公开(公告)号：US07932056B2

公开(公告)日：2011-04-26

申请号：US12489905

申请日：2009-06-23

Applicant: Ruth Barratt ,  F. C. Thomas Allnutt ,  Robert Bullis ,  David J. Kyle

Inventor： Ruth Barratt ,  F. C. Thomas Allnutt ,  Robert Bullis ,  David J. Kyle

IPC: C12P21/00 ,  C12N5/06 ,  C12N7/00

CPC classification number: C07K14/005 ,  A01K2227/70 ,  A01K2267/01 ,  A61K2039/5256 ,  C07K14/505 ,  C07K14/62 ,  C07K16/00 ,  C07K2317/10 ,  C12N7/00 ,  C12N9/16 ,  C12N15/86 ,  C12N2710/14043 ,  C12N2710/18043 ,  C12N2750/14043 ,  C12N2770/16022 ,  C12N2770/16034 ,  C12N2770/22043 ,  C12N2770/36143 ,  C12N2830/00 ,  C12N2830/75

Abstract: A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus replicates in the crustacean or rotifer cell cytoplasm. The infected crustacean or rotifer can be provided directly to humans or non-human animals, or, following production and harvest of the crustaceans or rotifers, purified recombinant protein or polypeptide can be provided. Large quantities of biopharmaceuticals can be produced rapidly and inexpensively using this production system.

Abstract translation: 用表达外源蛋白质的病毒的重组感染性病毒感染甲壳类动物或轮虫。 甲壳类或轮虫本身的基因组本身保持不变。 甲壳动物，轮虫，昆虫或病毒启动子驱动插入重组病毒基因组中的基因的转录，并且病毒在甲壳类或轮状细胞细胞质中复制。 受感染的甲壳动物或轮虫可以直接提供给人类或非人动物，或者在甲壳类动物或轮虫的生产和收获后，可提供纯化的重组蛋白或多肽。 可以使用该生产系统快速且廉价地生产大量的生物药物。

公开(公告)号：US20090258396A1

公开(公告)日：2009-10-15

申请号：US12489905

申请日：2009-06-23

Applicant: Ruth Barratt ,  F.C. Thomas Allnutt ,  Robert Bullis ,  David J. Kyle

Inventor： Ruth Barratt ,  F.C. Thomas Allnutt ,  Robert Bullis ,  David J. Kyle

IPC: C12P21/00 ,  C12N5/06 ,  C12N7/00

CPC classification number: C07K14/005 ,  A01K2227/70 ,  A01K2267/01 ,  A61K2039/5256 ,  C07K14/505 ,  C07K14/62 ,  C07K16/00 ,  C07K2317/10 ,  C12N7/00 ,  C12N9/16 ,  C12N15/86 ,  C12N2710/14043 ,  C12N2710/18043 ,  C12N2750/14043 ,  C12N2770/16022 ,  C12N2770/16034 ,  C12N2770/22043 ,  C12N2770/36143 ,  C12N2830/00 ,  C12N2830/75

Abstract: A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus replicates in the crustacean or rotifer cell cytoplasm. The infected crustacean or rotifer can be provided directly to humans or non-human animals, or, following production and harvest of the crustaceans or rotifers, purified recombinant protein or polypeptide can be provided. Large quantities of biopharmaceuticals can be produced rapidly and inexpensively using this production system.

Abstract translation: 用表达外源蛋白质的病毒的重组感染性病毒感染甲壳类动物或轮虫。 甲壳类或轮虫本身的基因组本身保持不变。 甲壳动物，轮虫，昆虫或病毒启动子驱动插入重组病毒基因组中的基因的转录，并且病毒在甲壳类或轮状细胞细胞质中复制。 受感染的甲壳动物或轮虫可以直接提供给人类或非人动物，或者在甲壳类动物或轮虫的生产和收获后，可提供纯化的重组蛋白或多肽。 可以使用该生产系统快速且廉价地生产大量的生物药物。

公开(公告)号：US07550647B2

公开(公告)日：2009-06-23

申请号：US10778175

申请日：2004-02-17

Applicant: Ruth Barratt ,  F. C. Thomas Allnutt ,  Robert Bullis ,  David J. Kyle

Inventor： Ruth Barratt ,  F. C. Thomas Allnutt ,  Robert Bullis ,  David J. Kyle

IPC: A01K67/00 ,  A01K67/033

CPC classification number: C07K14/005 ,  A01K2227/70 ,  A01K2267/01 ,  A61K2039/5256 ,  C07K14/505 ,  C07K14/62 ,  C07K16/00 ,  C07K2317/10 ,  C12N7/00 ,  C12N9/16 ,  C12N15/86 ,  C12N2710/14043 ,  C12N2710/18043 ,  C12N2750/14043 ,  C12N2770/16022 ,  C12N2770/16034 ,  C12N2770/22043 ,  C12N2770/36143 ,  C12N2830/00 ,  C12N2830/75

Abstract: A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus replicates in the crustacean or rotifer cell cytoplasm. The infected crustacean or rotifer can be provided directly to humans or non-human animals, or, following production and harvest of the crustaceans or rotifers, purified recombinant protein or polypeptide can be provided. Large quantities of biopharmaceuticals can be produced rapidly and inexpensively using this production system.

Abstract translation: 用表达外源蛋白质的病毒的重组感染性病毒感染甲壳类动物或轮虫。 甲壳类或轮虫本身的基因组本身保持不变。 甲壳动物，轮虫，昆虫或病毒启动子驱动插入重组病毒基因组中的基因的转录，并且病毒在甲壳类或轮状细胞细胞质中复制。 受感染的甲壳动物或轮虫可以直接提供给人类或非人动物，或者在甲壳类动物或轮虫的生产和收获后，可提供纯化的重组蛋白或多肽。 可以使用该生产系统快速且廉价地生产大量的生物药物。

公开(公告)号：US20070082008A1

公开(公告)日：2007-04-12

申请号：US10548363

申请日：2004-03-05

Applicant: Moti Harel ,  Diane Clayton ,  Robert Bullis

Inventor： Moti Harel ,  Diane Clayton ,  Robert Bullis

IPC: A61K36/06 ,  A61K36/02 ,  A23K1/165

CPC classification number: A61K36/02 ,  A23K10/12 ,  A23K10/16 ,  A23K10/30 ,  A23K20/142 ,  A23K20/158 ,  A23K20/174 ,  A23K50/30 ,  A23K50/75 ,  A23K50/80 ,  A61K36/06 ,  A61K2300/00

Abstract: The use of macroalgal, microalgal, and fungally-derived materials provide, in combination with higher-plant derived materials, complete feeds for animal husbandry. The products and methods of the invention provide nutritional feed formulations, that reduce or eliminate the need for animal-derived materials. The feeds are useful for terrestrial or aquatic animals, and comprise docosahexaenoic acid and eicosapentaenoic acid.

Abstract translation: 使用大型藻类，微藻类和真菌来源的材料与高等植物来源的材料结合提供完整的畜牧饲料。 本发明的产品和方法提供营养饲料制剂，其减少或消除对动物来源的材料的需要。 饲料对陆生或水生动物有用，并且包含二十二碳六烯酸和二十碳五烯酸。

公开(公告)号：US20060130162A1

公开(公告)日：2006-06-15

申请号：US10532344

申请日：2003-10-24

Applicant: David Kyle ,  Robert Bullis

Inventor： David Kyle ,  Robert Bullis

IPC: A01K67/033

CPC classification number: A23K50/80 ,  A01K61/59 ,  A01K67/033 ,  A23K10/12 ,  A23K10/30 ,  A23K20/111 ,  A23K20/158 ,  A23K20/179 ,  A23L17/40 ,  Y02A40/824

Abstract: This invention is directed to compositions comprising improved edible shrimp and other crustaceans. The shrimp or other crustaceans are enriched with one or more components that provide benefits, such as improved taste and/or appearance, or improved health benefits for humans consuming them. The invention also relates to methods of producing such shrimp and other crustaceans, and methods of making a feed to feed the shrimp and other crustaceans.

Abstract translation: 本发明涉及包含改良的食用虾和其他甲壳类动物的组合物。 虾或其他甲壳类动物富含一种或多种组分，其提供益处，例如改善的味道和/或外观，或改善对消费它们的人的健康益处。 本发明还涉及生产这种虾和其他甲壳类动物的方法，以及制造饲料以供应虾和其他甲壳类动物的方法。