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52 条记录 (耗时 0.028 秒)

    Multi-channel pipettor with variably repositionable tips
    1.
    发明授权
    Multi-channel pipettor with variably repositionable tips 有权
    多通道移液器，具有可变位置的尖端

    公开(公告)号：US08518345B2

    公开(公告)日：2013-08-27

    申请号：US13411675

    申请日：2012-03-05

    申请人： David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

    发明人： David E. Butz ,  Gregory Mathus ,  Richard Cote ,  George P. Kalmakis

    IPC分类号： B01L3/00 ,  B01L3/02 ,  G01N1/14

    CPC分类号： B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

    摘要： A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

    摘要翻译： 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

    Hand-held pipettor
    5.
    发明授权
    Hand-held pipettor 有权
    手持移液器

    公开(公告)号：US08088342B2

    公开(公告)日：2012-01-03

    申请号：US11081395

    申请日：2005-03-16

    申请人： Richard Cote ,  Robert Henry Zier

    发明人： Richard Cote ,  Robert Henry Zier

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0224 ,  B01L3/0227 ,  B01L3/0279 ,  G10L15/26

    摘要： The invention provides hand-held pipettor in accordance with an embodiment that includes a piston that is received in one end of a cylinder, a pipettor tip that is removably secured to an opposite end of said cylinder, a manually driven unit that reciprocates the piston through a selected stroke to aspirate fluid into and to expel the thus aspirated fluid from the pipettor tip, a mechanism including a stepper motor responsive to control signals for adjusting a range of the stroke, and a voice recognition system that decodes verbal commands and outputs the result to a central processing unit, which in turn generates the control signals.

    摘要翻译： 本发明提供了一种根据一个实施例的手持移液器，该移液器包括容纳在气缸的一端的活塞，可移除地固定到所述气缸的相对端的移液器末端，使得活塞 通过选择的行程来将流体从移液器吸头吸入和排出吸出的流体，包括响应于用于调节行程范围的控制信号的步进电机的机构，以及解码口头命令并输出 导致中央处理单元，其又产生控制信号。

    Unintended Motion Control For Manually Directed Multi-Channel Electronic Pipettor
    6.
    发明申请
    Unintended Motion Control For Manually Directed Multi-Channel Electronic Pipettor 有权
    手动定向多通道电子移液器的非预期运动控制

    公开(公告)号：US20110268628A1

    公开(公告)日：2011-11-03

    申请号：US13099953

    申请日：2011-05-03

    申请人： Julian Warhurst ,  Richard Cote

    发明人： Julian Warhurst ,  Richard Cote

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0234 ,  B01L3/0227 ,  B01L3/0237 ,  B01L2200/087 ,  B01L2300/027 ,  B01L2300/0829 ,  B01L2400/0478 ,  G01N35/1074

    摘要： A manually directed, electronic multi-channel pipettor uses servo controlled motors to drive a carriage and pipetting head in response to a user's manipulation of a control handle. The pipetting head include an array of tip fittings, e.g. 96. The system includes a check processor to avoid unintended motion in case of system faults or crashes. The system requires substantial force to attach the array of tips, and therefore includes controls that require both of the user's hands be occupied during the tip attachment process.

    摘要翻译： 手动导向的电子多通道移液器使用伺服控制的电动机来响应用户对控制手柄的操纵来驱动支架和移液头。 移液头包括尖端配件的阵列，例如 96.系统包括一个检查处理器，以避免系统故障或崩溃时的意外运动。 该系统需要相当大的力来附接尖端阵列，因此包括需要在尖端附着过程期间使用者的双手被占用的控制。

    Locking pipette tip and mounting shaft
    7.
    发明授权
    Locking pipette tip and mounting shaft 有权
    锁定吸头和安装轴

    公开(公告)号：US07662343B2

    公开(公告)日：2010-02-16

    申请号：US11552384

    申请日：2006-10-24

    申请人： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

    发明人： Gregory Mathus ,  Terrence Kelly ,  Richard Cote

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/087

    摘要： The invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip, the tip locks onto the mounting shaft. The bore of the pipette tip includes a circumferential shelf separating its upper collar from the tip sealing area which is located below the circumferential shelf. The locking lobes gently flexes and distorts the pipette tip collar out of round as the mounting shaft is inserted in the pipette tip, rather than stretching the tip collar. The circumferential shelf on the pipette tip between the tip collar and the barrel isolates the sealing area at the upper end of the barrel from distortion, thus facilitating reliable sealing engagement.

    摘要翻译： 本发明涉及移液器吸头安装轴构造和具有匹配构型的一次性吸头。 安装轴包括位于下密封部分上方的锁定部分。 锁定部分具有沿安装轴周向间隔开的向外延伸的锁定凸角，并且位于将下部密封部分与上部锁定部分分离的止挡部件上方。 当安装轴完全插入到匹配的一次性移液管尖端的轴环中时，尖端锁定在安装轴上。 移液管尖端的孔包括将其上部套环与位于周向架下方的尖端密封区域分开的周向架。 当安装轴插入移液管尖端时，锁定凸耳轻轻地弯曲和扭曲移液管尖端套环，而不是拉伸尖端套环。 吸头尖端在圆顶架和圆筒之间的圆周架子隔开了筒体上端的密封区域，使其不会变形，从而有利于可靠的密封接合。

    GRP78 as a Predictor of Responsiveness to Therapeutic Agents
    8.
    发明申请
    GRP78 as a Predictor of Responsiveness to Therapeutic Agents 审中-公开
    GRP78作为治疗剂反应的预测因子

    公开(公告)号：US20100015128A1

    公开(公告)日：2010-01-21

    申请号：US12444076

    申请日：2007-08-15

    申请人： Amy S. Lee ,  Richard Cote

    发明人： Amy S. Lee ,  Richard Cote

    IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/48 ,  A61K31/7088 ,  A61K31/435 ,  A61K31/337 ,  A61K31/352

    CPC分类号： G01N33/57434 ,  G01N33/57415 ,  G01N2800/44 ,  G01N2800/52

    摘要： The present application provides methods for detecting, diagnosing, monitoring, predicting responsiveness to therapeutic agents and staging cancer. The present application provides methods and compositions useful for suppression of GRP78 expression or activity in cancer cells to overcome resistance of certain therapeutic agents. The present application also provides methods for predicting whether a subject with cancer is at risk for developing resistance to certain therapeutic agents.

    摘要翻译： 本申请提供了用于检测，诊断，监测，预测对治疗剂的反应性和分期癌症的方法。 本申请提供了可用于抑制癌细胞中GRP78表达或活性以克服某些治疗剂的抗性的方法和组合物。 本申请还提供了用于预测患有癌症的受试者是否面临发展对某些治疗剂的抗性的风险的方法。