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公开(公告)号：US5423220A
公开(公告)日：1995-06-13
申请号：US10827
申请日：1993-01-29
CPC分类号： G10K11/32 , B06B1/0622 , B06B1/0633 , B06B1/0692 , B06B2201/20 , B06B2201/50 , B06B2201/56 , Y10T29/42
摘要： An ultrasonic transducer array, and a method for manufacturing it, having a plurality of transducer elements aligned along an array axis in an imaging plane. Each transducer element includes a piezoelectric layer and one or more acoustic matching layers. The piezoelectric layer has a concave front surface overlayed by a front electrode and a rear surface overlayed by a rear electrode. The shape of each transducer element is selected such that it is mechanically focused into the imaging plane. A backing support holds the plurality of transducer elements in a predetermined relationship along the array axis such that each element is mechanically focused in the imaging plane.
摘要翻译： 一种超声换能器阵列及其制造方法，具有沿成像平面中的阵列轴排列的多个换能器元件。 每个换能器元件包括压电层和一个或多个声匹配层。 压电层具有由前电极覆盖的凹前表面和由后电极覆盖的后表面。 选择每个换能器元件的形状使得其被机械地聚焦到成像平面中。 背衬支撑件沿着阵列轴将多个换能器元件保持在预定关系中，使得每个元件在成像平面中被机械地聚焦。
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公开(公告)号：US08323201B2
公开(公告)日：2012-12-04
申请号：US12186967
申请日：2008-08-06
CPC分类号： A61B8/4494 , A61B5/7264 , A61B8/0825 , A61B8/13 , A61B8/145 , A61B8/406 , A61B8/4461 , A61B8/4483 , A61B8/483 , A61B8/5207 , A61B8/5253 , A61B2560/0475 , B06B1/0629 , G01S7/52046 , G01S7/52085 , G01S15/892 , G01S15/8925 , G01S15/894 , G01S15/8993 , G10K11/30
摘要： Under one aspect, an ultrasound system for producing a representation of an object includes: a concave transducer array configured to transmit ultrasonic pulses into the object and to receive ultrasonic pulses from the object, the ultrasonic pulses from the object containing structural information about the object, each transducer in the array generating an output signal representative of a portion of the structural information about the object; a multi-focal lens structure for focusing the transmitted ultrasonic pulses; a multiplexing structure in operable communication with the concave transducer array and including logic for coupling the output signals from at least one pair of transducers in the concave transducer array; and a beamformer in operable communication with the multiplexing structure and including logic for constructing a representation of structural information about the object based on the coupled output signals from the multiplexing structure.
摘要翻译： 在一个方面，一种用于产生物体表示的超声系统包括：凹形换能器阵列，被配置为将超声波脉冲发射到物体中并从物体接收超声波脉冲，来自物体的超声波脉冲包含关于物体的结构信息， 阵列中的每个换能器产生代表关于物体的结构信息的一部分的输出信号; 用于聚焦发射的超声波脉冲的多焦点透镜结构; 与所述凹形换能器阵列可操作地通信的多路复用结构，并且包括用于将来自所述凹形换能器阵列中的至少一对换能器的输出信号耦合的逻辑; 以及与多路复用结构可操作地通信的波束形成器，并且包括用于基于来自多路复用结构的耦合输出信号构建关于对象的结构信息的表示的逻辑。
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公开(公告)号：US5469853A
公开(公告)日：1995-11-28
申请号：US264016
申请日：1994-06-22
CPC分类号： A61B10/04 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B2090/378
摘要： A bendable ultrasonic probe useful in endosurgical operations is provided having a therapy channel with a shape that is substantially unaffected by bending of the probe. The probe can be used to convey substantially nonbendable tools to the vicinity of an ultrasonic device that has been repositioned by bending the probe. A sheath is provided having a rigid, self-supporting body portion that may be used with the bendable ultrasonic probe. The sheath may have a therapy channel for conveying surgical tools. Also, the sheath may have a flexible balloon on one end for accommodating the bendable portion of the probe, which is disposed in the flexible balloon.
摘要翻译： 提供了可用于内科手术操作的可弯曲超声波探头，其具有基本上不受探针弯曲影响的形状的治疗通道。 探针可用于将基本上不可弯曲的工具传送到通过弯曲探针重新定位的超声波装置附近。 护套设置有可与可弯曲的超声波探头一起使用的刚性的自支撑主体部分。 护套可以具有用于输送外科手术工具的治疗通道。 此外，护套可以在一端具有柔性气囊，用于容纳设置在柔性气囊中的探针的可弯曲部分。
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4.发明授权
公开(公告)号：US5413107A
公开(公告)日：1995-05-09
申请号：US197327
申请日：1994-02-16
CPC分类号： A61M25/0138 , A61B8/12 , A61B8/445 , A61B8/4461 , A61B8/4483 , A61B8/4488 , A61B8/4494 , A61M25/0136 , A61M25/0147 , G10K11/352
摘要： An articulated ultrasonic probe for endoscopic examination comprises a transducer head, for example, having one or more rows of independently actuable transducer elements extending along the surface of the probe, parallel to the axis thereof. The probe comprises an articulable section while the transducer head is journaled for rotation with respect to the tip of the probe. In use the tip of the probe is juxtaposed to a structure to be examined; the articulated section of the probe and the rotation of the transducer are controlled separately, such that the transducer elements can be juxtaposed to the structure to be examined. A series of angularly-spaced images may be formed by rotation of the transducer about its axis after articulation of the probe.
摘要翻译： 用于内窥镜检查的铰接式超声波探头包括换能器头，例如具有平行于其轴线的沿探针表面延伸的一排或多排可独立致动的换能器元件。 探针包括可铰接部分，同时传感器头部相对于探针的尖端进行轴颈旋转。 在使用中，探针的尖端与待检查的结构并列; 探针的铰接部分和换能器的旋转被单独控制，使得换能器元件可以并置到被检查结构。 一系列角度间隔的图像可以通过在探头的铰接之后围绕其轴线旋转来形成。
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公开(公告)号：US5032393A
公开(公告)日：1991-07-16
申请号：US349999
申请日：1989-05-10
申请人： Stephen J. Douglas , Fiona R. Bird
发明人： Stephen J. Douglas , Fiona R. Bird
IPC分类号： C07D307/52 , A61K20060101 , A61K9/00 , A61K9/18 , A61K31/34 , A61K31/341 , A61K31/78 , A61K47/00 , A61K47/32 , A61K47/48 , A61P1/04 , A61P29/00
CPC分类号： A61K31/34 , A61K47/48184 , A61K9/0056 , Y10S514/974
摘要： The bitter taste of ranitidine may be masked by forming an adsorbate with a synthetic cation exchange resin. The adsorbate is particularly suitable for use in pharmaceutical compositions for oral administration such as chewable or suckable tablets, granules and aqueous or non-aqueous suspensions.
摘要翻译： 雷尼替丁的苦味可以通过用合成阳离子交换树脂形成吸附物来掩蔽。 被吸附物特别适用于口服给药的药物组合物，例如可咀嚼或可吸取的片剂，颗粒剂和水性或非水性悬浮液。
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公开(公告)号：US20090043206A1
公开(公告)日：2009-02-12
申请号：US12186967
申请日：2008-08-06
IPC分类号： A61B8/14
CPC分类号： A61B8/4494 , A61B5/7264 , A61B8/0825 , A61B8/13 , A61B8/145 , A61B8/406 , A61B8/4461 , A61B8/4483 , A61B8/483 , A61B8/5207 , A61B8/5253 , A61B2560/0475 , B06B1/0629 , G01S7/52046 , G01S7/52085 , G01S15/892 , G01S15/8925 , G01S15/894 , G01S15/8993 , G10K11/30
摘要： Under one aspect, an ultrasound system for producing a representation of an object includes: a concave transducer array configured to transmit ultrasonic pulses into the object and to receive ultrasonic pulses from the object, the ultrasonic pulses from the object containing structural information about the object, each transducer in the array generating an output signal representative of a portion of the structural information about the object; a multi-focal lens structure for focusing the transmitted ultrasonic pulses; a multiplexing structure in operable communication with the concave transducer array and including logic for coupling the output signals from at least one pair of transducers in the concave transducer array; and a beamformer in operable communication with the multiplexing structure and including logic for constructing a representation of structural information about the object based on the coupled output signals from the multiplexing structure.
摘要翻译： 在一个方面，一种用于产生物体表示的超声系统包括：凹形换能器阵列，被配置为将超声波脉冲发射到物体中并从物体接收超声波脉冲，来自物体的超声波脉冲包含关于物体的结构信息， 阵列中的每个换能器产生代表关于物体的结构信息的一部分的输出信号; 用于聚焦发射的超声波脉冲的多焦点透镜结构; 与所述凹形换能器阵列可操作地通信的多路复用结构，并且包括用于将来自所述凹形换能器阵列中的至少一对换能器的输出信号耦合的逻辑; 以及与多路复用结构可操作地通信的波束形成器，并且包括用于基于来自多路复用结构的耦合输出信号构建关于对象的结构信息的表示的逻辑。
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公开(公告)号：US5844349A
公开(公告)日：1998-12-01
申请号：US798561
申请日：1997-02-11
摘要： An improved composite ultrasonic transducer, and elements therefor, which may be made autoclavable, and a method of making these elements. A number of planar precursors comprising strips of piezoelectric ceramic material separated from one another by a polymer material are stacked one above another with the ceramic strips aligned with one another, and with electrical conductors disposed between each of the planar precursors. These precursors are then bonded to one another, to form a bonded assembly. The bonded assembly is then slit along parallel lines perpendicular to the direction of elongation of the ceramic strips, subdividing the strips into individual ceramic members and also subdividing the planar conductors, forming ribbon-like conductors extending between opposite sides of the array. The saw kerfs are filled with a hardening polymer material. The ribbon-like conductors reaching the edges of the assembly are then connected electrically in parallel, reducing the capacitance of the individual emitters. Criteria for selection of the materials of the ceramic members, the conductors, and other components of the transducer, and their relative proportions are given which allow the transducer to be steam-autoclavable.
摘要翻译： 一种改进的复合超声波换能器及其元件，其可以进行高压灭菌，以及制造这些元件的方法。 包括通过聚合物材料彼此分离的压电陶瓷材料条的多个平面前体彼此层叠，陶瓷条彼此对准，并且电导体设置在每个平面前体之间。 然后将这些前体彼此结合，形成结合组件。 然后将粘合组件沿着垂直于陶瓷条的伸长方向的平行线切割，将条细分成单独的陶瓷构件，并且还划分平面导体，形成在阵列的相对侧之间延伸的带状导体。 锯切切屑填充有硬化聚合物材料。 到达组件边缘的带状导体然后并联电连接，从而减小各个发射器的电容。 给出用于选择陶瓷构件，导体和换能器的其它部件的材料的标准及其相对比例，其允许换能器被蒸汽高压灭菌。
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公开(公告)号：US5219563A
公开(公告)日：1993-06-15
申请号：US843236
申请日：1992-02-28
申请人： Stephen J. Douglas , Fiona R. Bird
发明人： Stephen J. Douglas , Fiona R. Bird
CPC分类号： A61K9/0056 , A61K31/34 , A61K47/48184 , Y10S514/926 , Y10S514/927 , Y10S514/974
摘要： The bitter taste of ranitidine may be masked by forming an adsorbate with a synthetic cation exchange resin. The adsorbate is particularly suitable for use in pharmaceutical compositions for oral administration such as chewable or suckable tablets, granules and aqueous or non-aqueous suspensions.
摘要翻译： 可以通过用合成阳离子交换树脂形成吸附物来掩蔽雷尼替丁的苦味。 被吸附物特别适用于口服给药的药物组合物，例如可咀嚼或可吸取的片剂，颗粒剂和水性或非水性悬浮液。
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公开(公告)号：US6088894A
公开(公告)日：2000-07-18
申请号：US192600
申请日：1998-11-17
摘要： An improved composite ultrasonic transducer, and elements therefor, which may be made autoclavable, and a method of making these elements. A number of planar precursors comprising strips of piezoelectric ceramic material separated from one another by a polymer material are stacked one above another with the ceramic strips aligned with one another, and with electrical conductors disposed between each of the planar precursors. These precursors are then bonded to one another, to form a bonded assembly. The bonded assembly is then slit along parallel lines perpendicular to the direction of elongation of the ceramic strips, subdividing the strips into individual ceramic members and also subdividing the planar conductors, forming ribbon-like conductors extending between opposite sides of the array. The saw kerfs are filled with a hardening polymer material. The ribbon-like conductors reaching the edges of the assembly are then connected electrically in parallel, reducing the capacitance of the individual emitters. Criteria for selection of the materials of the ceramic members, the conductors, and other components of the transducer, and their relative proportions are given which allow the transducer to be steam-autoclavable.
摘要翻译： 一种改进的复合超声波换能器及其元件，其可以进行高压灭菌，以及制造这些元件的方法。 包括通过聚合物材料彼此分离的压电陶瓷材料条的多个平面前体彼此层叠，陶瓷条彼此对准，并且电导体设置在每个平面前体之间。 然后将这些前体彼此结合，形成结合组件。 然后将粘合组件沿着垂直于陶瓷条的伸长方向的平行线切割，将条细分成单独的陶瓷构件，并且还划分平面导体，形成在阵列的相对侧之间延伸的带状导体。 锯切切屑填充有硬化聚合物材料。 到达组件边缘的带状导体然后并联电连接，从而减小各个发射器的电容。 给出用于选择陶瓷构件，导体和换能器的其它部件的材料的标准及其相对比例，其允许换能器被蒸汽高压灭菌。
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公开(公告)号：US5635200A
公开(公告)日：1997-06-03
申请号：US411828
申请日：1995-04-12
申请人： Stephen J. Douglas , Jill Evans
发明人： Stephen J. Douglas , Jill Evans
CPC分类号： A61K9/0095 , A61K31/34 , A61K9/0056 , A61K9/1617 , A61K9/5015
摘要： This invention relates to a composition which is substantially free of the bitter taste associated with ranitidine and comprises: a) a dispersion of lipid coated particles of ranitidine or a physiologically acceptable salt thereof in a non-aqueous vehicle; b) particles comprising ranitidine or a physiologically acceptable salt thereof incorporated into a core and coated with a lipid coating; c) lipid coated particles of a form of ranitidine which is poorly soluble in water; and processes for the preparation thereof and pharmaceutical compositions thereof.
摘要翻译： PCT No.PCT / EP93 / 02832 Sec。 371日期：1995年4月12日 102（e）1995年4月12日PCT PCT 1993年10月14日PCT公布。 第WO94 / 08576号公报 日本1994年4月28日本发明涉及基本上不含与雷尼替丁相关的苦味的组合物，包括：a）在非水性载体中的雷尼替丁或其生理上可接受的盐的脂质包被颗粒的分散体; b）包含雷尼替丁或其生理上可接受的盐的颗粒，其掺入核心并涂覆有脂质包衣; c）难溶于水的雷尼替丁形式的脂质包衣颗粒; 及其制备方法及其药物组合物。
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