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1.发明授权公开(公告)号：US08846051B2
公开(公告)日：2014-09-30
申请号：US11576941
申请日：2005-10-07
申请人： Olen M. Kew , Cara C. Burns , Jing Shaw , Raymond Campagnoli , Jacqueline Quay
发明人： Olen M. Kew , Cara C. Burns , Jing Shaw , Raymond Campagnoli , Jacqueline Quay
IPC分类号： A61K39/12 , A61K39/21 , A61K39/145 , A61K39/155 , A61K39/193 , A61K39/215 , A61K39/00 , C12N7/00 , C12N15/67 , C07K14/245
CPC分类号： A61K39/0258 , A61K39/00 , A61K2039/522 , A61K2039/5254 , C07K14/245 , C12N7/00 , C12N15/67 , C12N2710/16162 , C12N2710/16662 , C12N2710/16762 , C12N2760/16162 , C12N2760/18462 , C12N2760/18562 , C12N2770/20062 , C12N2770/24162 , C12N2770/32162 , C12N2770/32762 , C12N2770/36262 , Y02A50/466 , Y02A50/472 , Y02A50/476
摘要： Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
摘要翻译： 公开了产生具有降低的复制适应性的病原体的方法，以及使用该方法产生的减毒病原体。 在具体实例中，该方法包括对编码序列中的一个或多个密码子进行去优化，从而降低病原体的复制适应性。 还公开了将减毒病原体用作免疫原性组合物的方法。
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公开(公告)号：US07776521B1
公开(公告)日：2010-08-17
申请号：US11748359
申请日：2007-05-14
申请人： Paul A. Rota , Larry J. Anderson , William J. Bellini , Michael D. Bowen , Cara Carthel Burns , Raymond Campagnoli , Qi Chen , James A. Comer , Byron T. Cook , Shannon L. Emery , Dean D. Erdman , Cynthia S. Goldsmith , Jeanette Guarner , Charles D. Humphrey , Joseph P. Icenogle , Thomas G. Ksiazek , Richard F. Meyer , Stephan S. Monroe , William Allan Nix , M. Steven Oberste , Christopher D. Paddock , Teresa C. T. Peret , Pierre E. Rollin , Mark A. Pallansch , Anthony Sanchez , Wun-Ju Shieh , Suxiang Tong , Sherif R. Zaki
发明人： Paul A. Rota , Larry J. Anderson , William J. Bellini , Michael D. Bowen , Cara Carthel Burns , Raymond Campagnoli , Qi Chen , James A. Comer , Byron T. Cook , Shannon L. Emery , Dean D. Erdman , Cynthia S. Goldsmith , Jeanette Guarner , Charles D. Humphrey , Joseph P. Icenogle , Thomas G. Ksiazek , Richard F. Meyer , Stephan S. Monroe , William Allan Nix , M. Steven Oberste , Christopher D. Paddock , Teresa C. T. Peret , Pierre E. Rollin , Mark A. Pallansch , Anthony Sanchez , Wun-Ju Shieh , Suxiang Tong , Sherif R. Zaki
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034
摘要： Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.
摘要翻译： 本文公开了新分离的人冠状病毒（SARS-CoV），严重急性呼吸综合征（SARS）的致病因子。 还提供了SARS-CoV基因组的核酸序列和SARS-CoV开放阅读框的氨基酸序列，以及使用这些分子检测SARS-CoV并检测其感染的方法。 还提供免疫刺激组合物及其使用方法。
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公开(公告)号：US07220852B1
公开(公告)日：2007-05-22
申请号：US10822904
申请日：2004-04-12
申请人： Paul A. Rota , Larry J. Anderson , William J. Bellini , Cara Carthel Burns , Raymond Campagnoli , Qi Chen , James A. Comer , Shannon L. Emery , Dean D. Erdman , Cynthia S. Goldsmith , Charles D. Humphrey , Joseph P. Icenogle , Thomas G. Ksiazek , Stephan S. Monroe , William Allan Nix , M. Steven Oberste , Teresa C. T. Peret , Pierre E. Rollin , Mark A. Pallansch , Anthony Sanchez , Suxiang Tong , Sherif R. Zaki
发明人： Paul A. Rota , Larry J. Anderson , William J. Bellini , Cara Carthel Burns , Raymond Campagnoli , Qi Chen , James A. Comer , Shannon L. Emery , Dean D. Erdman , Cynthia S. Goldsmith , Charles D. Humphrey , Joseph P. Icenogle , Thomas G. Ksiazek , Stephan S. Monroe , William Allan Nix , M. Steven Oberste , Teresa C. T. Peret , Pierre E. Rollin , Mark A. Pallansch , Anthony Sanchez , Suxiang Tong , Sherif R. Zaki
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , C12N2770/20034
摘要： Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.
摘要翻译： 本文公开了新分离的人冠状病毒（SARS-CoV），严重急性呼吸综合征（SARS）的致病因子。 还提供了SARS-CoV基因组的核酸序列和SARS-CoV开放阅读框的氨基酸序列，以及使用这些分子检测SARS-CoV并检测其感染的方法。 还提供免疫刺激组合物及其使用方法。
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公开(公告)号：US20080118530A1
公开(公告)日：2008-05-22
申请号：US11576941
申请日：2005-10-07
申请人： Olen M. Kew , Cara C. Burns , Jing Shaw , Raymond Campagnoli , Jacqueline Quay
发明人： Olen M. Kew , Cara C. Burns , Jing Shaw , Raymond Campagnoli , Jacqueline Quay
CPC分类号： A61K39/0258 , A61K39/00 , A61K2039/522 , A61K2039/5254 , C07K14/245 , C12N7/00 , C12N15/67 , C12N2710/16162 , C12N2710/16662 , C12N2710/16762 , C12N2760/16162 , C12N2760/18462 , C12N2760/18562 , C12N2770/20062 , C12N2770/24162 , C12N2770/32162 , C12N2770/32762 , C12N2770/36262 , Y02A50/466 , Y02A50/472 , Y02A50/476
摘要： Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
摘要翻译： 公开了产生具有降低的复制适应性的病原体的方法，以及使用该方法产生的减毒病原体。 在具体实例中，该方法包括对编码序列中的一个或多个密码子进行去优化，从而降低病原体的复制适应性。 还公开了将减毒病原体用作免疫原性组合物的方法。
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