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    Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus
    5.
    发明申请
    Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus 有权
    肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体和用于繁殖病毒的方法

    公开(公告)号：US20050019891A1

    公开(公告)日：2005-01-27

    申请号：US10831780

    申请日：2004-04-23

    申请人： Ronaldus Fouchier ,  Bernadetta Van Den Hoogen ,  Albertus Marcellinus Erasmus Osterhaus ,  Aurelia Haller ,  Roderick Tang

    发明人： Ronaldus Fouchier ,  Bernadetta Van Den Hoogen ,  Albertus Marcellinus Erasmus Osterhaus ,  Aurelia Haller ,  Roderick Tang

    IPC分类号： A61K39/00 ,  A61K39/155 ,  A61K39/295 ,  C07K14/115 ,  C12N20060101 ,  C12N7/00 ,  C12N7/02 ,  C12N7/04 ,  C12N15/86

    CPC分类号： C07K16/1027 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/505 ,  A61K2039/543 ,  A61K2039/544 ,  A61K2039/70 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/23 ,  C12N7/00 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18351 ,  C12N2760/18361 ,  C12N2760/18534 ,  G01N2333/115

    摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations. The invention also provide methods for propagating virus.

    摘要翻译： 本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。 本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 特别地，本发明提供哺乳动物MPV，亚组及其变体。 本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。 本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。 本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。 本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。 本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。 本发明还提供了传播病毒的方法。

    Yeast-Based Therapeutic for Chronic Hepatitis C Infection
    8.
    发明申请
    Yeast-Based Therapeutic for Chronic Hepatitis C Infection 失效
    基于酵母的慢性丙型肝炎感染治疗

    公开(公告)号：US20100150963A1

    公开(公告)日：2010-06-17

    申请号：US12631039

    申请日：2009-12-04

    申请人： Richard C. Duke ,  Alex Franzusoff ,  Aurelia Haller ,  Thomas H. King

    发明人： Richard C. Duke ,  Alex Franzusoff ,  Aurelia Haller ,  Thomas H. King

    IPC分类号： A61K39/29 ,  A61P31/12

    CPC分类号： A61K39/29 ,  A61K39/12 ,  A61K2039/521 ,  A61K2039/523 ,  A61K2039/5252 ,  C07K14/005 ,  C07K2319/35 ,  C12N2770/24222 ,  C12N2770/24234

    摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.

    摘要翻译： 公开了包括疫苗和疫苗接种丙型肝炎病毒（HCV）的组合物和用于治疗或预防动物中的丙型肝炎病毒感染的组合物。 本发明包括可以直接用作疫苗或与基于酵母的疫苗载体一起使用以在动物中引发针对HCV的免疫应答的多种新型HCV融合蛋白。 本发明还包括本文所述的HCV融合基因和蛋白质在任何诊断或治疗方案中用于检测和/或治疗或预防HCV感染的用途。