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公开(公告)号：US08628729B2
公开(公告)日：2014-01-14
申请号：US12934499
申请日：2009-03-27
申请人： Emanuel Carrilho , Andres W. Martinez , Katherine A. Mirica , Scott T. Phillips , Adam C. Siegel , Benjamin Wiley , George M. Whitesides
发明人： Emanuel Carrilho , Andres W. Martinez , Katherine A. Mirica , Scott T. Phillips , Adam C. Siegel , Benjamin Wiley , George M. Whitesides
IPC分类号： G01N21/75
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
摘要： Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
摘要翻译： 描述了包括多个图案化的多孔亲水层和设置在每两个相邻的图案化的多孔亲水层之间的流体不可渗透层的三维微流体装置。 每个图案化的多孔亲水层具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定图案化的多孔亲水层内的一个或多个亲水区域的边界。 流体不可渗透层具有与至少一个相邻的图案化的多孔亲水层内的亲水区域的至少一部分对准的开口。 还描述了微流控测定装置，微流体混合器，微流控流量控制装置。
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公开(公告)号：US20130133419A1
公开(公告)日：2013-05-30
申请号：US13594518
申请日：2012-08-24
申请人： George M. Whitesides , Matthew R. Lockett , Katherine A. Mirica , Charles R. Mace , Robert D. Blackledge
发明人： George M. Whitesides , Matthew R. Lockett , Katherine A. Mirica , Charles R. Mace , Robert D. Blackledge
IPC分类号： G01N9/00
摘要： A method for determining the density of contact trace objects with magnetic levitation is described. The density of samples of glitter and of gunpowder was determined, and the feasibility of magnetic levitation as a possible means of characterizing forensic-related evidence is discussed. The magnetic levitation device (composed of two permanent magnets with like poles facing) and the method described provides a means of accurately determining the density of trace objects that is inexpensive, rapid, verifiable, provides documentation, is independent of the specific apparatus or analyst, and provides numerical values (rather than a comparison between questioned and known samples) that may be entered into a searchable database.
摘要翻译： 描述了一种用磁悬浮确定接触痕迹物体的密度的方法。 确定了闪光和火药样品的密度，讨论了磁悬浮作为鉴定法证相关证据的可能手段的可行性。 磁悬浮装置（由具有相同磁极的两个永磁体组成）和所述方法提供了一种准确地确定跟踪物体的密度的方法，该物体廉价，快速，可验证，提供文件，独立于具体装置或分析者， 并提供可输入到可搜索数据库中的数值（而不是有疑问和已知样本之间的比较）。
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3.发明申请Lateral Flow and Flow-through Bioassay Devices Based On Patterned Porous Media, Methods of Making Same, and Methods of Using Same 有权基于图案化多孔介质的横向流动和流通生物测定装置，制备方法及其使用方法公开(公告)号：US20090298191A1
公开(公告)日：2009-12-03
申请号：US12425121
申请日：2009-04-16
申请人： George M. WHITESIDES , Scott T. PHILLIPS , Andres W. MARTINEZ , Manish J. BUTTE , Amy WONG , Samuel W. THOMAS , Hayat SINDI , Sarah J. VELLA , Emanuel CARRILHO , Katherine A. MIRICA , Yanyan LIU
发明人： George M. WHITESIDES , Scott T. PHILLIPS , Andres W. MARTINEZ , Manish J. BUTTE , Amy WONG , Samuel W. THOMAS , Hayat SINDI , Sarah J. VELLA , Emanuel CARRILHO , Katherine A. MIRICA , Yanyan LIU
CPC分类号： G01N33/558 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/12 , B01L2300/06 , B01L2300/0848 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , C12Q1/48 , G01N21/77 , G01N33/523 , G01N33/526 , G01N33/54386 , G06F3/005
摘要： Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
摘要翻译： 本发明的实施方案提供了基于图案化多孔介质的横向流动和流通生物测定装置，其制备方法及其使用方法。 在一个方面，测定装置包括多孔亲水介质; 包含聚合的光致抗蚀剂的流体不透过屏障，所述屏障基本上渗透所述多孔亲水介质的厚度，并且限定所述多孔亲水介质内的测定区域的边界; 和测定区域中的测定试剂。
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4.发明授权公开(公告)号：US09409265B2
公开(公告)日：2016-08-09
申请号：US13994595
申请日：2011-12-20
申请人： George M. Whitesides , Filip Ilievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
发明人： George M. Whitesides , Filip Ilievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
CPC分类号： B23P19/04 , B03C1/01 , B03C1/288 , B03C2201/18 , B81C3/005 , B81C2203/054 , B81C2203/057 , B81C2203/058 , C30B30/04 , Y10S117/901 , Y10T29/49826
摘要： The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
摘要翻译： 描述了使用悬浮在含有顺磁阳离子的溶液中的反磁性颗粒组装三维结构的能力。 这种分离装置的主要优点是：（i）它是一种不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）组装的结构可以在固定结构之后从顺磁溶液中除去以进一步处理; iii）装配快速; 和iv）它是小，便携式。
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公开(公告)号：US20130034869A1
公开(公告)日：2013-02-07
申请号：US13576804
申请日：2011-02-03
申请人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascarenas , Xinyu Liu , Xiujun Li
发明人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascarenas , Xinyu Liu , Xiujun Li
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/065
摘要： The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
摘要翻译： 本公开提供了用于执行多重测定的低成本便携式三维装置。 这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。
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公开(公告)号：US08821810B2
公开(公告)日：2014-09-02
申请号：US13576804
申请日：2011-02-03
申请人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascareñas , Xinyu Liu , Xiujun Li
发明人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascareñas , Xinyu Liu , Xiujun Li
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/065
摘要： The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
摘要翻译： 本公开提供了用于执行多重测定的低成本便携式三维装置。 这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。
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公开(公告)号：US20110123398A1
公开(公告)日：2011-05-26
申请号：US12934499
申请日：2009-03-27
申请人： Emanuel Carrilho , Andres W. Martinez , Katherine A. Mirica , Scott T. Phillips , Adam C. Siegel , Benjamin Wiley , George M. Whitesides
发明人： Emanuel Carrilho , Andres W. Martinez , Katherine A. Mirica , Scott T. Phillips , Adam C. Siegel , Benjamin Wiley , George M. Whitesides
IPC分类号： G01N33/00
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
摘要： Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
摘要翻译： 描述了包括多个图案化的多孔亲水层和设置在每两个相邻的图案化的多孔亲水层之间的流体不可渗透层的三维微流体装置。 每个图案化的多孔亲水层具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定图案化的多孔亲水层内的一个或多个亲水区域的边界。 流体不可渗透层具有与至少一个相邻的图案化的多孔亲水层内的亲水区域的至少一部分对准的开口。 还描述了微流控测定装置，微流体混合器，微流控流量控制装置。
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8.发明申请DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS 有权用于分离材料的基于密度的方法，监测固体支持反应和测量小液体和固体的浓度公开(公告)号：US20100285606A1
公开(公告)日：2010-11-11
申请号：US12666132
申请日：2008-06-30
申请人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
发明人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
IPC分类号： G01N33/553 , G01N33/44 , G01N33/53 , G01N33/20 , G01N33/14
CPC分类号： G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269
摘要： The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
摘要翻译： 描述了使用非均匀磁场悬浮在含有顺磁性阳离子的溶液中的反磁性颗粒悬浮，分离和检测密度变化的能力。 这种分离装置的主要优点是：i）不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）它与简单的光学检测（只要透明材料用于制造分离发生的容器/通道）兼容; iii）收集分离的颗粒进行进一步处理是简单的; iv）不需要对颗粒/材料进行磁性标记; 和v）它是小，便携。 所提供的方法和试剂盒用于分离和收集不同密度的材料，用于检测感兴趣的分析物的诊断，固体支持的化学反应的监测和固体和液体混合物的密度的测定。
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9.发明授权Density-based methods for separation of materials, monitoring of solid supported reactions and measuring densities of small liquid volumes and solids 有权用于分离材料的基于密度的方法，监测固体支持的反应和测量小液体体积和固体的密度公开(公告)号：US09551706B2
公开(公告)日：2017-01-24
申请号：US12666132
申请日：2008-06-30
申请人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
发明人： Scott T. Phillips , George M. Whitesides , Katherine A. Mirica , Emanuel Carrilho , Andres W. Martinez , Sergey S. Shevkoplyas , Phillip W. Snyder , Raquel Perez-Castillejos , Malancha Gupta , Adam Winkleman , Katherine L. Gudiksen
IPC分类号： G01N33/553 , G01N33/543 , B01L3/00 , G01R33/12 , B01D35/06
CPC分类号： G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269
摘要： The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
摘要翻译： 描述了使用非均匀磁场悬浮在含有顺磁性阳离子的溶液中的反磁性颗粒悬浮，分离和检测密度变化的能力。 这种分离装置的主要优点是：i）不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）它与简单的光学检测（只要透明材料用于制造分离发生的容器/通道）兼容; iii）收集分离的颗粒进行进一步处理是简单的; iv）不需要对颗粒/材料进行磁性标记; 和v）它是小，便携。 所提供的方法和试剂盒用于分离和收集不同密度的材料，用于检测感兴趣的分析物的诊断，固体支持的化学反应的监测和固体和液体混合物的密度的测定。
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10.发明申请公开(公告)号：US20140123461A1
公开(公告)日：2014-05-08
申请号：US13994595
申请日：2011-12-20
申请人： George M. Whitesids , Filip Iievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
发明人： George M. Whitesids , Filip Iievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
IPC分类号： B23P19/04
CPC分类号： B23P19/04 , B03C1/01 , B03C1/288 , B03C2201/18 , B81C3/005 , B81C2203/054 , B81C2203/057 , B81C2203/058 , C30B30/04 , Y10S117/901 , Y10T29/49826
摘要： The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
摘要翻译： 描述了使用悬浮在含有顺磁阳离子的溶液中的反磁性颗粒组装三维结构的能力。 这种分离装置的主要优点是：（i）它是一种不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）组装的结构可以在固定结构之后从顺磁溶液中除去以进一步处理; iii）装配快速; 和iv）它是小，便携式。
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