摘要:
The purpose of the present invention is to provide a phosphorus-containing compound having reactivity with a glycidyl group, specifically a phosphorus-containing compound represented by general formula (I). (In the formula, m represents a numerical value of 1 to 10; R1 and R2 independently represent a hydrogen atom, an alkyl group or an aryl group; R3 represents an alkyl group, an alkanediyl group, an alkanetriyl group, an alkanetetrayl group or an aromatic group; X represents an oxygen atom or a sulfur atom; Y represents an oxygen atom, a sulfur atom or —NR4—; and R4 represents a hydrogen atom, an alkyl group or an aryl group.)
摘要:
The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.
摘要:
The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
摘要:
The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
摘要:
Methoxy-substituted cyanophenyl ester derivatives of phosphinic, phosphonic, phosphoric, thiophosphinic, thiophosphonic, and thiophosphoric acids having the general formula: ##STR1## wherein R and R.sup.1 are independently selected from the group consisting of lower alkyl, chloro-substituted lower alkyl, lower alkoxy, phenyl, phenoxy and lower dialkylamide, and X is oxygen or sulfur. The compounds are effective pesticides especially in the control of houseflies, American cockroach, milkweed bug and two-spotted mite. Representative compounds are O-ethyl-O-(2-methoxy-4-cyanophenyl) ethyl phosphonothioate and O,O-dimethyl-O-(2-methoxy-4-cyanophenyl) phosphorothioate.
摘要:
Organic compounds which contain nitrogen, fluorine, and phosphorus atoms together with carbon atoms and hydrogen atoms and which can be used as a multi-element standard for 1H—, 13C—, 15N—, 19F—, and 31P nuclear magnetic resonance spectroscopy. Also, a nuclear magnetic resonance spectroscopy method, preferably a quantitative nuclear magnetic resonance spectroscopy method, using said compounds and a method for qualitatively and/or quantitatively determining an analyte using such a nuclear magnetic resonance spectroscopy method.
摘要:
This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.
摘要:
A process for the preparation of an alkane phosphonic acid diaryl ester or an alkane phosphinic acid aryl ester of the formula ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.20 alkyl or alkenyl group,R.sup.2 is a C.sub.1 -C.sub.20 alkyl or alkenyl group or a C.sub.6 -C.sub.10 aryl or aryloxy group,R.sup.3 is C.sub.6 -C.sub.10 aryl group,k is 0 or 1,p is 1 or 2,k+p=2,plus an alkane phosphonic acid diaryl ester, alkane phosphinic acid aryl ester or phosphine oxide of the formula ##STR2## R.sup.4 and R.sup.5 each independently is C.sub.1 -C.sub.20 alkyl group, a C.sub.6 -C.sub.10 aryl group or a C.sub.6 -C.sub.10 aryloxy group,R.sup.6 is C.sub.1 -C.sub.20 alkyl or alkenyl group,n and m each is 0, 1 or 2, andn+m=2,comprising reacting an aryloxy compound of trivalent phosphorus of the formula ##STR3## (a) with an alkyl phosphite or alkyl phosphonite of the formula ##STR4## in the presence of an Arbusow catalyst, or (b) a rearrangement product formed in the presence of an Arbusow catalyst and of the formula ##STR5##
摘要:
This invention relates to phosphorus containing compounds which are useful as herbicides.Additionally, they demonstrate tolerance towards desired crops, e.g., cotton, soybeans and sugarbeets.