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公开(公告)号:US08465741B2
公开(公告)日:2013-06-18
申请号:US11855943
申请日:2007-09-14
申请人: Gerhard Frey , Bruce E. Kimmel , Abraham Anderson
发明人: Gerhard Frey , Bruce E. Kimmel , Abraham Anderson
IPC分类号: A61K39/395 , C07K16/28 , C07K16/30 , C07K16/18
CPC分类号: C07K16/2887 , C07K16/2803 , C07K16/2809 , C07K2317/24 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要: The invention provides antibodies, including chimeric human antibodies, recombinant antibodies, synthetic antibodies, and the nucleic acids encoding them, and methods for making and using these immunoglobulins. The invention provides recombinant and synthetic polypeptide and nucleic acid embodiments of these polypeptides and/or antibodies. The invention also provides polypeptides comprising, or consisting of, consensus human framework regions, or “Independently Consensused Frameworks (ICFs)”, nucleic acids encoding them, and libraries and kits comprising these ICFs and/or antibodies of the invention, individually and in combinatorial libraries and combinations.
摘要翻译: 本发明提供抗体,包括嵌合人抗体,重组抗体,合成抗体和编码它们的核酸,以及制备和使用这些免疫球蛋白的方法。 本发明提供这些多肽和/或抗体的重组和合成多肽和核酸实施方案。 本发明还提供了包含共有人框架区或“独立共有框架(ICF)”的编码它们的核酸或包含本发明的这些ICF和/或抗体的文库和试剂盒的多肽,并且组合的多肽 图书馆和组合。
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公开(公告)号:US20120142890A1
公开(公告)日:2012-06-07
申请号:US11928106
申请日:2007-10-30
申请人: Roberto MARIANI , Bruce E. KIMMEL
发明人: Roberto MARIANI , Bruce E. KIMMEL
IPC分类号: C07K19/00
CPC分类号: C07K14/47
摘要: Modified biosynthetic polypeptide fusion inhibitors, methods for manufacturing, and uses thereof are provided.
摘要翻译: 提供了修饰的生物合成多肽融合抑制剂,制备方法及其用途。
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公开(公告)号:US20100104553A1
公开(公告)日:2010-04-29
申请号:US11855943
申请日:2007-09-14
申请人: Gerhard FREY , Bruce E. Kimmel , Abraham Anderson
发明人: Gerhard FREY , Bruce E. Kimmel , Abraham Anderson
IPC分类号: A61K39/395 , C07K16/00 , A61P31/00 , A61P37/06 , A61P35/00
CPC分类号: C07K16/2887 , C07K16/2803 , C07K16/2809 , C07K2317/24 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要: The invention provides antibodies, including chimeric human antibodies, recombinant antibodies, synthetic antibodies, and the nucleic acids encoding them, and methods for making and using these immunoglobulins. The invention provides recombinant and synthetic polypeptide and nucleic acid embodiments of these polypeptides and/or antibodies. The invention also provides polypeptides comprising, or consisting of, consensus human framework regions, or “Independently Consensused Frameworks (ICFs)”, nucleic acids encoding them, and libraries and kits comprising these ICFs and/or antibodies of the invention, individually and in combinatorial libraries and combinations.
摘要翻译: 本发明提供抗体,包括嵌合人抗体,重组抗体,合成抗体和编码它们的核酸,以及制备和使用这些免疫球蛋白的方法。 本发明提供这些多肽和/或抗体的重组和合成多肽和核酸实施方案。 本发明还提供了包含共有人框架区或“独立共有框架(ICF)”的编码它们的核酸或包含本发明的这些ICF和/或抗体的文库和试剂盒的多肽,并且组合的多肽 图书馆和组合。
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公开(公告)号:US09175083B2
公开(公告)日:2015-11-03
申请号:US11873372
申请日:2007-10-16
申请人: Ho Sung Cho , Thomas O. Daniel , Troy E. Wilson , Thomas P. Cujec , Feng Tian , Anna-Maria A. Hays , Bruce E. Kimmel , Lillian Ho
发明人: Ho Sung Cho , Thomas O. Daniel , Troy E. Wilson , Thomas P. Cujec , Feng Tian , Anna-Maria A. Hays , Bruce E. Kimmel , Lillian Ho
IPC分类号: C07K16/28 , C07K14/195 , C07K14/47 , C07K16/32
CPC分类号: C07K16/2863 , C07K14/195 , C07K14/47 , C07K16/32 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/622
摘要: Novel antigen-binding polypeptides (ABP) and uses thereof are provided.
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公开(公告)号:US08945550B2
公开(公告)日:2015-02-03
申请号:US12487422
申请日:2009-06-18
申请人: Gerhard Frey , Bruce E. Kimmel , Abraham Anderson
发明人: Gerhard Frey , Bruce E. Kimmel , Abraham Anderson
IPC分类号: A61K39/395
CPC分类号: C07K16/2887 , C07K16/2803 , C07K16/2809 , C07K2317/24 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要: The invention provides antibodies, including chimeric human antibodies, recombinant antibodies, synthetic anti-bodies, and the nucleic acids encoding them, and methods for making and using these immunoglobulins. The invention provides recombinant and synthetic polypeptide and nucleic acid embodiments of these polypeptides and/or antibodies. The invention also provides polypeptides comprising, or consisting of, consensus human framework regions, or “Independently Consensused Frameworks (ICFs)”, nucleic acids encoding them, and libraries and kits comprising these ICFs and/or antibodies of the invention, individually and in combinatorial libraries and combinations.
摘要翻译: 本发明提供抗体,包括嵌合人抗体,重组抗体,合成抗体和编码它们的核酸,以及制备和使用这些免疫球蛋白的方法。 本发明提供这些多肽和/或抗体的重组和合成多肽和核酸实施方案。 本发明还提供了包含共有人框架区或“独立共有框架(ICF)”的编码它们的核酸或包含本发明的这些ICF和/或抗体的文库和试剂盒的多肽,并且组合的多肽 图书馆和组合。
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公开(公告)号:US08093356B2
公开(公告)日:2012-01-10
申请号:US11925337
申请日:2007-10-26
申请人: Anna-Maria A. Hays , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
发明人: Anna-Maria A. Hays , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
CPC分类号: C07K14/555 , A61K38/00 , C07K14/56
摘要: Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids.
摘要翻译: 提供了修饰的人干扰素多肽及其用途,包括具有一个或多个非天然编码氨基酸的聚乙二醇化人干扰素多肽。
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7.
公开(公告)号:US07638299B2
公开(公告)日:2009-12-29
申请号:US11187687
申请日:2005-07-21
申请人: Ho Sung Cho , Thomas O. Daniel , Anna-Maria Hays , Troy E. Wilson , David C. Litzinger , Roberto Mariani , Bruce E. Kimmel , William M. Keefe
发明人: Ho Sung Cho , Thomas O. Daniel , Anna-Maria Hays , Troy E. Wilson , David C. Litzinger , Roberto Mariani , Bruce E. Kimmel , William M. Keefe
CPC分类号: C07K14/005 , C07K14/575 , C07K14/57563 , C07K14/605 , C07K2319/02 , C07K2319/20 , C12N15/62 , C12N2740/16122
摘要: Modified biosynthetic polypeptide molecules, methods for manufacturing, and uses thereof are provided.
摘要翻译: 提供了修饰的生物合成多肽分子,制备方法及其用途。
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公开(公告)号:US07632924B2
公开(公告)日:2009-12-15
申请号:US11155909
申请日:2005-06-17
申请人: Ho Sung Cho , Thomas O. Daniel , Troy E. Wilson , Thomas P. Cujec , Feng Tian , Anna-Maria Hays , Bruce E. Kimmel , Lillian Ho
发明人: Ho Sung Cho , Thomas O. Daniel , Troy E. Wilson , Thomas P. Cujec , Feng Tian , Anna-Maria Hays , Bruce E. Kimmel , Lillian Ho
IPC分类号: C12P21/08
CPC分类号: C07K16/2863 , C07K14/195 , C07K14/47 , C07K16/32 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/622
摘要: Novel antigen-binding polypeptides (ABP) and uses thereof are provided.
摘要翻译: 提供了新的抗原结合多肽(ABP)及其用途。
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公开(公告)号:US20080119640A1
公开(公告)日:2008-05-22
申请号:US11925275
申请日:2007-10-26
申请人: Anna-Maria A. HAYS , Bruce E. KIMMEL , Ho Sung CHO , Bee-Cheng SIM , David C. LITZINGER , Roberto MARIANI , Vadim KRAYNOV , Nick Knudsen , Thomas O. DANIEL , Alan KODER , Stuart BUSSELL , Junjie LIU , Zhenwei MIAO , Theresa MORROW
发明人: Anna-Maria A. HAYS , Bruce E. KIMMEL , Ho Sung CHO , Bee-Cheng SIM , David C. LITZINGER , Roberto MARIANI , Vadim KRAYNOV , Nick Knudsen , Thomas O. DANIEL , Alan KODER , Stuart BUSSELL , Junjie LIU , Zhenwei MIAO , Theresa MORROW
IPC分类号: C07K14/555
CPC分类号: C07K14/555 , A61K38/00 , C07K14/56
摘要: Modified human interferon polypeptides and uses thereof are provided.
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公开(公告)号:US20100135959A1
公开(公告)日:2010-06-03
申请号:US11916026
申请日:2006-06-02
申请人: Anna-Maria A. Hays Putnam , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
发明人: Anna-Maria A. Hays Putnam , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
CPC分类号: C07K14/555 , A61K38/00 , C07K14/56
摘要: Modified human interferon polypeptides and uses thereof are provided.
摘要翻译: 提供了修饰的人干扰素多肽及其用途。
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