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221 条记录 (耗时 0.022 秒)

    Bioswellable sutures
    1.
    发明授权
    Bioswellable sutures 有权
    生物可维护的缝线

    公开(公告)号：US08865205B2

    公开(公告)日：2014-10-21

    申请号：US12229142

    申请日：2008-08-20

    申请人： Shalaby W. Shalaby

    发明人： Shalaby W. Shalaby

    IPC分类号： A61K9/14 ,  A61K9/70 ,  A61L27/34 ,  A61L17/14 ,  A61L29/08 ,  A61B17/06 ,  A61B17/00

    CPC分类号： A61B17/06166 ,  A61B2017/00889 ,  A61L17/145 ,  A61L27/34 ,  A61L29/085

    摘要： Swellable, coated sutures have a swellable polymeric coating and a fibrous component, wherein the coating is formed of an absorbable or non-absorbable polymer, while the fibrous component is formed of a synthetic absorbable or non-absorbable monofilament yarn, synthetic absorbable or non-absorbable braided multifilament yarn, braided silk multifilament yarn or combinations thereof. In certain instances, the coating is used as a carrier for the controlled delivery of different types of bioactive agents, including those having antimicrobial, anti-inflammatory, anesthetic, tissue growth-promoting, and antineoplastic activities.

    摘要翻译： 可膨胀的涂层缝合线具有可溶胀的聚合物涂层和纤维组分，其中涂层由可吸收或不可吸收的聚合物形成，而纤维组分由合成的可吸收或不可吸收的单丝纱线，合成的可吸收或不可吸收的聚合物形成， 可吸收编织复丝纱，编织丝复丝纱或其组合。 在某些情况下，涂层用作用于受控递送不同类型的生物活性剂的载体，包括具有抗微生物，抗炎，麻醉，组织生长促进和抗肿瘤活性的生物活性剂。

    Multifaceted endovascular stent coating for preventing restenosis
    2.
    发明授权
    Multifaceted endovascular stent coating for preventing restenosis 有权
    用于预防再狭窄的多层血管内支架涂层

    公开(公告)号：US08414874B2

    公开(公告)日：2013-04-09

    申请号：US10510125

    申请日：2003-04-23

    申请人： Shalaby W Shalaby

    发明人： Shalaby W Shalaby

    IPC分类号： A61K31/74

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/45 ,  C08L67/04 ,  C08L71/02 ,  C08L101/02

    摘要： This invention deals with a carboxyl-bearing, amphiphilic, solid copolyester stent coating composition for multifaceted prevention of vascular restenosis through a plurality of physicopharmacological modes. The composition includes one or more bioactive compounds and a copolymerization product of polyalkylene glycol, end-grafted with one or more cyclic monomer and treated further to introduce carboxyl-bearing end- or side-groups. The invention also deals with bioactive agents in an ionically conjugated form. The present coating may be applied to a metallic or an absorbable polymeric stent for use in preventing vascular restenosis.

    摘要翻译： 本发明涉及通过多种物理药理学模式多元预防血管再狭窄的含羧基的两亲性固体共聚酯支架涂层组合物。 该组合物包括一种或多种生物活性化合物和与一种或多种环状单体端接的聚亚烷基二醇的共聚产物，并进一步处理以引入含羧基的端基或侧基。 本发明还涉及离子共轭形式的生物活性剂。 本发明的涂层可以应用于金属或可吸收聚合物支架，用于预防血管再狭窄。

    Tissue protecting spray-on copolymeric film composition
    4.
    发明授权
    Tissue protecting spray-on copolymeric film composition 有权
    组织保护喷雾共聚膜组成

    公开(公告)号：US07842749B2

    公开(公告)日：2010-11-30

    申请号：US11175636

    申请日：2005-07-05

    申请人： Shalaby W. Shalaby ,  James M. Lindsey, III

    发明人： Shalaby W. Shalaby ,  James M. Lindsey, III

    IPC分类号： C08L31/00

    CPC分类号： A61L26/0014 ,  A61L26/0076 ,  C08F293/005 ,  C08L53/00 ,  C08L2666/02

    摘要： This invention deals with a tissue protecting, spray-on film composition comprising an amphiphilic film-forming, segmented/block copolymer derived form at least one water-soluble monomer and at least another water-insoluble monomer, wherein the film can be formed from a water soluble organic solvent such as 2-propanol, acetone, and ethyl acetate. The film can contain a bioactive agent including those to have antimicrobial, anesthetic, anti-inflammatory, and wound-healing activities.

    摘要翻译： 本发明涉及包含形成至少一种水溶性单体和至少另一种水不溶性单体的两亲成膜，分段/嵌段共聚物的组织保护喷涂膜组合物，其中该膜可由 水溶性有机溶剂如2-丙醇，丙酮和乙酸乙酯。 该膜可以含有包括具有抗微生物剂，麻醉剂，抗炎和伤口愈合活性的生物活性剂。

    Method for radiochemical sterilization
    5.
    发明授权
    Method for radiochemical sterilization 有权
    放射化学灭菌方法

    公开(公告)号：US07771651B1

    公开(公告)日：2010-08-10

    申请号：US12658956

    申请日：2010-02-18

    申请人： Shalaby W Shalaby

    发明人： Shalaby W Shalaby

    IPC分类号： A61L2/08

    CPC分类号： A61L2/204 ,  A61L2/08 ,  B65D75/14 ,  B65D2205/025

    摘要： This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.

    摘要翻译： 本发明涉及医疗或药物产品的放射化学灭菌的包装组件，其由密封的箔包组成，其包含（1）在可吸收的缝合线和网眼中的固体装置，在穿孔保持器或密封的柔性分配器中的液体制剂中 ，如可吸收的氰基丙烯酸酯基组织粘合剂; （2）微囊化，未稳定的聚甲醛，作为包含在密封袋中的放射性产生的甲醛的源，其包含多孔，无纺布或机织织物; 和（3）能够与残留的甲醛反应的含氮化合物，例如三聚氰胺或尿素，其被封装在包含多孔，无纺布或机织织物的密封袋中。

    Package components for radiochemical sterilization
    6.
    发明授权
    Package components for radiochemical sterilization 失效
    用于放射化学灭菌的包装组件

    公开(公告)号：US07694815B2

    公开(公告)日：2010-04-13

    申请号：US12157516

    申请日：2008-06-11

    申请人： Shalaby W Shalaby

    发明人： Shalaby W Shalaby

    IPC分类号： A61L2/08

    CPC分类号： A61L2/08 ,  A61L2/204 ,  B65D81/18

    摘要： Package components for the radiochemical sterilization of medical devices contain paraformaldehyde as the precursor of the radiolytically generated, sterilizing dose of formaldehyde, premixed with a particulate solid dispersant of, preferably, polyethylene or silica gel, which facilitates the free passage of the formaldehyde to the package gaseous environment or additionally, absorbs trace amounts of moisture in the package, thus, facilitating the device manufacturing process and increasing shelf-stability.

    摘要翻译： 用于医疗器械放射化学灭菌的包装组件含有多聚甲醛作为放射学产生的灭菌剂量的甲醛的前体，与优选聚乙烯或硅胶的颗粒固体分散剂预混合，这有助于甲醛自由通过包装 气体环境或附加地，吸收包装中的痕量水分，从而便于装置制造过程和增加货架稳定性。