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公开(公告)号：US5432055A
公开(公告)日：1995-07-11
申请号：US72067
申请日：1993-06-02
CPC分类号： C12Q1/689
摘要： The present invention relates to novel compositions comprising P. gingivalis specific oligonucleotides which are useful as primers to amplify particular regions of the genome of P. gingivalis during enzymatic nucleic acid amplification. The invention also provides a method for the detection of P. gingivalis, which may be present in a clinical specimen, using the P. gingivalis-specific primers and enzymatic nucleic acid amplification. The present invention also relates to P. gingivalis-specific oligonucleotides which are useful as probes to facilitate detection of the amplified regions of P. gingivalis DNA.
摘要翻译： 本发明涉及包含牙龈卟啉单胞菌特异性寡核苷酸的新型组合物，其可用作扩增酶核酸扩增期间牙龈卟啉单胞菌基因组的特定区域的引物。 本发明还提供了使用牙龈卟啉单胞菌特异性引物和酶促核酸扩增来检测牙龈卟啉单胞菌的方法，其可存在于临床标本中。 本发明还涉及牙龈卟啉单胞菌特异性寡核苷酸，其可用作促进牙龈卟啉单胞菌DNA扩增区域检测的探针。
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2.发明授权
公开(公告)号：US4287191A
公开(公告)日：1981-09-01
申请号：US140098
申请日：1980-04-14
IPC分类号： A61K31/60 , A01N37/36 , A61K8/42 , A61K8/69 , A61K31/165 , A61P1/02 , A61P31/04 , A61Q11/00 , C07C65/40 , C07C233/12 , C07C101/74 , C07C119/02
摘要： The composition comprises certain 5-acylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: ##STR1## Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a substituted or unsubstituted alkyl or phenyl group of from 2 to 30 carbon atoms including substituents and M is a radical selected from the group consisting of --C.dbd.N,--F,--NO.sub.2,--H, lower alkyl or lower haloalkyl.The preferred compositions of the invention have a partition coefficient greater than 4 and the substituted moieties in the phenyl ring of the Z group have a combined overall electron withdrawing effect on the phenyl ring of the Z group.The method of the invention comprises contacting the microorganism with a sufficient concentration of the above composition for a sufficient time to inhibit the growth of the microorganism.The above compositions are effective antiseptics against a wide range of microorganisms, especially bacteria, and the compositions surprisingly are especially effective against microorganisms prevalent in dental plaque.
摘要翻译： 该组合物包含某些5-酰基水杨酰苯胺，更具体地包括由以下通式所包括的化合物：其中Z是包含取代基的6至30个碳原子的取代苯环，R是取代或未取代的烷基或苯基 包括2至30个碳原子，包括取代基，M是选自-C = N，-F，-NO 2，-H，低级烷基或低级卤代烷基的基团。 本发明的优选组合物具有大于4的分配系数，并且Z基团的苯环中的取代部分在Z基团的苯环上具有组合的总吸电子效应。 本发明的方法包括使足够浓度的上述组合物的微生物接触足够的时间以抑制微生物的生长。 上述组合物是针对广泛的微生物，特别是细菌的有效的防腐剂，并且该组合物令人惊奇地对抗牙菌斑中普遍存在的微生物特别有效。
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3.发明授权Method of relieving chronic inflammation by using 5-alkylsulfonylsalicylanilides 失效使用5-烷基磺酰基水杨酰胺缓解慢性炎症的方法
公开(公告)号：US6117859A
公开(公告)日：2000-09-12
申请号：US407244
申请日：1999-09-28
IPC分类号： A61K9/107 , A61K31/167 , A61K31/63
CPC分类号： A61K31/609 , A61K31/167 , A61K9/1075
摘要： A method of treating chronic inflammation in a mammal is disclosed which comprises contacting the affected area with an amount sufficient to ameliorate the inflammatory condition, of a compound of the following formula: ##STR1## wherein Z is a substituted phenyl ring, R is an alkylsulfonyl group of 1-20 carbon atoms, and X is selected from the group consisting of --CN, --NO.sub.2, --H, halogen, lower alkyl and lower haloalkyl.
摘要翻译： 公开了一种治疗哺乳动物慢性炎症的方法，其包括使受影响的区域与足以改善炎性病症的量接触下式的化合物：其中Z是取代的苯环，R是1的烷基磺酰基 -20个碳原子，X选自-CN，-NO 2，-H，卤素，低级烷基和低级卤代烷基。
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公开(公告)号：US5536497A
公开(公告)日：1996-07-16
申请号：US994277
申请日：1992-12-21
IPC分类号： A61K39/00 , C07K14/195 , A61K39/02 , A61K38/00 , C07K14/00
CPC分类号： C07K14/195 , A61K39/00
摘要： Polypeptides related to fimbriae of Porphyromonas gingivalis are described and claimed which exhibit inhibition of bacterial adhesion to saliva-coated surfaces. The polypeptides are selected from the group consisting of fimbriae, fimbrillin, and fimbrial-related. peptides derived therefrom. The polypeptides are used as active ingredients in various oral formulations designed to prevent adhesion of P. gingivalis to host mucosal surfaces and thus interfering with the development of periodontitis. The polypeptides are also used in subunit vaccine formulations for use against pathogenic, fimbriated P. gingivalis in the prophylactic treatment of periodontitis. Use of the polypeptides for inducing protective immunity in serum and gingival crevicular fluid may prevent primary infection with P. gingivalis as well as the spread of the organism between intraoral reservoirs.
摘要翻译： 描述和要求保护与牙龈卟啉单胞菌菌毛有关的多肽，其表现出抑制对唾液涂覆的表面的细菌粘附。 多肽选自菌毛，芬布林林和菌毛相关。 衍生自其的肽。 多肽用作各种口服制剂中的活性成分，其旨在防止牙龈卟啉单胞菌粘附到宿主粘膜表面，从而干扰牙周炎的发展。 多肽还用于亚单位疫苗制剂中，用于在牙周炎的预防性治疗中用于抵抗致病性，流汗的牙龈卟啉菌。 使用多肽在血清和牙龈沟液中诱导保护性免疫可以预防牙龈卟啉单胞菌的原发感染以及生物体在口内储库之间的扩散。
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公开(公告)号：US06407288B1
公开(公告)日：2002-06-18
申请号：US09969071
申请日：2001-10-02
IPC分类号： C07C23365
CPC分类号： C07C255/60 , C07C235/84
摘要： The present invention discloses novel naphthylsalicylanilides of the general formula wherein W is a substituted or unsubstituted naphthyl ring. The substitution on W includes replacing one or more —H with —OH, alkyl, O-alkyl, branched alkyl, or cycloalkyl, containing 1-6 carbon atoms or combinations thereof. Y is a substituted or unsubstituted phenyl ring or substituted or unsubstituted naphthyl ring. The substitution for Y includes replacement of one or more —H atoms with CN, CF3, NO2, methoxy, benzoyl, phenoxy, phenoxymethyl or combinations thereof. These compounds are useful as antibacterial against gram negative and gram positive bacteria and as antiinflammatory agents.
摘要翻译： 本发明公开了通式为W的取代或未取代的萘基萘基新的萘磺酰苯胺。 在W上的取代包括用含1-6个碳原子的-OH，烷基，O-烷基，支链烷基或环烷基取代一个或多个-H或其组合。 Y是取代或未取代的苯基环或取代或未取代的萘基环。 取代Y包括用CN，CF 3，NO 2，甲氧基，苯甲酰基，苯氧基，苯氧基甲基或其组合取代一个或多个-H原子。 这些化合物可用作抗革兰氏阴性和革兰氏阳性菌和抗炎剂的抗菌剂。
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6.发明授权Novel 5-alkylsulfonylsalicylanilides and microbiocidal compositions for controlling the growth of microorganisms 失效用于控制微生物生长的新型5-烷基磺酰基水杨酰胺和杀微生物组合物
公开(公告)号：US4939132A
公开(公告)日：1990-07-03
申请号：US723080
申请日：1985-04-15
IPC分类号： A61K31/60 , A61K8/46 , A61K8/69 , A61K31/165 , A61K31/18 , A61P1/02 , A61P31/04 , A61Q11/00 , C07C67/00 , C07C233/12 , C07C233/65 , C07C313/00 , C07C317/46 , C07C323/65
摘要： This invention relates to new 5-alkylsulfonylsalicylanilides and methods for their use. More particularly, the invention relates to compounds of the formula: ##STR1## Wherein Z is a substituted or unsubstituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a substituted or unsubstituted alkylsulfonyl group of from 1 to 20 carbon atoms including substitutents; and X is a radical selected from the group consisting of --CN, --NO.sub.2, --H, halogen, lower alkyl or lower haloalkyl.The above compounds and compositions containing them are effective antiseptics against a wide range of microorganisms, especially bacteria, and are surprisingly highly effective against microorganisms, particularly S. mutans, prevalent in dental plaque.
摘要翻译： 本发明涉及新的5-烷基磺酰基水杨酰胺及其使用方法。 更具体地说，本发明涉及下式的化合物：其中Z是取代或未取代的6至30个碳原子的苯环，包括取代基，R是1至20个碳原子的取代或未取代的烷基磺酰基，包括 替代品 X为选自-CN，-NO 2，-H，卤素，低级烷基或低级卤代烷基的基团。 上述含有它们的化合物和组合物是广泛的微生物，特别是细菌的有效的防腐剂，并且对于在牙菌斑中普遍存在的微生物，特别是变形链球菌，令人惊奇地高度有效。
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公开(公告)号：US4358443A
公开(公告)日：1982-11-09
申请号：US176419
申请日：1980-08-08
IPC分类号： A01N37/40 , A61K8/42 , A61K8/69 , A61Q11/00 , C07C65/40 , C07C233/12 , A01N37/36 , C07C103/29
摘要： The composition comprises certain 5-alkylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: ##STR1## Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, and R is a substituted or unsubstituted n-alkyl or phenyl group of from 4 to 30 carbon atoms including substituents.The preferred compositions of the invention have a partition coefficient greater than 4 and the substituted moieties in the phenyl ring of the Z group have a combined overall electron withdrawing effect on the phenyl ring of the Z group.The method of the invention comprises contacting a microorganism affected by the above composition with a sufficient concentration of the above composition for a sufficient time to inhibit the growth of the microorganism.The above compositions are effective antiseptics against a wide range of microorganisms, especially bacteria, and the compositions surprisingly are effective against microorganisms prevalent in dental plaque.
摘要翻译： 该组合物包含某些5-烷基水杨酰胺，更具体地包括由以下通式所包括的化合物：其中Z是含有6至30个碳原子的取代苯环，包括取代基，R是取代或未取代的正烷基 或含有4-30个碳原子的苯基，包括取代基。 本发明的优选组合物具有大于4的分配系数，并且Z基团的苯环中的取代部分在Z基团的苯环上具有组合的总吸电子效应。 本发明的方法包括使受上述组合物影响的微生物与足够浓度的上述组合物接触足够的时间以抑制微生物的生长。 上述组合物是针对广泛的微生物，特别是细菌的有效的防腐剂，并且该组合物令人惊奇地对于牙菌斑中普遍存在的微生物是有效的。
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8.发明授权Directional transition module for use in conjunction with a roller-type conveyor 失效与辊式输送机结合使用的定向过渡模块公开(公告)号：US07114608B2
公开(公告)日：2006-10-03
申请号：US10802263
申请日：2004-03-16
CPC分类号： B65G47/54 , B65G2201/02
摘要： A directional transition module for moving an article translating on a primary roller conveyor extending along a first axis to a secondary conveyor for translation along a second axis angularly disposed with respect to the first axis includes at least one flexible drive member supported by a chassis for cycling through a predetermined driver cycle having an upper cycle portion and a lower cycle portion. The upper cycle portion is such that, when the directional transition module is installed for use in conjunction with the primary roller conveyor, the drive member cycles between first and second rollers of the primary roller conveyor. The drive member includes first and second segments wherein the first segment has a profile sufficiently low such that, when the first segment cycles through the upper cycle portion, it does not extend above a plane defined by the tops of the first and second rollers. The second segment has a profile sufficiently high such that, when the second segment cycles through the upper cycle portion, at least one section of the second segment extends above the plane defined by the tops of the first and second rollers to engage and at least partially lift the article for directional transition.
摘要翻译： 用于移动在沿着第一轴线延伸的第一辊式输送机上平移的制品的辅助输送机用于沿着相对于第一轴线成角度地设置的第二轴线平移的定向转换模块包括至少一个由底盘支撑的柔性驱动构件， 通过具有上循环部分和下循环部分的预定的驱动器循环。 上循环部分使得当方向转换模块安装成与主辊式输送机一起使用时，驱动构件在主辊式输送机的第一和第二辊之间循环。 驱动构件包括第一和第二段，其中第一段具有足够低的轮廓，使得当第一段循环穿过上部循环部分时，其不延伸在由第一和第二辊的顶部限定的平面之上。 第二段具有足够高的轮廓，使得当第二段循环穿过上循环部分时，第二段的至少一个部分在由第一和第二辊的顶部限定的平面的上方延伸以接合并且至少部分地 提起文章进行定向转换。
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公开(公告)号：US07178659B2
公开(公告)日：2007-02-20
申请号：US11031731
申请日：2005-01-07
IPC分类号： B65G47/54
CPC分类号： B65G47/54 , B65G2201/025 , B65G2201/0264
摘要： An novel apparatus and technique may be used to induct articles onto a conveyor comprising at least one conveyor belt that moves articles along a first path that extends in a first direction. The apparatus may be used to move an article along a second path that extends in a second direction, which is transverse to the first direction, to a first position above but not in contact with the at least one conveyor belt. After the article has been moved to the first position above but not in contact with the at least one conveyor belt, the apparatus may be used to move the article onto the at least one conveyor belt.
摘要翻译： 可以使用新颖的装置和技术将物品引导到输送机上，该输送机包括沿着沿第一方向延伸的第一路径移动物品的至少一个输送带。 该装置可以用于沿着沿与第一方向横切的第二方向延伸到第二位置的第二路径移动物品到上述第一位置，但不与该至少一个传送带接触。 在物品已经移动到上面的第一位置而不与至少一个传送带接触之后，该设备可以用于将物品移动到至少一个传送带上。
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公开(公告)号：US06907978B2
公开(公告)日：2005-06-21
申请号：US10701823
申请日：2003-11-05
CPC分类号： B65G47/54 , B65G2201/025 , B65G2201/0264
摘要： An novel apparatus and technique may be used to induct articles onto a conveyor comprising at least one conveyor belt that moves articles along a first path that extends in a first direction. The apparatus may be used to move an article along a second path that extends in a second direction, which is transverse to the first direction, to a first position above but not in contact with the at least one conveyor belt. After the article has been moved to the first position above but not in contact with the at least one conveyor belt, the apparatus may be used to move the article onto the at least one conveyor belt.
摘要翻译： 可以使用新颖的装置和技术将物品引导到输送机上，该输送机包括沿着沿第一方向延伸的第一路径移动物品的至少一个输送带。 该装置可以用于沿着沿与第一方向横切的第二方向延伸到第二位置的第二路径移动物品到上述第一位置，但不与该至少一个传送带接触。 在物品已经移动到上面的第一位置而不与至少一个传送带接触之后，该设备可以用于将物品移动到至少一个传送带上。
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