公开(公告)号：US20130197270A1

公开(公告)日：2013-08-01

申请号：US13878090

申请日：2011-10-05

申请人： Naritoshi Yoshimura ,  Shinji Kiyono ,  Tetsuya Hamada ,  Eiji Watanabe ,  Saiko Sawada

发明人： Naritoshi Yoshimura ,  Shinji Kiyono ,  Tetsuya Hamada ,  Eiji Watanabe ,  Saiko Sawada

IPC分类号： C07C209/48

CPC分类号： C07C209/48 ,  B01J23/44 ,  B01J25/00 ,  B01J25/02 ,  C07B2200/09 ,  C07C253/22 ,  C07C253/34 ,  C07C2601/14 ,  C07C255/46 ,  C07C211/18

摘要： A method for producing trans-1,4-bis(aminomethyl)cyclohexane includes a nuclear hydrogenation step of producing a hydrogenated terephthalic acid or terephthalic acid derivative by nuclear hydrogenation of a terephthalic acid or terephthalic acid derivative, the terephthalic acid or terephthalic acid derivative being at least one selected from the group consisting of terephthalic acid, terephthalic acid ester, and terephthalic acid amide; a cyanation step of treating the hydrogenated terephthalic acid or terephthalic acid derivative with ammonia, thereby producing 1,4-dicyanocyclohexane, and producing trans-1,4-dicyanocyclohexane from the obtained 1,4-dicyanocyclohexane; and an aminomethylation step of treating the trans-1,4-dicyanocyclohexane with hydrogen, thereby producing trans-1,4-bis(aminomethyl)cyclohexane.Metal oxide is used as a catalyst in the cyanation step, and the obtained trans-1,4-dicyanocyclohexane has a metal content of 3000 ppm or less.

摘要翻译： 反式-1,4-双（氨基甲基）环己烷的制造方法包括通过对苯二甲酸或对苯二甲酸衍生物的核氢化制造氢化对苯二甲酸或对苯二甲酸衍生物的核氢化工序，对苯二甲酸或对苯二甲酸衍生物为 选自对苯二甲酸，对苯二甲酸酯和对苯二甲酸酰胺中的至少一种; 用氨处理氢化对苯二甲酸或对苯二甲酸衍生物的氰化步骤，从而得到1,4-二氰基环己烷，由所得的1,4-二氰基环己烷生产反式-1,4-二氰基环己烷; 和用氢处理反式-1,4-二氰基环己烷的氨基甲基化步骤，从而产生反式-1,4-双（氨基甲基）环己烷。 在氰化步骤中使用金属氧化物作为催化剂，得到的反式-1,4-二氰基环己烷的金属含量为3000ppm以下。

公开(公告)号：US06664365B2

公开(公告)日：2003-12-16

申请号：US09366046

申请日：1999-09-03

申请人： Tadahito Nobori ,  Masahiro Kouno ,  Toshiaki Suzuki ,  Kazumi Mizutani ,  Shinji Kiyono ,  Yoshiho Sonobe ,  Usaji Takaki

发明人： Tadahito Nobori ,  Masahiro Kouno ,  Toshiaki Suzuki ,  Kazumi Mizutani ,  Shinji Kiyono ,  Yoshiho Sonobe ,  Usaji Takaki

IPC分类号： C08G6510

CPC分类号： C07F9/065 ,  C07F9/067 ,  C08G65/2675

摘要： The present invention provides a novel salt useful as an active species in an organic reaction and represented by the following chemical formula (1): wherein n stands for an integer of from 1 to 8, Zn− represents an n-valent anion of an active hydrogen compound, a, b, c and d each stands for a positive integer, and Rs represent the same or different hydrocarbon groups. Also disclosed is a simple and efficient process for producing a poly(alkylene oxide) by polymerizing an alkylene oxide compound in the presence of the salt represented by the chemical formula (1).

摘要翻译： 本发明提供了可用作有机反应中的活性物质的新型盐，其由以下化学式（1）表示：其中n表示1至8的整数，Z n表示n价阴离子 的活性氢化合物，a，b，c和d分别表示正整数，Rs表示相同或不同的烃基。 还公开了通过在化学式（1）表示的盐的存在下聚合烯化氧化合物来制备聚（环氧烷）的简单和有效的方法。

公开(公告)号：US06528599B1

公开(公告)日：2003-03-04

申请号：US09549037

申请日：2000-04-13

申请人： Tadahito Nobori ,  Atsushi Shibahara ,  Shinji Kiyono ,  Takaomi Hayashi ,  Katsuhiko Funaki ,  Isao Hara ,  Kazumi Mizutani ,  Usaji Takaki

发明人： Tadahito Nobori ,  Atsushi Shibahara ,  Shinji Kiyono ,  Takaomi Hayashi ,  Katsuhiko Funaki ,  Isao Hara ,  Kazumi Mizutani ,  Usaji Takaki

IPC分类号： C08H200

CPC分类号： C08F297/00 ,  C08F2/38 ,  C08F4/00 ,  C08F220/14 ,  C08F220/28 ,  C08F220/44 ,  C08F297/02

摘要： The present invention provides a method of preparing a polymer, which comprises subjecting a monomer containing at least a polar unsaturated compound to anionic polymerization in the presence of a phosphazenium compound represented by the formula (1): (wherein Z− is an anion of an active hydrogen compound in the form where a proton is eliminated from the active hydrogen compound and transferred to the anion; a, b, c and d each represents 1 or 0, but all of them are not simultaneously 0; and R may the same or different and each represents a hydrocarbon group having 1 to 10 carbon atoms, and two R(s) on the same nitrogen atom are optionally combined each other to form a cyclic structure), or in the presence of the phosphazenium compound and the active hydrogen compound. The resulting polymer is characterized by narrow molecular weight distribution.

摘要翻译： 本发明提供一种制备聚合物的方法，该方法包括在式（1）表示的磷氮烯基鏻化合物的存在下使至少含有极性不饱和化合物的单体进行阴离子聚合:(其中Z-为 活性氢化合物以质子从活性氢化合物中除去并转移到阴离子的形式; a，b，c和d各自表示1或0，但它们都不同时为0; R可以相同或不同， 不同且各自表示具有1-10个碳原子的烃基，并且相同氮原子上的两个R（s）任选地相互结合形成环状结构），或者在磷氮烯基鏻化合物和活性氢化合物 。 所得聚合物的特征在于分子量分布窄。

公开(公告)号：US06444847B1

公开(公告)日：2002-09-03

申请号：US09935655

申请日：2001-08-24

申请人： Tadahito Nobori ,  Isao Hara ,  Katsuhiko Funaki ,  Takaomi Hayashi ,  Atsushi Shibahara ,  Shinji Kiyono ,  Kazumi Mizutani ,  Usaji Takaki

发明人： Tadahito Nobori ,  Isao Hara ,  Katsuhiko Funaki ,  Takaomi Hayashi ,  Atsushi Shibahara ,  Shinji Kiyono ,  Kazumi Mizutani ,  Usaji Takaki

IPC分类号： C07F922

摘要： A process for preparing phosphine oxides by reacting iminophosphoranes with phosphorus oxytrichloride by which highly purified phosphine oxides can be obtained industrially in a higher yield. Specifically, phosphine oxides are prepared in such a manner that iminophosphoranes are reacted with phosphorus oxytrichloride using an aprotic organic solvent with permittivity 2.2 or more at 20° C. as a solvent under special reaction conditions to give a liquid reaction product containing phosphine oxides and aminophosphonium chlorides which are yielded as a by-product at the same time as the phosphine oxides, and the above described chlorides are removed from the above described liquid reaction product by a solid-liquid separation process, and the solution having been subjected to the solid-liquid separation process is washed with water.

公开(公告)号：US06303815B1

公开(公告)日：2001-10-16

申请号：US09548624

申请日：2000-04-13

申请人： Tadahito Nobori ,  Isao Hara ,  Katsuhiko Funaki ,  Takaomi Hayashi ,  Atsushi Shibahara ,  Shinji Kiyono ,  Kazumi Mizutani ,  Usaji Takaki

发明人： Tadahito Nobori ,  Isao Hara ,  Katsuhiko Funaki ,  Takaomi Hayashi ,  Atsushi Shibahara ,  Shinji Kiyono ,  Kazumi Mizutani ,  Usaji Takaki

IPC分类号： C07F922

CPC分类号： C07F9/025 ,  C07F9/224

摘要： A process for preparing phosphine oxides by reacting iminophosphoranes with phosphorus oxytrichloride by which highly purified phosphine oxides can be obtained industrially in a higher yield. Specifically, phosphine oxides are prepared in such a manner that iminophosphoranes are reacted with phosphorus oxytrichloride using an aprotic organic solvent with permittivity 2.2 or more at 20° C. as a solvent under special reaction conditions to give a liquid reaction product containing phosphine oxides and aminophosphonium chlorides which are yielded as a by-product at the same time as the phosphine oxides, and the above described chlorides are removed from the above described liquid reaction product by a solid-liquid separation process, and the solution having been subjected to the solid-liquid separation process is washed with water.

摘要翻译： 通过使亚氨基磷腈与三氯氧化磷反应来制备氧化膦的方法，通过该方法可以以更高的产率在工业上获得高度纯化的氧化膦。 具体地说，在特殊的反应条件下，使亚氨基磷腈与二氧化磷与二氯化磷反应，使用介电常数为2.2以上，介电常数为2.2以上的溶剂，作为溶剂，在特殊的反应条件下反应生成含有氧化膦和氨基鏻的液体反应产物 与氧化膦同时作为副产物生成的氯化物，并且通过固液分离方法从上述液体反应产物中除去上述氯化物，并将溶液经受固体 - 液体分离过程用水洗涤。

公开(公告)号：US6090980A

公开(公告)日：2000-07-18

申请号：US201655

申请日：1998-12-01

申请人： Tadahito Nobori ,  Takaomi Hayashi ,  Katsuhiko Funaki ,  Atsushi Shibahara ,  Isao Hara ,  Shinji Kiyono ,  Kazumi Mizutani ,  Usaji Takaki

发明人： Tadahito Nobori ,  Takaomi Hayashi ,  Katsuhiko Funaki ,  Atsushi Shibahara ,  Isao Hara ,  Shinji Kiyono ,  Kazumi Mizutani ,  Usaji Takaki

IPC分类号： C07F9/06

CPC分类号： C07F9/065

摘要： A process is provided for preparing iminotris(dimethylamino)phosphorane at high purity and high yield from aminotris(dimethylamino)phosphonium chloride. Aminotris(dimethylamino)phosphonium chloride is first reacted with an aqueous solution of the hydroxide of an alkali metal or alkaline earth metal in the presence of a solvent in which the chloride and hydroxide of the alkali metal or alkaline earth metal are sparingly soluble, whereby iminotris(dimethylamino)phosphorane is formed. After water is dissolved off at a temperature of 70.degree. C. or lower from the reaction mixture, solids are removed from the thus-concentrated reaction mixture by solid-liquid separation. The resultant mother liquor is then distilled to obtain iminotris(dimethylamino)phosphorane.

摘要翻译： 提供了从氨基三（二甲基氨基）氯化鏻以高纯度和高收率制备亚氨基三（二甲基氨基）正膦的方法。 氨基三（二甲基氨基）鏻氯化物首先在碱金属或碱土金属的氢氧化物的水溶液中在碱金属或碱土金属的氯化物和氢氧化物微溶于其中的溶剂的存在下反应，由此亚氨基三 （二甲基氨基）正膦。 在反应混合物的70℃或更低的温度下将水溶解后，通过固液分离将固体从这样浓缩的反应混合物中除去。 然后将得到的母液蒸馏得到亚氨基三（二甲基氨基）正膦。

公开(公告)号：US06177593B1

公开(公告)日：2001-01-23

申请号：US09216864

申请日：1998-12-21

申请人： Tadahito Nobori ,  Takaomi Hayashi ,  Katsuhiko Funaki ,  Atsushi Shibahara ,  Isao Hara ,  Shinji Kiyono ,  Kazumi Mizutani ,  Usaji Takaki

发明人： Tadahito Nobori ,  Takaomi Hayashi ,  Katsuhiko Funaki ,  Atsushi Shibahara ,  Isao Hara ,  Shinji Kiyono ,  Kazumi Mizutani ,  Usaji Takaki

IPC分类号： C07F902

CPC分类号： C07F9/065

摘要： The compound [tris(dimethylamino)phosphonioamino]tris[tris(dimethylamino)phosphoranylideneamino]phosphonium dichloride can be prepared by contacting hydrogen chloride with tetrakis[tris(dimethylamino)phosphoranylideneamino]phosphonium chloride. The phosphonium dichloride compound can be used in a process wherein it is brought into contact with an OH−-form ion exchange resin to prepare tetrakis[tris(dimethylamino)phosphoranylideneamino]phosphonium hydroxide. Separate processes for separating or isolating the phosphonium chloride compound or isolating the phosphonium hydroxide compound from feed solutions wherein an extraction step is used are also set forth.

摘要翻译： 化合物[三（二甲基氨基）膦酰氨基]三[三（二甲基氨基）亚正膦基氨基]二氯化鏻可以通过使氯化氢与四[三（二甲基氨基）正膦亚基氨基]鏻氯化物接触来制备。 二氯化鏻化合物可以在与OH型离子交换树脂接触以制备四[三（二甲基氨基）正膦亚基氨基]鏻氢氧化物的方法中使用。 还提出了分离或分离氯化鏻化合物或从使用提取步骤的进料溶液中分离氢氧化鏻的分离方法。

公开(公告)号：US4831158A

公开(公告)日：1989-05-16

申请号：US117904

申请日：1987-11-02

申请人： Tomoyuki Ueno ,  Tadatoshi Honda ,  Takashi Jimbo ,  Makoto Kotani ,  Kazuhiro Terada ,  Shinji Kiyono

发明人： Tomoyuki Ueno ,  Tadatoshi Honda ,  Takashi Jimbo ,  Makoto Kotani ,  Kazuhiro Terada ,  Shinji Kiyono

IPC分类号： C07D209/04 ,  B01J23/90 ,  C07D209/08

CPC分类号： C07D209/08 ,  B01J23/90 ,  Y02P20/584

摘要： In a process for preparing an indole by reacting an aniline with a diol, a catalyst the activity of which has been reduced through its use in the reaction is brought into contact with an inert gas containing 5 vol. % or less of oxygen so that the catalyst is regenerated for its repeated utilization. The activity of the regenerated catalyst is enhanced further when it is subjected to a reducing treatment for activation upon its reutilization.

摘要翻译： 在通过使苯胺与二醇反应制备吲哚的方法中，其活性通过其在反应中的使用而降低的催化剂与含有5体积％的惰性气体接触。 氧气的百分比以下，使得催化剂被再生以便重复使用。 再生催化剂的活性在其再利用时进行还原处理以进行活化时进一步增强。

公开(公告)号：US08865938B2

公开(公告)日：2014-10-21

申请号：US13877595

申请日：2011-10-05

申请人： Naritoshi Yoshimura ,  Shinji Kiyono ,  Tetsuya Hamada ,  Eiji Watanabe ,  Saiko Sawada

发明人： Naritoshi Yoshimura ,  Shinji Kiyono ,  Tetsuya Hamada ,  Eiji Watanabe ,  Saiko Sawada

IPC分类号： C07C209/00 ,  C07C209/48 ,  C07C253/22

CPC分类号： C07C209/48 ,  C07C253/22 ,  C07C2601/14 ,  C07C255/46 ,  C07C211/18

摘要： A method for producing bis(aminomethyl)cyclohexanes includes a nuclear hydrogenation step of producing hydrogenated phthalic acids or phthalic acid derivatives by nuclear hydrogenation of phthalic acids or phthalic acid derivatives of at least one selected from the group consisting of phthalic acids, phthalic acid esters, and phthalic acid amides; a cyanation step of treating the hydrogenated phthalic acids or phthalic acid derivatives obtained in the nuclear hydrogenation step with ammonia, thereby producing dicyanocyclohexanes; and an aminomethylation step of treating the dicyanocyclohexanes obtained in the cyanation step with hydrogen, thereby producing bis(aminomethyl)cyclohexanes. In the cyanation step, metal oxide is used as a catalyst, and the obtained dicyanocyclohexanes have a metal content of 3000 ppm or less.

摘要翻译： 制备双（氨基甲基）环己烷的方法包括核氢化步骤，其通过邻苯二甲酸或邻苯二甲酸衍生物的核氢化制备氢化邻苯二甲酸或邻苯二甲酸衍生物，所述邻苯二甲酸或邻苯二甲酸衍生物选自邻苯二甲酸，邻苯二甲酸酯， 和邻苯二甲酸酰胺; 氰化步骤，用氨处理在核氢化步骤中得到的氢化邻苯二甲酸或邻苯二甲酸衍生物，从而产生二氰基环己烷; 和在氰化步骤中用氢处理二氰基环己烷的氨基甲基化步骤，从而产生双（氨基甲基）环己烷。 在氰化步骤中，使用金属氧化物作为催化剂，所得到的二氰基环己烷的金属含量为3000ppm以下。

公开(公告)号：US20110288240A1

公开(公告)日：2011-11-24

申请号：US13198397

申请日：2011-08-04

申请人： Naritoshi YOSHIMURA ,  Shinji Kiyono ,  Kazumi Mizutani ,  Isao Hara ,  Takaomi Hayashi ,  Tadahito Nobori ,  Yoshihiro Yamamoto ,  Miyuki Konno ,  Yoshihisa Inoue ,  Akira Matsuura ,  Tuneyuki Ohkubo

发明人： Naritoshi YOSHIMURA ,  Shinji Kiyono ,  Kazumi Mizutani ,  Isao Hara ,  Takaomi Hayashi ,  Tadahito Nobori ,  Yoshihiro Yamamoto ,  Miyuki Konno ,  Yoshihisa Inoue ,  Akira Matsuura ,  Tuneyuki Ohkubo

IPC分类号： C08F8/40 ,  C07C45/45 ,  C07C41/16 ,  C07C41/02 ,  C07F9/06 ,  C07F9/22

CPC分类号： C08G63/823 ,  B01J31/0265 ,  B01J2231/12 ,  C07F9/065 ,  C07F9/224

摘要： A phosphazene-supported catalyst in which a support is bonded to a group represented by the general formula (1): wherein n, Zn−, a, b, c, d, R, R1 and D are all defined. The phosphazene-supported catalyst is highly effective to catalyze various organic reactions, and further has no reduction of activity even after recovery and reuse of the catalyst, thus it being economically advantageous. In addition, the polymerization of cyclic monomers, substitution of substituents, carbon-carbon bond forming reactions and the like can be conducted with extremely high efficiency.

摘要翻译： 载体与由通式（1）表示的基团键合的磷腈担载催化剂：其中n，Zn-，a，b，c，d，R，R1和D全部定义。 磷腈担载的催化剂对于催化各种有机反应是非常有效的，即使在回收和再利用催化剂之后也不会降低活性，因此在经济上是有利的。 此外，可以极高效率进行环状单体的聚合，取代基的取代，碳 - 碳键形成反应等。