摘要:
The present invention relates to the use of isomerization inhibitors in olefin metathesis reactions. The inhibitors are low molecular weight organic acids such as formic acid, acetic acid, benzoic acid, and the like.
摘要:
The invention provides novel organometallic complexes useful as olefin metathesis catalysts. The complexes have an N-heterocyclic carbene ligand and a chelating carbene ligand associated with a Group 8 transition metal center. The molecular structure of the complexes can be altered so as to provide a substantial latency period. The complexes are particularly useful in catalyzing ring closing metathesis of acyclic olefins and ring opening metathesis polymerization of cyclic olefins.
摘要:
The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration.
摘要:
Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要:
The invention relates to a novel composition for improving the accommodation capability of an intraocular lens (IOL). In one embodiment, the composition can be injected into the capsular bag where it surrounds an implanted IOL anchoring the IOL to the capsular bag. Alternatively, for anterior chamber IOLs, the composition can be injected into the bag behind the lens. The material has a refractive index similar to that of aqueous thereby reducing any potential interference with the implanted IOL. Accommodation is provided by the mixture of the crosslinked composition caused by the flexing of the muscles. The novel composition is particularly useful in enhancing accommodation for adjustable intraocular lenses.
摘要:
The invention relates to a method of customizing lenses using an external stimulus such as light. Fine-tuning of the lens to match the precise optical requirements using the same lens is also possible. The lenses are self-contained and do not require the addition or removal of significant portions of the lens to achieve customization.
摘要:
Methods and materials are disclosed for the production of optical elements, in particular intraocular lenses (IOL) that incorporate any amount (0 to 99%) of refraction and/or shape modulating compound into a substantially crosslinked first polymeric matrix. The materials produced according to the inventive methods exhibit certain rheological parameters useful in defining medical lenses. These medical lenses have the ability to change their refractive power via changing the refractive index and/or by altering the shape by stimulus induced polymerization.
摘要:
Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要:
The present invention provides a class of sensors prepared from regions of conducting organic materials and conducting materials that show an increase sensitivity detection limit for amines. The present class of sensors have applications in the detection of spoiled food products and in testing for diseases, such as cholera and lung cancer, which have amines as biomarkers.
摘要:
The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. When at least a portion of the lens is exposed to an appropriate stimulus, the refraction modulating composition forms a second polymer matrix. The amount and location of the second polymer matrix may modify a lens characteristic such as lens power by changing its refractive index and/or by altering its shape. The inventive lenses have a number of applications in the electronics and medical fields as data storage means and as medical lenses, particularly intraocular lenses, respectively.