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11 条记录 (耗时 0.019 秒)

    Synthesis of 3-deazapurines
    1.
    发明授权
    Synthesis of 3-deazapurines 失效
    3-脱氮嘌呤的合成

    公开(公告)号：US5948903A

    公开(公告)日：1999-09-07

    申请号：US74503

    申请日：1998-05-08

    申请人： P. Dan Cook ,  Oscar L. Acevedo ,  Robert S. Andrews

    发明人： P. Dan Cook ,  Oscar L. Acevedo ,  Robert S. Andrews

    IPC分类号： C07H19/20 ,  C07H19/04 ,  C07H21/00

    CPC分类号： C07H19/20

    摘要： This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of "antisense" agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.

    摘要翻译： 本发明涉及基于3-脱氮嘌呤环体系的化合物及其制备方法。 本发明还通常涉及能够与RNA的核苷酸序列特异性杂交的“反义”药剂领域。 当掺入寡核苷酸时，本发明的含3-脱氮嘌呤的化合物可用于调节RNA的活性。 寡核苷酸及其类似物用于各种治疗和诊断目的，例如通过使用与这种RNA的反义相互作用来治疗疾病，调节实验系统中的基因表达，测定RNA和RNA产物，诊断疾病，调节生产 的蛋白质和切割RNA在现场特定的时尚。

    Wafer holding pin
    5.
    发明授权
    Wafer holding pin 失效
    晶圆固定销

    公开(公告)号：US06452195B1

    公开(公告)日：2002-09-17

    申请号：US09376506

    申请日：1999-08-18

    申请人： Theodore H. Smick ,  Robert S. Andrews ,  Bernhard F. Cordts, III

    发明人： Theodore H. Smick ,  Robert S. Andrews ,  Bernhard F. Cordts, III

    IPC分类号： H01J3720

    CPC分类号： H01L21/687

    摘要： A wafer holder assembly includes first and second main structural members from which first and second wafer-holding arms extend. The first arm is secured to the main structural members by a graphite distal retaining member. The second arm is pivotally biased to a wafer-hold position by a graphite bias member. This arrangement provides a conductive path from the wafer to the assembly for inhibiting electrical discharges from the wafer during the ion implantation process. The assembly can further include additional graphite retaining members for maintaining the structural integrity of the assembly during the extreme conditions associated with SIMOX wafer processing without the need for potentially wafer-contaminating adhesives and conventional fasteners. The wafer-contacting pins at the distal end of the arms can be formed from silicon. The silicon pins can be coated with titanium nitride to enhance electrical contact with the wafer and to provide an abrasion resistant surface. The pins can have a limited profile to minimize the amount of pin material proximate the wafer for reducing the likelihood of electrical arcing from the wafer to the pin.

    摘要翻译： 晶片保持器组件包括第一和第二主要结构构件，第一和第二晶片保持臂从该结构构件延伸。 第一臂通过石墨远端保持构件固定到主要结构构件。 第二臂通过石墨偏压构件枢转地偏置到晶片保持位置。 这种布置提供了从晶片到组件的导电路径，用于在离子注入过程期间抑制来自晶片的放电。 组件还可以包括附加的石墨保持构件，用于在与SIMOX晶片加工相关的极端条件下维持组件的结构完整性，而不需要潜在的晶片污染粘合剂和常规紧固件。 在臂的远端处的晶片接触销可以由硅形成。 硅引脚可以涂覆氮化钛以增强与晶片的电接触并提供耐磨表面。 引脚可以具有有限的轮廓以最小化靠近晶片的引脚材料的量，以减少从晶片到引脚的电弧的可能性。

    Arc inhibiting wafer holder assembly
    6.
    发明授权
    Arc inhibiting wafer holder assembly 失效
    防弧晶片保持器组件

    公开(公告)号：US6155436A

    公开(公告)日：2000-12-05

    申请号：US376799

    申请日：1999-08-18

    申请人： Theodore H. Smick ,  Robert S. Andrews ,  Bernhard F. Cordts, III

    发明人： Theodore H. Smick ,  Robert S. Andrews ,  Bernhard F. Cordts, III

    IPC分类号： C23C14/50 ,  C23C14/56 ,  H01L21/687 ,  A47G19/08

    CPC分类号： H01L21/68707 ,  C23C14/50 ,  C23C14/564

    摘要： A wafer holder assembly includes first and second main structural members from which first and second wafer-holding arms extend. The first arm is secured to the main structural members by a graphite distal retaining member. The second arm is pivotally biased to a wafer-hold position by a graphite bias member. This arrangement provides a conductive path from the wafer to the assembly for inhibiting electrical discharges from the wafer during the ion implantation process. The assembly can further include additional graphite retaining members for maintaining the structural integrity of the assembly during the extreme conditions associated with SIMOX wafer processing without the need for potentially wafer-contaminating adhesives and conventional fasteners. The wafer-contacting pins at the distal end of the arms can be formed from silicon. The silicon pins can be coated with titanium nitride to enhance electrical contact with the wafer and to provide an abrasion resistant surface. The pins can have a limited profile to minimize the amount of pin material proximate the wafer for reducing the likelihood of electrical arcing from the wafer to the pin.

    摘要翻译： 晶片保持器组件包括第一和第二主要结构构件，第一和第二晶片保持臂从该结构构件延伸。 第一臂通过石墨远端保持构件固定到主要结构构件。 第二臂通过石墨偏压构件枢转地偏置到晶片保持位置。 这种布置提供了从晶片到组件的导电路径，用于在离子注入过程期间抑制来自晶片的放电。 组件还可以包括附加的石墨保持构件，用于在与SIMOX晶片加工相关的极端条件下维持组件的结构完整性，而不需要潜在的晶片污染粘合剂和常规紧固件。 在臂的远端处的晶片接触销可以由硅形成。 硅引脚可以涂覆氮化钛以增强与晶片的电接触并提供耐磨表面。 引脚可以具有有限的轮廓以最小化靠近晶片的引脚材料的量，以减少从晶片到引脚的电弧的可能性。

    Hydraulic pressure intensifier
    8.
    发明授权
    Hydraulic pressure intensifier 失效
    液压增压器

    公开(公告)号：US4601642A

    公开(公告)日：1986-07-22

    申请号：US782630

    申请日：1985-10-01

    申请人： Robert S. Andrews

    发明人： Robert S. Andrews

    IPC分类号： F15B3/00 ,  F04B17/00

    CPC分类号： F15B3/00

    摘要： A hydraulic pressure intensifier is used to raise the pressure in an accumulator above a given input pressure. An oscillating piston provides a boost pressure while a pilot valve and a dump valve and restrictors allow the oscillating piston to move.

    摘要翻译： 使用液压增压器将蓄能器中的压力提高到高于给定的输入压力。 振荡活塞提供增压压力，而先导阀和倾卸阀和限流器允许摆动活塞移动。

    Flash chromatography
    9.
    发明授权
    Flash chromatography 失效
    快速色谱

    公开(公告)号：US4591442A

    公开(公告)日：1986-05-27

    申请号：US674600

    申请日：1984-11-26

    申请人： Robert S. Andrews

    发明人： Robert S. Andrews

    IPC分类号： B01D15/08 ,  C07D335/02 ,  G01N30/32 ,  G01N30/34

    CPC分类号： C07D335/02 ,  B01D15/165 ,  G01N30/34 ,  G01N2030/324

    摘要： A flash chromatography apparatus and method for rapid, moderate-resolution separation of organic compounds. A solvent reservoir is pressurized with a gas, forcing solvent under pressure through tubing into and through a sorbent-packed chromatography column. More than one solvent reservoir may be provided to permit mixed-solvent elution. Alternatively, instead of pressurizing the solvent with compressed air, one or more metering pumps may be used to deliver solvent to the column. The method includes introducing a sample to be eluted into the top of a flash chromatography column, beginning elution by introducing an elution solvent under pressure into the top of the column, the elution solvent comprising a first solvent and a second solvent in a ratio from 0:1 to 1:0, modifying the elution solvent by varying the ratio of the first solvent to the second solvent, and continuing elution with the modified elution solvent.

    摘要翻译： 用于快速，中等分辨率分离有机化合物的快速色谱仪和方法。 溶剂储存器用气体加压，迫使溶剂在压力下通过管道进入并通过吸附剂填充的色谱柱。 可以提供多于一个的溶剂容器以允许混合溶剂洗脱。 或者，代替用压缩空气加压溶剂，可以使用一个或多个计量泵将溶剂输送到塔中。 该方法包括将待洗脱的样品引入快速色谱柱的顶部，开始通过在压力下将洗脱溶剂引入柱的顶部进行洗脱，洗脱溶剂包含第一溶剂和第二溶剂，比例为0 ：1〜1：0，通过改变第一溶剂与第二溶剂的比例来改性洗脱溶剂，并用改性洗脱溶剂继续洗脱。

    Beam fabrication system
    10.
    发明授权
    Beam fabrication system 失效
    梁制造系统

    公开(公告)号：US06886251B1

    公开(公告)日：2005-05-03

    申请号：US10095511

    申请日：2002-03-11

    申请人： Robert S. Andrews

    发明人： Robert S. Andrews

    IPC分类号： B21D47/01

    CPC分类号： B21D47/01 ,  Y10T29/49625 ,  Y10T29/49634 ,  Y10T29/4978 ,  Y10T29/49829

    摘要： A method of making steel beams in accordance with the present invention comprises sending web fabrication information to a web cutting station indicative of web sizes needed to make webs for steel beams and indicative of a web discharge sequence in which the webs are to be discharged from the cutting station. Steel plate is cut at the cutting station to form webs having the indicated web sizes. A series of the webs are transported from the cutting station to a beam station according to the web discharge sequence. Flange fabrication information is sent to a flange station indicative of flange sizes needed to make flanges for the beams and a flange discharge sequence in which the flanges are to be discharged from the flange station corresponding to the web discharge sequence. Steel stock is cut so as to form flanges having the indicated flange sizes. The flanges are transported to the beam station according to the flange discharge sequence so as to match the flanges with an associated one of the webs. The flanges and the webs are welded together to form beams at the beam station. Also included is a cutting station conveyor for alternating the elevation of slats and conveyor rollers during the web cutting process and a method of cutting webs using the conveyor.

    摘要翻译： 根据本发明的制造钢梁的方法包括将幅材制造信息发送到卷筒纸切割站，其指示为钢梁制造卷材所需的卷材尺寸，并指示卷筒纸排出顺序，其中卷筒纸从 切割站。 在切割站处切割钢板以形成具有指定的纤维网尺寸的纤维网。 根据卷筒纸排放顺序，一系列的卷筒纸从切割站传送到横梁站。 法兰制造信息被发送到法兰站，其指示为梁制造法兰所需的法兰尺寸和法兰排出顺序，其中法兰将从对应于卷材排放顺序的凸缘站排出。 切割钢坯以形成具有指定法兰尺寸的凸缘。 凸缘根据凸缘排放顺序被输送到射束站，以便将凸缘与相关的一个腹板匹配。 凸缘和腹板焊接在一起，在梁台处形成梁。 还包括用于在卷筒纸切割过程中交替板条和输送辊的升高的切割站输送机以及使用输送机切割卷材的方法。