公开(公告)号：US08160751B2

公开(公告)日：2012-04-17

申请号：US13035388

申请日：2011-02-25

申请人： Stanley P. Pensak, Jr. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

发明人： Stanley P. Pensak, Jr. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

IPC分类号： G05D11/02 ,  G05D11/16 ,  G05B21/00 ,  G01F1/00 ,  G01F7/00 ,  G01F25/00 ,  F01N3/20 ,  G05B1/00

CPC分类号： G01N30/34 ,  G01N35/1097

摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream, to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.

摘要翻译： 用于减轻与将低压分析物样品注入高压HPLC流体流中相关联的压力扰动的系统，装置和方法，以增强与保留时间和再现性相关的色谱性能。 优选实施例通过二元溶剂输送系统的主动压力控制来协调注入运行，以在低压回路在线时基本上消除常规的压降。 通过强制喷射运行，输送泵活塞的机械位置以及开始和随后的梯度输送之间的一致的时间关系来实现增强再现性的另外的益处。

公开(公告)号：US20100043539A1

公开(公告)日：2010-02-25

申请号：US12282895

申请日：2007-03-16

申请人： Keith Fadgen ,  James E. Usowicz ,  Miguel Soares

发明人： Keith Fadgen ,  James E. Usowicz ,  Miguel Soares

IPC分类号： G01N30/02

CPC分类号： G01N30/20 ,  G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G05D7/0688 ,  G05D16/208

摘要： Embodiments of the present invention are directed to methods and apparatus for placing a sample in a chromatographic system. The device and method feature placing samples held in a sample loop to pressurization prior to placing such sample loop in communication with high pressure conduits.

摘要翻译： 本发明的实施方案涉及将样品置于色谱系统中的方法和装置。 该装置和方法的特征是将放置样品回路中的样品置于加压之前，使样品环与高压导管连通。

公开(公告)号：US20090062966A1

公开(公告)日：2009-03-05

申请号：US11658985

申请日：2005-08-19

申请人： Stanley P. Pensak, JR. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

发明人： Stanley P. Pensak, JR. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

IPC分类号： G05D11/02 ,  G05D7/00

CPC分类号： G01N30/34 ,  G01N35/1097

摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream (52), to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system (30) to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.

摘要翻译： 用于减轻与将低压分析物样品注入高压HPLC流体流（52）相关的压力扰动的系统，装置和方法，以增强与保留时间和再现性相关的色谱性能。 优选实施例通过二元溶剂输送系统（30）的主动压力控制来协调注入运行，以在低压回路在线时基本上消除常规的压降。 通过强制喷射运行，输送泵活塞的机械位置以及开始和随后的梯度输送之间的一致的时间关系来实现增强再现性的另外的益处。

公开(公告)号：US20130019695A1

公开(公告)日：2013-01-24

申请号：US13520189

申请日：2011-01-11

申请人： Joshua A. Shreve ,  James E. Usowicz ,  Miguel Soares

发明人： Joshua A. Shreve ,  James E. Usowicz ,  Miguel Soares

IPC分类号： G01N1/10

CPC分类号： B01L7/02 ,  B01L2300/0829 ,  B01L2300/1838 ,  G01N30/7233 ,  G01N35/028 ,  G01N2035/00356 ,  G01N2035/00386

摘要： Described is an apparatus for reducing a temperature variation of a liquid chromatography sample. A tray drive using at least one of linear or rotational motion moves a sample tray along a path inside a sample compartment of the liquid chromatography system. A control module coordinates the movement of the sample tray by the tray drive and the movement of a sample needle by a needle drive so that any sample in the sample tray can be injected into the mobile phase of the system during a sample load operation. The tray drive is also used to move the sample tray along the path during a temperature averaging period when no loading occurs. Differences in sample temperatures due to variations in the air temperature at different locations inside the sample compartment are reduced, leading to more accurate and repeatable chromatographic measurement results.

摘要翻译： 描述了一种用于降低液相色谱样品的温度变化的装置。 使用线性或旋转运动中的至少一种的托盘驱动器沿着液相色谱系统的样品室内的路径移动样品盘。 控制模块通过托盘驱动器来协调样品托盘的移动和通过针驱动器移动样品针，使得样品托盘中的任何样品可以在样品加载操作期间被注入到系统的流动相中。 托盘驱动器也可用于在温度平均期间沿着路径移动样品托盘，而不会发生加载。 由于样品室内不同位置的空气温度变化导致的样品温度差异减小，从而导致更精确和可重复的色谱测量结果。

公开(公告)号：US20120303167A1

公开(公告)日：2012-11-29

申请号：US13511691

申请日：2010-11-11

申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

IPC分类号： G05D7/00 ,  B01D15/08

CPC分类号： G01N30/20 ,  B01D15/163 ,  B01D15/166 ,  G01N30/24 ,  G01N30/32 ,  G01N30/34 ,  G01N30/36 ,  G01N30/8696 ,  G01N2030/322 ,  G01N2030/326 ,  G01N2030/8804

摘要： A liquid chromatography system includes an autosampler with an injector valve by which a sample at low pressure within a sample loop is introduced into a high-pressure solvent mixture stream. A solvent delivery system includes a pump in fluidic communication with the injector valve of the autosampler to deliver the solvent mixture stream thereto. The solvent delivery system further comprises a processor that calculates a number of strokes of the pump needed to deliver the solvent mixture stream to the injector valve of the autosampler. The processor counts strokes of the pump during delivery of the solvent mixture stream. In response to a stroke count equaling the calculated number of strokes, the processor signals the autosampler to switch the injector valve to introduce the sample to the solvent mixture stream during a pump transfer period within which the pump performs pressure control to compensate for a drop in pressure.

摘要翻译： 液相色谱系统包括具有喷射阀的自动进样器，通过该进样阀将样品环内的低压样品引入高压溶剂混合物流中。 溶剂输送系统包括与自动进样器的注射器阀流体连通以将溶剂混合物流输送到其中的泵。 溶剂输送系统还包括处理器，其计算将溶剂混合物流输送到自动进样器的注射器阀所需的泵的数量。 处理器在输送溶剂混合物流期间计算泵的冲程。 响应于等于所计算的冲程次数的冲程计数，处理器发信号通知自动进样器以在泵传送期间将样品引入溶剂混合物流中，在泵输送期间泵执行压力控制以补偿下降 压力。

公开(公告)号：US08312762B2

公开(公告)日：2012-11-20

申请号：US12282895

申请日：2007-03-16

申请人： Keith Fadgen ,  James E. Usowicz ,  Miguel Soares

发明人： Keith Fadgen ,  James E. Usowicz ,  Miguel Soares

IPC分类号： G01M30/02

CPC分类号： G01N30/20 ,  G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G05D7/0688 ,  G05D16/208

摘要： Embodiments of the present invention are directed to methods and apparatus for placing a sample in a chromatographic system. The device and method feature placing samples held in a sample loop to pressurization prior to placing such sample loop in communication with high pressure conduits.

摘要翻译： 本发明的实施方案涉及将样品置于色谱系统中的方法和装置。 该装置和方法的特征是将放置样品回路中的样品置于加压之前，使样品环与高压导管连通。

公开(公告)号：US07596988B2

公开(公告)日：2009-10-06

申请号：US10598071

申请日：2005-03-02

申请人： James E. Usowicz ,  Peyton C. Beals ,  Russell Keene ,  Richard Kent ,  Miguel Soares ,  John Heden

发明人： James E. Usowicz ,  Peyton C. Beals ,  Russell Keene ,  Richard Kent ,  Miguel Soares ,  John Heden

IPC分类号： G01N30/28 ,  G01N30/32

CPC分类号： G01N21/53 ,  G01N30/32 ,  G01N2030/207

摘要： A device (100) for detecting a condition in a fluid system (14) and initiating a response based on the condition. The device consists of a sensor (12) that responds to a first and second condition of the fluid (13) in the system and a control means (10) that receives the responses and generates command signals in based on the received response. In a liquid chromatography system, the device is used to determine the volume of components of the fluid system. In addition, the device allow leaks to be detected and permits the fluid in the system to be transported at a optimum speed. The device is well implemented utilizing to a light emitter and light receptor that are sensitive to the fluid in either a gaseous or liquid state.

摘要翻译： 一种用于检测流体系统（14）中的状况并基于该条件启动响应的装置（100）。 该装置包括响应系统中的流体（13）的第一和第二状态的传感器（12）和接收响应的控制装置（10），并基于所接收的响应产生命令信号。 在液相色谱系统中，该装置用于确定流体系统的部件的体积。 此外，该装置允许检测泄漏，并允许系统中的流体以最佳速度被输送。 该装置利用对气体或液态的流体敏感的光发射器和光接收器良好地实现。

公开(公告)号：US09519291B2

公开(公告)日：2016-12-13

申请号：US13511667

申请日：2010-11-11

申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

IPC分类号： G01N30/24 ,  G05D7/06

CPC分类号： G05D7/0676 ,  G01N30/24

摘要： A liquid chromatography system includes an autosampler that prepares a sample for introduction to a solvent stream and a solvent delivery system that delivers a solvent stream to the autosampler. Delivery of the solvent stream occurs in parallel with the autosampler's pre-injection operations. The autosampler starts pre-injection operations to make the sample ready for injection into the mixture stream, and the solvent delivery system starts delivery of a solvent stream to the autosampler. The start of the solvent stream delivery is coordinated with the start of the pre-injection operations such that the solvent stream arrives at the autosampler approximately coincident with when the autosampler completes the pre-injection operations, making the sample ready for injection.

摘要翻译： 液相色谱系统包括制备用于引入溶剂流的样品的自动进样器和将溶剂流输送到自动进样器的溶剂递送系统。 溶剂流的传送与自动进样器的预注射操作并行发生。 自动进样器开始预注射操作，使样品准备好注入混合物流，溶剂输送系统开始将溶剂流输送到自动进样器。 溶剂流输送的开始与预喷射操作的开始协调，使得溶剂流到达自动进样器时与自动进样器完成预喷射操作大致一致，使得样品准备好进行注射。

公开(公告)号：US09289768B2

公开(公告)日：2016-03-22

申请号：US13520189

申请日：2011-01-11

申请人： Joshua A. Shreve ,  James E. Usowicz ,  Miguel Soares

发明人： Joshua A. Shreve ,  James E. Usowicz ,  Miguel Soares

IPC分类号： G01N21/13 ,  B01L7/02 ,  G01N30/72 ,  G01N35/00 ,  G01N35/02

CPC分类号： B01L7/02 ,  B01L2300/0829 ,  B01L2300/1838 ,  G01N30/7233 ,  G01N35/028 ,  G01N2035/00356 ,  G01N2035/00386

摘要： Described is an apparatus for reducing a temperature variation of a liquid chromatography sample. A tray drive using at least one of linear or rotational motion moves a sample tray along a path inside a sample compartment of the liquid chromatography system. A control module coordinates the movement of the sample tray by the tray drive and the movement of a sample needle by a needle drive so that any sample in the sample tray can be injected into the mobile phase of the system during a sample load operation. The tray drive is also used to move the sample tray along the path during a temperature averaging period when no loading occurs. Differences in sample temperatures due to variations in the air temperature at different locations inside the sample compartment are reduced, leading to more accurate and repeatable chromatographic measurement results.

摘要翻译： 描述了一种用于降低液相色谱样品的温度变化的装置。 使用线性或旋转运动中的至少一种的托盘驱动器沿着液相色谱系统的样品室内的路径移动样品盘。 控制模块通过托盘驱动器来协调样品托盘的移动和通过针驱动器移动样品针，使得样品托盘中的任何样品可以在样品加载操作期间被注入到系统的流动相中。 托盘驱动器也可用于在温度平均期间沿着路径移动样品托盘，而不会发生加载。 由于样品室内不同位置的空气温度变化导致的样品温度差异减小，从而导致更精确和可重复的色谱测量结果。

公开(公告)号：US20120304745A1

公开(公告)日：2012-12-06

申请号：US13511667

申请日：2010-11-11

申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

IPC分类号： G01N1/28 ,  G01N30/84

CPC分类号： G05D7/0676 ,  G01N30/24

摘要： A liquid chromatography system includes an autosampler that prepares a sample for introduction to a solvent stream and a solvent delivery system that delivers a solvent stream to the autosampler. Delivery of the solvent stream occurs in parallel with the autosampler's pre-injection operations. The autosampler starts pre-injection operations to make the sample ready for injection into the mixture stream, and the solvent delivery system starts delivery of a solvent stream to the autosampler. The start of the solvent stream delivery is coordinated with the start of the pre-injection operations such that the solvent stream arrives at the autosampler approximately coincident with when the autosampler completes the pre-injection operations, making the sample ready for injection.

摘要翻译： 液相色谱系统包括制备用于引入溶剂流的样品的自动进样器和将溶剂流输送到自动进样器的溶剂递送系统。 溶剂流的传送与自动进样器的预注射操作并行发生。 自动进样器开始预注射操作，使样品准备好注入混合物流，溶剂输送系统开始将溶剂流输送到自动进样器。 溶剂流输送的开始与预喷射操作的开始协调，使得溶剂流到达自动进样器时与自动进样器完成预喷射操作大致一致，使得样品准备好进行注射。