutaka Yasue ,  Ellen Laird ,  Masahiro Yokota ,  Julia Haas ,  Hiroto Imai ,  Katsuya Maeda ,  Yuichi Shinozaki ,  Yoshikazu Hori

Inventor： Andrew Fryer ,  Makoto Shiozaki ,  Nicole Littmann ,  Takashi Inaba ,  Steven Andrews ,  Katsutaka Yasue ,  Ellen Laird ,  Masahiro Yokota ,  Julia Haas ,  Hiroto Imai ,  Katsuya Maeda ,  Yuichi Shinozaki ,  Yoshikazu Hori

IPC: A61K31/18 ,  A61K31/33 ,  A61K31/381 ,  A61K31/496 ,  A61K31/5377 ,  C07C311/20 ,  C07C311/51 ,  C07C381/06 ,  C07C381/08 ,  C07D207/34 ,  C07D209/52 ,  C07D211/46 ,  C07D211/60 ,  C07D213/42 ,  C07D213/65 ,  C07D213/74 ,  C07D213/79 ,  C07D213/80 ,  C07D231/14 ,  C07D231/20 ,  C07D233/90 ,  C07D235/10 ,  C07D235/14 ,  C07D249/10 ,  C07D257/04 ,  C07D257/06 ,  C07D261/18 ,  C07D271/06 ,  C07D271/07 ,  C07D277/56 ,  C07D285/06 ,  C07D285/08 ,  C07D295/088 ,  C07D295/092 ,  C07D295/13 ,  C07D295/15 ,  C07D295/185 ,  C07D307/68 ,  C07D333/18 ,  C07D333/34 ,  C07D409/12 ,  C07D413/02 ,  C07D413/04 ,  C07D413/12 ,  C07D49/02

CPC classification number: C07C311/20 ,  C07C311/51 ,  C07C381/06 ,  C07C381/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/34 ,  C07D209/52 ,  C07D211/46 ,  C07D211/60 ,  C07D213/42 ,  C07D213/65 ,  C07D213/74 ,  C07D213/79 ,  C07D213/80 ,  C07D231/14 ,  C07D231/20 ,  C07D233/90 ,  C07D235/14 ,  C07D249/10 ,  C07D257/04 ,  C07D257/06 ,  C07D261/18 ,  C07D271/07 ,  C07D277/56 ,  C07D285/06 ,  C07D285/08 ,  C07D295/088 ,  C07D295/13 ,  C07D295/15 ,  C07D295/185 ,  C07D307/68 ,  C07D333/18 ,  C07D333/34 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12

Abstract: The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1): wherein R1 is —W-A1—W1-A2, W is —(CH2)m—X—(CH2)n—, wherein W1 is —(CH2)m1—X1—(CH2)n1—, m, m1, n and n1 are the same or different and each is 0 to 6, X and X1 are the same or different and each is a single bond, etc., A1 is an optionally substituted C3-14 hydrocarbon ring group, etc. and A2 is a substituted C3-14 hydrocarbon ring group etc.; R2 is —(CH2)r—CO—R8, etc., wherein r is 0 to 6 and R8 is a C1-6 alkoxy group, etc.; R3 and R4 are the same or different and each is a hydrogen atom, a C1-6 alkyl group, etc.; and R5 is —CO2R21 etc.; R30 and R31 are the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体而言，可以使用式（1）所示的N-取代-N-磺酰氨基环丙烷化合物： 其中R 1是-WA 1 -W 1 -A 2，W是 - （CH 3） 其中W 1是 - （CH 2）n - 其中W 1是 - （CH 2）n1 - （CH 2）n1 - （CH 2）n1 - ，m，m1，n和n1相同或不同，各自为0〜6，X和X 1相同或不同，均为单键等。 1是任选取代的C 3-14烃环基等，而A 2是取代的C 3-14烃基， 烃环组等; R 2是 - （CH 2 CH 2）n -CO-R 8等，其中r是0 至6和R 8是C 1-6烷氧基等; R 3和R 4相同或不同，各自为氢原子，C 1-6烷基等; 和R 5是-CO 2 R 21等; R 30和R 31相同或不同，各自为氢原子等; 或其前药或其药学上可接受的盐。