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    Convalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites
    1.
    发明申请
    Convalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites 审中-公开
    生物活性化合物与氨基酸和氨基酸衍生物的共价缀合物用于靶向生理保护部位

    公开(公告)号：US20070129312A1

    公开(公告)日：2007-06-07

    申请号：US11436972

    申请日：2006-05-16

    申请人： Milton Yatvin ,  Richard Pederson

    发明人： Milton Yatvin ,  Richard Pederson

    IPC分类号： A61K38/05 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/498 ,  A61K31/522 ,  A61K31/445 ,  A61K31/19 ,  A61K31/525 ,  A61K31/137 ,  A61K31/195

    CPC分类号： A61K47/542

    摘要： This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmacokinetically useful levels and also a method of targeting drugs to physiologically protected sites in vivo. Also provided are drug conjugates with an amino acid or derivative thereof for facilitating such targeted drug delivery. The conjugates and methods of this invention provide an advance over other drug targeting methods known in the prior art, because the invention provides drug concentrations in such physiologically protected sites that can reach therapeutically-effective levels after administration of systemic levels much lower than are currently administered to achieve a therapeutic dose. This technology is appropriate for use with psychotropic, neurotropic, neurological, antibiotic, antibacterial, antimycotic, antiviral, antiproliferative or antineoplastic drugs, agents and conjugates, for rapid and efficient introduction of such agents across, e.g., the blood-brain barrier. Further, the invention provides means for retention and prolonged enzymatic release of such drugs, agents and conjugates comprising the conjugates of the invention, in the brain and central nervous system and other physiologically-protected sites.

    摘要翻译： 本发明在此描述了一种促进药物进入生理保护部位的细胞和组织的药代动力学有用水平的方法，还包括将药物靶向体内生理保护部位的方法。 还提供了具有氨基酸或其衍生物的药物缀合物，用于促进这种靶向药物递送。 本发明的缀合物和方法提供了与现有技术中已知的其它药物靶向方法相比的进步，因为本发明提供在这样的生理保护位点中的药物浓度，其在施用远低于目前施用的系统水平之后可达到治疗有效水平 达到治疗剂量。 该技术适用于精神药物，神经营养因子，神经系统，抗生素，抗细菌剂，抗真菌药，抗病毒药，抗增殖药或抗肿瘤药物，药物和缀合物，用于快速有效地将这些药物引入例如血脑屏障。 此外，本发明提供了在脑和中枢神经系统和其他生理保护部位中包含本发明缀合物的这类药物，试剂和缀合物的保留和延长的酶促释放的方法。

    Methods and apparatus to present recipe progress status information
    2.
    发明授权
    Methods and apparatus to present recipe progress status information 有权
    提供食谱进度状态信息的方法和装置

    公开(公告)号：US08555206B2

    公开(公告)日：2013-10-08

    申请号：US11963492

    申请日：2007-12-21

    申请人： Alan Richard Pederson ,  Bryan Michael Jones ,  Dawn Marie Marruchella

    发明人： Alan Richard Pederson ,  Bryan Michael Jones ,  Dawn Marie Marruchella

    IPC分类号： G06F3/00 ,  G06F3/048

    CPC分类号： G05B19/409 ,  G05B2219/31472

    摘要： Example methods and apparatus to present recipe progress status information are disclosed. A disclosed example method involves displaying a user interface screen associated with a recipe being executed in a process control system. The recipe includes a plurality of process phases. A plurality of process stage progress indicator are displayed in the user interface screen in an arrangement representative of the process flow of the recipe. Each of the process stage progress indicators is representative of at least one of the process phases of the recipe. A first one of the process stage progress indicators is indicative of a progress of at least one of the process phases. The first process stage progress indicator is updated in substantially real-time based on information received from the process control system.

    摘要翻译： 公开了呈现配方进度状态信息的示例性方法和装置。 所公开的示例性方法涉及显示与在过程控制系统中执行的配方相关联的用户界面屏幕。 配方包括多个处理阶段。 多个处理阶段进度指示器以表示食谱的处理流程的布置显示在用户界面屏幕中。 每个过程阶段进度指标代表食谱的至少一个过程阶段。 过程阶段进度指标中的第一个指示至少有一个过程阶段的进展。 基于从过程控制系统接收的信息，基本上实时地更新第一进程阶段进度指示符。

    METHODS AND APPARATUS TO PRESENT RECIPE PROGRESS STATUS INFORMATION
    7.
    发明申请
    METHODS AND APPARATUS TO PRESENT RECIPE PROGRESS STATUS INFORMATION 有权
    提出进展状态信息的方法和装置

    公开(公告)号：US20090164933A1

    公开(公告)日：2009-06-25

    申请号：US11963492

    申请日：2007-12-21

    申请人： Alan Richard Pederson ,  Bryan Michael Jones ,  Dawn Marie Marruchella

    发明人： Alan Richard Pederson ,  Bryan Michael Jones ,  Dawn Marie Marruchella

    IPC分类号： G06F3/048

    CPC分类号： G05B19/409 ,  G05B2219/31472

    摘要： Example methods and apparatus to present recipe progress status information are disclosed. A disclosed example method involves displaying a user interface screen associated with a recipe being executed in a process control system. The recipe includes a plurality of process phases. A plurality of process stage progress indicator are displayed in the user interface screen in an arrangement representative of the process flow of the recipe. Each of the process stage progress indicators is representative of at least one of the process phases of the recipe. A first one of the process stage progress indicators is indicative of a progress of at least one of the process phases. The first process stage progress indicator is updated in substantially real-time based on information received from the process control system.

    摘要翻译： 公开了呈现配方进度状态信息的示例性方法和装置。 所公开的示例性方法涉及显示与在过程控制系统中执行的配方相关联的用户界面屏幕。 配方包括多个处理阶段。 多个处理阶段进度指示器以表示食谱的处理流程的布置显示在用户界面屏幕中。 每个过程阶段进度指标代表食谱的至少一个过程阶段。 过程阶段进度指标中的第一个指示至少有一个过程阶段的进展。 基于从过程控制系统接收的信息，基本上实时地更新第一进程阶段进度指示符。

    In-Field Control Module for Managing Wireless Seismic Data Acquisition Systems and Related Methods
    8.
    发明申请
    In-Field Control Module for Managing Wireless Seismic Data Acquisition Systems and Related Methods 有权
    用于管理无线地震数据采集系统的现场控制模块及相关方法

    公开(公告)号：US20080114548A1

    公开(公告)日：2008-05-15

    申请号：US11864195

    申请日：2007-09-28

    申请人： Dennis R. Pavel ,  Scott T. Hoenmans ,  Richard Eperjesi ,  Andra Streho ,  Gerardo Garcia ,  Richard Pederson ,  Dmitry Grinblat

    发明人： Dennis R. Pavel ,  Scott T. Hoenmans ,  Richard Eperjesi ,  Andra Streho ,  Gerardo Garcia ,  Richard Pederson ,  Dmitry Grinblat

    IPC分类号： G01V1/28

    CPC分类号： G01V1/223

    摘要： An exemplary system for managing the deployment of a seismic data acquisition system uses a module configured to execute a plurality of task in the field by receiving one or more seismic devices. The module may include a power source that provides electrical power to the seismic devices. The module may also include a processor programmed to retrieve data stored in the seismic devices, perform diagnostics, facilitate inventory and logistics control, configure seismic devices and update data or pre-programmed instructions in the seismic device. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).

    摘要翻译： 用于管理地震数据采集系统的部署的示例性系统使用被配置为通过接收一个或多个地震装置来在现场执行多个任务的模块。 模块可以包括向地震装置提供电力的电源。 模块还可以包括被编程为检索存储在地震装置中的数据的处理器，执行诊断，便于库存和物流控制，配置地震装置和更新地震装置中的数据或预先编程的指令。 要强调的是，该摘要被提供以符合要求摘要的规则，这将允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR 1.72（b）。

    CHELATING CARBENE LIGAND PRECURSORS AND THEIR USE IN THE SYNTHESIS OF METATHESIS CATALYSTS
    9.
    发明申请
    CHELATING CARBENE LIGAND PRECURSORS AND THEIR USE IN THE SYNTHESIS OF METATHESIS CATALYSTS 审中-公开
    卡特彼勒前驱剂及其在合成催化剂合成中的应用

    公开(公告)号：US20080108841A1

    公开(公告)日：2008-05-08

    申请号：US11853598

    申请日：2007-09-11

    申请人： Richard Pederson ,  Jason Woertink ,  Christopher Haar ,  David Gindelberger ,  Yann Schrodi

    发明人： Richard Pederson ,  Jason Woertink ,  Christopher Haar ,  David Gindelberger ,  Yann Schrodi

    IPC分类号： C07F15/00

    CPC分类号： B01J31/2414 ,  B01J31/1805 ,  B01J31/2204 ,  B01J31/2208 ,  B01J31/2265 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/2404 ,  B01J2231/50 ,  B01J2231/54 ,  B01J2231/543 ,  B01J2531/821 ,  B01J2531/825 ,  C07F15/002 ,  C07F15/0046

    摘要： Chelating ligand precursors for the preparation of olefin metathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various metathesis reactions efficiently, which can be recovered from the reaction mixture and reused. Internal olefin compounds, specifically beta-substituted styrenes, are used as ligand precursors. Compared to terminal olefin compounds such as unsubstituted styrenes, the beta-substituted styrenes are easier and less costly to prepare, and more stable since they are less prone to spontaneous polymerization. Methods of preparing chelating-carbene metathesis catalysts without the use of CuCl are disclosed. This eliminates the need for CuCl by replacing it with organic acids, mineral acids, mild oxidants or even water, resulting in high yields of Hoveyda-type metathesis catalysts. The invention provides an efficient method for preparing chelating-carbene metathesis catalysts by reacting a suitable ruthenium complex in high concentrations of the ligand precursors followed by crystallization from an organic solvent.

    摘要翻译： 公开了用于制备烯烃复分解催化剂的螯合配体前体。 所得催化剂是能够有效促进各种复分解反应的空气稳定的单体物质，其可以从反应混合物中回收并重复使用。 使用内部烯烃化合物，特别是β-取代的苯乙烯作为配体前体。 与末端烯烃化合物如未取代的苯乙烯相比，β-取代的苯乙烯更容易制备成本更低，更稳定，因为它们不易于自发聚合。 公开了不使用CuCl制备螯合 - 碳烯复分解催化剂的方法。 这通过用有机酸，无机酸，温和氧化剂甚至水代替它来消除对CuCl的需要，导致Hoveyda型复分解催化剂的高产率。 本发明提供了一种制备螯合碳烯复分解催化剂的有效方法，该方法是通过在高浓度配体前体中合适的钌络合物，然后从有机溶剂中结晶而制备。