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    Dilatation Catheter with Enhanced Distal End for Crossing Occluded Lesions
    3.
    发明申请
    Dilatation Catheter with Enhanced Distal End for Crossing Occluded Lesions 审中-公开
    扩张导管，增强远端，用于穿过闭塞的病变

    公开(公告)号：US20100286721A1

    公开(公告)日：2010-11-11

    申请号：US12842825

    申请日：2010-07-23

    申请人： Richard Goodin ,  Robert E. Burgmeier

    发明人： Richard Goodin ,  Robert E. Burgmeier

    IPC分类号： A61M29/02

    CPC分类号： A61M25/104 ,  A61M2025/1086

    摘要： A catheter for crossing an occluding lesion with an inflatable balloon and dilating the lesion includes an inner tube that defines a longitudinal axis. The balloon includes a distal section that is bonded to the tube's distal end, a working section, and a conically shaped distal transition section connecting the working and distal section. A plurality of rigid ribs are spaced around the circumference of the balloon near the catheter's distal end. Each rib includes a first elongated portion attached to the balloon's distal section and aligned substantially parallel with the longitudinal axis. A second portion extending from the first portion and at an angle thereto is attached to and lies along the surface of the balloon's distal transition section. The plurality of ribs combine to simulate a stiff, tapered surface that can be wedged into the occluding lesion to create a passageway to cross the lesion with the balloon.

    摘要翻译： 用于使闭塞性病变与可充气气囊交叉并扩张病变的导管包括限定纵向轴线的内管。 气囊包括接合到管的远端的远侧部分，工作部分和连接工作部分和远端部分的锥形远端过渡部分。 多个刚性肋在导管的远端附近围绕球囊的圆周间隔开。 每个肋包括附接到气囊的远侧部分并基本上平行于纵向轴线排列的第一细长部分。 从第一部分延伸并且以其一定角度的第二部分附接到气囊的远端过渡部分的表面并且位于其中。 多个肋组合以模拟刚性的锥形表面，其可以楔入阻塞性损伤中以产生用气球穿过病变的通道。

    ANTIOXIDANTS AND ANTIMICROBIAL ACCESSORIES INCLUDING ANTIOXIDANTS
    4.
    发明申请
    ANTIOXIDANTS AND ANTIMICROBIAL ACCESSORIES INCLUDING ANTIOXIDANTS 审中-公开

    公开(公告)号：US20100278895A1

    公开(公告)日：2010-11-04

    申请号：US12725083

    申请日：2010-03-16

    申请人： Robert E. Burgmeier

    发明人： Robert E. Burgmeier

    IPC分类号： A61F2/00 ,  A61K9/00 ,  A61K31/65 ,  A61K31/7028 ,  A61K38/12 ,  A61K31/7036 ,  A61P43/00 ,  A61P41/00 ,  A61P31/04

    CPC分类号： A61L27/54 ,  A61L27/18 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/404 ,  A61L2300/61 ,  C08L67/04

    摘要： An antimicrobial accessory may include a polymer an antimicrobial mixed in the polymer, and an antioxidant. The antioxidant may include, for example, at least one of citric acid, maltol, kojic acid, malic acid, or vitamin A. In some examples, the antioxidant may include an ascorbate peroxidase in combination with ascorbic acid, a glutathione peroxidase in combination with glutathione, or a superoxide dismutase in combination with a metal such as Ni, Cu, Mn, or Fe. In some examples, the antimicrobial accessory may include at least three polymer layers. For example, the antimicrobial accessory may include a first layer comprising a biodegradable polymer and an antimicrobial. The antimicrobial accessory may further include a sacrificial diffusion layer formed on a surface of the first layer. The sacrificial diffusion layer may include a biodegradable polymer, which may be the same biodegradable polymer as in the first layer or may be a different biodegradable polymer. The antimicrobial accessory may also include a topcoat formed on the sacrificial diffusion layer. The topcoat may include a biodegradable polymer and at least one antioxidant mixed in the biodegradable polymer.

    ANTIOXIDANTS AND ANTIMICROBIAL ACCESSORIES INCLUDING ANTIOXIDANTS
    6.
    发明申请
    ANTIOXIDANTS AND ANTIMICROBIAL ACCESSORIES INCLUDING ANTIOXIDANTS 有权
    抗氧化剂和抗微生物配件，包括抗氧化剂

    公开(公告)号：US20100278894A1

    公开(公告)日：2010-11-04

    申请号：US12725072

    申请日：2010-03-16

    申请人： Robert E. Burgmeier

    发明人： Robert E. Burgmeier

    IPC分类号： A61F2/00 ,  A61K9/00 ,  A61K38/12 ,  A61K31/7028 ,  A61K31/7036 ,  A61K31/65 ,  A61P41/00 ,  A61P31/04 ,  A61P43/00

    CPC分类号： A61L27/54 ,  A61L27/18 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/404 ,  A61L2300/61 ,  C08L67/04

    摘要： An antimicrobial accessory may include a polymer an antimicrobial mixed in the polymer, and an antioxidant. The antioxidant may include, for example, at least one of citric acid, maltol, kojic acid, malic acid, or vitamin A. In some examples, the antioxidant may include an ascorbate peroxidase in combination with ascorbic acid, a glutathione peroxidase in combination with glutathione, or a superoxide dismutase in combination with a metal such as Ni, Cu, Mn, or Fe. In some examples, the antimicrobial accessory may include at least three polymer layers. For example, the antimicrobial accessory may include a first layer comprising a biodegradable polymer and an antimicrobial. The antimicrobial accessory may further include a sacrificial diffusion layer formed on a surface of the first layer. The sacrificial diffusion layer may include a biodegradable polymer, which may be the same biodegradable polymer as in the first layer or may be a different biodegradable polymer. The antimicrobial accessory may also include a topcoat formed on the sacrificial diffusion layer. The topcoat may include a biodegradable polymer and at least one antioxidant mixed in the biodegradable polymer.

    摘要翻译： 抗微生物附件可以包括在聚合物中混合的抗微生物的聚合物和抗氧化剂。 抗氧化剂可以包括例如柠檬酸，麦芽酚，曲酸，苹果酸或维生素A中的至少一种。在一些实例中，抗氧化剂可包括与抗坏血酸组合的抗坏血酸过氧化物酶，谷胱甘肽过氧化物酶与 谷胱甘肽或超氧化物歧化酶与金属如Ni，Cu，Mn或Fe组合。 在一些实例中，抗微生物附件可以包括至少三个聚合物层。 例如，抗微生物附件可以包括包含可生物降解的聚合物和抗微生物剂的第一层。 抗微生物附件还可以包括形成在第一层的表面上的牺牲扩散层。 牺牲扩散层可以包括可生物降解的聚合物，其可以是与第一层中相同的可生物降解的聚合物，或者可以是不同的可生物降解的聚合物。 抗微生物附件还可以包括形成在牺牲扩散层上的面漆。 面漆可以包括可生物降解的聚合物和在可生物降解的聚合物中混合的至少一种抗氧化剂。

    Coextruded balloon and method of making same
    7.
    发明授权
    Coextruded balloon and method of making same 失效
    共挤气球及其制作方法

    公开(公告)号：US5769817A

    公开(公告)日：1998-06-23

    申请号：US810162

    申请日：1997-02-28

    申请人： Robert E. Burgmeier

    发明人： Robert E. Burgmeier

    IPC分类号： A61F2/84 ,  A61L29/00 ,  A61L29/04 ,  A61M25/00 ,  A61M25/10 ,  A61M25/16 ,  A61M29/00

    CPC分类号： A61M25/1029 ,  A61L29/04 ,  A61M2025/1084 ,  A61M25/1038

    摘要： An expander member for a balloon catheter to be used in stent delivery applications comprises a double-walled tubular member that is adapted for attachment to a distal end portion of an elongated, flexible, tubular catheter body. The outer wall is preferably a polyamide, such as Nylon-12, and the inner wall is PET. By properly controlling the percentage of the polyamide relative to the PET content, the distension characteristics of the resulting expander member can be tailored to fall in a range less than 15 percent. The outer Nylon-12 layer provides the expander member with high abrasion resistance. By appropriately temperature annealing the expander member, any tendency toward winging upon deflation thereof is reduced.

    摘要翻译： 用于支架输送应用的球囊导管的扩张器构件包括适于附接到细长的，柔性的管状导管体的远端部分的双壁管状构件。 外壁优选为尼龙-12等聚酰胺，内壁为PET。 通过适当地控制聚酰胺相对于PET含量的百分比，所得到的膨胀机构的膨胀特性可以被定制成小于15％的范围。 外层尼龙-12层为膨胀机构提供高耐磨性。 通过对膨胀机构进行适当的温度退火，减少了在其放气时翼片的任何倾向。

    Antioxidants and antimicrobial accessories including antioxidants
    8.
    发明授权
    Antioxidants and antimicrobial accessories including antioxidants 有权
    抗氧化剂和抗菌配方，包括抗氧化剂

    公开(公告)号：US08858983B2

    公开(公告)日：2014-10-14

    申请号：US12725072

    申请日：2010-03-16

    申请人： Robert E. Burgmeier

    发明人： Robert E. Burgmeier

    IPC分类号： A61F2/00 ,  A61K9/00 ,  A61K38/12 ,  A61K31/7028 ,  A61K31/7036 ,  A61K31/65 ,  A61P41/00 ,  A61P31/04 ,  A61P43/00 ,  A61L27/18 ,  A61L27/54

    CPC分类号： A61L27/54 ,  A61L27/18 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/404 ,  A61L2300/61 ,  C08L67/04

    摘要： An antimicrobial accessory may include a polymer an antimicrobial mixed in the polymer, and an antioxidant. The antioxidant may include, for example, at least one of citric acid, maltol, kojic acid, malic acid, or vitamin A. In some examples, the antioxidant may include an ascorbate peroxidase in combination with ascorbic acid, a glutathione peroxidase in combination with glutathione, or a superoxide dismutase in combination with a metal such as Ni, Cu, Mn, or Fe. In some examples, the antimicrobial accessory may include at least three polymer layers. For example, the antimicrobial accessory may include a first layer comprising a biodegradable polymer and an antimicrobial. The antimicrobial accessory may further include a sacrificial diffusion layer formed on a surface of the first layer. The sacrificial diffusion layer may include a biodegradable polymer, which may be the same biodegradable polymer as in the first layer or may be a different biodegradable polymer. The antimicrobial accessory may also include a topcoat formed on the sacrificial diffusion layer. The topcoat may include a biodegradable polymer and at least one antioxidant mixed in the biodegradable polymer.

    摘要翻译： 抗微生物附件可以包括在聚合物中混合的抗微生物的聚合物和抗氧化剂。 抗氧化剂可以包括例如柠檬酸，麦芽酚，曲酸，苹果酸或维生素A中的至少一种。在一些实例中，抗氧化剂可包括与抗坏血酸组合的抗坏血酸过氧化物酶，谷胱甘肽过氧化物酶与 谷胱甘肽或超氧化物歧化酶与金属如Ni，Cu，Mn或Fe组合。 在一些实例中，抗微生物附件可以包括至少三个聚合物层。 例如，抗微生物附件可以包括包含可生物降解的聚合物和抗微生物剂的第一层。 抗微生物附件还可以包括形成在第一层的表面上的牺牲扩散层。 牺牲扩散层可以包括可生物降解的聚合物，其可以是与第一层中相同的可生物降解的聚合物，或者可以是不同的可生物降解的聚合物。 抗微生物附件还可以包括形成在牺牲扩散层上的面漆。 面漆可以包括可生物降解的聚合物和在可生物降解的聚合物中混合的至少一种抗氧化剂。