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    Humanized immunoglubulin reactive with alph4beta7 integrin
    1.
    发明申请
    Humanized immunoglubulin reactive with alph4beta7 integrin 审中-公开
    人源化免疫球蛋白与alph4beta7整合素反应

    公开(公告)号：US20090011464A1

    公开(公告)日：2009-01-08

    申请号：US12214304

    申请日：2008-06-18

    申请人： Paul D. Ponath ,  Douglas J. Ringler ,  S. Tarran Jones ,  Walter Newman ,  Jose Saldanha ,  Mary M. Bendig

    发明人： Paul D. Ponath ,  Douglas J. Ringler ,  S. Tarran Jones ,  Walter Newman ,  Jose Saldanha ,  Mary M. Bendig

    IPC分类号： C12P21/00 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00

    摘要： The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.

    摘要翻译： 本发明涉及编码对α4β7整联蛋白具有结合特异性，编码人源化免疫球蛋白重链的分离的核酸和编码具有α4β7整联蛋白的结合特异性的人源化轻链的分离的核酸的分离的核酸。 本发明还涉及包含编码具有对α4β7具有结合特异性的人源化免疫球蛋白或其抗原结合片段的核苷酸序列的表达载体和宿主细胞。 本发明还涉及制备对α4β7整联蛋白具有结合特异性的人源化免疫球蛋白，人源化免疫球蛋白重链和人源化免疫球蛋白轻链的方法。

    Humanized immunoglobulin reactive with α4β7 integrin
    2.
    发明授权
    Humanized immunoglobulin reactive with α4β7 integrin 有权
    人源化免疫球蛋白与α4β7整合素反应

    公开(公告)号：US07402410B2

    公开(公告)日：2008-07-22

    申请号：US11511164

    申请日：2006-08-28

    申请人： Paul D. Ponath ,  Douglas J. Ringler ,  S. Tarran Jones ,  Walter Newman ,  José Saldanha ,  Mary M. Bendig

    发明人： Paul D. Ponath ,  Douglas J. Ringler ,  S. Tarran Jones ,  Walter Newman ,  José Saldanha ,  Mary M. Bendig

    IPC分类号： C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  C12P21/04

    CPC分类号： C07K16/2839 ,  A61K38/00 ,  C07K14/70503 ,  C07K2317/24 ,  C07K2319/00

    摘要： The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host cells comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7. The invention further relates to methods of preparing a humanized immunoglobulin, humanized immunoglobulin heavy chain and humanized immunoglobulin light chain that has binding specificity for α4β7 integrin.

    摘要翻译： 本发明涉及编码对α4β7整联蛋白具有结合特异性，编码人源化免疫球蛋白重链的分离的核酸和编码具有α4β7整联蛋白的结合特异性的人源化轻链的分离的核酸的分离的核酸。 本发明还涉及包含编码具有对α4β7具有结合特异性的人源化免疫球蛋白或其抗原结合片段的核苷酸序列的表达载体和宿主细胞。 本发明还涉及制备对α4β7整联蛋白具有结合特异性的人源化免疫球蛋白，人源化免疫球蛋白重链和人源化免疫球蛋白轻链的方法。