公开(公告)号：US20140235921A1

公开(公告)日：2014-08-21

申请号：US14346539

申请日：2012-09-24

申请人： SurgicEye GmbH ,  humediQ GmbH

发明人： Thomas Wendler ,  Christian Hieronimi ,  Jörg Traub

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61N5/1064 ,  A61N5/107 ,  A61N2005/1052 ,  A61N2005/1059 ,  F04C2270/041

摘要： The invention relates to a system for determining the position of radioactively marked target tissue of a patient in radiation therapy by means of a radiation therapy device. The system comprises at least one detector for the imaging detection of the radiation distribution of a radioactive radiation source that is located in target tissue region, a computing unit that is designed to calculate the pose of the target tissue region from measurement data of the detector and to calculate a correction variable as the difference between the calculated pose and comparison values, and an interface by means of which the data for the calculated pose of radioactively marked target tissue region and the correction variable can be transmitted by the computing unit to a radiation therapy device or a patient positioning device. The invention further relates to a corresponding method.

摘要翻译： 本发明涉及一种用于通过放射治疗装置确定放射治疗中的患者放射性标记的目标组织的位置的系统。 该系统包括用于成像检测位于目标组织区域中的放射性辐射源的辐射分布的至少一个检测器，被设计成根据检测器的测量数据计算目标组织区域的姿态的计算单元，以及 计算校正变量作为计算出的姿势与比较值之间的差异，以及通过计算单元将放射性标记的目标组织区域的计算姿态的数据和校正变量的数据传输到放射治疗的界面 装置或患者定位装置。 本发明还涉及相应的方法。

公开(公告)号：US20190381214A1

公开(公告)日：2019-12-19

申请号：US16463860

申请日：2017-11-24

申请人： SURGICEYE GMBH

发明人： Axel BOESE ,  Michael FRIEBE ,  Dietmar W. HUTMACHER

IPC分类号： A61L27/54 ,  A61K51/12

摘要： The invention relates to a material for the 3-dimensional printing of scaffold structures on a 3D printer as well as to a medical implant (1) made of this type of material and the use of this type of material for manufacturing a medical implant (1) of this type. According to the invention, the material has integrated microspheres (5) which emit radioactive rays.

公开(公告)号：US20150305700A1

公开(公告)日：2015-10-29

申请号：US14647070

申请日：2013-11-25

申请人： SURGICEYE GMBH

发明人： Thomas WENDLER ,  Stefan WIESNER ,  Jörg TRAUB ,  Martin FREESMEYER

IPC分类号： A61B6/00 ,  A61B8/08 ,  A61B8/00 ,  G06T11/00 ,  A61B6/03

CPC分类号： A61B6/4417 ,  A61B6/037 ,  A61B6/4258 ,  A61B6/4405 ,  A61B6/5247 ,  A61B6/547 ,  A61B8/0841 ,  A61B8/4245 ,  A61B8/4254 ,  A61B8/4263 ,  A61B8/5261 ,  G06T11/003 ,  G06T2207/10081

摘要： A combined nuclear and ultrasonic system for hybrid imaging is proposed. It comprises a hand-held nuclear radiation detector, a hand-held ultrasonic probe, a nuclear tracking system for tracking the nuclear radiation detector while measuring a nuclear radiation and obtaining nuclear radiation detector coordinates representing a position of the tracked nuclear radiation detector in relation to an image coordinate system of a hybrid image, an ultrasonic tracking system for tracking of the ultrasonic probe during the receiving of ultrasonic signals so that ultrasonic probe coordinates are obtained which represent a position of the tracked ultrasonic probe in relation to an image coordinate system of the hybrid image, and a data acquisition module, which gathers the nuclear radiation detector measurements, nuclear radiation detector coordinates, ultrasonic signals from the ultrasonic probe, and ultrasonic probe coordinates, and matches them with an image coordinate system of a hybrid image. A nuclear image reconstruction module is for reconstructing a nuclear image from nuclear radiation detector measurements, ultrasonic signals, nuclear radiation detector coordinates and ultrasonic probe coordinates in the image coordinate system of the hybrid image, and an evaluation system calculates a nuclear-image-quality-value of nuclear radiation detector measurements and nuclear radiation detector coordinates. Further, a method for hybrid imaging is proposed.

摘要翻译： 提出了用于混合成像的组合核和超声系统。 它包括手持式核辐射探测器，手持式超声波探头，用于在测量核辐射的同时跟踪核辐射探测器的核跟踪系统，并获得表示跟踪的核辐射探测器相对于 混合图像的图像坐标系，用于在接收超声波信号期间跟踪超声波探头的超声波跟踪系统，从而获得表示跟踪的超声波探头相对于图像坐标系的位置的超声波探头坐标 混合图像和数据采集模块，其收集核辐射检测器测量，核辐射检测器坐标，来自超声波探头的超声信号和超声探头坐标，并将其与混合图像的图像坐标系相匹配。 核图像重建模块用于从混合图像的图像坐标系中的核辐射检测器测量，超声信号，核辐射探测器坐标和超声波探头坐标重构核图像，并且评估系统计算核图像质量 - 核辐射探测器测量值和核辐射探测器坐标值。 此外，提出了一种用于混合成像的方法。

公开(公告)号：US10429518B2

公开(公告)日：2019-10-01

申请号：US16070698

申请日：2017-01-18

申请人： SURGICEYE GMBH

发明人： Joerg Traub ,  Philipp Matthies ,  Matthias Keicher

IPC分类号： G01T1/161 ,  G01T1/02 ,  A61N5/10 ,  G01T1/16

摘要： An image generating apparatus for image generation and dose calculation is provided. The image generating apparatus includes a movable detector for detecting nuclear radiation during a detection period and an evaluation system. The evaluation system includes an interface system for transmitting detector data to the evaluation system. The detector data include information about the detected radiation for image generation. The evaluation system further includes a data memory portion for storing the detector data. The evaluation system further includes a program memory portion with a program for repeatedly determining at least one quality value with respect to image generation during the detection period. The image generating apparatus includes an output system including at least one output unit. The at least one output unit includes one output unit for outputting an instruction to a user for further moving the detector in dependence of the detector data. The instruction relates to at least a part of the remaining detection period.

公开(公告)号：US20150065875A1

公开(公告)日：2015-03-05

申请号：US14473674

申请日：2014-08-29

申请人： SurgicEye GmbH

发明人： Michael FRIEBE

IPC分类号： A61B19/00 ,  A61B8/00 ,  A61B6/02

CPC分类号： A61B8/54 ,  A61B6/022 ,  A61B34/30 ,  A61B34/32 ,  A61B90/10 ,  A61B90/361 ,  A61B2034/2055 ,  A61B2090/061 ,  A61B2090/067

摘要： A navigation attachment for a manually guided instrument which is designated for the surgical and/or therapeutic treatment of a body and/or for implementation of a diagnostic procedure on the body is provided. The navigation attachment includes a fastener adapted to be fixedly connected with the instrument; at least one image pickup unit, including a device to determine a distance between the navigation attachment and a surface of the body; wherein at least three distances are usable to represent a position (x, y, z, t) of the instrument and/or a front section of the instrument in relation to the body or to a component of the body. Further, a navigation procedure is provided.

摘要翻译： 提供了用于手术和/或治疗体内和/或用于在身体上实施诊断程序的手动引导器械的导航附件。 导航附件包括适于与仪器固定连接的紧固件; 至少一个图像拾取单元，包括用于确定导航附件与身体表面之间的距离的装置; 其中至少三个距离可用于表示器具的位置（x，y，z，t）和/或器械的前部相对于身体或身体的部件。 此外，提供导航过程。

公开(公告)号：US20190018149A1

公开(公告)日：2019-01-17

申请号：US16070698

申请日：2017-01-18

申请人： SURGICEYE GMBH

发明人： Joerg TRAUB ,  Philipp MATTHIES ,  Matthias KEICHER

IPC分类号： G01T1/161 ,  G01T1/02 ,  A61N5/10

CPC分类号： G01T1/161 ,  A61N5/1048 ,  A61N5/1071 ,  A61N2005/1021 ,  A61N2005/1076 ,  G01T1/02 ,  G01T1/1603

摘要： An image generating apparatus for image generation and dose calculation is provided. The image generating apparatus includes a movable detector for detecting nuclear radiation during a detection period and an evaluation system. The evaluation system includes an interface system for transmitting detector data to the evaluation system. The detector data include information about the detected radiation for image generation. The evaluation system further includes a data memory portion for storing the detector data. The evaluation system further includes a program memory portion with a program for repeatedly determining at least one quality value with respect to image generation during the detection period. The image generating apparatus includes an output system including at least one output unit. The at least one output unit includes one output unit for outputting an instruction to a user for further moving the detector in dependence of the detector data. The instruction relates to at least a part of the remaining detection period.

公开(公告)号：US20130338490A1

公开(公告)日：2013-12-19

申请号：US13722294

申请日：2012-12-20

申请人： SURGICEYE GMBH

发明人： Thomas Wendler

IPC分类号： A61B6/00 ,  A61B1/267 ,  A61B1/233 ,  A61B1/313 ,  A61B1/273 ,  A61B1/31 ,  A61B1/307 ,  A61B1/303 ,  A61B1/227 ,  A61B1/06 ,  A61B1/04 ,  A61B1/00 ,  A61B8/12 ,  A61B6/03 ,  A61B5/06 ,  A61B8/08 ,  A61B1/317

CPC分类号： A61B6/466 ,  A61B1/00045 ,  A61B1/043 ,  A61B1/063 ,  A61B1/227 ,  A61B1/233 ,  A61B1/2676 ,  A61B1/2733 ,  A61B1/2736 ,  A61B1/303 ,  A61B1/307 ,  A61B1/31 ,  A61B1/3135 ,  A61B1/317 ,  A61B5/061 ,  A61B5/067 ,  A61B6/037 ,  A61B6/12 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/4417 ,  A61B6/464 ,  A61B6/481 ,  A61B6/483 ,  A61B6/5258 ,  A61B6/56 ,  A61B6/583 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4263 ,  A61B8/5261 ,  A61B34/20 ,  A61B34/30 ,  A61B2090/365 ,  G01T1/161

摘要： A system for endoscopic nuclear imaging, a nuclear probe and related methods are provided. In one embodiment, a system includes a movable endoscopic nuclear probe which comprises a collimator and a detector, the endoscopic nuclear probe having an elongated body with a longitudinal axis (X), wherein the detector and the collimator are arranged on the elongated body, and the collimator having a field of view with an axis (Y) and the axis (Y) is angled with respect to the axis (X) of the elongated body of the endoscopic nuclear probe; means for determining the position and orientation of the elongated body of the endoscopic nuclear probe; an evaluation unit including means for computationally determining an actual position and actual orientation of the elongated body of the endoscopic nuclear probe; and a program storage section and means for computing at least one quality parameter of the image.

摘要翻译： 提供了内窥镜核成像系统，核探针和相关方法。 在一个实施例中，系统包括可移动的内窥镜核探针，其包括准直器和检测器，所述内窥镜核探针具有带纵向轴线（X）的细长主体，其中所述检测器和准直器布置在细长主体上，以及 具有轴线（Y）和轴线（Y）的视野的准直器相对于内窥镜核探头的细长主体的轴线（X）成角度; 用于确定内窥镜核探针的细长体的位置和取向的装置; 评估单元，其包括用于计算地确定内窥镜核探针的细长体的实际位置和实际取向的装置; 以及程序存储部分和用于计算图像的至少一个质量参数的装置。

公开(公告)号：US09345441B2

公开(公告)日：2016-05-24

申请号：US13722294

申请日：2012-12-20

申请人： SURGICEYE GMBH

发明人： Thomas Wendler

IPC分类号： A61B6/00 ,  A61B1/317 ,  A61B1/267 ,  A61B1/233 ,  A61B1/313 ,  A61B1/273 ,  A61B1/31 ,  A61B1/307 ,  A61B1/303 ,  A61B1/227 ,  A61B1/06 ,  A61B1/04 ,  A61B1/00 ,  A61B6/03 ,  A61B5/06 ,  A61B8/08 ,  G01T1/161 ,  A61B8/00 ,  A61B8/12 ,  A61B6/12 ,  A61B19/00

CPC分类号： A61B6/466 ,  A61B1/00045 ,  A61B1/043 ,  A61B1/063 ,  A61B1/227 ,  A61B1/233 ,  A61B1/2676 ,  A61B1/2733 ,  A61B1/2736 ,  A61B1/303 ,  A61B1/307 ,  A61B1/31 ,  A61B1/3135 ,  A61B1/317 ,  A61B5/061 ,  A61B5/067 ,  A61B6/037 ,  A61B6/12 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/4417 ,  A61B6/464 ,  A61B6/481 ,  A61B6/483 ,  A61B6/5258 ,  A61B6/56 ,  A61B6/583 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4263 ,  A61B8/5261 ,  A61B34/20 ,  A61B34/30 ,  A61B2090/365 ,  G01T1/161

摘要： A system for endoscopic nuclear imaging, a nuclear probe and related methods are provided. In one embodiment, a system includes a movable endoscopic nuclear probe which comprises a collimator and a detector, the endoscopic nuclear probe having an elongated body with a longitudinal axis (X), wherein the detector and the collimator are arranged on the elongated body, and the collimator having a field of view with an axis (Y) and the axis (Y) is angled with respect to the axis (X) of the elongated body of the endoscopic nuclear probe; means for determining the position and orientation of the elongated body of the endoscopic nuclear probe; an evaluation unit including means for computationally determining an actual position and actual orientation of the elongated body of the endoscopic nuclear probe; and a program storage section and means for computing at least one quality parameter of the image.

摘要翻译： 提供了内窥镜核成像系统，核探针和相关方法。 在一个实施例中，系统包括可移动的内窥镜核探针，其包括准直器和检测器，所述内窥镜核探针具有带纵向轴线（X）的细长主体，其中所述检测器和准直器布置在细长主体上，以及 具有轴线（Y）和轴线（Y）的视野的准直器相对于内窥镜核探头的细长主体的轴线（X）成角度; 用于确定内窥镜核探针的细长体的位置和取向的装置; 评估单元，其包括用于计算地确定内窥镜核探针的细长体的实际位置和实际取向的装置; 以及程序存储部分和用于计算图像的至少一个质量参数的装置。

公开(公告)号：US09286732B2

公开(公告)日：2016-03-15

申请号：US14344972

申请日：2012-09-17

申请人： SurgicEye GmbH

发明人： Thomas Wendler

IPC分类号： G06K9/00 ,  G06T19/20 ,  A61B6/00 ,  G01T1/164 ,  G01T1/16 ,  G06T7/00 ,  G06T7/20 ,  A61B6/03 ,  A61B6/04

CPC分类号： G06T19/20 ,  A61B6/037 ,  A61B6/0492 ,  A61B6/4258 ,  A61B6/5205 ,  A61B6/5235 ,  A61B6/547 ,  F04C2270/041 ,  G01T1/16 ,  G01T1/164 ,  G01T1/1648 ,  G06T7/0012 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/30004 ,  G06T2207/30196 ,  G06T2207/30204

摘要： A nuclear image system for updating an original nuclear image, the nuclear image system comprising: a data memory for storing the original three-dimensional nuclear image; a nuclear radiation detector, which is movable along a freely variable path, for measuring nuclear radiation, in order to obtain nuclear radiation values; a tracking system for tracking the nuclear radiation detector while measuring the nuclear radiation, so that detector coordinates are obtained which indicate a posture of the tracked nuclear radiation detector in relation to an image coordinate system of the nuclear image; a nuclear data input configured to receive the nuclear radiation values from the nuclear radiation detector and the detector coordinates from the tracking system, and to associate the nuclear radiation values with the respective detector coordinates; and an image updating module including an updating rule for changing the original nuclear image on the basis of the nuclear radiation values and the detector coordinates, wherein the image updating module is configured to generate an updated three-dimensional nuclear image by applying the updating rule to the original nuclear image.

摘要翻译： 一种用于更新原始核图像的核图像系统，所述核图像系统包括：用于存储原始三维核图像的数据存储器; 核辐射探测器，其可沿着自由变化的路径移动，用于测量核辐射，以获得核辐射值; 跟踪系统，用于在测量核辐射的同时跟踪核辐射探测器，从而获得指示跟踪的核辐射探测器相对于核图像的图像坐标系的姿势的探测器坐标; 核数据输入，其被配置为从所述核辐射检测器接收核辐射值，并且从所述跟踪系统接收所述检测器坐标，并且将所述核辐射值与所述检测器坐标相关联; 以及图像更新模块，其包括基于所述核辐射值和所述检测器坐标来改变所述原始核图像的更新规则，其中，所述图像更新模块被配置为通过将所述更新规则应用于 原始核形象。

公开(公告)号：US20140369560A1

公开(公告)日：2014-12-18

申请号：US14344972

申请日：2012-09-17

申请人： SurgicEye GmbH

发明人： Thomas Wendler

IPC分类号： G06T19/20 ,  G06T7/00 ,  G06T7/20 ,  G01T1/16 ,  G01T1/164

CPC分类号： G06T19/20 ,  A61B6/037 ,  A61B6/0492 ,  A61B6/4258 ,  A61B6/5205 ,  A61B6/5235 ,  A61B6/547 ,  F04C2270/041 ,  G01T1/16 ,  G01T1/164 ,  G01T1/1648 ,  G06T7/0012 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/30004 ,  G06T2207/30196 ,  G06T2207/30204

摘要： A nuclear image system for updating an original nuclear image, the nuclear image system comprising: a data memory for storing the original three-dimensional nuclear image; a nuclear radiation detector, which is movable along a freely variable path, for measuring nuclear radiation, in order to obtain nuclear radiation values; a tracking system for tracking the nuclear radiation detector while measuring the nuclear radiation, so that detector coordinates are obtained which indicate a posture of the tracked nuclear radiation detector in relation to an image coordinate system of the nuclear image; a nuclear data input configured to receive the nuclear radiation values from the nuclear radiation detector and the detector coordinates from the tracking system, and to associate the nuclear radiation values with the respective detector coordinates; and an image updating module including an updating rule for changing the original nuclear image on the basis of the nuclear radiation values and the detector coordinates, wherein the image updating module is configured to generate an updated three-dimensional nuclear image by applying the updating rule to the original nuclear image.

摘要翻译： 一种用于更新原始核图像的核图像系统，所述核图像系统包括：用于存储原始三维核图像的数据存储器; 核辐射探测器，其可沿着自由变化的路径移动，用于测量核辐射，以获得核辐射值; 跟踪系统，用于在测量核辐射的同时跟踪核辐射探测器，从而获得指示跟踪的核辐射探测器相对于核图像的图像坐标系的姿势的探测器坐标; 核数据输入，被配置为从所述核辐射检测器接收核辐射值，并且从所述跟踪系统接收所述检测器坐标，并且将所述核辐射值与所述检测器坐标相关联; 以及图像更新模块，其包括基于所述核辐射值和所述检测器坐标来改变所述原始核图像的更新规则，其中，所述图像更新模块被配置为通过将所述更新规则应用于 原始核形象。