公开(公告)号：US07690831B2

公开(公告)日：2010-04-06

申请号：US11176655

申请日：2005-07-08

申请人： Akihiro Mori ,  Toshiyuki Yoneda

发明人： Akihiro Mori ,  Toshiyuki Yoneda

IPC分类号： F21V7/04

CPC分类号： G02B6/0013 ,  F21Y2103/10 ,  F21Y2115/10 ,  G02B6/0021 ,  G02B6/0065 ,  G02B6/0073 ,  G02B6/0091

摘要： A surface light source device includes two or more point light sources that are arranged linearly, a light guide plate having an incident surface on which light emitted from each of the point light sources shines, for outputting input light from a front surface thereof, and light diffusing means provided on a back surface of the light guide plate, for diffusing light. The incident surface of the light guide plate is inclined toward a back side.

摘要翻译： 一种面光源装置，包括直线状配置的两个以上的点光源，具有入射面的导光板，从各个点光源射出的光从该入射面射出，从其前表面输出输入光， 设置在导光板背面的扩散装置，用于漫射光。 导光板的入射面向后侧倾斜。

公开(公告)号：US07656398B2

公开(公告)日：2010-02-02

申请号：US11190949

申请日：2005-07-28

申请人： Seiji Sakai ,  Takuya Sakamoto ,  Toshiyuki Yoneda

发明人： Seiji Sakai ,  Takuya Sakamoto ,  Toshiyuki Yoneda

IPC分类号： G09G5/00

CPC分类号： G09G3/3413 ,  G02B6/0028 ,  G02B6/0031 ,  G02B6/0055 ,  G02B6/0076 ,  G02B6/0078 ,  G09G3/3611 ,  G09G2360/145

摘要： A surface light source device includes light source driving means for driving light sources on a light emission block basis, a light exit area being sectioned into two or more light emission blocks, light quantity detecting means for detecting light quantities on the basis of output light beams that are led out from the two or more light emission blocks, and drive control means for adjusting emission light quantities of the light sources corresponding to the respective light emission blocks on the basis of light quantities that are detected during lighting periods when only one of the light emission blocks is lit up that are subjected to light quantity detection by the light quantity detecting means.

摘要翻译： 面光源装置包括基于发光块驱动光源的光源驱动装置，被分成两个或更多个发光块的光出射区域，用于基于输出光束检测光量的光量检测装置 以及驱动控制装置，用于基于在点亮期间检测到的光量来调节与各个发光块对应的光源的发光量，当仅仅一个 发光块被点亮，由光量检测装置进行光量检测。

公开(公告)号：US07618630B2

公开(公告)日：2009-11-17

申请号：US10086217

申请日：2002-02-21

申请人： Gregory R. Mundy ,  Toshiyuki Yoneda

发明人： Gregory R. Mundy ,  Toshiyuki Yoneda

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K14/70542 ,  A61K38/00 ,  C07K16/2836 ,  C07K16/2839 ,  C07K16/2842

摘要： Antagonists of α4 integrin/α4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of multiple myeloma cells to bone marrow and their α4 integrin-dependent release of bone-resorbing factors, resulting in bone destruction in patients with multiple myeloma, is inhibited.

公开(公告)号：US07211252B2

公开(公告)日：2007-05-01

申请号：US09805840

申请日：2001-03-13

申请人： Gregory R. Mundy ,  Toshiyuki Yoneda

发明人： Gregory R. Mundy ,  Toshiyuki Yoneda

IPC分类号： A61K39/395

CPC分类号： C07K16/2836 ,  A61K38/00 ,  C07K14/70542 ,  C07K16/2839 ,  C07K16/2842

摘要： Antagonists of alpha 4 integrin/alpha 4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of multiple myeloma cells to bone marrow and their alpha 4 integrin-dependent release of bone-resorbing factors, resulting in bone destruction in patients with multiple myeloma, is inhibited.

摘要翻译： 描述了抑制这种粘附的生物学作用的α4整联蛋白/α4整联蛋白配体粘附的拮抗剂，并详细说明了其使用方法。 这样的拮抗剂可用于抑制与多发性骨髓瘤相关的骨破坏。 多发性骨髓瘤细胞归巢到骨髓及其α4整联蛋白依赖性释放的骨吸收因子，导致多发性骨髓瘤患者骨质破坏。

公开(公告)号：US07078021B2

公开(公告)日：2006-07-18

申请号：US10344046

申请日：2001-08-09

申请人： Toshiyuki Yoneda ,  Motoyoshi Nomizu ,  Yoshinari Kumagai

发明人： Toshiyuki Yoneda ,  Motoyoshi Nomizu ,  Yoshinari Kumagai

IPC分类号： A61K7/16 ,  A61K38/00 ,  C07K17/00

CPC分类号： A61Q11/00 ,  A61K8/64 ,  A61K38/1709 ,  Y10S514/899 ,  Y10S514/90 ,  Y10S514/901

摘要： Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing an integrin binding motif such as RGD sequence and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for dispersed in toothpaste or a mouthwash and administered to enhance bone/tooth growth. When the dental products are used repeatedly over time they enhance good dental health.

公开(公告)号：US06911425B2

公开(公告)日：2005-06-28

申请号：US09812485

申请日：2001-03-19

申请人： Yoshinari Kumagai ,  Toshiyuki Yoneda ,  Russell Wayne Blacher

发明人： Yoshinari Kumagai ,  Toshiyuki Yoneda ,  Russell Wayne Blacher

IPC分类号： A61K9/08 ,  A61K8/00 ,  A61K8/64 ,  A61K9/70 ,  A61K38/00 ,  A61K47/04 ,  A61P3/00 ,  A61P19/08 ,  A61P19/10 ,  A61Q11/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/78 ,  C07K11/00

CPC分类号： A61K8/64 ,  A61K38/06 ,  A61K38/08 ,  A61K38/12 ,  A61K38/16 ,  A61K38/1709 ,  A61Q11/00 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4728 ,  C07K14/705 ,  C07K14/78

摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.

摘要翻译： 公开了包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，糖胺聚糖结合基序和钙结合基序中的至少一种，并且与基质细胞外磷酸糖蛋白中的RGD序列连续的氨基酸的其余部分。 这些序列可以配制用于注射或分散在牙膏或漱口剂或牙龈贴片中并且被施用以增强骨/牙齿生长和/或减少体内过量的尿中磷酸盐的损失。

公开(公告)号：US06533428B1

公开(公告)日：2003-03-18

申请号：US09759366

申请日：2001-01-16

申请人： Ikuo Ogo ,  Shigeru Yachi ,  Yoshihide Nishida ,  Atsushi Ito ,  Toshiyuki Yoneda

发明人： Ikuo Ogo ,  Shigeru Yachi ,  Yoshihide Nishida ,  Atsushi Ito ,  Toshiyuki Yoneda

IPC分类号： F21V704

CPC分类号： G02F1/133615 ,  G02F1/13452

摘要： A thin flat-surface type display device having a transmissive display panel is provided, which is capable of securing a space of an essential electric circuit for driving the display device without deteriorating an optical performance (luminance and uniformity thereof) of a surface light source device of an edge light system employed as a backlight. A light guide plate forming the surface light source device of the edge light system has a flat light emitting surface, and a back surface arranged so as to include (1) an inclined flat surface portion where a thickness of the light guide plate decreases linearly from a light-incident portion on which light emitted from a linear light source is incident toward a light-anti-incident portion, and (2) a parallel flat surface portion which is parallel with the light emitting surface in the vicinity of the light-anti-incident portion. Also, the two adjacent surfaces are connected to each other at an interface portion with an interface curved surface such that makes the two adjacent surfaces tangential. In addition, reflection dots are formed at the back surface side of the light guide plate in a predetermined shape at a predetermined density.

摘要翻译： 提供一种具有透射显示面板的薄平面型显示装置，其能够确保用于驱动显示装置的基本电路的空间，而不会降低表面光源装置的光学性能（亮度和均匀性） 用作背光的边缘光系统。 形成边缘光系统的表面光源装置的导光板具有平坦的发光面，背面被配置为包括：（1）倾斜的平坦表面部分，其中导光板的厚度从 从线性光源发射的光入射到光反入射部分的光入射部分，以及（2）在光反射附近平行于发光表面的平行平面部分 - 固定部分。 此外，两个相邻的表面在与界面弯曲表面的界面部分处彼此连接，使得两个相邻的表面相切。 此外，在导光板的背面侧以预定的密度形成预定形状的反射点。

公开(公告)号：US08657456B2

公开(公告)日：2014-02-25

申请号：US13259204

申请日：2010-04-23

申请人： Yusuke Yamagata ,  Naoki Nakagawa ,  Toshiaki Fujino ,  Takanori Okumura ,  Toshiyuki Yoneda ,  Toru Kokogawa ,  Kenji Arita

发明人： Yusuke Yamagata ,  Naoki Nakagawa ,  Toshiaki Fujino ,  Takanori Okumura ,  Toshiyuki Yoneda ,  Toru Kokogawa ,  Kenji Arita

IPC分类号： G02F1/13357

CPC分类号： G09F9/33 ,  G02F1/133308 ,  G02F2001/133302 ,  G02F2001/133354 ,  G02F2202/28 ,  G09F9/35 ,  H01L51/0097

摘要： A display device where concentration of a stress in a display panel is suppressed, to allow improvement in display quality, reliability and the like. A display device includes a display panel, an adhesive layer and a supporting substrate. The adhesive layer is provided on the display panel. The supporting substrate is made up of a member previously provided with curved surfaces. The display panel is bonded onto the curved surface of the supporting substrate by the adhesive layer. The supporting substrate supports the display panel in a curved form along the curved surface.

摘要翻译： 抑制显示面板中的应力集中的显示装置，能够提高显示质量，可靠性等。 显示装置包括显示面板，粘合剂层和支撑基板。 粘合剂层设置在显示面板上。 支撑基板由预先设置有曲面的部件构成。 显示面板通过粘合剂层粘合到支撑基板的弯曲表面上。 支撑基板沿着曲面将弯曲形式支撑显示面板。

公开(公告)号：US07762705B2

公开(公告)日：2010-07-27

申请号：US11609488

申请日：2006-12-12

申请人： Seiji Sakai ,  Toshiyuki Yoneda

发明人： Seiji Sakai ,  Toshiyuki Yoneda

IPC分类号： G02B6/10

CPC分类号： G02B6/0021 ,  G02B6/0031 ,  Y10S362/80

摘要： A surface light source device according to the invention includes a housing having an opening portion on at least one face, an LED light source held by one face of the housing opposing the opening portion, and a light guiding plate arranged at a position so as to cover the opening portion and the LED light source. The light guiding plate includes a recess provided at a position corresponding to the LED light source for storing a part of the LED light source. A light quantity adjusting means is provided at a bottom part of the recess for adjusting light from the LED light source. The light quantity adjusting means includes a reflection sheet having a reflection function and a transmission function in which a total light transmittance t satisfies t≧πr2 cos θ/{(1−cos θ)(S−πr2)}, supposing that an average radius is defined as r, a distance from the LED light source is defined as H, a light-emitting area of the LED light source is defined as S, and a total light quantity is defined as L.

摘要翻译： 根据本发明的表面光源装置包括壳体，其在至少一个面上具有开口部分，由与壳体的开口部分相对的壳体的一个面保持的LED光源和布置在一个位置上的导光板， 覆盖开口部分和LED光源。 导光板包括设置在与LED光源相对应的位置处的凹部，用于存储一部分LED光源。 光量调节装置设置在凹部的底部，用于调节来自LED光源的光。 光量调节装置包括具有反射函数和透光功能的反射片，其中总透光率t满足t≥＆pgr; r2 cos＆Thetas; / {（1-cos＆Thetas;）（S-＆pgr; r2）} 假设将平均半径定义为r，将距离LED光源的距离定义为H，将LED光源的发光面积定义为S，将总光量定义为L.

公开(公告)号：US20100183599A1

公开(公告)日：2010-07-22

申请号：US12620050

申请日：2009-11-17

申请人： Gregory R. Mundy ,  Toshiyuki Yoneda

发明人： Gregory R. Mundy ,  Toshiyuki Yoneda

IPC分类号： A61K39/395 ,  A61P35/00

CPC分类号： C07K14/70542 ,  A61K38/00 ,  C07K16/2836 ,  C07K16/2839 ,  C07K16/2842

摘要： Antagonists of α4 integrin/α4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of multiple myeloma cells to bone marrow and their α4 integrin-dependent release of bone-resorbing factors, resulting in bone destruction in patients with multiple myeloma, is inhibited.

摘要翻译： 描述了抑制这种粘附的生物学作用的α4整联蛋白/α4整联蛋白配体粘附的拮抗剂，并详细说明了其使用方法。 这样的拮抗剂可用于抑制与多发性骨髓瘤相关的骨破坏。 多发性骨髓瘤细胞归巢到骨髓及其骨吸收因子的α4整联蛋白依赖性释放，导致多发性骨髓瘤患者的骨破坏被抑制。