公开(公告)号：US08841433B2

公开(公告)日：2014-09-23

申请号：US12284347

申请日：2008-09-18

申请人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Jan Cornelius De Jong ,  Jan Groen

发明人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Jan Cornelius De Jong ,  Jan Groen

IPC分类号： C12N15/45 ,  G01N33/50 ,  C07K14/005 ,  C12N15/86 ,  C12N7/00 ,  A61K39/155 ,  G01N33/569 ,  C07K16/10 ,  A61K39/00

CPC分类号： C12Q1/701 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/58 ,  A61K2039/70 ,  A61K2123/00 ,  C07K14/005 ,  C07K16/1027 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/22034 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18621 ,  C12N2760/18622 ,  C12N2760/18634 ,  C12N2760/18643 ,  C12N2840/203 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5088 ,  G01N33/56983 ,  G01N2333/08 ,  Y02A90/26

摘要： Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular, provided is a mammalian MPV, subgroups and variants thereof. Also provided are genomic nucleotide sequences of different isolates of mammalian MPV, in particular, human MPV. Disclosed is the use of the sequence information of different isolates of mammalian MPV for diagnostic and therapeutic methods. Provided are nucleotide sequences encoding the genome of a MPV or a portion thereof, including both mammalian and avian MPV. Further described are chimeric or recombinant viruses encoded by the nucleotide sequences, and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. Also provided are vaccine formulations comprising mammalian or avian MPV, including recombinant and chimeric forms thereof. The vaccine preparations encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.

摘要翻译： 提供了副粘病毒科家族肺炎链球菌中分离的哺乳动物负链RNA病毒，偏肺病毒（MPV）。 还提供了分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 特别地，提供哺乳动物MPV，亚组及其变体。 还提供了哺乳动物MPV，特别是人MPV的不同分离物的基因组核苷酸序列。 公开了哺乳动物MPV的不同分离株的序列信息用于诊断和治疗方法。 提供编码MPV或其部分的基因组的核苷酸序列，包括哺乳动物和禽类MPV。 还描述了由核苷酸序列编码的嵌合或重组病毒，以及包含一个或多个非天然或异源序列的嵌合和重组哺乳动物MPV。 还提供了包含哺乳动物或禽类MPV的疫苗制剂，包括其重组和嵌合形式。 疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。

公开(公告)号：US20100297730A1

公开(公告)日：2010-11-25

申请号：US12317496

申请日：2008-12-22

申请人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Aurelia Haller ,  Roderick Tang

发明人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Aurelia Haller ,  Roderick Tang

IPC分类号： C12N7/01

CPC分类号： G01N33/502 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/543 ,  A61K2039/70 ,  A61K2123/00 ,  C07K14/005 ,  C07K16/1027 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18621 ,  C12N2760/18622 ,  C12N2760/18634 ,  C12N2760/18643 ,  C12N2840/203 ,  G01N33/5008 ,  G01N33/56983

摘要： The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.

摘要翻译： 本发明涉及可用于在合适的宿主细胞系统中表达异源基因产物的重组牛副流感病毒（bPIV）cDNA或RNA，和/或挽救表达，包装和/或呈递异源的负链RNA重组病毒 基因产物。 特别地，异源基因产物包括另一种PIV或另一种负链RNA病毒的基因产物，包括但不限于流感病毒，呼吸道合胞病毒，人偏肺病毒和禽肺病毒。 嵌合病毒和表达产物可有利地用于疫苗制剂中，包括针对各种病原体和抗原的疫苗。

公开(公告)号：US07531342B2

公开(公告)日：2009-05-12

申请号：US10371122

申请日：2003-02-21

申请人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Aurelia Haller ,  Roderick Tang

发明人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Aurelia Haller ,  Roderick Tang

IPC分类号： C12N7/01 ,  C12N7/04 ,  C12Q1/68 ,  C12Q1/70 ,  C12N15/00 ,  A61K39/155

CPC分类号： C12Q1/701 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/1027 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18622 ,  C12N2840/203 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5091 ,  G01N33/56983

摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae , of the family Paramyxoviridae . The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.

摘要翻译： 本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。 本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 特别地，本发明提供哺乳动物MPV，亚组及其变体。 本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。 本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。 本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。 本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。 本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。

公开(公告)号：US08715922B2

公开(公告)日：2014-05-06

申请号：US10722045

申请日：2003-11-25

申请人： Jan Cornelius De Jong ,  Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Jan Groen

发明人： Jan Cornelius De Jong ,  Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Jan Groen

IPC分类号： G01N33/53 ,  C12Q1/68 ,  C12Q1/70

CPC分类号： C12Q1/701 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/1027 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18622 ,  C12N2840/203 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5091 ,  G01N33/56983

摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the subfamily Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.

摘要翻译： 本发明涉及病毒学领域。 本发明提供分离的基本上哺乳动物的负义义单链RNA病毒（MPV），其在副粘病毒科的肺炎链球菌亚科内，并且可被鉴定为与亚属肺炎病毒属及其组分的系统发育相关。

公开(公告)号：US20100278813A1

公开(公告)日：2010-11-04

申请号：US12001458

申请日：2007-12-11

申请人： James F. Young ,  Peter Kiener ,  Albertus Dominicus Erasmus Osterhaus ,  Ronaldus Adrianus Maria Fouchier

发明人： James F. Young ,  Peter Kiener ,  Albertus Dominicus Erasmus Osterhaus ,  Ronaldus Adrianus Maria Fouchier

IPC分类号： A61K39/42 ,  A61P31/12

CPC分类号： C07K16/1027 ,  A61K2039/505

摘要： The present invention relates to methods for broad spectrum prevention and treatment of viral respiratory infection. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with respiratory syncytial virus (RSV), parainfluenza virus (PIV), and/or human metapneumovirus (hMPV) infection, the methods comprising administering to a subject an effective amount of one or more anti-RSV-antigen antibodies or antigen-binding fragments thereof, one or more anti-hMPV-antigen antibodies or antigen-binding fragments thereof, and/or one or more anti-PIV-antigen antibodies or antigen-binding fragments thereof. In certain embodiments, a certain serum titer of the anti-RSV-antigen antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof is achieved in said subject. In certain specific embodiments, the subject is human and, preferably, the anti-RSV-antigen antibody, anti-PIV-antigen antibody, and/or anti-hMPV-antigen antibodies are human or humanized. The present invention relates further to compositions comprising the anti-RSV-antigen is antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof. The present invention also relates to detectable or diagnostic compositions comprising the one or more anti-RSV-antigen antibodies, anti-PIV-antigen antibodies, and/or anti-hMPV-antigen antibodies or antigen-binding fragments thereof and methods for detecting or diagnosing RSV, PIV and/or hMPV infection utilizing the compositions.

摘要翻译： 本发明涉及广谱预防和治疗病毒性呼吸道感染的方法。 特别地，本发明涉及用于预防，治疗或改善与呼吸道合胞病毒（RSV），副流感病毒（PIV）和/或人类偏肺病毒（hMPV）感染相关的症状的方法，所述方法包括向受试者施用有效的 一种或多种抗RSV抗原抗体或其抗原结合片段，一种或多种抗hMPV抗原抗体或其抗原结合片段，和/或一种或多种抗PIV-抗原抗体或抗原结合 片段。 在某些实施方案中，在所述受试者中实现抗RSV抗原抗体，抗PIV抗原抗体和/或抗hMPV抗原抗体或其抗原结合片段的某一血清滴度。 在某些具体实施方案中，受试者是人，优选抗RSV抗原抗体，抗PIV抗原抗体和/或抗hMPV-抗原抗体是人或人源化的。 本发明进一步涉及包含抗RSV抗原的组合物是抗体，抗PIV抗原抗体和/或抗hMPV-抗原抗体或其抗原结合片段。 本发明还涉及包含一种或多种抗RSV抗原抗体，抗-PIV-抗原抗体和/或抗-hMPV-抗原抗体或其抗原结合片段的可检测或诊断组合物和用于检测或诊断的方法 使用组合物的RSV，PIV和/或hMPV感染。

公开(公告)号：US08927206B2

公开(公告)日：2015-01-06

申请号：US10466811

申请日：2002-01-18

申请人： Jan Cornelius De Jong ,  Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Jan Groen

发明人： Jan Cornelius De Jong ,  Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Jan Groen

IPC分类号： C12Q1/70 ,  C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC分类号： C12Q1/701 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/1027 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18622 ,  C12N2840/203 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5091 ,  G01N33/56983

摘要： The invention relates to the field of virology. The invention provides an isolated essentially mammalian negative-sense single stranded RNA virus (MPV) within the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus and components thereof.

摘要翻译： 本发明涉及病毒学领域。 本发明提供了一种分离的基本上哺乳动物的负义义单链RNA病毒（MPV），其在副粘病毒亚科家族肺炎链球菌中，并且可以鉴定为与亚属肺炎病毒属及其组分的系统发育相关。

公开(公告)号：US20090246855A1

公开(公告)日：2009-10-01

申请号：US12284347

申请日：2008-09-18

申请人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Jan Cornelius De Jong ,  Jan Groen

发明人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Jan Cornelius De Jong ,  Jan Groen

IPC分类号： C12N7/04 ,  C07H21/04 ,  C12N7/00

CPC分类号： C12Q1/701 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/58 ,  A61K2039/70 ,  A61K2123/00 ,  C07K14/005 ,  C07K16/1027 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/22034 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18621 ,  C12N2760/18622 ,  C12N2760/18634 ,  C12N2760/18643 ,  C12N2840/203 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5088 ,  G01N33/56983 ,  G01N2333/08 ,  Y02A90/26

摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.

摘要翻译： 本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。 本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 特别地，本发明提供哺乳动物MPV，亚组及其变体。 本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。 本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。 本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。 本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。 本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。

公开(公告)号：US07449324B2

公开(公告)日：2008-11-11

申请号：US10371099

申请日：2003-02-21

申请人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Jan Cornelius De Jong ,  Jan Groen

发明人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Jan Cornelius De Jong ,  Jan Groen

IPC分类号： C12N7/02

CPC分类号： C12Q1/701 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/58 ,  A61K2039/70 ,  A61K2123/00 ,  C07K14/005 ,  C07K16/1027 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/22034 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18621 ,  C12N2760/18622 ,  C12N2760/18634 ,  C12N2760/18643 ,  C12N2840/203 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5088 ,  G01N33/56983 ,  G01N2333/08 ,  Y02A90/26

摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.

摘要翻译： 本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。 本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 特别地，本发明提供哺乳动物MPV，亚组及其变体。 本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。 本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。 本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。 本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。 本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。

公开(公告)号：US08722341B2

公开(公告)日：2014-05-13

申请号：US12319152

申请日：2008-12-31

申请人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Aurelia Haller ,  Roderick Tang

发明人： Ronaldus Adrianus Maria Fouchier ,  Bernadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Aurelia Haller ,  Roderick Tang

IPC分类号： C07K16/00 ,  C07K16/10 ,  G01N33/53

CPC分类号： C12Q1/701 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/1027 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18622 ,  C12N2840/203 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5091 ,  G01N33/56983

摘要： Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV). Described are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. Also described is mammalian MPV, subgroups and variants thereof, and genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods is provided. Nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus are described. Also provided are chimeric or recombinant viruses encoded by said nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences.

摘要翻译： 提供了分离的哺乳动物负链RNA病毒，偏肺病毒（MPV）。 描述的是分离的哺乳动物负链RNA病毒，其被鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 还描述了哺乳动物MPV，亚组及其变体，以及哺乳动物偏肺病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 提供了用于诊断和治疗方法的哺乳动物偏肺炎病毒的不同分离株的序列信息的使用。 描述了编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 还提供了由所述核苷酸序列编码的嵌合或重组病毒以及包含一个或多个非天然或异源序列的嵌合和重组哺乳动物MPV。

公开(公告)号：US20100143407A1

公开(公告)日：2010-06-10

申请号：US12319152

申请日：2008-12-31

申请人： Ronaldus Adrianus Maria Fouchier ,  Benadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Aurelia Haller ,  Roderick Tang

发明人： Ronaldus Adrianus Maria Fouchier ,  Benadetta Gerarda Van Den Hoogen ,  Albertus Dominicus Marcellinus Erasmus Osterhaus ,  Aurelia Haller ,  Roderick Tang

IPC分类号： A61K39/12 ,  C12Q1/70 ,  C12N7/00 ,  C12N5/00 ,  C07K14/005 ,  C07K16/08 ,  C07H21/02

CPC分类号： C12Q1/701 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/1027 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18622 ,  C12N2840/203 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5091 ,  G01N33/56983

摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.

摘要翻译： 本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。 本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 特别地，本发明提供哺乳动物MPV，亚组及其变体。 本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。 本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。 本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。 本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。 本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。