公开(公告)号：US20110202188A1

公开(公告)日：2011-08-18

申请号：US13035388

申请日：2011-02-25

申请人： Stanley P. Pensak, JR. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

发明人： Stanley P. Pensak, JR. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

IPC分类号： G05D16/00 ,  G05D11/02

CPC分类号： G01N30/34 ,  G01N35/1097

摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream, to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.

摘要翻译： 用于减轻与将低压分析物样品注入高压HPLC流体流中相关联的压力扰动的系统，装置和方法，以增强与保留时间和再现性相关的色谱性能。 优选实施例通过二元溶剂输送系统的主动压力控制来协调注入运行，以在低压回路在线时基本上消除常规的压降。 通过强制喷射运行，输送泵活塞的机械位置以及开始和随后的梯度输送之间的一致的时间关系来实现增强再现性的另外的益处。

公开(公告)号：US08535016B2

公开(公告)日：2013-09-17

申请号：US11631354

申请日：2005-07-06

申请人： Jose de Corral ,  Stanley P. Pensak, Jr.

发明人： Jose de Corral ,  Stanley P. Pensak, Jr.

IPC分类号： F04B49/06 ,  F04B49/00

CPC分类号： F04B49/065 ,  F04B11/0058 ,  F04B11/0075 ,  F04B23/06 ,  F04B2205/01 ,  F04B2205/05 ,  F04B2205/09 ,  F04B2205/10 ,  F04B2205/11 ,  G01N2030/326

摘要： A feedback control loop for a high pressure pump modifies the accumulator velocity and pressure during solvent transfer. The accumulator velocity is adjusted to maintain the system pressure equal to the expected pressure to thereby eliminate the effect of the flow deficit created by a thermal effect.

摘要翻译： 用于高压泵的反馈控制回路在溶剂转移期间改变储液器的速度和压力。 调节蓄能器速度以保持系统压力等于预期的压力，从而消除由热效应产生的流量缺陷的影响。

公开(公告)号：US20100202897A1

公开(公告)日：2010-08-12

申请号：US12689491

申请日：2010-01-19

申请人： Jose de Corral ,  Stanley P. Pensak, JR.

发明人： Jose de Corral ,  Stanley P. Pensak, JR.

IPC分类号： F04B49/08 ,  F04B41/06

CPC分类号： F04B49/065 ,  F04B11/0058 ,  F04B11/0075 ,  F04B23/06 ,  F04B2205/01 ,  F04B2205/05 ,  F04B2205/09 ,  F04B2205/10 ,  F04B2205/11 ,  G01N2030/326

摘要： A feedback control loop for a high pressure pump modifies the accumulator velocity and pressure during solvent transfer. The accumulator velocity is adjusted to maintain the system pressure equal to the expected pressure to thereby eliminate the effect of the flow deficit created by a thermal effect.

公开(公告)号：US20080260558A1

公开(公告)日：2008-10-23

申请号：US10598310

申请日：2005-03-04

申请人： Joseph A. Luongo ,  John Angelosanto ,  Frank Rubino ,  Stanley P. Pensak Jr. ,  David J. First ,  Jean-Pierre Pugnaire ,  Richard R. Venable

发明人： Joseph A. Luongo ,  John Angelosanto ,  Frank Rubino ,  Stanley P. Pensak Jr. ,  David J. First ,  Jean-Pierre Pugnaire ,  Richard R. Venable

IPC分类号： F04B39/00 ,  G01L9/04

CPC分类号： F04B53/162 ,  F04B53/16 ,  F04B2205/03 ,  G01N2030/326

摘要： Embodiments of the present invention are directed to method and devices for measuring the pressure of a pump chamber in which no internal opening or connections are needed. One embodiment of the present invention is directed to an apparatus for pumping fluid. The apparatus comprises at least one housing having a transducer surface. The transducer surface has a thickness exhibiting measurable deformation upon the chamber holding a fluid under pressure such that the transducer surface has a first position at which the chamber is at one pressure and a second position at which the chamber is at a second pressure. A strain sensor is affixed to the transducer surface producing; at least one signal upon the transducer surface assuming the first position and at least one signal upon the transducer surface assuming the second position to function as an integrated pressure transducer.

摘要翻译： 本发明的实施例涉及用于测量不需要内部开口或连接的泵室的压力的方法和装置。 本发明的一个实施例涉及一种用于泵送流体的装置。 该装置包括具有换能器表面的至少一个壳体。 换能器表面具有在腔室上保持流体的压力下呈现可测量变形的厚度，使得换能器表面具有腔室处于一个压力的第一位置和腔室处于第二压力的第二位置。 应变传感器固定在传感器表面上; 在换能器表面上的至少一个信号假设第一位置，并且在换能器表面上的至少一个信号假设第二位置用作集成的压力换能器。

公开(公告)号：US20080206067A1

公开(公告)日：2008-08-28

申请号：US11631354

申请日：2005-07-06

申请人： Jose De Corral ,  Stanley P. Pensak Jr.

发明人： Jose De Corral ,  Stanley P. Pensak Jr.

IPC分类号： F04B49/06 ,  F04B49/20 ,  F04B49/00 ,  G05D7/00 ,  G05D16/00

CPC分类号： F04B49/065 ,  F04B11/0058 ,  F04B11/0075 ,  F04B23/06 ,  F04B2205/01 ,  F04B2205/05 ,  F04B2205/09 ,  F04B2205/10 ,  F04B2205/11 ,  G01N2030/326

摘要： A feedback control loop for a high pressure pump modifies the accumulator velocity and pressure during solvent transfer. The accumulator velocity is adjusted to maintain the system pressure equal to the expected pressure to thereby eliminate the effect of the flow deficit created by a thermal effect.

摘要翻译： 用于高压泵的反馈控制回路在溶剂转移期间改变储液器的速度和压力。 调节蓄能器速度以保持系统压力等于预期的压力，从而消除由热效应产生的流量缺陷的影响。

公开(公告)号：US08160751B2

公开(公告)日：2012-04-17

申请号：US13035388

申请日：2011-02-25

申请人： Stanley P. Pensak, Jr. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

发明人： Stanley P. Pensak, Jr. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

IPC分类号： G05D11/02 ,  G05D11/16 ,  G05B21/00 ,  G01F1/00 ,  G01F7/00 ,  G01F25/00 ,  F01N3/20 ,  G05B1/00

CPC分类号： G01N30/34 ,  G01N35/1097

摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream, to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.

摘要翻译： 用于减轻与将低压分析物样品注入高压HPLC流体流中相关联的压力扰动的系统，装置和方法，以增强与保留时间和再现性相关的色谱性能。 优选实施例通过二元溶剂输送系统的主动压力控制来协调注入运行，以在低压回路在线时基本上消除常规的压降。 通过强制喷射运行，输送泵活塞的机械位置以及开始和随后的梯度输送之间的一致的时间关系来实现增强再现性的另外的益处。

公开(公告)号：US20090205409A1

公开(公告)日：2009-08-20

申请号：US12280585

申请日：2007-03-16

申请人： Steven J. Ciavarini ,  Stanley P. Pensak, JR. ,  Jeffrey W. Finch ,  Keith Fadgen ,  Hongji Liu

发明人： Steven J. Ciavarini ,  Stanley P. Pensak, JR. ,  Jeffrey W. Finch ,  Keith Fadgen ,  Hongji Liu

IPC分类号： G01N30/02

CPC分类号： G01N30/34 ,  G01N30/32 ,  G01N2030/326 ,  G05D11/132

摘要： A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.

摘要翻译： 用于色谱装置的溶剂递送子系统执行溶剂的相对低压，高流动混合以形成梯度并随后将高梯度梯度递送到分离塔。 梯度的混合是独立的，并且不干扰梯度递送。 为了形成梯度，将水性泵和有机泵的输出混合以填充储存毛细管，同时从储存毛细管的下游点排放到大气中。 梯度形成后，关闭空气，溶剂输送系统升高至高压，只有水泵运行梯度输送。 为了保持流体流的完整性，溶剂输送系统使用前馈补偿并且控制选自管道装置中的压力和流量的至少一个参数以跟随逐渐斜坡。

公开(公告)号：US20090062966A1

公开(公告)日：2009-03-05

申请号：US11658985

申请日：2005-08-19

申请人： Stanley P. Pensak, JR. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

发明人： Stanley P. Pensak, JR. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

IPC分类号： G05D11/02 ,  G05D7/00

CPC分类号： G01N30/34 ,  G01N35/1097

摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream (52), to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system (30) to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.

摘要翻译： 用于减轻与将低压分析物样品注入高压HPLC流体流（52）相关的压力扰动的系统，装置和方法，以增强与保留时间和再现性相关的色谱性能。 优选实施例通过二元溶剂输送系统（30）的主动压力控制来协调注入运行，以在低压回路在线时基本上消除常规的压降。 通过强制喷射运行，输送泵活塞的机械位置以及开始和随后的梯度输送之间的一致的时间关系来实现增强再现性的另外的益处。

公开(公告)号：US09103814B2

公开(公告)日：2015-08-11

申请号：US12280585

申请日：2007-03-16

申请人： Steven J. Ciavarini ,  Stanley P. Pensak, Jr. ,  Jeffrey W. Finch ,  Keith Fadgen ,  Hongji Liu

发明人： Steven J. Ciavarini ,  Stanley P. Pensak, Jr. ,  Jeffrey W. Finch ,  Keith Fadgen ,  Hongji Liu

IPC分类号： G01N30/34

CPC分类号： G01N30/34 ,  G01N30/32 ,  G01N2030/326 ,  G05D11/132

摘要： A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.

摘要翻译： 用于色谱装置的溶剂递送子系统执行溶剂的相对低压，高流动混合以形成梯度并随后将高梯度梯度递送到分离塔。 梯度的混合是独立的，并且不干扰梯度递送。 为了形成梯度，将水性泵和有机泵的输出混合以填充储存毛细管，同时从储存毛细管的下游点排放到大气中。 梯度形成后，关闭空气，溶剂输送系统升高至高压，只有水泵运行梯度输送。 为了保持流体流的完整性，溶剂输送系统使用前馈补偿并且控制选自管道装置中的压力和流量的至少一个参数以跟随逐渐斜坡。

公开(公告)号：US07917250B2

公开(公告)日：2011-03-29

申请号：US11658985

申请日：2005-08-19

申请人： Stanley P. Pensak, Jr. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

发明人： Stanley P. Pensak, Jr. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

IPC分类号： G05D11/02 ,  G05D11/16 ,  G05B21/00 ,  G01F1/00 ,  G01F7/00 ,  G01F25/00 ,  F01N3/20 ,  G05B1/00

CPC分类号： G01N30/34 ,  G01N35/1097

摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream to enhance chromatographic performance related to retention time and reproducibility. The injection event is coordinated with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. Consistent timing with the injection event of the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery generates reproducible results.

摘要翻译： 用于减轻与将低压分析物样品注入高压HPLC流体流相关的压力扰动以提高与保留时间和再现性相关的色谱性能的系统，装置和方法。 喷射事件与二元溶剂输送系统的主动压力控制协调，以实际消除低压回路在线时的常规压降。 与输送泵活塞的机械位置的注射事件以及起始和随后的梯度递送的一致的时间产生可重现的结果。