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公开(公告)号：US06359114B1
公开(公告)日：2002-03-19
申请号：US08484740
申请日：1995-06-07
IPC分类号： C07K114
CPC分类号： B01D61/145 , B01J19/0046 , B01J2219/00283 , B01J2219/00355 , B01J2219/00479 , B01J2219/00725 , C07K1/02 , C07K1/34 , C40B40/10 , C40B60/14
摘要： A system is described for conjugating, isolating, and purifying proteins. The system contains an ultrafiltration apparatus which is connected with a reaction vessel reservoir.
摘要翻译： 描述了用于共轭，分离和纯化蛋白质的系统。 该系统包含与反应容器储存器连接的超滤装置。
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2.发明授权Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease 失效用于治疗和预防胃和十二指肠溃疡疾病的免疫原性组合物和方法
公开(公告)号：US5622702A
公开(公告)日：1997-04-22
申请号：US219773
申请日：1994-03-30
CPC分类号： A61K39/0005 , C07K14/595 , C07K16/26 , A61K2039/6037 , A61K2039/627 , C07K2317/34
摘要： Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
摘要翻译： 公开了可用于治疗或预防胃或十二指肠溃疡疾病的免疫原性组合物。 免疫原性组合物通过在受试者中诱导抗体有效地起作用，所述抗体选择性中和特异性肽胃激素并抑制激素与生理受体的结合，从而限制胃酸的分泌。 还公开了包含有效量的免疫原性组合物和使用组合物的治疗方法的药物组合物。
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3.发明授权Method for immunization against and treatment of infection by ectoparasites and endoparasites 失效免疫接种和治疗外寄生虫和内寄生虫感染的方法
公开(公告)号：US4891219A
公开(公告)日：1990-01-02
申请号：US96699
申请日：1987-09-14
CPC分类号： A61K39/0003 , A61K39/44 , A61K47/4833 , A61K2039/6081 , Y10S514/885 , Y10S530/808 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/816
摘要： This invention relates to a method for the active or passive immunization of a vertebrate against ectoparasites and endoparasites, and a method of treating a vertebrate host infected by ectoparasites or endoparasites, comprising administering to the vertebrate an immunogen comprising one or more endocrine products of ectoparasites and endoparasites, coupled with an immunogenic carrier, or administering to the vertebrate, monoclonal antibodies capable of binding to the native form of the endocrine product.
摘要翻译： 本发明涉及一种针对外寄生虫和内寄生虫的脊椎动物的主动或被动免疫的方法，以及一种治疗由外寄生虫或内寄生虫感染的脊椎动物宿主的方法，包括向脊椎动物施用包含一种或多种外寄生物的内分泌产物的免疫原和 与天然形式的内分泌产物结合的免疫原性载体或向脊椎动物施用能够结合天然形式的单克隆抗体的内寄生虫。
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公开(公告)号：US5866128A
公开(公告)日：1999-02-02
申请号：US465546
申请日：1995-06-05
CPC分类号： A61K39/0005 , C07K14/595 , C07K16/26 , A61K2039/6037 , A61K2039/627 , C07K2317/34
摘要： Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
摘要翻译： 公开了可用于治疗或预防胃或十二指肠溃疡疾病的免疫原性组合物。 免疫原性组合物通过在受试者中诱导抗体有效地起作用，所述抗体选择性中和特异性肽胃激素并抑制激素与生理受体的结合，从而限制胃酸的分泌。 还公开了包含有效量的免疫原性组合物和使用组合物的治疗方法的药物组合物。
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5.发明授权Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease 失效用于治疗和预防胃和十二指肠溃疡疾病的免疫原性组合物和方法
公开(公告)号：US5023077A
公开(公告)日：1991-06-11
申请号：US301353
申请日：1989-01-24
IPC分类号： A61K39/00 , C07K14/595 , C07K16/26
CPC分类号： A61K39/0005 , C07K14/595 , C07K16/26 , A61K2039/6037 , A61K2039/627 , C07K2317/34
摘要： Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
摘要翻译： 公开了可用于治疗或预防胃或十二指肠溃疡疾病的免疫原性组合物。 免疫原性组合物通过在受试者中诱导抗体有效地起作用，所述抗体选择性中和特异性肽胃激素并抑制激素与生理受体的结合，从而限制胃酸的分泌。 还公开了包含有效量的免疫原性组合物和使用组合物的治疗方法的药物组合物。
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公开(公告)号：US20120219605A1
公开(公告)日：2012-08-30
申请号：US13505971
申请日：2010-11-05
申请人： Peter Blackburn , Stephen Grimes
发明人： Peter Blackburn , Stephen Grimes
IPC分类号： A61K9/107 , A61J1/00 , A61P31/16 , A61K39/145 , A61P37/04
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/55555 , A61K2039/55566 , A61K2039/58 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： Vaccine compositions comprising influenza antigens formulated as nanoparticulate water in oil miniemulsions. The vaccines may be formulated at the point of use and are useful in emergency response conditions.
摘要翻译： 包含流感抗原的疫苗组合物，其被配制为纳米颗粒水中的微型乳状液。 疫苗可以在使用时配制，并且在紧急反应条件下有用。
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公开(公告)号：US20070066809A1
公开(公告)日：2007-03-22
申请号：US11499261
申请日：2006-08-03
申请人： Stephen Grimes , Ronald Makishima
发明人： Stephen Grimes , Ronald Makishima
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/73 , G01N33/577 , G01N33/74 , G01N2333/595
摘要： The present invention provides monoclonal antibodies (MAbs) selective for the N-termini and C-termini of the gastrin hormone forms, gastrin-17 (G17), glycine-extended gastrin-17 (G17-Gly), gastrin-34 (G34) and glycine-extended gastrin-34 (G34-Gly); and the hybridomas that produce these MAbs. Also provided are panels of MAbs useful for the detection and quantitation of gastrin-17 (G17), glycine-extended gastrin-17 (G17-Gly), gastrin-34 (G34) and glycine-extended gastrin-34 (G34-Gly). These assays are useful for monitoring a gastrin-mediated disease or condition, or for monitoring the progress of a course of therapy. The invention further provides solid phase assays including immunohistochemical (IHC) and immunofluorescence (IF) assays suitable for detection and visualization of gastrin species in solid samples, such as biopsy samples or tissue slices. Pharmaceutical compositions of the MAbs of the invention are also provided, along with methods of diagnosis, prevention and treatment of gastrin-mediated diseases or conditions. Methods of evaluating a gastrin hormone-blocking treatment are described. The course of a gastrin-mediated disease or condition may be monitored in a patient by means of assay methods provided.
摘要翻译： 本发明提供对胃泌素激素形式的N-末端和C-末端选择性的单克隆抗体（MAb），胃泌素-17（G17），甘氨酸延长胃泌素-17（G17-Gly），胃泌素-34（G34） 和甘氨酸延长胃泌素-34（G34-Gly）; 和产生这些MAb的杂交瘤。 还提供了可用于检测和定量胃泌素-17（G17），甘氨酸延长胃泌素-17（G17-Gly），胃泌素-34（G34）和甘氨酸延长胃泌素-34（G34-Gly） 。 这些测定法可用于监测胃泌素介导的疾病或病症，或用于监测治疗过程的进展。 本发明进一步提供固相测定法，包括免疫组织化学（IHC）和免疫荧光（IF）测定法，其适于检测和可视化固体样品例如活检样本或组织切片中的胃泌素种类。 还提供本发明的MAb的药物组合物以及胃泌素介导的疾病或病症的诊断，预防和治疗的方法。 描述了评估胃泌素激素阻断治疗的方法。 胃泌素介导的疾病或病症的过程可以通过提供的测定方法在患者体内监测。
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公开(公告)号：US20070065454A1
公开(公告)日：2007-03-22
申请号：US11489775
申请日：2006-07-20
CPC分类号： A61K38/24 , A61K9/127 , A61K38/09 , A61K38/2207 , A61K38/27 , A61K39/0005 , A61K2039/55555 , A61K2039/6031
摘要： The invention provides liposomal vehicles for encapsulating relatively high levels of water-soluble substances including immunogens directed against gastrin and gonadotropin releasing hormone. The liposome encapsulating large amounts of immunogens can be injected parentally to induce effective immune responses without exhibiting significant adverse tissue reactogenicity.
摘要翻译： 本发明提供用于包封相对高水平的水溶性物质的脂质体载体，包括针对胃泌素和促性腺激素释放激素的免疫原。 包封大量免疫原的脂质体可以亲本注射以诱导有效的免疫应答，而不显示显着的不利组织反应原性。
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9.发明授权公开(公告)号：US09498522B2
公开(公告)日：2016-11-22
申请号：US13057952
申请日：2009-08-06
申请人： Peter Blackburn , Stephen Grimes
发明人： Peter Blackburn , Stephen Grimes
IPC分类号： A61K39/385 , A61K39/39 , A61K39/00
CPC分类号： A61K39/0007 , A61K2039/55566 , A61K2039/6037 , A61K2039/6081 , Y02A50/466
摘要： A safe and effective vaccine to prevent, slow, halt or reverse progression of Alzheimer's disease in human patients is disclosed. The vaccine includes Aβ1-42 or an beta amyloid self epitope (e.g. Aβ1-15, or other 7-mer or 15-mer peptide epitopes derived from Aβ1-42) conjugated to an immunogenic carrier (e.g. DT) formulated in a water-in-oil Th2-biased adjuvant/delivery system.
摘要翻译： 公开了一种安全有效的预防，缓慢，停止或逆转老年痴呆症进展的疫苗。 疫苗包括与在水中配制的免疫原性载体（例如DT）缀合的Aβ1-42或β淀粉样蛋白自身表位（例如Aβ1-15或衍生自Aβ1-42的其他7-聚体或15聚体肽表位） - Th2偏向的辅助/输送系统。
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公开(公告)号：US08808695B2
公开(公告)日：2014-08-19
申请号：US13407321
申请日：2012-02-28
申请人： Stephen Grimes
发明人： Stephen Grimes
IPC分类号： A61K39/395
CPC分类号： G01N33/6893 , A61K2039/505 , C07K16/26 , C07K2317/34 , G01N33/74 , G01N2333/595 , G01N2800/06
摘要： The present invention provides progastrin-binding molecules that are useful therapeutically for passive immunization against progastrin in gastrin-promoted diseases or conditions. The progastrin-binding molecules are specific for progastrin but do not bind gastrin-17(G17), gastrin-34(G34), glycine-extended gastrin-17(G17-Gly) or glycine-extended gastrin-34(G34-Gly). The progastrin-binding molecules include monoclonal antibodies (MAbs) selective for sequences at the N-terminus and the C-terminus of the gastrin precursor molecule, progastrin.
摘要翻译： 本发明提供了促胃泌素结合分子，其可用于胃泌素促进的疾病或病症中针对前胃泌素的被动免疫。 促胃泌素结合分子对泌乳素具有特异性，但不结合胃泌素-17（G17），胃泌素-34（G34），甘氨酸延长胃泌素-17（G17-Gly）或甘氨酸延长胃泌素-34（G34-Gly） 。 促胃泌素结合分子包括对胃泌素前体分子的N-末端和C-末端的序列选择性的单克隆抗体（MAb），前肽原。
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