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1.发明授权Integrin binding motif containing peptides and methods of treating skeletal diseases 有权含有肽的整合素结合基序和治疗骨骼疾病的方法公开(公告)号：US06911425B2
公开(公告)日：2005-06-28
申请号：US09812485
申请日：2001-03-19
IPC分类号： A61K9/08 , A61K8/00 , A61K8/64 , A61K9/70 , A61K38/00 , A61K47/04 , A61P3/00 , A61P19/08 , A61P19/10 , A61Q11/00 , C07K14/00 , C07K14/47 , C07K14/705 , C07K14/78 , C07K11/00
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
摘要翻译： 公开了包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，糖胺聚糖结合基序和钙结合基序中的至少一种，并且与基质细胞外磷酸糖蛋白中的RGD序列连续的氨基酸的其余部分。 这些序列可以配制用于注射或分散在牙膏或漱口剂或牙龈贴片中并且被施用以增强骨/牙齿生长和/或减少体内过量的尿中磷酸盐的损失。
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2.发明申请INTEGRIN BINDING MOTIF CONTAINING PEPTIDES AND METHODS OF TREATING SKELETAL DISEASES 审中-公开含有胶原蛋白的蛋白结合胶原和治疗骨质疏松症的方法公开(公告)号：US20090042791A1
公开(公告)日：2009-02-12
申请号：US11925411
申请日：2007-10-26
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
摘要翻译： 公开了包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，糖胺聚糖结合基序和钙结合基序中的至少一种，并且与基质细胞外磷酸糖蛋白中的RGD序列连续的氨基酸的其余部分。 这些序列可以配制用于注射或分散在牙膏或漱口剂或牙龈贴片中并且被施用以增强骨/牙齿生长和/或减少体内过量的尿中磷酸盐的损失。
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公开(公告)号：US20090062201A1
公开(公告)日：2009-03-05
申请号：US12167491
申请日：2008-07-03
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
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4.发明授权Integrin binding motif containing peptides and methods of treating skeletal diseases 有权含有肽的整合素结合基序和治疗骨骼疾病的方法公开(公告)号：US07160862B2
公开(公告)日：2007-01-09
申请号：US11042492
申请日：2005-01-24
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
摘要翻译： 公开了包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，糖胺聚糖结合基序和钙结合基序中的至少一种，并且与基质细胞外磷酸糖蛋白中的RGD序列连续的氨基酸的其余部分。 这些序列可以配制用于注射或分散在牙膏或漱口剂或牙龈贴片中并且被施用以增强骨/牙齿生长和/或减少体内过量的尿中磷酸盐的损失。
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公开(公告)号：US07498021B2
公开(公告)日：2009-03-03
申请号：US11379316
申请日：2006-04-19
CPC分类号： A61Q11/00 , A61K8/64 , A61K38/1709 , Y10S514/899 , Y10S514/90 , Y10S514/901
摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.
摘要翻译： 公开了牙膏，漱口剂和牙线等牙科产品，其中通过溶解，分散或涂覆促进骨生长的化合物来增强产品。 优选的化合物是包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，并且在基质细胞外磷酸糖蛋白中与RGD序列连续的氨基酸残基。 可以将这些序列配制成用于分散在牙膏或漱口剂中并施用以增强骨/牙齿生长。 当牙科产品随着时间的推移被多次使用时，它们可以提高牙齿健康。
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公开(公告)号：US07078021B2
公开(公告)日：2006-07-18
申请号：US10344046
申请日：2001-08-09
CPC分类号： A61Q11/00 , A61K8/64 , A61K38/1709 , Y10S514/899 , Y10S514/90 , Y10S514/901
摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.
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公开(公告)号：US20050163728A1
公开(公告)日：2005-07-28
申请号：US11042492
申请日：2005-01-24
IPC分类号： A61K9/08 , A61K8/00 , A61K8/64 , A61K9/70 , A61K38/00 , A61K47/04 , A61P3/00 , A61P19/08 , A61P19/10 , A61Q11/00 , C07K14/00 , C07K14/47 , C07K14/705 , C07K14/78 , A61K38/10 , A61K7/28 , A61K38/08
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
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8.发明申请INTEGRIN BINDING MOTIF CONTAINING PEPTIDES AND METHODS OF TREATING SKELETAL DISEASES 审中-公开含有胶原蛋白的蛋白结合胶原和治疗骨质疏松症的方法公开(公告)号：US20070014742A1
公开(公告)日：2007-01-18
申请号：US11531583
申请日：2006-09-13
CPC分类号： A61K8/64 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/16 , A61K38/1709 , A61Q11/00 , C07K14/47 , C07K14/4705 , C07K14/4728 , C07K14/705 , C07K14/78
摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
摘要翻译： 公开了包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，糖胺聚糖结合基序和钙结合基序中的至少一种，并且与基质细胞外磷酸糖蛋白中的RGD序列连续的氨基酸的其余部分。 这些序列可以配制用于注射或分散在牙膏或漱口剂或牙龈贴片中并且被施用以增强骨/牙齿生长和/或减少体内过量的尿中磷酸盐的损失。
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公开(公告)号：US20060210493A1
公开(公告)日：2006-09-21
申请号：US11379316
申请日：2006-04-19
IPC分类号： A61K8/96 , C07K14/475
CPC分类号： A61Q11/00 , A61K8/64 , A61K38/1709 , Y10S514/899 , Y10S514/90 , Y10S514/901
摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.
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公开(公告)号：US20050002875A1
公开(公告)日：2005-01-06
申请号：US10344046
申请日：2001-08-09
IPC分类号： A61K8/00 , A61K8/64 , A61K38/00 , A61K38/16 , A61K38/17 , A61P1/02 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K17/00 , A61K7/28 , C07K14/47
CPC分类号： A61Q11/00 , A61K8/64 , A61K38/1709 , Y10S514/899 , Y10S514/90 , Y10S514/901
摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.
摘要翻译： 公开了牙膏，漱口剂和牙线等牙科产品，通过溶解，分散或涂覆促进骨生长的化合物来增强产品。 优选的化合物是包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，并且在基质细胞外磷酸糖蛋白中与RGD序列连续的氨基酸残基。 可以将这些序列配制成用于分散在牙膏或漱口剂中并施用以增强骨/牙齿生长。 当牙科产品随着时间的推移被多次使用时，它们可以提高牙齿健康。
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