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1.发明申请Inhibition and Dispersion of Bacterial Biofilms with Benzimidazole Derivatives 有权用苯并咪唑衍生物抑制和分散细菌生物膜公开(公告)号：US20120171129A1
公开(公告)日：2012-07-05
申请号：US13377388
申请日：2010-06-10
IPC分类号： A61K8/49 , C07D403/02 , C07D211/32 , C07D221/20 , C07D471/06 , C09D5/16 , A01N25/00 , C08G83/00 , B32B1/08 , D04H11/00 , B32B27/06 , B32B17/06 , B32B15/04 , B32B21/04 , A61K31/4184 , A61K31/454 , A61K31/438 , A61K31/435 , A01P1/00 , A61P31/04 , C07D235/30
CPC分类号： C07D235/30 , C07D401/04 , C07D403/04 , Y10T428/13 , Y10T428/1393 , Y10T428/23986 , Y10T428/31678 , Y10T428/31989
摘要： Disclosure is provided for benzimidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.
摘要翻译： 本发明提供了用于预防，除去和/或抑制生物膜形成的苯并咪唑衍生物化合物，包括这些化合物的组合物，包括这些化合物的装置及其使用方法。
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公开(公告)号：US20080181923A1
公开(公告)日：2008-07-31
申请号：US12020112
申请日：2008-01-25
IPC分类号： A01N43/52 , C07D235/04 , A01N43/50 , C07D233/00 , A61K8/49 , A01N25/08 , A61L27/28 , A01P1/00
CPC分类号： A01N43/52 , A01N43/50 , A61K8/4946 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/204 , A61L2300/404 , A61Q11/00 , A61Q17/005 , C07D233/88 , C07D235/30 , C07D401/14 , C07D403/12
摘要： Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
摘要翻译： 提供了用于预防，去除和/或抑制生物膜形成的咪唑衍生物化合物的公开，包含这些化合物的组合物，包含这些化合物的装置及其使用方法。
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3.发明授权Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives 有权用苯并咪唑衍生物抑制和分散细菌生物膜公开(公告)号：US09221765B2
公开(公告)日：2015-12-29
申请号：US13377388
申请日：2010-06-10
IPC分类号： A61K8/41 , C07D235/30 , C07D401/04 , C07D403/04
CPC分类号： C07D235/30 , C07D401/04 , C07D403/04 , Y10T428/13 , Y10T428/1393 , Y10T428/23986 , Y10T428/31678 , Y10T428/31989
摘要： Disclosure is provided for benzimidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.
摘要翻译： 本发明提供了用于预防，除去和/或抑制生物膜形成的苯并咪唑衍生物化合物，包括这些化合物的组合物，包括这些化合物的装置及其使用方法。
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公开(公告)号：US07906544B2
公开(公告)日：2011-03-15
申请号：US12020112
申请日：2008-01-25
申请人： Christian Melander , John Cavanagh , Robert W. Huigens, III , T. Eric Ballard , Justin J. Richards
发明人： Christian Melander , John Cavanagh , Robert W. Huigens, III , T. Eric Ballard , Justin J. Richards
IPC分类号： A61K31/4168 , C07D233/64
CPC分类号： A01N43/52 , A01N43/50 , A61K8/4946 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/204 , A61L2300/404 , A61Q11/00 , A61Q17/005 , C07D233/88 , C07D235/30 , C07D401/14 , C07D403/12
摘要： Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
摘要翻译： 提供了用于预防，去除和/或抑制生物膜形成的咪唑衍生物化合物的公开，包含这些化合物的组合物，包含这些化合物的装置及其使用方法。
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5.发明申请INHIBITION AND DISPERSION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-TRIAZOLE DERIVATIVES 有权用咪唑 - 三唑衍生物抑制和分散细菌生物素公开(公告)号：US20090263438A1
公开(公告)日：2009-10-22
申请号：US12426742
申请日：2009-04-20
IPC分类号： A01N25/08 , C07D249/04 , A61K31/4192 , C07D413/14 , A61K31/5377 , A01N43/647 , A01N43/84 , A61P31/04 , A01P15/00 , A01P1/00
CPC分类号： C07D403/06 , A01N43/647 , A01N43/653 , A01N43/84 , A61K31/4192 , A61K31/5377 , A61K45/06 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/404 , C07D403/14 , C07D405/14 , C07D409/14
摘要： Disclosure is provided for imidazole-triazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
摘要翻译： 提供了用于预防，去除和/或抑制生物膜形成的咪唑 - 三唑衍生物化合物的公开，包含这些化合物的组合物，包含这些化合物的装置及其使用方法。
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公开(公告)号：US08653124B2
公开(公告)日：2014-02-18
申请号：US13019450
申请日：2011-02-02
申请人： Christian Melander , John Cavanagh , Robert W. Huigens, III , T. Eric Ballard , Justin J. Richards
发明人： Christian Melander , John Cavanagh , Robert W. Huigens, III , T. Eric Ballard , Justin J. Richards
IPC分类号： C07D233/64 , A61K31/4168
CPC分类号： A01N43/52 , A01N43/50 , A61K8/4946 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/204 , A61L2300/404 , A61Q11/00 , A61Q17/005 , C07D233/88 , C07D235/30 , C07D401/14 , C07D403/12
摘要： Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
摘要翻译： 提供了用于预防，去除和/或抑制生物膜形成的咪唑衍生物化合物的公开，包含这些化合物的组合物，包含这些化合物的装置及其使用方法。
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公开(公告)号：US20090143230A1
公开(公告)日：2009-06-04
申请号：US12324346
申请日：2008-11-26
申请人： Christian Melander , John Cavanagh , David Ritchie , Robert W. Huigens, III , T. Eric Ballard , Justin J. Richards , Thomas W. Lindsey , Jonathan S. Lindsey
发明人： Christian Melander , John Cavanagh , David Ritchie , Robert W. Huigens, III , T. Eric Ballard , Justin J. Richards , Thomas W. Lindsey , Jonathan S. Lindsey
摘要： Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an active compound as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an active compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or plant defense activator.
摘要翻译： 提供了用于预防，去除或抑制植物或植物部分中的微生物生物膜形成或微生物感染的方法的公开，包括向其施用有效量的本文所述的活性化合物或其农业上可接受的盐。 还提供了增强杀微生物剂（例如包括铜，抗生素，噬菌体等）和/或植物防御活化剂的方法，包括施用如本文所述的活性化合物。 还提供了包含本文所述在农业上可接受的载体中的活性化合物的组合物，并且在一些实施方案中，组合物还包括杀微生物剂（例如包括铜，抗生素，噬菌体等）和/或植物防御活化剂。
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公开(公告)号：US10081592B2
公开(公告)日：2018-09-25
申请号：US14387028
申请日：2013-03-25
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , Paul J. Hergenrother , Robert W. Huigens, III , Karen C. Morrison , Robert W. Hicklin, II , Timothy A. Flood, Jr.
发明人： Paul J. Hergenrother , Robert W. Huigens, III , Karen C. Morrison , Robert W. Hicklin, II , Timothy A. Flood, Jr.
IPC分类号： C07D401/14 , C07C69/757 , C07D311/94 , C07D313/06 , C07D223/14 , C07D401/04 , C07D471/04 , C07D471/08 , C07D493/08 , C07D513/04 , C07D519/00 , C07D303/10 , C07C59/205 , C07C62/32 , C07C62/38 , C07B37/06 , C07B37/08 , C07D307/93 , C07D313/08 , C07D405/06 , C07D405/12 , C07D413/06 , C07J21/00 , C07J69/00 , C07J71/00 , C07J73/00 , C07J75/00
CPC分类号： C07C69/757 , C07B37/06 , C07B37/08 , C07C59/205 , C07C62/32 , C07C62/38 , C07C2601/16 , C07C2602/44 , C07C2603/86 , C07D223/14 , C07D303/10 , C07D307/93 , C07D311/94 , C07D313/06 , C07D313/08 , C07D401/04 , C07D401/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D471/04 , C07D471/08 , C07D493/08 , C07D513/04 , C07D519/00 , C07J21/008 , C07J69/00 , C07J71/001 , C07J71/0031 , C07J73/005 , C07J73/008 , C07J75/005
摘要： The invention a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.
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9.发明申请INHIBITION AND DISPERSION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-TRIAZOLE DERIVATIVES 有权用咪唑 - 三唑衍生物抑制和分散细菌生物素公开(公告)号：US20110117158A1
公开(公告)日：2011-05-19
申请号：US13011532
申请日：2011-01-21
IPC分类号： A01N25/08 , C07D249/04 , C07D413/14 , A01N59/08 , A01N43/647 , A01N43/84 , A01P1/00
CPC分类号： C07D403/06 , A01N43/647 , A01N43/653 , A01N43/84 , A61K31/4192 , A61K31/5377 , A61K45/06 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/404 , C07D403/14 , C07D405/14 , C07D409/14
摘要： Disclosure is provided for imidazole-triazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
摘要翻译： 提供了用于预防，去除和/或抑制生物膜形成的咪唑 - 三唑衍生物化合物的公开，包含这些化合物的组合物，包含这些化合物的装置及其使用方法。
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10.发明授权Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives 有权用咪唑三唑衍生物抑制和分散细菌生物膜公开(公告)号：US07897631B2
公开(公告)日：2011-03-01
申请号：US12426742
申请日：2009-04-20
IPC分类号： C07D409/14 , C07D405/14 , C07D403/06 , C07D403/14 , A61K31/4192
CPC分类号： C07D403/06 , A01N43/647 , A01N43/653 , A01N43/84 , A61K31/4192 , A61K31/5377 , A61K45/06 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/404 , C07D403/14 , C07D405/14 , C07D409/14
摘要： Disclosure is provided for imidazole-triazole derivative compounds such as those given in Formulas (I)-(VI) that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
摘要翻译： 提供了咪唑 - 三唑衍生化合物的公开，例如式（I） - （VI）中给出的那些化合物，其防止，除去和/或抑制生物膜的形成，包含这些化合物的组合物，包含这些化合物的装置，以及使用 相同。
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