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    Method of coupling polysaccharides to proteins
    1.
    发明授权
    Method of coupling polysaccharides to proteins 失效
    将多糖与蛋白质偶联的方法

    公开(公告)号：US06361777B1

    公开(公告)日：2002-03-26

    申请号：US09331029

    申请日：1999-08-16

    申请人： Peter Hoogerhout

    发明人： Peter Hoogerhout

    IPC分类号： A61K39385

    CPC分类号： C07K9/00 ,  A61K47/61 ,  A61K47/65 ,  C07K1/1077 ,  Y02P20/55

    摘要： A novel method of covalently coupling polysaccharides to other biopolymers is provided, using an amino-thiol linker represented by formula (1): H2N—[(CH2)m—CHR1—CR2R3—A]q—CHR4—(CHR5)p—CHR6—S—R7 wherein A is a direct bond or a group having the formula —{Z—(CH2)m—CHR1—CHR2R3}nZ—, m is an integer form 0 to 5; n is an integer form 0 to 3; p is an integer from 0 to 2; q is the integer 0 or 1; R1 is hydrogen or C1-C6 alkyl, optionally substituted by amino, hydroxyl, carboxyl, C1-C4 alkoxycarbonyl, carbamoyl, mono- or di(C1-C4alkyl)carbamoyl or N-(&agr;-carboxyalkyl)carbamoyl, or, if m ≠0, R1 is hydroxyl, amino or peptidylamino; R2 and R3 are independently hydrogen or C1-C4 alkyl, or together from an oxo group; R4 is hydrogen, C1-C4 alkyl, carboxyl, C1-C4 alkoxycarbonyl, carbamoly, mono-or di(C1-C4 alkyl)carbamoyl or N-(&agr;-carboxyalkyl) carbamoyl; R5 is hydrogen, methyl, hydroxy or C1-C7 acyloxy; R6 is hydrogen or methyl; R7 is hydrogen or thiol-protecting group or group having the formula —S—CHR6—(CHR5)p—CHR4—[A—CR2R3—CHR1—(CH2)m]q—NH2; and Z is imino, methylimino, oxygen or sulphur.

    摘要翻译： 提供了使用由式（1）表示的氨基硫醇连接体共价连接多糖与其它生物聚合物的新方法：H2N - [（CH2）m-CHR1-CR2R3-A] q-CHR4-（CHR5）p-CHR6 -S-R7其中A是直接键或具有式 - {Z-（CH2）m-CHR1-CHR2R3} nZ-的基团，m是0至5的整数形式; n为0〜3的整数; p是从0到2的整数; q是整数0或1; 羟基，羧基，C 1 -C 4烷氧基羰基，氨基甲酰基，一或二（C 1 -C 4烷基）氨基甲酰基或N-（α-羧基烷基）氨基甲酰基，或如果m < > 0，R1是羟基，氨基或肽基氨基; R2和R3独立地是氢或C1-C4烷基，或一起来自氧代基; R4是氢，C1-C4烷基，羧基，C1-C4烷氧基羰基，氨基甲酰基，一或二（C1-C4烷基）氨基甲酰基或N-（α-羧基烷基）氨基甲酰基; R5是氢，甲基，羟基或C1-C7酰氧基; R6是氢或甲基; R7是氢或硫醇保护基或具有式-S-CHR6-（CHR5）p-CHR4- [A-CR2R3-CHR1-（CH2）m] q-NH2的基团; Z是亚氨基，甲基亚氨基，氧或硫。

    Immunogenic meningococcal LPS and other membrane vesicles and vaccine therefrom
    2.
    发明授权
    Immunogenic meningococcal LPS and other membrane vesicles and vaccine therefrom 失效
    免疫原性脑膜炎球菌LPS和其他囊泡和疫苗

    公开(公告)号：US5705161A

    公开(公告)日：1998-01-06

    申请号：US411727

    申请日：1995-05-01

    申请人： Peter Andre Van Der Ley ,  Jan Theunis Poolman ,  Peter Hoogerhout

    发明人： Peter Andre Van Der Ley ,  Jan Theunis Poolman ,  Peter Hoogerhout

    IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/095 ,  A61P31/04 ,  C07K9/00 ,  C07K14/195 ,  C07K14/22 ,  C08B37/00 ,  C12N20060101 ,  C12N1/21 ,  C12N15/31 ,  C12N15/61 ,  C12P19/04 ,  C12R1/36 ,  A61K45/00 ,  C07H1/00 ,  C12N15/00

    CPC分类号： C07K14/22 ,  A61K39/00

    摘要： The invention is directed to an immunity providing B cell activating molecule derived from a meningococcal lipopolysaccharide (LPS) having at least one epitope, said molecule comprising at least the communal part of the oligosaccharide part (core region) of lipopolysaccharides specific for at least two meningococcal immunotypes, preferably immunotypes L2 and L3 and wherein in galactose is absent in the B cell activating part, as well as derivatives of the molecules with immuno reaction inducing capacity. The invention is also directed at an outer membrane vesicle provided with a group of polypeptides having at least the immunoactivity of outer membrane proteins (OMP's) bound to a membrane, a polypeptide from the group of said outer membrane vesicles being a membrane anchored OMP or OMP fragment with a mutation in one of the surface loops, preferably in a 2, 3, 5, 6, 7 or 8-loop of a class I OMP. Furthermore, the invention is directed at a vaccine comprising such an outer membrane vesicle and/or lipopolysaccharide, as well as methods for preparing a lipopolysaccharide and an outer membrane vesicle as described above.

    摘要翻译： PCT No.PCT / NL93 / 00163 Sec。 371日期：1995年5月1日 102（e）日期1995年5月1日PCT提交1993年7月30日PCT公布。 第WO94 / 08021号公报 日期1994年04月14日本发明涉及提供具有至少一个表位的脑膜炎球菌性脂多糖（LPS）的B细胞活化分子的免疫力，所述分子至少包含脂多糖特异性的寡糖部分（核心区域）的共同部分 对于至少两种脑膜炎球菌免疫型，优选免疫型L2和L3，并且其中在B细胞活化部分中不存在半乳糖，以及具有免疫反应诱导能力的分子的衍生物。 本发明还涉及一种外膜囊泡，其具有至少具有与膜结合的外膜蛋白（OMP）的免疫活性的一组多肽，来自所述外膜囊泡的组的多肽是膜锚定的OMP或OMP 片段，其中一个表面循环中的突变，优选地在I类OMP的2,3,5,6,7或8-环中。 此外，本发明涉及包含这种外膜囊泡和/或脂多糖的疫苗，以及如上所述制备脂多糖和外膜囊泡的方法。

    VACCINE AGAINST NICOTINE ADDICTION
    5.
    发明申请
    VACCINE AGAINST NICOTINE ADDICTION 审中-公开
    疫苗对尼古丁的补充

    公开(公告)号：US20090196886A1

    公开(公告)日：2009-08-06

    申请号：US12297800

    申请日：2007-04-20

    申请人： Peter Hoogerhout ,  Gijsbert Zomer

    发明人： Peter Hoogerhout ,  Gijsbert Zomer

    IPC分类号： A61K39/00 ,  C07D401/04 ,  C07K14/76

    CPC分类号： A61K39/0013 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/6081 ,  C07D401/04

    摘要： The present invention provides a hapten in the form of a novel nicotine derivative that may suitably be conjugated with an appropriate carrier to yield an effective vaccine against nicotine addiction. More particularly, the invention relates to a nicotine derivative of the following formula (I): The present invention also relates to a hapten-carrier conjugate derived from the aforementioned nicotine derivative and a vaccine composition comprising said hapten-carrier conjugate.

    摘要翻译： 本发明提供了一种新型尼古丁衍生物形式的半抗原，其可适当地与合适的载体缀合以产生针对尼古丁成瘾的有效疫苗。 更具体地，本发明涉及下式（I）的尼古丁衍生物：本发明还涉及由上述尼古丁衍生物衍生的半抗原 - 载体缀合物和包含所述半抗原 - 载体缀合物的疫苗组合物。