Abstract:
The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
Abstract:
The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
Abstract:
The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use.
Abstract:
The implementation of periodic flight for enhancing aircraft's endurance or range is described having at least two components in the periodic flight embodiments. The first component is the trajectory optimization which determines the optimal periodic trajectory (such as altitude, velocity and flight path angle) that produces maximal endurance or range for a given fuel. The second component is the periodic guidance law which mechanizes the optimal periodic trajectory. For certain aircraft, periodic flight improves that aircraft's endurance or range over steady state flight.
Abstract:
A system, processing structure and method for performing vehicle intercept includes target acceleration estimation or blocking via a filter prior to deriving an interceptor acceleration time history via a guidance law. In the processing structure where the unknown target accelerations are blocked from affecting estimates, a guidance law is generated, stored and retrieved accounting for worst case target acceleration. In the processing structure where the target acceleration is presumed constant with a constant bank angle, the guidance law is closed form, exploiting constant heading angular velocity, and thus generated online.
Abstract:
The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
Abstract:
The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
Abstract:
The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
Abstract:
The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
Abstract:
The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.